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COVID-19 vaccine-associated myocarditis

World Journal of Cardiology 2022年第7期14卷 382-391页

作者： Michael C Morgan Lavannya Atri Sean Harrell Wael Al-Jaroudi adam berman Division of Cardiology Medical College of GeorgiaAugustaGA 30912United States Baptist Heart Baptist Medical CenterJacksonMS 39202United States Department of Population Health Sciences Medical College of GeorgiaAugustaGA 30912United States

Myocarditis is now recognized as a rare complication of coronavirus disease 2019(COVID-19)mRNA vaccination,particularly in adolescent and young adult *** the authorization of the Pfizer-BioNTech^(TM)and Moderna^(TM)mRNA vaccines targeting the severe acute respiratory syndrome coronavirus-2(SARSCoV-2)spike protein,the Centers for Disease Control and Prevention(CDC)has reported 1175 confirmed cases of myocarditis after COVID-19 vaccination in individuals ages 30 years and younger as of January *** to CDC data in June 2021,the incidence of vaccine-mediated myocarditis in males ages 12-29 years old was estimated to be 40.6 cases per million second doses of COVID-19 mRNA vaccination *** with cases of COVID-19 vaccinemediated myocarditis typically present with acute chest pain and elevated serum troponin levels,often within one week of receiving the second dose of mRNA COVID-19 *** cases follow a benign clinical course with prompt resolution of *** mechanisms of COVID-19 vaccine myocarditis include molecular mimicry between SARS-CoV-2 spike protein and self-antigens and the triggering of preexisting dysregulated immune pathways in predisposed *** higher incidence of COVID-19 vaccine myocarditis in young males may be explained by testosterone and its role in modulating the immune response in *** is limited data on long-term outcomes in these cases given the recency of their *** CDC continues to recommend COVID-19 vaccination for everyone 5 years of age and older given the greater risk of serious complications related to natural COVID-19 infection including hospitalization,multisystem organ dysfunction,and *** study is needed to better understand the immunopathology and long-term outcomes behind COVID-19 mRNA vaccine-mediated myocarditis.

关键词： COVID-19 SARS-CoV-2 mRNA vaccine Myocarditis Pericarditis

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Role of cardiac magnetic resonance imaging in the diagnosis and management of COVID-19 related myocarditis: Clinical and imaging considerations

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World Journal of Radiology 2021年第9期13卷 283-293页

作者： Lavannya Atri Michael Morgan Sean Harrell Wael AlJaroudi adam E berman Division of Cardiology Medical College of GeorgiaAugusta UniversityAugustaGA 30912United States Division of Health Policy Medical College of GeorgiaAugusta UniversityAugustaGA 30912United States Division of Health Economics and Modeling Medical College of GeorgiaAugusta UniversityAugustaGA 30912United States

There is a growing evidence of cardiovascular complications in coronavirusdisease 2019 (COVID-19) patients. As evidence accumulated of COVID-19 mediatedinflammatory effects on the myocardium, substantial attention has beendirected towards cardiovascular imaging modalities that facilitate this *** magnetic resonance imaging (CMRI) is the gold standard for thedetection of structural and functional myocardial alterations and its role inidentifying patients with COVID-19 mediated cardiac injury is growing. Despiteits utility in the diagnosis of myocardial injury in this population, CMRI’s impacton patient management is still evolving. This review provides a framework for theuse of CMRI in diagnosis and management of COVID-19 patients from theperspective of a cardiologist. We review the role of CMRI in the management ofboth the acutely and remotely COVID-19 infected patient. We discuss patientselection for this imaging modality;T1, T2, and late gadolinium enhancementimaging techniques;and previously described CMRI findings in other cardiomyopathieswith potential implications in COVID-19 recovered patients.

关键词： Cardiac magnetic resonance imaging COVID-19 Cardiovascular magnetic resonance Myocarditis Coronavirus Cardiovascular complications

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Status and prospects for symmetric organic redox flow batteries

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Journal of Energy Chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan C.adam Dyker Department of Chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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Amyloid-β-induced disruption of axon-initial-segment mitochondria localization:consequences for TAU missorting in Alzheimer's disease pathology

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Neural Regeneration Research 2025年第5期20卷 1407-1408页

作者： Daniel adam Felix Langerscheidt Hans Zempel Institute of Human Genetics University Hospital CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany

TAU is a neuronal microtubule-associated protein preferentially located in *** a battery of neurodegenerative diseases termed"tauopathies,"including Alzheimer's disease (AD),TAU is missorted and abnormally phosphorylated,leading to filamentous accumulations of hyperphosphorylated TAU,a pathological hallmark and potential disease driver of AD and related tauopathies (Zempel,2024).

关键词： Alzheimer tau diseases

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng adam M.R.Groh Moein Yaqubi Qiao-Ling Cui Jo Anne Stratton G.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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典型草原两种菊科植物生长对道路建设的响应

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生态学报 2025年

作者：王星奇赵欣周 GULRAIZ Ahmad 张育文李佳欣 BHARELDIN adam MERGA Daba Tuli 侯扶江草种创新与草地农业生态系统全国重点实验室兰州大学草地农业科技学院国家林业草原局西北退化草原生态修复与利用工程技术研究中心农业农村部草牧业创新重点实验室

近几十年来，由于道路网络的扩张和城市化的蓬勃发展，道路建设对典型草原的影响引起了广泛的关注。然而，道路类型和距离对植物种群生长的综合影响仍然知之甚少。因此，本研究以陇东黄土高原微温微干典型草原为研究对象，探讨了道路建... 详细信息

近几十年来，由于道路网络的扩张和城市化的蓬勃发展，道路建设对典型草原的影响引起了广泛的关注。然而，道路类型和距离对植物种群生长的综合影响仍然知之甚少。因此，本研究以陇东黄土高原微温微干典型草原为研究对象，探讨了道路建设（道路类型、距离）对菊科优势种茵陈蒿（Artemisia capillaris）和伴生种阿尔泰狗娃花（Aster altaicus）生长繁殖影响的驱动因素及其作用机制。结果表明，道路建设促进茵陈蒿的横向生长和无性繁殖，促进阿尔泰狗娃花的垂直生长和有性繁殖。阿尔泰狗娃花具有更强的更新潜力。普通公路茵陈蒿和阿尔泰狗娃花的地上生物量分别比其它两种道路平均高49%和27%，因此其对普通公路建设的响应更加敏感。此外，道路建设主要通过影响土壤进一步影响两个种群的地上生物量在群落中的占比。阿尔泰狗娃花的地上生物量及其在群落中的占比在距离20—35 m的范围存在明显阈值。因此需要注意将此范围内的植被保护和恢复措施与道路管理动态结合，影响植物生长繁殖，调控群落构建过程，以应对道路建设对种群和群落关系扰动的巨大挑战。

关键词：道路建设道路生态地上生物量生长权衡繁殖策略种间关系

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Solid rocket propulsion technology for de-orbiting spacecraft

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Chinese Journal of Aeronautics 2022年第3期35卷 128-154页

作者： adam OKNINSKI Center of Space Technologies Lukasiewicz Research Network-Institute of AviationWarsaw 02-256Poland

This paper presents the topic of using solid rocket propulsion for de-orbiting spacecraft,in order to fulfil space debris mitigation *** benefits and disadvantages of using such means are discussed.A dedicated system can be implemented in the satellite design phase and shall be a key subsystem of platforms inserted into ***,semi-controlled and controlled de-orbit can be completed using solid rocket *** impact on the space debris environment is *** requirements for dedicated propellants and systems are *** the majority of presently developed rocket systems worldwide require high burn rates,several applications,including de-orbiting,benefit from solid propellants with decreased regression *** allows limiting spacecraft accelerations and loads during de-orbit ***,the requirement of minimising solid particle generation is *** technology from the Mercury and Gemini human spaceflight programmes,where de-orbit motors were used,is *** Soviet,American and Chinese film-return-capsule solid propellant retrorockets,enabling deorbit,are also presented.A detailed survey of current work worldwide on end-of-life disposal using solid propulsion is *** of developing dedicated systems are ***,an outlook on solid rocket motor utilisation for space debris mitigation is provided.

关键词： De-orbit De-orbiting technology End-of-life disposal Satellite propulsion system development Solid propellant Solid rocket motor Space debris mitigation Space traffic management

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Proactive interburden fracturing using UIS drilling with validation monitoring

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International Journal of Mining Science and Technology 2021年第1期31卷 3-7页

作者： adam Lines Anglo American Grosvenor MineMoranbah 4744Australia

A series of gas inrush events occurred during development at Grosvenor Mine resulting in exposure to elevated levels of methane at the production face.A total of 22 gas inrush events occurred,with between 15 and 130 m3 of methane released during each *** presence of an undrained seam in the immediate floor,geotechnical characteristics of the floor,and the stress environment all contributed to these dynamic floor events,while the geological characteristics of the seam below,such as the seam thickness and ash content of 75%,prevented effective ***,events only occurred in headings mined parallel to the principal horizontal stress *** cut-throughs(C/T)perpendicular to the principal stress direction no events occurred,and higher methane levels were observed at the production *** solution to preventing the gas inrush events involved creating a conduit in the interburden between the mined seam and the seam in the immediate floor to allow the gas to be drained during the development of the headings,as occurred in the cut-throughs(cut-through and cross-cut are regional terms that are analogous).A series of underground inseam(UIS)holes were drilled using the directional drill rig with the aim of fracturing this interburden ahead of the face and promote floor failure to allow the gas to release *** floor fracturing was conducted using water pressure generated from a longwall salvage pump,with the current UIS drilling equipment retrofitted with a series of subs,packers and a fracturing *** packers and the fracturing tool were shifted to desired locations along the drilled UIS borehole to achieve the required *** fractures were monitored using a proving hole and with a HYDAC data logger attached to the salvage pack,with the results analysed on the surface to ensure connectivity to the working seam.

关键词： Gas drainage Floor fracking UIS drilling

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Distributional Considerations for Transboundary Risk Governance of Environmental Threats

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International Journal of Disaster Risk Science 2018年第4期9卷 445-453页

作者： adam Rose Price School of Public Policy University of Southern California

Most policy analyses of both short-term and long-term disasters focus on aggregate impacts of their costs and the benefits of policy remedies. Distributional considerations relating to the costs of these disasters and the benefits of their risk management, however, are very important in many cases. This article examines two broad categories of cases in terms of distributional considerations. The first category is where transboundary considerations strongly affect risk governance, as in the case of climate change. The second relates to ordinary, short-term disasters, which include fewer, but still important, transboundary issues. Climate change policy requires information regarding the distribution of impacts and policy responses across countries because it is a global *** disasters involve transboundary considerations much less frequently, so the attention typically shifts to the distribution of benefits and costs within a jurisdiction. In both cases distributional information is needed to evaluate the equity of policies and to provide information for public participation in the policy process. This article offers modeling and policy approaches to address these issues.

关键词： Climate change Disasters Distributional effects Policy analysis Risk governance Transboundary impacts

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Protection of armoured vehicles against chemical, biological and radiological contamination

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Defence Technology（防务技术） 2021年第2期17卷 384-392页

作者： adam Wisniewski Jacek Pirszel Military Institute of Armament Technology Wyszynskiego 705-220ZielonkaPoland Military Institute of Chemistry and Radiometry al.gen.Antoniego Chrusciela“Montera”10500-910WarszawaPoland

The article presents problems related to mechanical protection of vehicles with different add-on armours against chemical,biological and radiological *** applies to vehicles with additional passive,reactive and hybrid protection in the form of cassettes against piercing with anti-tank projectiles,piercing with their kinetic energy of impact,and as a result of chemical energy of shaped charges as well as explosively formed *** has been shown how increased ballistic protection of these vehicles at the same time reduces their decontaminability in various places of the vehicle due to the increased additional surface of the vehicle with *** of contamination of these cassettes has been presented as a way of reducing hard to reach surface for decontamination and a method of insulating construction elements(stands),fixing these cassettes to the vehicle,from the environment to prevent contact with contaminated liquids and *** selection of appropriate materials is shown,which may affect the improvement of the decontamination efficiency of the vehicle with such *** applies to the use of materials with low absorption of chemical warfare agents,which prevent the accumulation of large amounts of these agents on contaminated surfaces and improve the effectiveness of *** also shows how to ensure better access of the disinfectant to as much of the vehicle surface as possible,covered with cassettes that have been *** shows how a vehicle,in particular with such cassettes,can provide protection against radar detection when Radar Absorbent Material is used on vehicle cassettes.

关键词： Protection of ERA CBR defence Chemical warfare agents Vehicle decontamination Radar absorbent material Additive manufacturing

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