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Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： Daniel adam Felix Langerscheidt Hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

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深圳湾超级总部基地城市设计

建筑实践 2020年第1期 62-65页

作者： Claude Godefroy Elva Tang Hannah Zhang Richard Wood Thomas Bormann Adrian Fong adam busko Kasia Piekarczyk Isabelle Lee Elaine Tsang Fai Lam Jess Yu Henning Larsen建筑事务所

地点:广东省深圳市Location:Shenzhen, Guangdong Province深圳湾超级总部基地将成为粤港澳大湾区发展的关键核心。大湾区作为世界最大的湾区经济中心,拥有超过7,000万人口,包括了深圳、广州、香港、澳门等重要城市。为了确立深圳在粤... 详细信息

地点:广东省深圳市Location:Shenzhen, Guangdong Province深圳湾超级总部基地将成为粤港澳大湾区发展的关键核心。大湾区作为世界最大的湾区经济中心,拥有超过7,000万人口,包括了深圳、广州、香港、澳门等重要城市。为了确立深圳在粤港澳大湾区和科技创新领域的核心地位,Henning Larsen设想的深圳湾总体规划,将转变中国城市规划范式,并成为未来绿色城市、可持续建筑和宜居城市的范例。深圳现有的商务中心都与海滨相距甚远,而深圳湾超级总部的地理位置优势,将重新联系在过去处于分裂状态的城市与海洋。为了使深圳回归真正的滨水城市,打造吸

关键词：深圳湾总部基地城市设计中央峡谷总体规划

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng adam M.R.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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提尔皮茨博物馆

城市环境设计 2019年第2期118卷 128-141页

作者： David Zahle Andreas K.Pedersen Snorre Emanuel Nash J?rgensen Michael Andersen Hugo Soo Marcella Martinez Geoffrey Eberle adam busko Hanna Johansson Jakob Andreassen Charlotte Cocco Mikkel Marcker Stubgaard Michael Sch?nemann Jensen Alejandro Mata Gonzales Kyle Thomas David Tousant Jesper Boye Andersen Alberte Danvig Jan Magasanik Enea Michelesio Alina Tamosiunaite Ryohei Koike Brigitta Gulyás Katarzyna Krystyna Siedlecka Andrea Scalco Tobias Hjortdal Maria Teresa Fernandez Rojo Rasmus Hjortshoj 运小红

新落成的提尔皮茨博物馆是沙漠中的一处庇佑所,它的存在就像是对曾经发生在丹麦西海岸的战争历史的一次平静的隔空对话。这座面积为2 800m2的"隐形博物馆"开创性地将德国二战时期的战壕延伸转变为一个文化容器,其中的四个展厅,运用简单... 详细信息

新落成的提尔皮茨博物馆是沙漠中的一处庇佑所,它的存在就像是对曾经发生在丹麦西海岸的战争历史的一次平静的隔空对话。这座面积为2 800m2的"隐形博物馆"开创性地将德国二战时期的战壕延伸转变为一个文化容器,其中的四个展厅,运用简单的结构体系无缝嵌入大地。初到这里,参观者首先将看到的是原有的战壕,直到他们穿过荒草丛生的小径,才会渐渐感知这些深深刻入沙丘的墙体,从各个方向

关键词：卫生间博物馆群 Section 提尔皮茨

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典型草原两种菊科植物生长对道路建设的响应

生态学报 2025年

作者：王星奇赵欣周 GULRAIZ Ahmad 张育文李佳欣 BHARELDIN adam MERGA Daba Tuli 侯扶江草种创新与草地农业生态系统全国重点实验室兰州大学草地农业科技学院国家林业草原局西北退化草原生态修复与利用工程技术研究中心农业农村部草牧业创新重点实验室

近几十年来，由于道路网络的扩张和城市化的蓬勃发展，道路建设对典型草原的影响引起了广泛的关注。然而，道路类型和距离对植物种群生长的综合影响仍然知之甚少。因此，本研究以陇东黄土高原微温微干典型草原为研究对象，探讨了道路建... 详细信息

近几十年来，由于道路网络的扩张和城市化的蓬勃发展，道路建设对典型草原的影响引起了广泛的关注。然而，道路类型和距离对植物种群生长的综合影响仍然知之甚少。因此，本研究以陇东黄土高原微温微干典型草原为研究对象，探讨了道路建设（道路类型、距离）对菊科优势种茵陈蒿（Artemisia capillaris）和伴生种阿尔泰狗娃花（Aster altaicus）生长繁殖影响的驱动因素及其作用机制。结果表明，道路建设促进茵陈蒿的横向生长和无性繁殖，促进阿尔泰狗娃花的垂直生长和有性繁殖。阿尔泰狗娃花具有更强的更新潜力。普通公路茵陈蒿和阿尔泰狗娃花的地上生物量分别比其它两种道路平均高49%和27%，因此其对普通公路建设的响应更加敏感。此外，道路建设主要通过影响土壤进一步影响两个种群的地上生物量在群落中的占比。阿尔泰狗娃花的地上生物量及其在群落中的占比在距离20—35 m的范围存在明显阈值。因此需要注意将此范围内的植被保护和恢复措施与道路管理动态结合，影响植物生长繁殖，调控群落构建过程，以应对道路建设对种群和群落关系扰动的巨大挑战。

关键词：道路建设道路生态地上生物量生长权衡繁殖策略种间关系

Solid rocket propulsion technology for de-orbiting spacecraft

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Chinese Journal of Aeronautics 2022年第3期35卷 128-154页

作者： adam OKNINSKI Center of Space Technologies Lukasiewicz Research Network-Institute of AviationWarsaw 02-256Poland

This paper presents the topic of using solid rocket propulsion for de-orbiting spacecraft,in order to fulfil space debris mitigation *** benefits and disadvantages of using such means are discussed.A dedicated system can be implemented in the satellite design phase and shall be a key subsystem of platforms inserted into ***,semi-controlled and controlled de-orbit can be completed using solid rocket *** impact on the space debris environment is *** requirements for dedicated propellants and systems are *** the majority of presently developed rocket systems worldwide require high burn rates,several applications,including de-orbiting,benefit from solid propellants with decreased regression *** allows limiting spacecraft accelerations and loads during de-orbit ***,the requirement of minimising solid particle generation is *** technology from the Mercury and Gemini human spaceflight programmes,where de-orbit motors were used,is *** Soviet,American and Chinese film-return-capsule solid propellant retrorockets,enabling deorbit,are also presented.A detailed survey of current work worldwide on end-of-life disposal using solid propulsion is *** of developing dedicated systems are ***,an outlook on solid rocket motor utilisation for space debris mitigation is provided.

关键词： De-orbit De-orbiting technology End-of-life disposal Satellite propulsion system development Solid propellant Solid rocket motor Space debris mitigation Space traffic management

Enhanced photoluminescence of a microporous quantum dot color conversion layer by inkjet printing

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Nano Research 2024年第8期17卷 7717-7725页

作者： Junchi Chen Qihao Jin Yidenekachew.J.Donie Orlando.T.Perales Dmitry busko Bryce.S.Richards Uli Lemmer Light Technology Institute(LTI) Karlsruhe Institute of Technology(KIT)Engesserstrasse 1376131 KarlsruheGermany Department of Chemical Engineering and Materials Science University of Minnesota(UMN)421 Washington Ave.SEMinneapolisMN 55455-0132USA Institute for Microstructure Technology Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtz-Platz 176344 Eggenstein-LeopoldshafenGermany

Owing to their high color purity,tunable bandgap,and high efficiency,quantum dots(QDs)have gained significant attention as color conversion materials for high-end display ***,inkjet-printed QD pixels show great potential for realizing full-color mini/micro-light emitting diode(micro-LED)-based *** a color conversion layer,the photoluminescence intensity of QDs is limited by the insufficient absorptance of the excitation light due to the lack of *** scatterers,such as titanium dioxide microparticles,have been applied after additional surface engineering for sufficient dispersity to prevent nozzle clogging in inkjet printing *** our work,as an alternative approach,we use inkjet printing for depositing a phase separating polymer ink based on polystyrene(PS)and polyethylene glycol(PEG).QD/polymer composite pixels with scattering micropores are *** morphology of the micropores can be tailored by the weight ratio between PS and PEG which enables the manipulation of scattering *** the presence of the microporous structure,the photoluminescence intensity of the QD film is enhanced by 110%in drop-cast films and by 35.3%in inkjet-printed QD pixel arrays compared to the reference samples.

关键词： porous structure inkjet printing phase separation quantum dots display technology

Proactive interburden fracturing using UIS drilling with validation monitoring

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International Journal of Mining Science and Technology 2021年第1期31卷 3-7页

作者： adam Lines Anglo American Grosvenor MineMoranbah 4744Australia

A series of gas inrush events occurred during development at Grosvenor Mine resulting in exposure to elevated levels of methane at the production face.A total of 22 gas inrush events occurred,with between 15 and 130 m3 of methane released during each *** presence of an undrained seam in the immediate floor,geotechnical characteristics of the floor,and the stress environment all contributed to these dynamic floor events,while the geological characteristics of the seam below,such as the seam thickness and ash content of 75%,prevented effective ***,events only occurred in headings mined parallel to the principal horizontal stress *** cut-throughs(C/T)perpendicular to the principal stress direction no events occurred,and higher methane levels were observed at the production *** solution to preventing the gas inrush events involved creating a conduit in the interburden between the mined seam and the seam in the immediate floor to allow the gas to be drained during the development of the headings,as occurred in the cut-throughs(cut-through and cross-cut are regional terms that are analogous).A series of underground inseam(UIS)holes were drilled using the directional drill rig with the aim of fracturing this interburden ahead of the face and promote floor failure to allow the gas to release *** floor fracturing was conducted using water pressure generated from a longwall salvage pump,with the current UIS drilling equipment retrofitted with a series of subs,packers and a fracturing *** packers and the fracturing tool were shifted to desired locations along the drilled UIS borehole to achieve the required *** fractures were monitored using a proving hole and with a HYDAC data logger attached to the salvage pack,with the results analysed on the surface to ensure connectivity to the working seam.

关键词： Gas drainage Floor fracking UIS drilling

Distributional Considerations for Transboundary Risk Governance of Environmental Threats

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International Journal of Disaster Risk Science 2018年第4期9卷 445-453页

作者： adam Rose Price School of Public Policy University of Southern California

Most policy analyses of both short-term and long-term disasters focus on aggregate impacts of their costs and the benefits of policy remedies. Distributional considerations relating to the costs of these disasters and the benefits of their risk management, however, are very important in many cases. This article examines two broad categories of cases in terms of distributional considerations. The first category is where transboundary considerations strongly affect risk governance, as in the case of climate change. The second relates to ordinary, short-term disasters, which include fewer, but still important, transboundary issues. Climate change policy requires information regarding the distribution of impacts and policy responses across countries because it is a global *** disasters involve transboundary considerations much less frequently, so the attention typically shifts to the distribution of benefits and costs within a jurisdiction. In both cases distributional information is needed to evaluate the equity of policies and to provide information for public participation in the policy process. This article offers modeling and policy approaches to address these issues.

关键词： Climate change Disasters Distributional effects Policy analysis Risk governance Transboundary impacts