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ATM performance measurement in Europe,the US and China

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Chinese Journal of Aeronautics 2017年第2期30卷 479-490页

作者： Andrew cook Seddik Belkoura Massimiliano Zanin Department of Planning and Transport University of Westminster 35 Marylebone Road London NW1 5LS United Kingdom The Innaxis Foundation and Research Institute Jose Ortega y Gasset 20 Madrid 28006 Spain Faculdade de Ciencias e Tecnologia Departamento de Engenharia Electrotecnica Universidade Nova de Lisboa Lisboa 2829-516 Portugal

Air traffic management（ATM） performance and the metrics used in its assessment are investigated for the first time across the three largest ATM world regions：Europe,the US and *** market structure and flow management practices of each region are presented.A wide range of performance data across these three regions is *** topological and performance assessment,the notion of a ＇sufficient＇ sample is often non-intuitive：many metrics may behave non-monotonically as a function of sampling *** and under-developed metrics are identified,and the need for a balance between standardisation and flexibility is *** and cross-sectional metric trade-offs are identified.

关键词： Air traffic management Data Metric Performance Sampling Topology

Net zero emission goals demand worldwide cooperation

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National Science Review 2023年第11期10卷 93-95页

作者： Shi Xue Dou Wei-Hong Lai Chris cook Institute of Energy Materials Science University of Shanghai for Science and Technology Institute for Superconducting and Electronic Materials University of Wollongong Faculty of Engineering and Information Sciences University of Wollongong

The serious threat of climate change has become a reality of daily life all over the world. There is no priority facing humans at present more urgent than climate change. The goal of achieving net zero emissions (NZEs) within a time frame short enough to avoid catastrophic changes can only be accomplished through worldwide cooperation.

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The East London glaucoma prediction score: web-based validation of glaucoma risk screening tool

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International Journal of Ophthalmology(English edition) 2013年第1期6卷 95-102页

作者： cook Stephen Longo-Mbenza Benjamin The Eye Centre East London Eastern Cape Province Faculty of Health Sciences Walter Sisulu University

AIM:It is difficult for Optometrists and General Practitioners to know which patients are at risk. The East London glaucoma prediction score (ELGPS) is a web based risk calculator that has been developed to determine Glaucoma risk at the time of screening. Multiple risk factors that are available in a low tech environment are assessed to provide a risk assessment. This is extremely useful in settings where access to specialist care is difficult. Use of the calculator is educational. It is a free web based service. Data capture is user specific. METHODS:The scoring system is a web based questionnaire that captures and subsequently calculates the relative risk for the presence of Glaucoma at the time of screening. Three categories of patient are described:Unlikely to have Glaucoma; Glaucoma Suspect and Glaucoma. A case review methodology of patients with known diagnosis is employed to validate the calculator risk assessment. RESULTS:Data from the patient records of 400 patients with an established diagnosis has been captured and used to validate the screening tool. The website reports that the calculated diagnosis correlates with the actual diagnosis 82% of the time. Biostatistics analysis showed:Sensitivity = 88% ; Positive predictive value = 97%; Specificity = 75%. CONCLUSION:Analysis of the first 400 patients validates the web based screening tool as being a good method of screening for the at risk population. The validation is ongoing. The web based format will allow a more widespread recruitment for different geographic, population and personnel variables.

关键词： glaucoma score diagnosis tomography management South Africa

Mining diversity of the natural biorefinery housed within Tipula abdominalis larvae for use in an industrial biorefinery for production of lignocellulosic ethanol

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Insect Science 2010年第3期17卷 303-312页

作者： Dana M. cook Joy Doran-Peterson Microbiology Department University of Georgia Athens Georgia USA

Although they are the largest taxonomic group of animals, relatively few insects have been examined for symbiotic relationships with micro-organisms. However, this is rapidly changing because of the potential for examination of the natural insectmicrobe-lignocellulose interactions to provide insights for biofuel technology. Micro-organisms associated with lignocellulose-consuming insects often facilitate the digestion of the recalcitrant plant diet; therefore these microbial communities may be mined for novel lignocellulose-degrading microbes, or for robust and inexpensive biocatalysts necessary for economically feasible biofuel production from lignocellulose. These insect-microbe interactions are influenced by the ecosystem and specific lignocellulose diet, and appre- ciating the whole ecosystem-insect-microbiota-lignocellulose as a natural biorefinery provides a rich and diverse framework from which to design novel industrial processes. One such natural biorefinery, the Tipula abdominalis larvae in riparian ecosystems, is reviewed herein with applications for biochemical processes and overcoming challenges involved in conversion of lignocellulosic biomass to fuel ethanol. From the dense and diverse T. abdominalis larval hindgut microbial community, a cellulolytic bacterial isolate, 27C64, demonstrated enzymatic activity toward many model plant polymers and also produced a bacterial antibiotic. 27C64 was co-cultured with yeast in fermentation of pine to ethanol, which allowed for a 20% reduction of commercial enzyme. In this study, a micro-organism from a lignocellulose-consuming insect was successfully applied for improvement of biomass-to-biofuel technology.

关键词： ethanol hydrolytic enzymes insect-associated microorganisms lignocellulose

Embracing Revenge and Logical Consequence

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学术界 2017年第2期 257-272页

作者： Roy T cook University of Minnesota-Twin Cities

Ⅰ.A philosophical sketch of embracing revenge We begin on familiar ground,with the Liar paradox,which arises when we consider the Liar sentence:

关键词：逻辑哲学发展现状社会学

Optimized Hot Spot and Directional Distribution Analyses Characterize the Spatiotemporal Variation of Large Wildfires in Washington,USA,1970-2020

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International Journal of Disaster Risk Science 2022年第1期13卷 139-150页

作者： Kevin Zerbe Chris Polit Stacey McClain Tim cook Washington Emergency Management Division Camp MurrayTacomaWA 98430USA

Spatiotemporal analysis of fire activity is vital for determining why wildfires occur where they do,assessing wildfire risks,and developing locally relevant wildfire risk reduction *** various spatial statistical methods,we determined hot spots of large wildfires(>100 acres)in Washington,the United States,and mapped spatiotemporal variations in large wildfire activity from 1970 to *** results found that all hot spots are located east of the crest of the Cascade *** spatiotemporal analysis found that the geographic area wherein most of the state’s acres burned has shrunk considerably since 1970 and has become concentrated over the north-central portion of the state over *** concentration of large wildfire activity in north-central Washington was previously unquantified and may provide important information for hazard mitigation efforts in that *** results highlight the advantages of using spatial statistical methods that could aid the development of natural hazard mitigation plans and risk reduction strategies by characterizing previous hazard occurrences spatially and spatiotemporally.

关键词： Hazard mitigation Natural hazards Spatial statistics Washington state Wildfire

Modeling murine yolk sac hematopoiesis with embryonic stem cell culture systems

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Frontiers in Biology 2014年第5期9卷 339-346页

作者： Brandoch D. cook Department of Surgery Weill Cornell Medical College New York NY 10065 USA

The onset of hematopoiesis in mammals is defined by generation of primitive erythrocytes and macrophage progenitors in embryonic yolk sac. Laboratories have met the challenge of transient and swiftly changing specification events from ventral mesoderm through multipotent progenitors and maturing lineage-restricted hematopoietic subtypes, by developing powerful in vitro experimental models to interrogate hematopoietic ontogeny. Most importantly, studies of differentiating embryonic stem cell derivatives in embryoid body and stromal coculture systems have identified crucial roles for transcription factor networks （e.g. Gatal, Runxl, Scl） and signaling pathways （e.g. BMP, VEGF, WNT） in controlling stem and progenitor cell output. These and other relevant pathways have pleiotropic biological effects, and are often associated with early embryonic lethality in knockout mice. Further refinement in subsequent studies has allowed conditional expression of key regulatory genes, and isolation of progenitors via cell surface markers （e.g. FLK1） and reporter-tagged constructs, with the purpose of measuring their primitive and definitive hematopoietic potential. These observations continue to inform attempts to direct the differentiation, and augment the expansion, of progenitors in human cell culture systems that may prove useful in cell replacement therapies for hematopoietic deficiencies. The purpose of this review is to survey the extant literature on the use of differentiating murine embryonic stem cells in culture to model the developmental process of yolk sac hematopoiesis.

关键词： hematopoietic progenitors embryonic stem cells differentiation

The First Documented Experience of Qi and an Account of Healing Failure:4th-Century BCE

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Chinese Medicine and Culture 2023年第2期6卷 139-146页

作者： Constance A.cook Professor&Chair Modern Languages and LiteraturesLehigh UniversityBethlehemPA 18015USA

This essay will review the earliest case that documents a patient’s experience of qi,one found on a bamboo text buried with the patient who died in the 318 *** of the healing encounter and of concepts of illness show how non-transmitted documents hidden from later editors in tombs preserve an older layer of medical understanding than that in transmitted canons,such as the Huang Di Nei Jing(Inner Canon of the Yellow Emperor).The 4th-century BCE case record described below is the longest early medical record concerning the treatment of a specific *** is also an account of failure formally recorded for the sake of the survivors and buried with the dead to be transmitted to the world of the *** essay begins with a reevaluation of ancient concept of qi and then moves on to the individual case record.

关键词： Ancient Divination Heart Magic Manuscript Qi Wu Xing Yin-yang

China's Urbanization in 1949–2015: Processes and Driving Forces

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Chinese Geographical Science 2017年第6期27卷 847-859页

作者： GU Chaolin HU Lingqian Ian G.cook School of Architecture Tsinghua University School of Architecture and Urban Planning University of Wisconsin-Milwaukee School of Humanities and Social Science Liverpool John Moores University

The pace and scale of China＇s contemporary urbanization are stunning. This paper reviews process and the underlying driving forces of China＇s urbanization between 1949-2015. Contemporary China＇s urbanization has experienced four stages, and each has had different driving forces： 1） economic re-construction and industrialization-led urbanization 0949-1977）; 2） economic reform and mar- ket-led urbanization （1978-1995）; 3） economic globalization and the global-local urbanization （1996-2010）; and 4） the land-economy- led urbanization （2010-）. These urbanization processes and driving forces will undoubtedly provide scientific reference and have sig- nificant implications for developing countries, especially African countries, to formulate their urbanization public policies.

关键词： urbanization Contemporary China urbanization level urbanization process driving forces public policies