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c-reactive protein may be a prognostic factor for the whole gastroenteropancreatic neuroendocrine tumor group

World Journal of Gastrointestinal Oncology 2019年第2期11卷 139-152页

作者： ?mer Koma? G?ksel Bengi ?zgül Sa?ol Mesut Akarsu Department of Internal Medicine Dokuz Eylul University Faculty of Medicine Department of Gastroenterology Dokuz Eylul University Faculty of Medicine Department of Pathology Dokuz Eylul University Faculty of Medicine

BAcKGROUND Long non-coding RNAs(lncRNAs) are a kind of single-stranded RNA of more than 200 nucleotides in length and have no protein-coding function. Amounting studies have indicated that lncRNAs could play a vital role in the initiation and development of cancers, including gastric cancer(Gc). considering the crucial functions of lncRNAs, the identification and exploration of novel lncRNAs in Gc is *** To identify independent prognostic markers for the whole gastroenteropancreatic neuroendocrine tumor(GEP-NET) *** Ninety-three patients diagnosed with GEP-NETs within a specified period were included in this study. Patient data were retrospectively analyzed. The relationships between all independent variables and 5-year survival status calculated during the follow-up period(months) were assessed. In addition, the relationships between the independent variables were *** When 5-year survival rate was compared, a statistically significant relationship between the age at diagnosis, male gender, tumor size, tumor stage, liver and/or distant metastasis, and tumor grade determined by the Ki-67 level and mitotic count, and the level of c-reactive protein(cRP), was observed. The meansurvival(overall survival) of the study group was 102.5 ± 6.3(SD) mo. The percentages of 1, 3 and 5-year survival were 90%, 72%, and 61%, respectively. In63 of 93 patients, Ki-67 and the mitotic count determined the same grade. The Ki-67 levels in 29 patients and the mitotic count in only 1 patient were in the higher grade. The risk of death increased by 4% for every 1 year increase at the diagnosis age and was 2.0-fold higher for male patients, 3.0-fold higher for G3 according to the mitotic count, 3.7-fold higher for G3 according to the Ki-67 level, 12.7-fold higher for cases with tumor stage 3 or 4 by a 1 cm increase in the ratio of 9% in tumor size, and 6.1-fold higher for patients with liver metastasis for every 1 mg/dL increase in the ratio of 1.5% in cR

关键词： Gastroenteropancreatic neuroendocrine tumors c-reactive protein Prognostic factor Neuroendocrine tumors Gastrointestinal system

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Development of a multiprimer metabarcoding approach to understanding trophic interactions in agroecosystems

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Insect Science 2022年第4期29卷 1195-1210页

作者： Ivan Batuecas Oscar Alomar cristina castañe Josep Piñol Stéphane Boyer Lorena Gallardo-Montoya Nuria Agustí IRTA Sustainable Plant ProtectionCabrilsBarcelonaSpain Universitat Autònoma Barcelona Cerdanyola del VallèsSpain cREAF Cerdanyola del VallèsSpain Institut de Recherche sur la Biologie de l'Insecte(IRBI) Tours UniversityToursFrance

To understand trophic interactions and the precise ecological role of each predatory species,it is important to know which arthropod and plant resources are used by generalist predators in *** approaches,such as the use of high-throughput sequencing(HTS),play a key role in identifying these *** study develops a multiprimer metabarcoding approach for screening the most common trophic interactions of two predatory arthropods with contrasting morphologies,Rhagonycha fulva(coleoptera:cantharidae)and Anthocoris nemoralis(Hemiptera:Anthocoridae)collected from a peach *** reduce the time and cost of this metabarcoding approach,we first evaluated the effect of using two different predator-pools of different size(10 and 23 individuals of the same species).We also used our system to analyze the performance of one and two primer pairs in the same *** results show that the analysis of 23 individuals together with the use of two primer pairs in the same library optimize the HTS *** these best-performing conditions,we then analyzed the entire bodies of field-collected predators as well as the washing solutions used to clean the insect *** were able to identify both gut content(i.e.,diet)and external pollen load(i.e.,on the insects’bodies).This study also demonstrates the importance of washing predatory insects’bodies prior to HTS analysis when the target species have a considerable size(>10 mm)and hairy *** metabarcoding approach has significant potential for the study of trophic links in agriculture,revealing expected and unexpected trophic relationships.

关键词： high-throug hput sequencing metabarcoding molecular diet analysis multiprimer approach predatory arthropods trophic interactions

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香椿的树木年轮宽度与超年生殖行为的相互关系:对树轮学研究的警示

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Journal of Plant Ecology 2024年第1期17卷 165-171页

作者： Monique Silva costa Thaís Jorge de Vasconcellos claudio Sergio Lisi Arno Fritz Neves Brandes Mario Tomazello-Filho cátia Henriques callado Instituto de Aplicação Fernando Rodrigues da Silveira Universidade do Estado do Rio de JaneiroRua Barão de Itapagipe96.Rio Comprido 20261-005Rio de JaneiroBrazil Laboratório de Anatomia Vegetal Universidade do Estado do Rio de JaneiroRua São Francisco Xavier524Maracanã20550-013Rio de JaneiroBrazil Departamento de Biologia Universidade Federal de SergipeAv.Marechal Rondon s/n-Rosa Elze.São Cristóvão 49100-000SergipeBrazil Departamento de Biologia Geral Universidade Federal FluminenseRua Prof.Marcos Waldemar de Freitas ReisS/N.Gragoatá24210-201Rio de JaneiroBrazil Escola Superior de Agricultura Luiz de Queiroz Universidade de São PauloAv.Pádua Dias11.Piracicaba 13418-900São PauloBrazil

资源分配到生殖过程涉及到生态和进化因素,可能会减少植物的营养生长。这种相互关系在自然界中不容易观察到,因为有许多参数可以限制生殖结构的产生或生物量的增加。我们将香椿(cedrela odorata L.,楝科)在里约热内卢州大西洋森林中的... 详细信息

资源分配到生殖过程涉及到生态和进化因素,可能会减少植物的营养生长。这种相互关系在自然界中不容易观察到,因为有许多参数可以限制生殖结构的产生或生物量的增加。我们将香椿(cedrela odorata L.,楝科)在里约热内卢州大西洋森林中的树木年轮宽度与超年生殖行为相关联。总体而言,生殖结构的发育发生在湿润的年份,在生长季初期没有出现水分亏缺。然而,在这些年份,树木年轮宽度较小。这些结果可能与树木年轮宽度与当地气候之间缺乏相关性有关。因此,我们强调在径向生长研究中纳入生殖数据的重要性,以扩大对热带森林生长变异性的理解。

关键词：植物生长策略树木年轮学树木生态学生殖权衡

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Improved Design of a 25 MW Gas Turbine Plant Using combined cycle Application

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Journal of Power and Energy Engineering 2015年第8期3卷 1-14页

作者： Barinaadaa Thaddeus Lebele-Alawa Anthony Kpegele Le-ol Department of Mechanical Engineering Rivers State University of Science and Technology Port Harcourt Nigeria

This paper presents the improved design of a 25 MW gas turbine power plant at Omoku in the Niger Delta area of Nigeria, using combined cycle application. It entails retrofitting a steam bottoming plant to the existing 25 MW gas turbine plant by incorporating a heat recovery steam generator. The focus is to improve performance as well as reduction in total emission to the environment. Direct data collection was performed from the HMI monitoring screen, log books and manufacturer’s manual. Employing the application of MATLAB, the thermodynamics equations were modeled and appropriate parameters of the various components of the steam turbine power plant were determined. The results show that the combined cycle system had a total power output of 37.9 MW, made up of 25.0 MW from the gas turbine power plant and 12.9 MW (an increase of about 51%) from the steam turbine plant, having an HRSG, condenser and feed pump capacities of 42.46 MW, 29.61 MW and 1.76 MW respectively. The condenser cooling water parameters include a mass flow of 1180.42 kg/s, inlet and outlet temperatures of 29.8°c and 35.8°c respectively. The cycle efficiency of the dry mode gas turbine was 26.6% whereas, after modification, the combined cycle power plant overall efficiency is 48.8% (about 84% increases). Hence, SIEMENS steam turbine product of MODEL: SST-150 was recommended as the steam bottoming plant. Also the work reveals that a heat flow of about 42.46 MW which was otherwise being wasted in the exhaust gas of the 25 MW gas turbine power plant could be converted to 12.9 MW of electric power, thus reducing the total emission to the environment.

关键词： Gas Turbine Steam Turbine HRSG combined cycle Power Output Overall Efficiency condenser cooling Water

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Breast cancer:Muscarinic receptors as new targets for tumor therapy

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World Journal of clinical Oncology 2021年第6期12卷 404-428页

作者： Alejandro Español Agustina Salem Yamila Sanchez María Elena Sales Laboratory of Immunopharmacology and Tumor Biology CEFYBO CONICET University of Buenos AiresBuenos Aires C1121ABGArgentina

The development of breast cancer is a complex process that involves the participation of different *** authors have demonstrated the overexpression of muscarinic acetylcholine receptors(mAchRs)in different tumor tissues and their role in the modulation of tumor biology,positioning them as therapeutic targets in *** conventional treatment for breast cancer involves surgery,radiotherapy,and/or *** latter presents disadvantages such as limited specificity,the appearance of resistance to treatment and other side *** prevent these side effects,several schedules of drug administration,like metronomic therapy,have been *** therapy is a type of chemotherapy in which one or more drugs are administered at low concentrations ***,two chemotherapeutic agents usually used to treat breast cancer have been considered able to activate *** combination of low concentrations of these chemotherapeutic agents with muscarinic agonists could be a useful option to be applied in breast cancer treatment,since this combination not only reduces tumor cell survival without affecting normal cells,but also decreases pathological neo-angiogenesis,the expression of drug extrusion proteins and the cancer stem cell *** this review,we focus on the previous evidences that have positioned mAchRs as relevant therapeutic targets in breast cancer and analyze the effects of administering muscarinic agonists in combination with conventional chemotherapeutic agents in a metronomic schedule.

关键词： Muscarinic receptors Drug therapy Breast cancer Drug combination Metronomic therapy Drug resistance

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Nicotinic receptors modulate antitumor therapy response in triple negative breast cancer cells

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World Journal of clinical Oncology 2022年第6期13卷 505-519页

作者： Alejandro Español Yamila Sanchez Agustina Salem Jaqueline Obregon Maria Elena Sales Laboratory of Immunopharmacology and Tumor Biology CEFYBO CONICET University of Buenos AiresBuenos Aires C1121ABGArgentina

BAcKGROUND Triple negative breast cancer is more aggressive than other breast cancer subtypes and constitutes a public health problem worldwide since it has high morbidity and mortality due to the lack of defined therapeutic *** to chemotherapy complicates the course of patients’*** authors have highlighted the participation of nicotinic acetylcholine receptors(nAchR)in the modulation of conventional chemotherapy treatment in cancers of the ***,in breast cancer,less is known about the effect of nAchR activation by nicotine on chemotherapy treatment in smoking *** To investigate the effect of nicotine on paclitaxel treatment and the signaling pathways involved in human breast MDA-MB-231 tumor *** cells were treated with paclitaxel alone or in combination with nicotine,administered for one or three 48-h *** effect of the addition of nicotine(at a concentration similar to that found in passive smokers’blood)on the treatment with paclitaxel(at a therapeutic concentration)was determined using the 3-(4,5 dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** signaling mediators involved in this effect were determined using selective *** also investigated nAchR expression,and ATP“binding cassette”G2 drug transporter(ABcG2)expression and its modulation by the different treatments with Western *** effect of the treatments on apoptosis induction was determined by flow cytometry using annexin-V and 7AAD *** Our results confirmed that treatment with paclitaxel reduced MDA-MB-231 cell viability in a concentration-dependent manner and that the presence of nicotine reversed the cytotoxic effect induced by paclitaxel by involving the expression of functionalα7 andα9 nAchRs in these *** action of nicotine on paclitaxel treatment was linked to modulation of the protein kinase c,mitogen-activated protein kinase,extracellular signal-regulated kinase,and NF-κB signaling pathways,

关键词： Breast cancer Paclitaxel Nicotinic acetylcholine receptors Drug therapy Signal transduction Drug transporter

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Ethyl and butyl acetate oxidation over manganese oxides

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chinese Journal of catalysis 2018年第1期39卷 27-36页

作者： olívia Salomé G.P.Soares Raquel P.Rocha Jose J.M.Orfao Manuel F.R.Pereira José L.Figueiredo Laboratory of Separation and Reaction Engineering‐Laboratory of catalysis and Materials (LSRE‐LcM) Faculty of Engineering University of Porto Rua Dr. Roberto Frias s/n 4200‐465 Porto Portugal

Mangenese oxides were synthesized using two new methods,a novel solvent‐free reaction and a reflux technique,that produced cryptomelane‐type products(K‐OMS‐2).Oxides were also synthesized using conventional methods and all specimens were applied to the oxidation of ethyl acetate and butyl acetate,acting as models for the volatile organic compounds found in industrial *** catalysts were also characterized using N2adsorption,X‐ray diffraction,scanning electron microscopy,temperature programmed reduction and X‐ray photoelectron *** of the manganese oxides was found to be very active during the oxidation of both esters to cO2,and the synthesis methodology evidently had a significant impact on catalytic *** K‐OMS‐2nanorods synthesized by the solvent‐free method showed higher activity than K‐OMS‐2materials prepared by the reflux technique,and samples with cryptomelane were more active than those prepared by the conventional *** catalyst with the highest performance also exhibited good stability and allowed90%conversion of ethyl and butyl acetate to cO2at213and202°c,*** differences in the catalyst performance were observed,clearly indicating that K‐OMS‐2nanorods prepared by the solvent‐free reaction were better catalysts for the selected VOc oxidations than the mixtures of manganese oxides traditionally obtained with conventional synthesis *** superior performance of the K‐OMS‐2catalysts might be related to the increased average oxidation state of the manganese in these *** correlations between the catalytic performance and the surface chemical properties were also identified,hig-hlighting the K‐OMS‐2properties associated with the enhanced catalytic performance of the materials.?2018,Dalian Institute of chemical Physics,chinese Academy of *** by Elsevier *** rights reserved.

关键词： Volatile organic compound Ethyl acetate Butyl acetate Manganese oxide catalytic oxidation

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营养不良儿童菌群导向性辅食中生物活性聚糖的相关研究

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中国临床药理学杂志 2024年第1期40卷 125-125页

作者： HIBBERD M c 戴荣源

引自:HIBBERD M c,et *** glycans in a microbiome-directed food for children with malnutrition[J/ol].Nature,2023.2023-12-13[2023-12-15].https://***/38093016/.美国圣路易斯华盛顿大学HIBBERD研究团队分析了一项随机对照试验的生物样本,与热量更高的常规即食补充食品相比,菌群导向性辅食(MDcF-2)能为12~18个月大的孟加拉中度急性营养不良儿童带来更高的体质量增加率。研究人员从试验参与者的粪便微生物组中重建了1000个细菌基因组[宏基因组组装基因组(metagenome-assembled genomes,MAG)],确定了75种MAG的丰度与体质量增长[体质量身长Z评分(weight-for-length Z score,WLZ)变化]呈正相关,描述了MAG基因表达随治疗类型和WLZ反应的变化,并量化了MDcF-2和粪便中的碳水化合物结构。

关键词：辅食生物样本华盛顿大学

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富含复合维生素的基因工程玉米对小鼠没有亚急性毒性和亚慢性毒性

富含复合维生素的基因工程玉米对小鼠没有亚急性毒性和亚慢性毒性

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作者： Arjo G capell T Matias-Guiu X Zhu c christou P Pi?ol c 胡贻椿 Departament de Medicina Universitat de Lleida-Institut de Recerca Biomedica de Lleida

复合维生素玉米是一种新的基因工程品种,其可以同时产生高水平的β-胡萝卜素、抗坏血酸和叶酸,因此有潜力解决同时缺乏维生素A、叶酸和维生素c的发展中国家的多种微量营养素缺乏的问题。作为基因工程作物开发过程的一个环节,欧洲食品安... 详细信息

复合维生素玉米是一种新的基因工程品种,其可以同时产生高水平的β-胡萝卜素、抗坏血酸和叶酸,因此有潜力解决同时缺乏维生素A、叶酸和维生素c的发展中国家的多种微量营养素缺乏的问题。作为基因工程作物开发过程的一个环节,欧洲食品安全局(EFSA)的建议,必须对该多种维生素玉米进行全食物/饲料的亚慢性动物饲喂研究,从而确保其无不良反应。同时必须鉴定潜在的过敏原。我们采用小鼠开展了为期28天的毒性评估,结果表明,多种维生素大米没有发现与膳食有关的短期亚急性不良健康效应的证据。在食物消费、体重、脏器系数、血液学、血生化以及组织病理学指标等方面与对照饲料组无差异。随后开展的小鼠的90天亚慢性毒性实验研究表明,与对照组相比富含多种维生素的玉米组没有任何毒性迹象。我们的数据证实,富含多种维生素的玉米对小鼠没有不良影响,不会引起任何毒性的临床症状,也不含有已知的过敏原。

关键词：基因工程玉米安全性评估亚慢性毒性

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High-density mapping suggests cytoplasmic male sterility with two restorer genes in almond×peach progenies

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Horticulture Research 2015年第1期2卷 234-241页

作者： JoséManuel Donoso Iban Eduardo Roger Picañol Ignasi Batlle Werner Howad María JoséAranzana Pere Arús IRTA Centre de Recerca en Agrigenòmica CSIC-IRTA-UAB-UB campus UAB Bellaterra(Cerdanyola del Vallès)08193 BarcelonaSpain IRTA.centre de Mas de Bover.crta.De Reus–El Morell Km 3.8.43120 constantί TarragonaSpain INIA Av.Salamanca s/nSector Los ChoapinosRengoChile Rijk Zwaan Finca La Marina-Pj Lo Contreras s/n30395 La PueblaCartagenaSpain

Peach(Prunus persica)and almond(Prunus dulcis)are two sexually compatible species that produce fertile ***,a highly polymorphic species,is a potential source of new genes for peach that has a strongly eroded gene *** we describe the genetics of a male sterile phenotype that segregated in two almond(‘Texas’)×peach(‘Earlygold’)progenies:an F2(T×E)and a backcross one(T1E)to the‘Earlygold’***-density maps were developed using a 9k peach SNP chip and 135 simple-sequence *** highly syntenic and collinear maps were obtained:one for the F2(T×E)and two for the backcross,T1E(for the hybrid)and E(for‘Earlygold’).A major reduction of recombination was observed in the interspecific maps(T×E and T1E)compared to the intraspecific parent(E).The E map also had extensive monomorphic genomic regions suggesting the presence of large DNA fragments identical by *** data for the male sterility character were consistent with the existence of cytoplasmic male sterility,where individuals having the almond cytoplasm required the almond allele in at least one of two independent restorer genes,Rf1 and Rf2,to be *** restorer genes were located in a 3.4 Mbp fragment of linkage group 2(Rf1)and 1.4 Mbp of linkage group 6(Rf2).Both fragments contained several genes coding for pentatricopeptide proteins,demonstrated to be responsible for restoring fertility in other *** implications of these results for using almond as a source of novel variability in peach are discussed.

关键词： linkage restore mapping

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