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Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating and nuclear accumulation

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Frontiers of Chemical Science and Engineering 2020年第5期14卷 889-901页

作者： Xinghong Duo Lingchuang Bai Jun Wang Jintang Guo Xiangkui Ren Shihai Xia Wencheng Zhang abraham domb Yakai Feng School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China School of Chemistry and Chemical Engineering Qinghai University for NationalitiesXining 810007China Collaborative Innovation Center of Chemical Science and Chemical Engineering(Tianjin) Tianjin 300350China Key Laboratory of Systems Bioengineering(Ministry of Education) Tianjin UniversityTianjin 300072China Department of Hepatopancreatobiliary and Splenic Medicine Afiliated HospitalLogistics University of People's Amed Police ForceTianjin 300162China Department of Physiology and Pathophysiology Logistics University of People's Armed Police ForceTianjin 300162China Institute of Drug Research(IDR) School of Pharmacy Faculty of MedicineThe Hebrew University of JerusalemJerusalem 91905Israel

Gene therapy has drawn great attention in the treatments of many diseases,especially for cardiovascular ***,the development of gene carriers with low cytotoxicity and multitargeting function is still a ***,the multitargeting REDV-G-TATG-NLS peptide was conjugated to amphiphilic cationic copolymer poly(e-caprolactone-co-3(S)-methyl-morpho-line-2,5-dione)-g-polyethyleneimine(PCLMD-g-PEI)via a heterobifunctional orthopyridyl disulfde-poly(ethylene glycol)-N-hydroxysuccinimide(OPSS-PEG-NHS)linker to prepare PCLMD-g-PEI-PEG-REDV-G-TAT-G-NLS copolymers with the aim to develop the gene carriers with low cytotoxicity and high transfection *** multitargeting micelles were prepared from PCLMD-g-PEI-PEG-REDV-G-TAT-G-NLS copolymers by self-assembly method and used to load pEGFP-ZNF580 plasmids(pDNA)to form gene complexes for enhancing the proliferation and migration of endothelial cells(ECs).The loading pDNA capacity was proved by agarose gel electrophoresis *** multitargeting gene com-plexes exhibited low cytotoxicity by 3-(4,-dimethylthia-zol-2-yl)-2,5-diphenyltetrazolium bromide *** high internalization efficiency of these gene complexes was confirmed by flow *** results of in vitro transfection demonstrated that these multitargeting gene complexes possessed relatively high transfection *** rapid migration of ECs transfected by these gene complexes was verified by wound healing *** to ECs-targeting ability,cell-penetrating ability and nuclear targeting capacity of REDV-G-TAT-G-NLS pep-tide,the multitargeting polycationic gene carrier with low cytotoxicity and high transfection efficiency has great potential in gene therapy.

关键词： gene carriers multitargeting function ECs transfection efficiency

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Alpha7 nicotinic receptors as potential theranostic targets for experimental stroke

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Neural Regeneration Research 2024年第5期19卷 939-940页

作者： Maider Garbizu Laura Aguado abraham Martín Achucarro Basque Center for Neuroscience LeioaSpain CIC biomaGUNE Basque Research and Technology AllianceSan SebastianSpain Ikerbasque Basque Foundation for Science BilbaoSpain

Inflammatory reflex and cholinergic anti-inflammatory pathway:Innate immune system triggers a local inflammatory response following an injury or a pathogen ***,this inflammatory response is limited by rapid,localized,and adaptive anti-inflammatory responses which are crucial for maintaining ***,the loss of these responses converts a limited and protective inflammatory response into an excessive and harmful ***-inflammatory responses are integrated into the central nervous system,since the central nervous system accumulates information about harmful events,activates defenses,and builds memory for *** the same time,it has been demonstrated that hypothalamic neuronal signaling can be altered by inflammation in peripheral ***,immune cells release neuropeptides and neurotransmitters such as acetylcholine(ACh),the main neurotransmitter of the parasympathetic autonomic nervous system,evidencing the communication between the immune and nervous systems(Tracey,2002).

关键词： protective invasion Alpha

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Erratum to: Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating and nuclear accumulation

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Frontiers of Chemical Science and Engineering 2021年第1期15卷 220-220页

作者： Xinghong Duo Lingchuang Bai Jun Wang Jintang Guo Xiangkui Ren Shihai Xia Wencheng Zhang abraham domb Yakai Feng School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China School of Chemistry and Chemical Engineering Qinghai University for NationalitiesXining 810007China Collaborative Innovation Center of Chemical Science and Chemical Engineering(Tianjin) Tianjin 300350China Key Laboratory of Systems Bioengineering(Ministry of Education) Tianjin UniversityTianjin 300072China Department of Hepatopancreatobiliary and Splenic Medicine Affiliated HospitalLogistics University of People’s Armed Police ForceTianjin 300162China Department of Physiology and Pathophysiology Logistics University of People’s Armed Police ForceTianjin 300162China Institute of Drug Research(IDR) School of Pharmacy-Faculty of MedicineThe Hebrew University of JerusalemJerusalem 91905Israel

The authors regret that there was an error in our *** Lingchuang Bai made great contributions to this work,Xinghong Duo and Lingchuang Bai should be co-first authors,but there was no statement that“Xinghong Duo and L... 详细信息

关键词： statement cationic equally

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Current state of the art and future directions: Augmented reality data visualization to support decision-making

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Visual Informatics 2024年第2期8卷 80-105页

作者： Mengya Zheng David Lillis abraham G.Campbell School of Computer Science University College DublinDublinIreland

Augmented Reality(AR),as a novel data visualization tool,is advantageous in revealing spatial data patterns and data-context ***,recent research has identified AR data visualization as a promising approach to increasing decision-making efficiency and *** a result,AR has been applied in various decision support systems to enhance knowledge conveying and comprehension,in which the different data-reality associations have been constructed to aid ***,how these AR visualization strategies can enhance different decision support datasets has not been reviewed *** given the rise of big data in the modern world,this support is critical to decision-making in the coming *** AR to embed the decision support data and explanation data into the end user’s physical surroundings and focal contexts avoids isolating the human decision-maker from the relevant *** the decision-maker’s contexts and the DSS support in AR is a difficult *** paper outlines the current state of the art through a literature review in allowing AR data visualization to support *** facilitate the publication classification and analysis,the paper proposes one taxonomy to classify different AR data visualization based on the semantic associations between the AR data and physical *** on this taxonomy and a decision support system taxonomy,37 publications have been classified and analyzed from multiple *** of the contributions of this literature review is a resulting AR visualization taxonomy that can be applied to decision support *** with this novel tool,the paper discusses the current state of the art in this field and indicates possible future challenges and directions that AR data visualization will bring to support decision-making.

关键词： Augmented reality Decision support Data visualization Taxonomy

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Optoelectronic and thermoelectric properties of spinel chalcogenides HgLa2X4（X=S and Se）:A first-principles study

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Journal of Rare Earths 2024年第10期42卷 1927-1936页

作者： Aparna Dixit Inas A.Ahmed Jisha Annie abraham Zeinhom M.El-Bahy Mumtaz Manzoor Sajad Ahmad Dar Ramesh Sharma Department of Basic Science and Humanities Pranveer Singh Institute of Technology Department of Chemistry Faculty of ScienceKing Khalid University Department of Physics National Defence Academy Department of Chemistry Faculty of ScienceAl-Azhar University Institute of Physics Slovak Academy of Sciences Department of Physics Motilal Vigyan Mahavidyalya College Department of Applied Science Feroze Gandhi Institute of Engineering and Technology

We investigated spinel chalcogenides HgLa2（S/Se）4by using density function theory,and scrutinized the structural,optical,electrical,mechanical and thermoelectric transport characteristics of HgLa2（S/Se）4spinel *** enthalpy of formation,energy of cohesion,and energy volume optimum plots were used to obtain the stability as well as the perfect ground state of these *** ductility of these materials was the best illustrated with the help of Poisson's and Pugh's *** band gap results were obtained using Trans and Blaha modified Becke-Johanson potential（TB-mBJ）.Both the materials present semi-conducting nature with direct band gap equal to 1.449 and 0.892 eV respectively for HgLa2S4and *** were also made for optical characteristics with the values of dielectric function,absorption coefficient,optical conductivity,reflectivity,and refractive *** to the findings,both of these materials are suitable for infrared optoelectronic *** materials were found to have promising optoelectronic and thermoelectric applications after their optical properties and transport aspects were *** tiny levels of temperature conductivities,substantial am ounts of power conductivities,the figure of merit（more than unity）,as well as Seebecs coefficients all point to the potential use of both the materials in thermoelectric power generators.

关键词： Density functional theory Direct band gap Optoelectronic Power factor Semiconductors Thermoelectric

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Let’s Talk LGBTQIA+:Strategies and Activities for Teaching Diversity and Inclusion in the Foreign Language Classroom at the College Level

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Sino-US English Teaching 2024年第4期21卷 143-170页

作者： Joseph abraham Levi George Washington University WashingtonUSA University of MacaoMacaoChina

In this presentation,the author explores strategies and activities that create a welcoming and nurturing environment for LGBTQIA+foreign language students at the college level in the United ***,as it is commonly stated,there is a clear lack of visibility,acceptance/tolerance,and inclusion of LGBTQIA+voices(active and proactive)in foreign language teaching and learning(pedagogical material as well as in-class attitudes and delivery).The reasons for this deficiency are diverse since they cover not only outward discrimination against and/or indifference(passive-aggressive behavior)toward the LGBTQIA+community and its plight,but they also illustrate the sheer,physical inexistence of quality material that can be used to create,present,and foster a welcoming and all-encompassing classroom environment that addresses the diverse spectrum of the LGBTQIA+community while its members try to learn a foreign language and(positively)negotiate how to express their very identity in their new language of ***,the scant material that is available in the United States as well as in other Western countries where the LGBTQIA+community by and large is accepted-at least from the legal point of view-hardly represents and covers the subject matter in a satisfactory *** address this gap,the author will provide some examples in European Portuguese(EP)and Italian(IT),followed by a courtesy translation in English,to illustrate some positive activities and strategies for including LGBTQIA+-related subject matter in the foreign language classroom at the college *** is his desire that instructors of other foreign languages duplicate in their respective vernaculars the strategies and activities herein presented in order to create a welcoming and safe classroom environment that embraces the LGBTQIA+community as it goes through the enjoyable journey of learning a new language and culture.

关键词： diversity foreign language (trans-)gender inclusion LGBTQIA+community

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Long COVID:From olfactory dysfunctions to viral Parkinsonism

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第2期10卷 137-147页

作者： Sanyukta Pandey Vibha Bapat Jancy Nixon abraham Nixon M.abraham Department of Biology Laboratory of Neural Circuits and Behaviour(LNCB)Indian Institute of Science Education and Research(IISER)PuneMaharashtraIndia Department of Life Sciences Centre of Excellence in EpigeneticsShiv Nadar Institution of EminenceGautam Buddha NagarUttar PradeshIndia

Neurological and psychiatric complications continue to be a public health concern in long coronavirus disease 2019(COVID-19).This varies from olfactory dysfunctions such as parosmia to cognitive and emotional ***,the surge of neurological disorders followed the viral pandemics,for example,the emergence of Encephalitis Lethargica after the outbreak of Spanish *** and after COVID-19 infection,the problems associated with the sense of smell and the reports of affected olfactory and limbic brain areas are leading to a growing concern about the similarity with the symptoms and the pattern of degeneration observed at the onset of Parkinson's disease and Alzheimer's *** reports reveal the essentiality of long-term studies of olfactory and cognitive functions in the post-COVID era and the experiments using animal models to dissect the neural basis of these *** this manuscript,we summarize the research reporting the potential correlation between neurological disorders and viral pandemic outbreaks with a historical ***,we discuss the studies providing evidence of neurodegeneration due to severe acute respiratory syndrome coronavirus 2 infection by focusing on viral Parkinsonism.

关键词： long COVID neurodegeneration neurotropism olfactory dysfunctions viral parkinsonism

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Assessment of CO_(2)storage prospect based on physical properties of Rio Bonito Formation rock units

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Energy Geoscience 2024年第1期5卷 321-330页

作者： Richardson M.abraham-A Stephanie San Martín Cañas Isabella F.S.Miranda Colombo C.G.Tassinari Institute of Energy and Environment(IEE) University of São Paulo(USP)Brazil Research Centre for Greenhouse Gas Innovation(RCGI) University of Sãao Paulo(USP)Brazil

The physical properties of the rock units associated with the Rio Bonito Formation are presented in this study with the focus on modelling reservoir quality based on petrophysics-derived parameters to evaluate CO_(2)storage *** involves the modelling of the reservoir depths,thicknesses,flow zone indicators(FZI),and effective permeability(Keff)and presenting the CO_(2)storage efficiency factors peculiar to the rock units of the study *** results presented by this study for the stated objectives are not quite common in the *** values range from 200 mD to higher than 2000 mD,and FZI values are generally above 1.0 mm and up to 13.0 mm within the portions covered by the drilled *** sandstone units recorded are up to 20 m thick in some *** Keff and FZI models indicate the sandstone reservoirs as permeable units to support the injection and circulation of CO_(2)within the potential reservoir units of the Rio Bonio Formation across São Paulo *** from some points in the southeastern part of the study location,where the Rio Bonito are delineated at depths less than 800 m(minimum CO_(2)storage depth based on best practices),other portions are deeper,ranging from 950 m to 3500 ***-bedded layers will affect the integrity of the rocks as CO_(2)storage tanks or reservoir seals/traps/overburden within the *** bed thicknesses are up to 20 m in some ***,hybrid CO_(2)reservoir units are feasible,especially in portions where thin siltstone layers are sandwiched between sandstone units to provide considerable thicknesses based on CO_(2)storage *** current study shows that useable areas considering reservoir thickness,depth,and other physical qualities will significantly control the CO_(2)storage efficiency of the study *** studies featuring a detailed geophysical exploration of the site to confirm the availability and saturations of preexisting fluid(hydrocarbon and water)are encouraged

关键词： Rio Bonito Effective permeability Fluid transmissibility CO_(2)storage prospect Reservoir quality Overburden integrity Flow zones

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Exploring the Reasons for Selfie-Taking and Selfie-Posting on Social Media with Its Effect on Psychological and Social Lives:A Study among Indian Youths

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International Journal of Mental Health Promotion 2024年第5期26卷 389-398页

作者： Divya P.Vijayan Tokani Ghuhato Eslavath Rajkumar Allen Joshua George Romate John John abraham Department of Psychology Central University of KarnatakaKalaburagi585367India Department of Liberal Arts Indian Institute of Technology BhilaiChhattisgarh491002India Liberal Arts&Sciences Indian Institute of Management RanchiJharkhand834001India Department of Family Medicine/Geriatrics St.John’s National Academy of Health SciencesBangalore560034India

‘Selfie’taking was introduced to the common people by smartphones and has become a common practice across the globe in no *** technological advancement and the popularity of smartphones,selfie-taking has grown rapidly within a short *** light of the new trend set by the generation,this study aimed to explore reasons for selfie-taking and selfie-posting on social media and their effects on the social and psychological lives of young adults.A purposive sampling method was adopted to select 20 Indian citizens,between 18 and 24 *** data were collected through semi-structured interviews and analysed using thematic ***-taking and posting on social media give positive feelings,and it acts as a mood modifier dependent mostly on the favourability and feedback about the post which in turn affects emotions and self-satisfaction.

关键词： Selfie social media social networking sites obsessive selfie-taking Indian youth

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聚苯乙烯—聚丙烯酸胶束的制备及其与铀酰的络合作用

聚苯乙烯—聚丙烯酸胶束的制备及其与铀酰的络合作用

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作者： Owusu abraham 西南科技大学

学位级别：硕士

铀是一种重要的战略资源,它的开发与利用可能会严重危害生态系统。深入研究铀元素与环境介质的相互作用,对于揭示铀在生态系统中的归宿和迁移行为具有重要的意义。在氧化性水环境中,铀以六价态铀酰的形式存在。传统的研究主要集中在铀... 详细信息

铀是一种重要的战略资源,它的开发与利用可能会严重危害生态系统。深入研究铀元素与环境介质的相互作用,对于揭示铀在生态系统中的归宿和迁移行为具有重要的意义。在氧化性水环境中,铀以六价态铀酰的形式存在。传统的研究主要集中在铀酰与粘土矿物的相互作用,离子交换、表面吸附、表面沉积是其主要作用机制。然而,天然有机物与铀酰具有强烈的亲和作用,会影响铀酰在生态系统中的存在形式。由于天然有机物自身结构的复杂性,天然有机物与铀酰的相互作用尚没有明确的结论,因此有必要开展深入系统的研究。本实验提出使用一种准单分散的“平头”聚苯乙烯-聚丙烯酸（PS-b-PAA）嵌段聚合物胶束,用于模拟天然腐殖酸胶体与铀酰的相互作用。重点使用X射线小角散射技术研究铀酰对PS-b-PAA胶束结构的影响,样品的散射曲线具有明显的核-壳结构振荡峰,吸附铀酰后,振荡峰强度增加,同时发现低q区域散射强度增加。核-壳模型拟合分析表明:弱酸性水溶液中,PAA壳层厚度2.6 nm,聚集数135,PS核表面积1641 nm,平均每个PAA链占据12 nm;胶束与铀酰混合后,PAA壳层厚度降低、衬度增加。随着铀酰浓度的增加,胶束发生团聚,进而产生沉淀。根据铀酰浓度变化和X射线小角散射的分析结果可计算出一个PS（279）-b-PAA（69）胶束平均能吸附600个铀酰离子,即15个PAA段能吸附1个铀酰。该工作的研究方法和研究思路对于深入认识腐殖酸胶体与锕系元素的相互作用具有重要意义。

关键词：聚苯乙烯-聚丙烯酸胶束铀酰小角散射

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