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Multi-national observational study to assess quality of life and treatment preferences in patients with Crohn’s perianal fistulas

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World Journal of Gastrointestinal Surgery 2023年第11期15卷 2537-2552页

作者： Chitra Karki Amod Athavale Vijay Abilash Gary Hantsbarger Parnia Geransar Kate Lee Slobodan Milicevic Marko Perovic Leanne Raven Magdalena Sajak-Szczerba abigail silber Annabelle Yoon Phil Tozer Global Evidence and Outcomes-Gastroenterology Takeda Pharmaceuticals United StatesIncCambridgeMA 02139United States Trinity Partners LLCWalthamMA 02451-7528United States Observational Research Takeda Pharmaceuticals United StatesIncCambridgeMA 02139United States Medical Affairs Takeda Pharmaceuticals International Co.Opfikon 8152ZurichSwitzerland Research and Patient Programs Crohn’s and Colitis Canada600-60 St.Clair Avenue EastToronto M4T 1N5OntarioCanada Treasurer European Federation of Crohn’s&Ulcerative Colitis AssociationsBrussels B 1000Belgium Crohn’s and Colitis Australia Camberwell SouthVIC 3124Australia European Federation of Crohn’s&Ulcerative Colitis Associations Brussels B 1000Belgium Japan Medical Office Takeda Pharmaceutical Company LimitedTokyo 103-8668Japan Department of Colorectal Surgery St Mark’s Hospital and Academic InstituteLondon HA13UJUnited Kingdom

BACKGROUND Patients with Crohn’s disease(CD)are at risk of developing complications such as perianal *** with Crohn’s perianal fistulas(CPF)are affected by fecal incontinence(FI),bleeding,pain,swelling,and purulent perianal discharge,and METHODS This cross-sectional observational study was conducted in patients with CD aged 21-90 years via a web-enabled questionnaire in seven countries(April-August 2021).Patients were recruited into three cohorts:Cohort 1 included patients without perianal fistulas;cohort 2 included patients with perianal fistulas without fistula-related surgery;and cohort 3 included patients with perianal fistulas and fistula-related *** patient-reported outcome measures were used to assess quality of *** of treatment preferences were measured using a discrete choice experiment(DCE).RESULTS In total,929 patients were recruited(cohort 1,n=620;cohort 2,n=174;cohort 3,n=135).Short Inflammatory Bowel Disease Questionnaire scores were worse for patients with CPF(cohorts 2 and 3)than for those with CD without CPF(cohort 1):Mean score 3.8 and 3.7 vs 4.1,respectively,(P<0.001).Similarly,mean Revised FI and FI Quality of Life scores were worse for patients with CPF than for those with CD without *** of Life with Anal Fistula scores were similar in patients with CPF with or without CPF-related surgery(cohorts 2 and 3):Mean score 41 and 42,*** the DCE,postoperative discomfort and fistula healing rate were the most important treatment attributes influencing treatment choice:Mean relative importance 35.7 and 24.7,*** The burden of illness in CD is significantly higher for patients with CPF and patients rate lower postoperative discomfort and higher healing rates as the most desirable treatment attributes.

关键词： Burden of illness Crohn’s disease Discrete choice experiment Perianal fistulas Patient-reported outcomes Treatment preferences

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Measures of Relative and Absolute Convergence and Pro-poor Growth with an Illustration based on China(2010–2018)

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China & World Economy 2024年第2期32卷 1-41页

作者： Elena Bárcena-Martin Jacques silber Yuan Zhang Facultad de Ciencias Económicas y Empresariales Universidad de MálagaSpain Department of Economics Bar-Ilan UniversityIsrael China Center for Economic Studies Fudan UniversityChina

Income mobility is a key issue for understanding the process of economic growth and distributional *** economists have used the concept of“pro-poor growth”to examine,with individual-level panel data,whether the poor benefit more than the rich from economic growth by tracking the extent of income mobility among different population *** is also literature in macroeconomics on the measurement of *** paper introduces population-weighted relative and absolute indices of mobility,convergence,and pro-poor growth;it also distinguishes between anonymous and nonanonymous approaches to these *** empirical analysis is based on Chinese panel data for the period 2010–*** both absolute and relative terms,income growth in China was greater for individuals with an initially lower income but only for lower income deciles in relative *** was also an overall increase in individual welfare from anonymous and nonanonymous perspectives,which was higher among younger *** welfare of the poor did not increase more than that of the *** results shed light on the evolution of income distribution in China during the past decade's rapid economic growth.

关键词： anonymous and nonanonymous approach convergence exchange and structural mobility pro-poor growth

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Facile synthesis of intra-nanogap enhanced Raman tags with different shapes

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Nano Research 2024年第9期17卷 8415-8423页

作者： Sanjun Fan Brian T.Scarpitti Zhewen Luo abigail E.Smith Jian Ye Zachary D.Schultz Department of Chemistry and Biochemistry The Ohio State UniversityColumbusOhio 43210USA School of Biomedical Engineering Shanghai Jiao Tong UniversityShanghai 200030China

Hot spot engineering in plasmonic nanostructures plays a significant role in surface-enhanced Raman scattering(SERS)for bioanalysis and cell ***,creating stable,reproducible,and strong SERS signals remains challenging due to the potential interference from surrounding chemicals and locating SERS-active analytes into hot-spot ***,we developed a straightforward approach to synthesize intra-gap nanoparticles encapsulating 4-nitrobenzenethiol(4-NBT)as a reporter molecule within these gaps to avoid outside *** made three kinds of intra-gap nanoparticles using nanorods,bipyramids,and nanospheres as cores,in which the nanorods based intra-gap nanoparticles exhibit the highest SERS *** advantage of our method is the ease of preparation of high-yield and stable intra-gap nanoparticles characterized by a short incubation time(10 min)with 4-NBT and quick synthesis without requiring an additional step to centrifuge for the purification of core *** intense localized field in the synthesized hot spots of these plasmonic gap nanostructures holds great promise as a SERS substrate for a broad range of quantitative optical applications.

关键词： hot spot engineering surface enhanced Raman scattering intra-gap nanoparticles 4-nitrobenzenethiol

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Pulsed electromagnetic field stimulation enhances neurite outgrowth in neural cells and modulates inflammation in macrophages

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Engineered Regeneration 2024年第1期5卷 80-91页

作者： Francesco Fontana Andrea Cafarelli Francesco Iacoponi Soria Gasparini Tiziano Pratellesi abigail NKoppes Leonardo Ricotti The BioRobotics Institute Scuola Superiore Sant’Anna56127 PisaItaly Department of Excellence in Robotics&AI Scuola Superiore Sant’Anna56127 PisaItaly BAC Technology s.r.l. 50063 FlorenceItaly Department of Chemical Engineering Northeastern UniversityBostonMA 02115USA Department of Bioengineering Northeastern UniversityBostonMA 02115USA Department of Biology Northeastern UniversityBostonMA 02115USA

Nerve regeneration following traumas remains an unmet *** application of pulsed electromagnetic field(PEMF)stimulation has gained traction for a minimally invasive regeneration of ***,a sys-tematic exploration of different PEMF parameters influencing neuron function at a cellular level is not *** this study,we exposed neuroblastoma F11 cells to PEMF to trigger beneficial effects on neurite *** carrier frequencies,pulse repetition frequencies,and duty cycles were screened with a custom ad hoc setup to find the most influential parameters values.A carrier frequency of 13.5 MHz,a pulse repetition frequency of 20 Hz,and a duty cycle of 10%allowed maximal neurite outgrowth,with unaltered viability with respect to non-stimulated ***,in a longer-term analysis,such optimal conditions were also able to in-crease the gene expression of neuronal expression markers NeuN and Tuj-1 and transcription factor ***,the same optimal stimulation conditions were also applied to THP-1 macrophages,and both pro-inflammatory(TNF-α,IL-1β,IL-6,IL-8)and anti-inflammatory cytokines(IL-10,CD206)were *** optimal PEMF stimulation parameters did not induce differentiation towards an M1 macrophage phenotype,decreased IL-1β and IL-8 gene expression,decreased TNF-α and IL-8 cytokine release in M1-differentiated cells,increased IL-10 and CD206 gene expression,as well as IL-10 cytokine release in M0 *** specific PEMF stimulation regime,which is optimal in vitro,might have a high potential for a future in vivo translation targeting neural regeneration and anti-inflammatory action for treating peripheral nerve injuries.

关键词： Nerve regeneration Biophysical stimulation Pulsed electromagnetic fields(PEMF) Neurite outgrowth Anti-inflammatory Peripheral nerve injuries

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Adenovirus F40/41 Gastroenteritis-Associated Emphysematous Gastritis:A Case Report

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Infectious Diseases & Immunity 2024年第2期4卷 93-95页

作者： Maulik K.Lathiya abigail T.La Nou Maria E.Linnaus Susan M.Cullinan Emergency Department Mayo Clinic Health SystemEau Claire 54703WIUSA Critical Care Medicine Mayo Clinic Health SystemEau Claire 54703WIUSA General Surgery Department Mayo Clinic Health SystemEau Claire 54703WIUSA

Emphysematous gastritis(EG)is a rare form of gastritis characterized by gastric wall *** is associated with a high mortality *** case report describes a patient with a history of atrial fibrillation treated with apixaban,prior stroke,and schizoaffective disorder who showed epigastric tenderness on ***,no peritonitis signs were recorded,and laboratory values revealed high lactate levels and the presence of adenovirus F40/*** computed tomography scan showed extensive portal venous gas in the left hepatic lobe of the liver,as well as pneumatosis involving the entire stomach,indicating *** diagnosis was histologically confirmed and initially managed medically,which proved inefficacious,necessitating surgical intervention in the form of a laparotomy and esophagojejunostomy with Roux-en-Y *** case report suggests a potential association between EG and adenovirus F40/41–induced gastroenteritis,thereby emphasizing the challenging nature of *** underscores the need for comprehensive research to enhance our understanding of its underlying causes and effective treatment strategies.

关键词： Emphysema Gastritis Human adenovirus F40/41 Immunocompromised

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Soil Organic Carbon Stock Variation under Different Soil Types and Land Uses in the Sub-Humid Noun Plain, Western Cameroon

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Open Journal of Soil Science 2024年第4期14卷 191-209页

作者： Frank abigail Sobze Kenfack Georges Kogge Kome Achille Bienvenue Ibrahim Viviane Pauline Mandah Dieudonne Bitondo Department of Soil Science Faculty of Agronomy and Agricultural Sciences (FASA) University of Dschang Dschang Cameroon Department of Land Surveying National Advanced School of Public Works Yaound&#233 Cameroon International Institute of Tropical Agriculture Cameroon Eco-Regional Center HFS Yaound&#233 Cameroon Department of Earth Science Faculty of Science University of Dschang Dschang Cameroon

This study was conducted to assess the current stock of soil organic carbon under different agricultural land uses, soil types and soil depths in the Noun plain in western Cameroon. Three sites were selected for the study, namely Mangoum, Makeka and Fossang, representative of the three dominant soil types of the noun plain (Andosols, Acrisols and Ferralsols). Three land uses were selected per site including natural vegetation, agroforest and crop field. Soil was sampled at three depths;0 - 20 cm, 20 - 40 cm, and 40 - 60 cm. Analysis of variance showed that soil type did not significantly influence carbon storage, but rather land uses and soil depth. SOCS decreased significantly with depth in all the sites, with an average stock of 66.3 ± 15.8 tC/ha at 0 - 20 cm, compared to an average stock of 33.3 ± 7.4 tC/ha at 40 - 60 cm. SOCS was significantly highest in the natural formation with 57.2 ± 19.7 tC/ha, and lowest in cultivated fields, at 37.7 ± 10.6 tC/ha. Andosols, with their high content of coarse fragments, stored less organic carbon than Ferralsols and Acrisols.

关键词： Carbon Stocks Soil Type Soil Depth Agricultural Land Use Noun Plain

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体验经济推动体育和音乐旅游业爆发式增长

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商业周刊（中文版） 2024年第13期 39-40页

作者： abigail Glickman 孟洁冰(译) 不详

一项新研究表明,这两个行业的经济影响力将在未来八年增长一倍以上.如果你记不清身边有多少人最近发布了他们去看一级方程式赛车或泰勒·斯威夫特(Taylor Swift)演唱会的照片,那么你很可能并不孤单。根据在全球拥有Priority Pass和Loung... 详细信息

一项新研究表明,这两个行业的经济影响力将在未来八年增长一倍以上.如果你记不清身边有多少人最近发布了他们去看一级方程式赛车或泰勒·斯威夫特(Taylor Swift)演唱会的照片,那么你很可能并不孤单。根据在全球拥有Priority Pass和LoungeKey机场贵宾室的科领盛国际公司(Collinson International Ltd.)的最新研究报告,体育和音乐旅游业正在以前所未有的速度增长,预计到2032年将成为价值高达1.5万亿美元的产业。

关键词：一级方程式赛车斯威夫特经济影响力贵宾室旅游业

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Quantitative Architectural Anatomy of the Meandering Fluvial Deposits of the Neogene Upper Guantao Formation in Zhanhua Sag,Bohai Bay Basin,China

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Journal of Earth Science 2023年第6期34卷 1861-1872页

作者： Yupeng Qiao Longwei Qiu Jun Wang Fan Song Ziyi Song abigail Kuttin Colloge of Petroleum&Gas Engineering Liaoning Petrochemical UniversityFushun 113001China School of Geosciences China University of PetroleumQingdao 266580China Exploration and Development Research Institute Shengli Oilfield CompanySINOPECDongying 257015China

The residual oil in the fluvial reservoir of Gudong Oilfield is still widely developed even after decades of *** order to explore the remaining oil in the subsurface fluvial reservoir,we need to have a better understanding on fluvial sandbody *** paper aims to demonstrate how to quantify anatomy on meandering fluvial *** data from core descriptions of Guantao Formation in Gudong Oilfield were used to identify architectural *** upper Guantao Formation consists of ten lithofacies composing five different types of architectural *** integrating the available core,well logs,and seismic data,the fluvial sandbody distribution was *** characterize the fluvial channel geomorphology,we used seismic inversion to explore the stratigraphic correlation and stacking patterns of different channels,and the sandbody isopach map was obtained by the sandbody thickness in each *** architectural elements distribution in the plane was mapped by the sandbody isopach map and its profile *** to the investigation of meandering fluvial outcrops,subsurface meandering fluvial seismic geomorphology,and modern river morphology,the upstream-bar portions are always eroded because of the downstream channel *** on the morphometric parameters(bar width/looplength,upstream deflection angle,downstream deflection angle,etc.)of modern meandering river(Ob River)were obtained from the Google *** is found that the bar width/looplength and upstream deflection angle,upstream deflection angle and downstream deflection angle in modern meandering river have a good relationship,and we can have a quantitative architectural characterization on the point *** study quantified lithofacies thickness and proportion in different architectural elements of Guantao Formation,which ensures a high resolution anatomy on the small scale *** using this method,the lithofacies proportion in

关键词： meandering fluvial architectural characteristics point bar migration quantitative architectural anatomy Guantao Formation Zhanhua sag stratigraphy petroleum industry

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Associations of self-reported and device-assessed physical activity with fatigue,quality of life,and sleep quality in adults living with and beyond cancer

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Journal of Sport and Health Science 2023年第6期12卷 664-673,F0003页

作者： Phillippa Lally Natalie Ella Miller Claire Lawrence Rebecca J Beeken abigail Fisher Department of Behavioural Science and Health University College LondonLondon WC1E 6BTUK Department of Psychology University of SurreyGuildford GU27XHUK Leeds Institute of Health Sciences Leeds LS29NLUK

Background Greater physical activity is associated with improved outcomes in people living with and beyond ***,most studies in exercise oncology use self-reported measures of physical *** have explored agreement between self-reported and device-based measures of physical activity in people living with and beyond *** study aimed to describe physical activity in adults affected by cancer across self-reported and device-assessed activity,to explore levels of agreement between these measures in terms of their utility for categorizing participants as meeting/not meeting physical activity guidelines,and to explore whether meeting guidelines is associated with fatigue,quality of life,and sleep *** A total of 1348 adults living with and beyond cancer from the Advancing Survivorship Cancer Outcomes Trial completed a survey assessing fatigue,quality of life,sleep quality,and physical *** Godin-Shephard Leisure-Time Physical Activity Questionnaire was used to calculate a Leisure Score Index(LSI)and an estimate of moderate-to-vigorous physical activity(MVPA).Average daily steps and weekly aerobic steps were derived from pedometers worn by *** The percentage of individuals meeting physical activity guidelines was 44.3%using LSI,49.5%using MVPA,10.8%using average daily steps,and 28.5%using weekly aerobic ***(Cohen'sκ)between self-reported and pedometer measures ranged from 0.13(LSI *** daily steps)to 0.60(LSI ***).After adjusting for sociodemographic and health-related covariates,meeting activity guidelines using all measures was associated with not experiencing severe fatigue(odds ratios(ORs):1.43–1.97).Meeting guidelines using MVPA was associated with no quality-of-life issues(OR=1.53).Meeting guidelines using both self-reported measures were associated with good sleep quality(ORs:1.33–1.40).Conclusion Less than half of all adults affected by cancer are meeting physical activity guidelines,

关键词： Cancer survivorship Fatigue Physical activity Quality of life SleepTagedAPTARAEnd

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Exploring the role of interleukin-27 as a regulator of neuronal survival in central nervous system diseases

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Neural Regeneration Research 2022年第10期17卷 2149-2152页

作者： Andrea N.Nortey Kimberly N.Garces abigail S.Hackam Bascom Palmer Eye Institute University of Miami Miller School of MedicineMiamiFLUSA

Interleukin-27 is a pleiotropic cytokine that is involved in tissue responses to infection,cell stress,neuronal disease,and *** studies in various tissues indicate that interleukin-27 has complex activating and inhibitory properties in innate and acquired *** availability of recombinant interleukin-27 protein and mice with genetic deletions of interleukin-27,its receptors and signaling mediators have helped define the role of interleukin-27 in neurodegenerative ***-27 has been well-characterized as an important regulator of T cell activation and differentiation that enhances or suppresses T cell responses in autoimmune conditions in the central nervous *** is also accumulating that interleukin-27 has neuroprotective activities in the retina and ***-27 is secreted from and binds to infiltrating microglia,macrophage,astrocytes,and even neurons and it promotes neuronal survival by regulating pro-and anti-inflammatory cytokines,neuroinflammatory pathways,oxidative stress,apoptosis,autophagy,and epigenetic ***,interleukin-27 can have the opposite effect and induce inflammation and cell death in certain *** this review,we describe the current understanding of regulatory activities of interleukin-27 on cell survival and inflammation and discuss its mechanisms of action in the brain,spinal cord,and *** also review evidence for and against the therapeutic potential of interleukin-27 for dampening harmful neuroinflammatory responses in central nervous system diseases.

关键词： central nervous system cytokine inflammatory interleukin-27 neuroprotection retina

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