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Efficacy of vasopressin, steroid, and epinephrine protocol for in-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis

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Journal of Geriatric Cardiology 2022年第9期19卷 705-711页

作者： Danish Iltaf Satti Yan Hiu Athena Lee Keith Sai Kit Leung Jeremy Man Ho Hui Thompson Ka Ming Kot Arslan Babar Gauranga Mahalwar abraham kc wai Tong Liu Leonardo Roever Gary Tse Jeffrey Shi Kai Chan International Health Informatics Study(IHIS)Network Cardiovascular Analytics Group Hong KongChina-UK Collaboration Emergency Medicine Unit Li Ka Shing Fac-ulty of MedicineThe University of Hong KongHong KongChina Aston Medical School Faculty of Health&Life SciencesAston UniversityBirminghamUnited Kingdom Li Ka Shing Faculty of Medicine The University of Hong KongHong KongChina Department of Anaesthesia and Pain Service Princess Margaret HospitalLai Chi KokKowloonHong KongChina Department of Medicine Cleveland Clinic FoundationClevelandUSA Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease Department of CardiologyTianjin Institute of Cardi-ologySecond Hospital of Tianjin Medical UniversityTianjinChina Department of Clinical Research Federal Uni-versity of UberlândiaUberlândiaBrazil Kent and Medway Medical School CanterburyKentUnited Kingdom 不详

OBJECTIVES To assess the effect of vasopressin,steroid and epinephrine(VSE)combination therapy on return of spontan-eous circulation(ROSC)after in-hospital cardiac arrest(IHCA),and test the conclusiveness of evidence using trial sequential ana-lysis(TSA).METHODS The systematic search included PubMed,EMBASE,Scopus,and Cochrane Central Register of Controlled *** controlled trials(RCTs)that included adult patients with IHCA,with at least one group receiving combined VSE therapy were *** was extracted independently by two *** main outcome of interest was *** out-comes included survival to hospital discharge or survival to 30 and 90 days,with good neurological *** We included a total of three RCTs(n=869).Results showed that VSE combination therapy increased ROSC(risk ra-tio=1.41;95%CI:1.25-1.59)as compared to *** demonstrated that the existing evidence is *** was also validated by the alpha-spending adjusted relative risk(1.32[1.16,1.49],P<0.0001).Other outcomes could not be meta-analysed due to differences in timeframe in the included *** VSE combination therapy administered in cardiopulmonary resuscitation led to improved rates of ***-ture trials of VSE therapy should evaluate survival to hospital discharge,neurological function and long-term survival.

关键词： resuscitation analysis return

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Is Terzaghi's effective stress a stress variable under seepage conditions?

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Journal of Central South University 2015年第6期22卷 2316-2321页

作者：雷国辉赵仲辉吴宏伟 Key Laboratory of Geomechanics and Embankment Engineering of Ministry of Education (Geotechnical Research Institute Hohai University) Department of Civil and Environmental Engineering The Hong Kong University of Science and Technology

From the continuum mechanics perspective, an attempt was made to clarify the role of Terzaghi's effective stress in the theoretical analysis of saturated soil subjected to seepage. The necessity of performing a coupled hydromechanical analysis to solve the seepage-deformation interaction problem was illustrated by examining the equations of static equilibrium among the effective stress, seepage force, pore-water pressure and total stress. The conceptual definition of stress variable that satisfies the principles of continuum mechanics is applied in the coupled hydromechanical analysis. It is shown that Terzaghi's effective stress is in fact not a stress variable under seepage conditions, and the seepage force acting on the soil skeleton cannot be viewed as a body force. This offers a clue to the underlying cause of a paradox between the real Pascal's hydrostatic state and the hydrostatic state predicted by a class of continuum hydromechanical theories.

关键词： seepage-deformation interaction coupled hydromechanical analysis representative elementary volume stress variable stress state variable

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Multiparametric magnetic resonance imaging/transrectal ultrasound fusion prostate biopsy with semi-robotic navigation in the Chinese population： initial results

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Asian Journal of Andrology 2018年第1期20卷 93-94页

作者： wai Kit Ma Brian SH HO Andrew SH Lai Ka Cheong Lam Yun Sang Chan Lawrance kc Yip Ada TL Ng James HL Tsu Ming Kwong Yiu Division of Urology Department of Surgery The University of Hong Kong Queen Mary Hospital Hong Kong China Department of Diagnostic Radiology The University of Hong Kong Queen Mary Hospital Hong Kong China

Dear Editor, The current standard 12-core systematic transrectal ultrasound （TRUS）-guided biopsy in prostate cancer diagnosis has the disadvantages of overdetecting indolent tumors, while failing to identify clinically significant cancers in up to 35%.1 Advances in imaging techniques, notably the multiparametric magnetic resonance imaging （mpMRI）, allow clinically significant prostate cancers to be detected with more precise localization） Fusion of MRI and real-time TRUS enables targeted biopsy of suspicious lesions, overcoming human error, and inability of biopsy site tracking in cognitive fusion？ Multiple Western series have suggested a higher detection rate, higher specificity, and better risk stratification with fusion biopsy.

关键词： CANCER GUIDANCE SYSTEM

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Vitamin E isoform γ-tocotrienol alleviates cigarette smoke-induced chronic obstructive pulmonary disease

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中国药理学与毒理学杂志 2015年第S1期29卷 51-51页

作者： HongYongPEH WanShunDanielTAN TzeKheeCHAN ChenWeiPOW ChoonNamONG wai-ShiuFredWONG Department of Pharmacology Yong Loo Lin School of Medicine National University Health System Singapore Immunology Program Life Science Institute National University of Singapore Singapore-MIT Alliance for Research and Technology Singapore Saw Swee Hock School of Public Health National University Health System Singapore

OBJECTIVE Cigarette smoke-induced chronic obstructive pulmonary disease(COPD)is a leading cause of death,where inflammation and oxidative stress are involved in the *** E isoformγ-tocotrienol possesses both anti-oxidative and anti-inflammatory *** hypothesized thatγ-tocotrienol may have protective effects against *** BALB/c mice were exposedto cigarette smoke daily for 2 weeks with oralγ-tocotrienol treatment in the second *** lavage(BAL)fluid was assessed for total and differential cell counts,oxidative damage biomarkers,and cytokine *** tissues were examined for the expression of antioxidants and pro-inflammatory *** order to measure changes in lung functions in COPD,another set of mice was exposed to cigarette smoke for 2 months with oralγ-tocotrienol treatment in the last 2 ***γ-Tocotrienol dose-dependently abated cigarette smoke-induced elevation of BAL fluid total and neutrophil cell counts,cytokine and chemokine(IL-1β,IL-6,IL-17,LIX,G-CSF,kc,RANTES and VEGF)levels,as well as oxidative/nitrosative damage biomarker(advanced oxidation of protein products,8-isoprostane,8-hydroxy-2-deoxyguanosine and 3-nitrotyrosine)levels.γ-Tocotrienol promoted total lung antioxidant capacity and endogenous antioxidant activities of superoxide dismutase,catalase and glutathione *** importantly,γ-tocotrienol markedly restored work of breathing and lung functions(total lung capacity,static compliance and FEV100/FVC)in chronic experimental ***,γ-tocotrienol demonstrated better anti-oxidative,anti-inflammatory,and restoration of lung functions in COPD than *** We have shown for the first time the efficacy of vitamin E isomerγ-tocotrienol in protection against cigarette smoke-induced COPD by direct neutralization of free radicals,abating oxidative damage,and restoring antioxidants activities,coupled with anti-inflammatory actions in the inflamed airways.

关键词： cigarette smoke inflammation oxidative damage lung

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兔网织红细胞乙酰转移酶的纯化及性质研究

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中国医学科学院学报 1991年第1期13卷 33-38页

作者：邱长春 abraham EC 基础医学研究所 Medical College of Georgia

本文报告兔网织红细胞中与核糖体相连组蛋白乙酰转移酶的分离、纯化及性质的研究。核糖体的高盐提取物经bistone-sepharose 4B亲和层析、DEAE-cellulose 52及phosphoce-llulose P_(11)离子交换层析和非变性聚丙烯酰胺凝胶电泳分离,酶比... 详细信息

本文报告兔网织红细胞中与核糖体相连组蛋白乙酰转移酶的分离、纯化及性质的研究。核糖体的高盐提取物经bistone-sepharose 4B亲和层析、DEAE-cellulose 52及phosphoce-llulose P_(11)离子交换层析和非变性聚丙烯酰胺凝胶电泳分离,酶比活性提高100倍以上。在非变性聚丙烯酰胶电泳胶上,该酶活性主要分布在3个区带,其分子量依次为120 000、70 000和40 000。最适pH为7.5～8.0,当反应体系pH升至8～9时,非酶促乙酰化作用明显增加。1mmol/L MgCl_2和25mmol/L kcl对酶有激活作用,而100mmol/L MgCl_2则使酶活性抑制70％。经磷酸纤维素P_(11)柱层析纯化的组蛋白乙酰转移酶对乙酰辅酶A的米氏常数(Km)和对小牛胸腺组蛋白的Km分别为1.2μmol/L和18～20μmol/L。组蛋白乙酰转移酶在体外也可乙酰化牛清蛋白和人血红蛋白。

关键词：乙酰转移酶免网织红细胞纯化

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Non-typeable haemophilus influenzae-induced exacerbation on a cigarette smoke lung injury model:Protective effect of andrographolide

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中国药理学与毒理学杂志 2015年第S1期29卷 54-54页

作者： Wan-shunDanielTAN Hong-yonPEH Chu-huiPANG Wu-pengLIAO Tze-kheeCHAN Suk-hiangLAU VincentT.K.CHOW wai-shiuFredWONG Immunology Program Life Science Institute National University of Singapore Department of Pharmacology Yong Loo Lin School of Medicine National University Health System Interdisciplinary Research Group in Infectious Diseases Singapore-MIT Alliance for Research and Technology Department of Microbiology Yong Loo Lin School of Medicine National University of Singapore

OBJECTIVE To develop a 2-week cigarette smoke(CS)acute lung injury model exacerbated by haemophilus influenzae(NTHi)and study the protective effect of andrographolide in this COPD *** Female BALB/c mice,6-8-week-old,were exposed to 4% 3R4 FCS delivered using aperistaltic pump daily for 2 weeks to induce an acute lung injury *** 2 weeks of smoking,mice were inoculated intratracheally with NTHi to induce exacerbation on the *** were sacrificed 48 h after last bacteria challenge and lung samples were collected for various *** After developing a 2-week CS acute lung injury model exacerbated by NTHi,the CS+NTHi group was shown to have a higher inflammatory response,higher bacterial clearance,an upregulation of MMP12 mRNA levels and decrease in TIMP1 mRNA levels in the *** of Andrographolide suppressed BALF lung cellular infiltrates,TNF-α,CXCL1/kc,IL-1βand 8-OHdG protein levels,together with increased HO-1 and GR mRNA levels and decreased MMP-8 and MMP-9 mRNA *** was able to ameliorate lung histopathology as observed with H&E staining and inflammation *** was also shown to reduce Keap-1 level in lungs without affecting DJ-1 *** This study demonstrates the protective effect of andrographolide in a novel 2-week CS acute lung injury model exacerbated by NTHi and presents it as a potential therapeutic for COPD.

关键词： COPD haemophilus influenzae smoke andrographolide

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