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A review of regenerative therapies as penile rehabilitation in men following primary prostate cancer treatment:Evidence for erectile restoration and cavernous nerve regeneration

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Asian Journal of Urology 2022年第3期9卷 287-293页

作者： eric Chung AndroUrology Centre BrisbaneQLDAustralia University of Queensland Princess Alexandra HospitalBrisbaneQLDAustralia Macquarie University Hospital SydneyNSWAustralia

Objective:The following article explores our evolving understandings of the role of regenerative technology as an effective penile rehabilitation tool in men with erectile dysfunction(ED)in the setting of prostate cancer(PCa)treatment and PCa ***:This narrative clinical review paper summarizes what is currently known about various modalities of regenerative therapy in restoring spontaneous erectile function(EF)in men following PCa treatment with an emphasis on penile rehabilitation ***:Conventional medical therapy often does not reverse underlying endothelial dysfunction or promote neuro-vasculogenesis to preserve penile health in men with *** the past decade,there has been considerable interest in the role of regenerative therapy to restore endothelial dysfunction and ED without future dependency on medical *** therapy can be classified into cellular-based(immunomodulators,stem cells,and platelet-rich plasma),biomaterials(nerve graft transfer),and device-related technology(low-intensity shockwave).Although published literature shows early promise in the role of regenerative technology for ED,there is a paucity of high-quality clinical trials in the setting of penile rehabilitation and PCa survivorship to support their use as standard care and be adopted in clinical guidelines.

关键词： Regenerative therapy Low-intensity shockwave therapy Stem cell therapy Platelet-rich plasma Immunomodulator Nerve transfer Erectile dysfunction Penile rehabilitation

A genomic approach to active surveillance： a step toward precision medicine

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Asian Journal of Andrology 2013年第3期15卷 340-341页

作者： eric A Klein Glickman Urological and Kidney Institute Cleveland Clinic Cleveland OH 44195 USA

In the last 25 years, Prostate Specific Antigen （PSA） screening has resulted ina large gap between the likelihood of being diagnosed with and of dying of prostate cancer, leading to the clinical problems of overdiagnosis and overtreatment. Despite the favorable outcomes reported for active surveil- lance, its clinical use is limited, with 〉90% of men in the US diagnosed with potentially indol- ent disease undergoing immediate treatment with radiation or surgery. We have designed a novel strategy of molecular profiling of prostate cancers, allowing an assessment of tumor aggres- siveness to be based on tumor tissue obtained at biopsy.

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A comparative review of artificial muscles for microsystem applications

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Microsystems & Nanoengineering 2021年第6期7卷 25-43页

作者： Mayue Shi eric M.Yeatman Department of Electrical and Electronic Engineering Imperial College LondonExhibition RoadLondon SW72AZUK

Artificial muscles are capable of generating actuation in microsystems with outstanding *** years have witnessed a growing academic interest in artificial muscles and their application in many areas,such as soft robotics and biomedical *** paper aims to provide a comparative review of recent advances in artificial muscle based on various operating *** advantages and limitations of each operating mechanism are analyzed and *** to the unique application requirements and electrical and mechanical properties of the muscle types,we suggest suitable artificial muscle mechanisms for specific microsystem ***,we discuss potential strategies for energy delivery,conversion,and storage to promote the energy autonomy of microrobotic systems at a system level.

关键词： artificial generating limitations

Timed-pNets： a communication behavioural semantic model for distributed systems

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Frontiers of Computer Science 2015年第1期9卷 87-110页

作者： Yanwen CHEN Yixiang CHEN eric MadELAINE MoE Engineering Research Center for Software/Hardware Co-design Technology and Application Shanghai Key Laboratory of Trustworthy Computing East China Normal University Shanghai 200062 China INRIA Sophia Antipolis Mediterannee Sophia Antipolis 06902 France University of Nice Sophia Antipolis CNRS Sophia Antipolis 06900 France

This paper presents an approach to build a communication behavioural semantic model for heterogeneous distributed systems that include synchronous and asynchronous communications. Since each node of such system has its own physical clock, it brings the challenges of correctly specifying the system time constraints. Based on the logical clocks proposed by Lamport, and CCSL proposed by Aoste team in INRIA, as well as pNets from Oasis team in INRIA, we develop timed-pNets to model communication behaviours for distributed systems. Timed-pNets are tree style hierarchical structures. Each node is associated with a timed specification which consists of a set of logical clocks and some relations on clocks. The leaves are represented by timed-pLTSs. Non-leaf nodes （called timed-pNets nodes） are synchronisation devices that synchronize the behaviours of subnets （these subnets can be leaves or non-leaf nodes）. Both timed-pLTSs and timed-pNets nodes can be translated to timed specifications. All these notions and methods are illustrated on a simple use-case of car insertion from the area of intelligent transportation systems （ITS）. In the end the TimeSquare tool is used to simulate and check the validity of our model.

关键词： ITS logical time formal method timed specification synchronous and asynchronous communication

Regional-scale relationship among biological soil crusts,invasive annual grasses,and disturbance

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Ecological Processes 2013年第1期2卷 18-25页

作者： eric B Peterson Nevada Natural Hertage Program State of NevadaCarson CityNV 89701USA Curent address Trinity River Restoration Program US Bureau of ReclamationWeavervilleCA 96093USA

Introduction:Sagebrush ecosystems in western North America are being replaced by the invasion of annual grasses,particularly Bromus *** experimental situations and in localized landscapes,prior studies have documented that biological soil crusts(biocrusts)can reduce annual grass presence and that biocrusts are highly vulnerable to physical *** conservation would benefit from verification of these patterms at scales that matter to local *** study tests if these patterns appear at a regional ***:A previously collected data set of vegetation provided sampling of biocrust cover across the Great Basin within the state of Nevada,USA Data were analyzed with non-par ametric methods including odds ratios and generalized aditive models(GAM).Results:From a data set of 608 vegetation plots within the Great Basin ecoregion,proportion of plots with high annual grass cover differed between sites with high versus low biocrust cover(p=0.0015).A negative relationship between annual grass cover and biocrust cover was confirmed with GAM(p=0.009).For a model of biocrust cover,cattle disturbance was found to be an explanatory variable(p<0.00001).Conclusions:The patterns do appear at the regional scale,with high levels of cattle activity corresponding to low cover of biocrusts,and low cover of biocrusts corresponding to high cover of annual grasses.

关键词： Biological soil crusts Cryptogamic crust Microphytic crust Great basin ecoregion Sagebrush ecosystem Landscape ecology Disturbance Cattle grazing Odds ratio Generalized additive models

Sarcopenia and liver transplant: The relevance of too little muscle mass

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World Journal of Gastroenterology 2015年第39期21卷 10982-10993页

作者： eric R Kallwitz Loyola University

Loss of muscle mass and function is a common occurrence in both patients with decompensated cirrhosis and those undergoing liver transplantation. Sarcopenia is associated with morbidity and mortality before and after liver transplantation. The ability of skeletal muscle mass to recover after transplant isquestionable, and long term adverse events associated with persistent sarcopenia have not been well studied. Limited data is available examining mechanisms by which decreased muscle mass might develop. It is not clear which interventions might reduce the prevalence of sarcopenia and associated health burdens. However, measures to either decrease portal hypertension or improve nutrition appear to have benefit. Research on sarcopenia in the liver transplant setting is hampered by differing methodology to quantify muscle mass and varied thresholds determining the presence of sarcopenia. One area highlighted in this review is the heterogeneity used when defining sarcopenia. The health consequences, clinical course and potential pathophysiologic mechanisms of sarcopenia in the setting of cirrhosis and liver transplantation are further discussed.

关键词： Sarcopenia Liver transplantation Cirrhosis Body co

Microparticles with tunable,cell-like properties for quantitative acoustic mechanophenotyping

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Microsystems & Nanoengineering 2023年第4期9卷 129-141页

作者： Ryan Dubay eric MDarling Jason Fiering Center for Biomedical Engineering Brown UniversityProvidenceRI 02912USA Biological Microsystems DraperCambridgeMA 02139USA Department of Pathology and Laboratory Medicine Brown UniversityProvidenceRI 02912USA School of Engineering Brown UniversityProvidenceRI 02912USA Department of Orthopaedics Brown UniversityProvidenceRI 02912USA

Mechanical properties of biological cells have been shown to correlate with their biomolecular state and function,and therefore methods to measure these properties at scale are of *** microfluidic technologies can measure the mechanical properties of cells at rates over 20,000 cells/s,which is more than four orders of magnitude faster than conventional ***,precise and repeatable means to calibrate and test these new tools remain lacking,since cells themselves are by nature ***,microfluidic tools use rigid polymer microspheres for calibration because they are widely available in cell-similar sizes,but conventional microspheres do not fully capture the physiological range of other mechanical properties that are equally important to device function(e.g.,elastic modulus and density).Here,we present for the first time development of monodisperse polyacrylamide microparticles with both tunable elasticity and tunable *** these size,elasticity,and density tunable particles,we characterized a custom acoustic microfluidic device that makes single-cell measurements of mechanical *** then applied the approach to measure the distribution of the acoustic properties within samples of human leukocytes and showed that the system successfully discriminates lymphocytes from other *** initial demonstration shows how the tunable microparticles with properties within the physiologically relevant range can be used in conjunction with microfluidic devices for efficient high-throughput measurements of mechanical properties at single-cell resolution.

关键词： tunable elasticity function

Spectral Aspects of the Skew-Shift Operator:A Numerical Perspective

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Communications in Computational Physics 2014年第3期15卷 712-732页

作者： eric Bourgain-Chang Mechanical Engineering Department University of CaliforniaBerkeleyCA 94720USA

In this paper we perform a numerical study of the spectra,eigenstates,and Lyapunov exponents of the skew-shift counterpart to Harper’s *** study is motivated by various conjectures on the spectral theory of these’pseudo-random’models,which are reviewed in detail in the initial sections of the *** numerics carried out at different scales are within agreement with the conjectures and show a striking difference compared with the spectral features of the Almost Mathieu *** particular our numerics establish a small upper bound on the gaps in the spectrum(conjectured to be absent).

关键词： Schrödinger operator skew-shift spectrum localization

The effect of hemicellulose on the interparticle frictional behavior of lignocellulosic biomass particulates

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Particuology 2021年第2期19卷 16-22页

作者： Ekramul Haque Ehite eric Drumm Nourredine Abdoulmoumine Biosystems Engineering and Soil Science Department University of TennesseeKnoxvilleTN 37996USA Center for Renewable Carbon University of TennesseeKnoxvilleTN 37996USA

Lignocellulosic biomass material sourced from plants and herbaceous sources is considered as a prospective feedstock of inexpensive,potentially carbon-neutral *** biomass is structurally built on cellulose,hemicellulose,and lignin,which are present in varying concentrations based on the feedstock type and play distinct and not well understood mechanical functions in the flow *** frictional characteristics of lignocellulosic biomass particulates influence their flow behavior in ***,it is important to fundamentally investigate the relative contribution of cellulose,hemicellulose,and lignin to the frictional ***,these three biopolymers are interwoven into a complex matrix in the lignocellulosic biomass,thus making it hard to quantify the contribution of each *** this study,we selectively remove hemicellulose from switchgrass and investigate the effects of its diminishing concentration on the coefficient of *** observed that the angle of repose and,therefore,the coefficient of friction for a loose assembly of the control and treated switchgrass samples decrease with decreasing hemicellulose *** indicates the frictional resistance to flow for biomass particulate assemblies is at least proportional to the hemicellulose *** also established that the observed changes in the frictional behavior were not due to particle morphological characteristics.

关键词： Lignocellulosic biomass Frictional behavior Angle of repose Hot water extraction Switchgrass Hemicellulose removal