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Schwann-like adipose-derived stem cells as a promising therapeutic tool for peripheral nerve regeneration:effects of cholinergic stimulation

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Neural Regeneration Research 2021年第6期16卷 1218-1220页

作者： Roberta Piovesana Alessandro Faroni Ada maria Tata adam J.reid Department of Biology and Biotechnologies“Charles Darwin” SapienzaUniversity of RomeRomeItaly Blond mcIndoe Laboratories Division of Cell Matrix Biology and Regenerative MedicineSchool of Biological SciencesFaculty of BiologyMedicine and HealthThe University of ManchesterManchester Academic Health Science CentreManchesterUK Research Centre of Neurobiology“Daniel Bovet” SapienzaUniversity of RomeRomeItaly Department of Plastic Surgery&Burns Wythenshawe HospitalManchester University NHS Foundation TrustManchester Academic Health Science CentreManchesterUK

Schwann-like adipose-derived stem cells and nerve injury:Peripheral nerve injuries(PNIs)are a common clinical problem usually as a consequence of *** optimal surgical management,PNI has a lifelong impact on function and wellbeing of the *** peripheral nervous system(PNS)has regenerative capability,in contrast to the central nervous system(CNS),and is dependent on the plasticity of the peripheral glia,Schwann cells(SCs).Despite this regenerative capability,PNI recovery of sensorial and motor function is always incomplete causing pain,cold intolerance,paralysis and impairment of activities of daily living.

关键词： stimulation injuries paralysis

Surfactant protein A (SP-A) binds to phosphatidylserine and competes with annexin V binding on late apoptotic cells

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Protein & Cell 2010年第2期1卷 188-197页

作者： Anne Jäkel Kenneth B.m.reid Howard Clark Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK mRC Immunochemistry Unit Department of BiochemistryUniversity of OxfordSouth Parks RoadOxford OX13QUUK University of Southampton MP 803 Level FSouth BlockSouthampton General HospitalSouthampton SO166YDUK

The role of surfactant protein A(SP-A)in the recognition and clearance of apoptotic cells is well established,but to date,it is still not clear which surface molecules of apoptotic cells are involved in the *** we present evidence that phosphatidylserine(PS)is a relevant binding molecule for human *** binding is Ca^(2+)-dependent and is not inhibited by mannose,suggesting that the sugar-binding site of the carbohydrate recognition domain(CRD)of SP-A is not *** cytometry studies on apoptotic Jurkat cells revealed apparent inhibition of annexin V binding by increasing concentrations of SP-A in late apoptotic but not early apoptotic cells,and this was consistent for Jurkat cells and *** these data,confocal microscopy results show a co-localisation of annexin V and SP-A in late apoptotic but not early apoptotic ***,we cannot conclude that this inhibition is exclusively due to the binding of SP-A to PS on the cell surface,as annexin V is not wholly specific for PS and SP-A also interacts with other phospholipids that might become exposed on the apoptotic cell surface.

关键词： surfactant proteins phosphatidylserine apoptotic cells

Recent Advances in Simple model for 4f-5d Transitions of Lanthanide Ions in Solids

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Journal of Rare Earths 2007年第S1期25卷 262-267页

作者： ma Chonggeng m F.reid Duan Changkui Xia Shangda Yin min Department of Physics and Hefei National Laboratory for Physical Science at microscale University of Science and Technology of ChinaHeifei 230026 Department of Physics and Astronomy and MacDiarmid Institute for Advanced Materials and NanotechnologyUniversity of CanterburyChristchurch8140New Zealand Department of Biology and Chemistry City University of Hong KongKowloon.Hong Kong S.A.R.China Institute of modern Physics Chongqing University of Post and TelecommunicationsChongqing 400065 China

The simple model for 4f-5d transitions of lanthanide ions in crystals was extended to deal with the case of the octahedral crystal field,where for the t_(2)component of 5d orbitals the spin-orbit interaction could not be neglected due to incomplete quenching of the 5d orbital angular *** energy levels for the 4f^(N-1)5d configuration and the relative line strengths for the 4f^(N)\4f^(N-1)5d transition were calculated in *** result was applied to the interpretation of the low-temperature 4f-5d excitation spectrum of Cs_(2)NaYCl_(6)∶Tb^(3+).

关键词： simple model f-d transition 5d spin-orbit interaction crystal field Tb^(3+) rare earths

APPROXImATE ESTImATION OF HARDENING-SOFTENING BEHAVIOUR OF CIRCULAR PIPES SUBJECTED TO PURE BENDING

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Acta mechanica Sinica 1997年第3期13卷 227-240页

作者：杨嘉陵 S.R.reid The Solid mechanics Research Centre Beijing University of Aeronautics and AstronauticsBeijing 100083China Department of mechanical Engineering UMISTP.O.Box 88Manchester M60 1QDUK

An approximate method for describing the plastic hardening-softening behaviour of circular pipes subjected to pure bending is presented. Theoretical estimation based on the uniform ovalization model and local collapse model proposed in the paper is incorporated to give several simple formulations with reasonable accuracy for determining the relationship between bending moment (m) and curvature (kappa) in the purely bended pipes. Attention is focused on the critical curvature associated with maximum resistant moment and the maximum change in the original diameter before the end of uniform ovalization stage as well as the local collapse behaviour. Some comparisons between analytical results and experimental results are made in order to examine the theory.

关键词： hardening-softening behaviour pure bended pipes circular pipes deformation characteristics of pipes

Liver resection versus chemoembolization for patients with multifocal hepatocellular carcinoma

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Hepatobiliary Surgery and Nutrition 2019年第5期8卷 543-545页

作者： Victor m.Zaydfudim reid B.adams Department of Surgery Section of Hepatobiliary and Pancreatic SurgeryUniversity of VirginiaCharlottesvilleVAUSA

Curative intent treatment strategies for patients withhepatocellular carcinoma(HCC)include liver resection,livertransplantation,and arguably tumor ablation.

关键词： hepatocellular patients resection

Surface-bound myeloperoxidase is a ligand for recognition of late apoptotic neutrophils by human lung surfactant proteins A and D

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Protein & Cell 2010年第6期1卷 563-572页

作者： Anne Jäkel Howard Clark Kenneth B.m.reid Robert B.Sim Department of Pharmacology University of OxfordMansfield RoadOxford OX13QTUK University of Southampton School of MedicineDivision of Infection Inflammation&ImmunitySouthampton General HospitalSouthampton SO166YDUK mRC Immunochemistry Unit Department of BiochemistryUniversity of OxfordSouth Parks RoadOxford OX13QUUK

Surfactant proteins A(SP-A)and D(SP-D),both members of the collectin family,play a well established role in apoptotic cell recognition and *** in vitro data show that SP-A and SP-D interact with apoptotic neutrophils in a distinct ***-A and SP-D bind in a Ca^(2+)-dependent manner to viable and early apoptotic neutrophils whereas the much greater interaction with late apoptotic neutrophils is Ca^(2+)-*** surface molecules on the apoptotic target cells responsible for these interactions had not been identified and this study was done to find candidate target ***(mPO),a specific intracellular defense molecule of neutrophils that becomes exposed on the outside of the cell upon apoptosis,was identified by affinity purification,mass-spectrometry and western blotting as a novel binding molecule for SP-A and *** confirm its role in recognition,it was shown that purified immobilised mPO binds SP-A and SP-D,and that mPO is surface-exposed on late apoptotic ***-A and SP-D inhibit binding of an anti-mPO monoclonal Ab to late apoptotic *** microscopy confirmed that anti-mPO mAb and SP-A/SP-D colocalise on late apoptotic *** was identified as a further potential ligand for SP-A,and neutrophil defensin as a target for both proteins.

关键词： SP-A SP-D myeloperoxidase neutrophils flow cytometry mass spectrometry

molecular basis of cranial suture biology and disease:Osteoblastic and osteoclastic perspectives

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Genes & Diseases 2014年第1期1卷 120-125页

作者： maureen Beederman Evan m.Farina Russell R.reid Section of Plastic&Reconstructive Surgery Department of SurgeryThe University of Chicago Medical Center5841 South Maryland AvenueMC 6035ChicagoIL 60637USA Pritzker School of medicine and The Laboratory of Craniofacial BiologyUniversity of Chicago MedicineChicagoIL 60637USA

The normal growth and development of the skull is a tightly regulated process that occurs along the osteogenic interfaces of the cranial ***,the borders of the calvarial bones and neighboring tissues above and below,function as a *** coordinated remodeling efforts of bone deposition and resorption,the cranial sutures maintain a state of patency from infancy through early adulthood as the skull continues to grow and accommodate the developing brain’s demands for ***,when this delicate balance is disturbed,a number of pathologic conditions ensue;and if left uncorrected,may result in visual and neurocognitive impairments.A prime example includes craniosynostosis,or premature fusion of one or more cranial and/or facial suture(s).At the present time,the only therapeutic measure for craniosynostosis is surgical correction by cranial vault ***,elegant studies performed over the past decade have identified several genes critical for the maintenance of suture patency and induction of suture *** deeper understandings of the pathogenesis and molecular mechanisms that regulate suture biology may provide necessary insights toward the development of non-surgical therapeutic alternatives for patients with cranial suture *** this review,we discuss the intricate cellular and molecular interplay that exists within the suture among its three major components:dura mater,osteoblastic related molecular pathways and osteoclastic related molecular pathways.

关键词： Cranial sutures Craniosynostosis Dura mater Osteoblasts Osteoclasts

molecular Analysis of Legume Nodule Development and Autoregulation

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Journal of Integrative Plant Biology 2010年第1期52卷 61-76页

作者： Brett J. Ferguson Arief Indrasumunar Satomi Hayashi Yu-Hsiang Lin Dugald E. reid Peter m. Gresshoff ARC Centre of Excellence for Integrative Legume Research The University of Queensland

Legumes are highly important food, feed and biofuel crops. With few exceptions, they can enter into an intricate symbiotic relationship with specific soil bacteria called rhizobia. This interaction results in the formation of a new root organ called the nodule in which the rhizobia convert atmospheric nitrogen gas into forms of nitrogen that are useable by the plant. The plant tightly controls the number of nodules it forms, via a complex root-to-shoot-to-root signaling loop called autoregulation of nodulation （AON）. This regulatory process involves peptide hormones, receptor kinases and small metabolites. Using modern genetic and genomic techniques, many of the components required for nodule formation and AON have now been isolated. This review addresses these recent findings, presents detailed models of the nodulation and AON processes, and identifies gaps in our understanding of these process that have yet to be fully explained.

关键词： molecular Analysis of Legume Nodule Development and Autoregulation

Fibroblast growth factor(FGF)signaling in development and skeletal diseases

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Genes & Diseases 2014年第2期1卷 199-213页

作者： Chad m.Teven Evan m.Farina Jane Rivas Russell R.reid The Laboratory of Craniofacial Biology Section of Plastic&Reconstructive SurgeryDepartment of SurgeryThe University of Chicago Medical Center5841 South Maryland AvenueMC 6035ChicagoIL 60637USA The University of Chicago Pritzker School of medicine ChicagoIL 60637USA

Fibroblast growth factors(FGF)and their receptors serve many functions in both the developing and adult *** contain 18 FGF ligands and four FGF receptors(FGFR).FGF ligands are polypeptide growth factors that regulate several developmental processes including cellular proliferation,differentiation,and migration,morphogenesis,and ***-FGFR signaling is also critical to the developing axial and craniofacial *** particular,the signaling cascade has been implicated in intramembranous ossification of cranial bones as well as cranial suture *** the adult,FGFs and FGFRs are crucial for tissue *** signaling generally follows one of three transduction pathways:RAS/mAP kinase,PI3/AKT,or *** pathway likely regulates specific cellular *** expression of FGF and improper activation of FGFRs are associated with various pathologic conditions,unregulated cell growth,and ***,aberrant signaling has been implicated in many skeletal abnormalities including achondroplasia and *** biology and mechanisms of the FGF family have been the subject of significant research over the past 30 ***,work has focused on the therapeutic targeting and potential of FGF ligands and their associated *** majority of FGF-related therapy is aimed at age-related *** understanding of FGF signaling and biology may reveal additional therapeutic roles,both in utero and *** review discusses the role of FGF signaling in general physiologic and pathologic embryogenesis and further explores it within the context of skeletal development.

关键词： Craniosynostosis FGF signaling Fibroblast growth factor Fibroblast growth factor receptor Genetics Pathogenesis Signal transduction Skeletal development