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Androgen receptor in bladder cancer:A promising therapeutic target

Asian Journal of Urology 2020年第3期7卷 284-290页

作者： abhishek tripathi Shilpa Gupta Section of Hematology Oncology University of Oklahoma Stephenson Cancer CenterOklahoma CityOKUSA Department of Hematology and Medical Oncology Cleveland Clinic Taussig Cancer InstituteClevelandOHUSA

There has been a significant progress in the treatment of metastatic urothelial carcinoma in the last few years with the advent of immunotherapy after a long gap of no drug approvals for over 4 *** immunotherapy with checkpoint inhibitors has revolutionized the treatment of urothelial carcinoma,unfortunately,only a minority of patients respond to *** options for patients who do not respond and/or progress on immunotherapy are very limited and overall prognosis remains dismal in metastatic urothelial *** first targeted therapy targeting the fibroblast growth factor receptor(FGFR)was recently approved for bladder cancer,but it is effective only in select patients harboring the FGFR2 and FGFR 3 *** drug conjugates like enfortumab vedotin have shown promising activity in clinical *** of novel targeted therapies remains an area of investigation and an unmet need in bladder *** of androgen receptor(AR)is a potential strategy for targeted drug development in bladder cancer.A significant proportion of urothelial carcinoma patients express AR irrespective of *** signaling in urothelial carcinoma has been linked to progression through multiple mechanisms,including activation of human epidermal growth factor receptor-2(EGFR or HER-2)signaling and epithelial to mesenchymal transition(EMT).Furthermore,AR is enriched in the luminal papillary mRNA subtype of urothelial carcinoma and also mediates resistance to cisplatin-based *** evidence suggests that AR inhibition can successfully inhibit urothelial carcinoma growth as monotherapy and is synergistic with cisplatin-based *** review the preclinical and clinical evidence supporting the putative role of AR signaling in urothelial carcinoma pathogenesis,progression and its role as a novel therapeutic target and future directions.

关键词： Androgen receptor Urothelial carcinoma Bladder cancer Targeted therapy Enzalutamide Cisplatin Testosterone

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Emergence of the stromal vascular fraction and secretome in regenerative medicine

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World Journal of Stem Cells 2024年第10期16卷 896-899页

作者： Ratan Kumar Choudhary Shanti Choudhary abhishek tripathi College of Animal Biotechnology Guru Angad Dev Veterinary and Animal Sciences UniversityLudhiana 141004PunjabIndia Hilltop Animal Hospital PalatineIL 60074United States

Recently,we read a mini-review published by Jeyaraman et *** article explored the optimal methods for isolating mesenchymal stromal cells from adipose tissue-derived stromal vascular fraction(SVF).Key factors include tissue source,processing techniques,cell viability assessment,and the advantages/disadvantages of autologous vs allogeneic *** authors emphasized the need for standardized protocols for SVF isolation,ethical and regulatory standards for cell-based therapy,and safety to advance mesenchymal stromal cell-based therapies in human *** manuscript shares our perspective on SVF isolation in *** discussed future directions to potentiate effective regenerative medicine therapeutics in human and veterinary medicine.

关键词： Stromal vascular fraction Mesenchymal stem cells Veterinary regenerative medicine Isolation procedures,Canine model Secretome

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Microstructure and texture evolution in AZ31 magnesium alloy during caliber rolling at different temperatures

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Journal of Magnesium and Alloys 2017年第3期5卷 340-347页

作者： abhishek tripathi S.V.S.Narayana Murty P.Ramesh Narayanan Department of Metallurgical Engineering and Materials Science Indian Institute of Technology BombayMumbai 400076India Materials Characterisation Division Materials and Metallurgy GroupVikram Sarabhai Space CentreTrivandrum 695022India

Magnesium alloy AZ31 was caliber rolled at different temperatures viz.523K,573K,623K,673K and 723K imposing a total cumulative reduction of 92%and a cumulative strain of *** associated microstructure and texture evolution were studied using Electron Back Scattered Diffraction(EBSD)and X-ray macro-texture observations *** refinement was observed in all the caliber rolled bars indicating the occurrence of dynamic *** parameter and texture index were used to study the evolution of *** doubling of the yield strength at room temperature was observed by caliber rolling at a temperature of *** improvement in mechanical properties was explained on the basis of the fine grain microstructures and suitable development of crystallographic *** on the present study,warm caliber rolling can be used as a good production method for obtaining long bars of high strength magnesium alloy AZ31.

关键词： Magnesium alloy AZ31 Microstructure Caliber rolling Texture

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Effect of Ficus benghalensis Latex Based Combinatorial Formulations on Various Bio-Molecules in Indian White Termite Odontotermes obesus

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Journal of Biosciences and Medicines 2023年第4期11卷 82-102页

作者： abhishek Kumar tripathi Ravi Kant Upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

In present investigation, various bioassays were conducted to evaluate the alteration in levels of certain biomolecules, such as glycogen, protein, amino acid, DNA, RNA and lipids. For this purpose, worker termites were treated with sub-lethal dose 40% and 80% of 24 hrs LD50 values and observations were taken at 4 hrs interval up to 24 hrs. Crude latex and its combinatorial mixtures, like S-MLT-A, B-MLT-A, C-MLT-A, CU-MLT-A, AQ-MLT significantly altered level of bio-molecules in Odontotermes obesus. This effect was found time and dose dependent. Reduction or increase in biomolecules was calculated by using corresponding control. Maximum decrease in glycogen level was observed at 16 h when termites were treated with 80% of LD50 of Ficus benghalensis aqueous extract i.e. 56.88% at 16 h of treatment. A similar dose caused very slight decrease in lipid contents at 4 h of treatment but it was found further significantly (p > 0.05) decreased in other successive treatments. 40% and 80% of LD50 of C-MLT-B mixture caused significant (p > 0.05) decrease in DNA and RNA level at 16 h treatment. The level of DNA and RNA level was recorded 83.90%, 90.18% and 85.42% and 74.05% respectively. Similarly, total proteins were also found to be decreased with 40% and 80% of LD50 of C-MLT-B mixture i.e. 71.47% and 66.45% respectively. All these alterations found in levels of various bio-molecules confirm the action of latex ingredients on worker termites that was antifeedant or deterrent types. These ingredients can be used to control not only termites but also other phytophagous insects in a sustainable and eco-friendly way.

关键词： Ficus benghalensis Odontotermes obesus Latexes Antifeedant or Deterrent Termiticides

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Toxic Effects of Ficus benghalensis Latex Based Combinatorial Formulations on Various Enzymatic Parameters in Indian White Termite Odontotermes obesus

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Advances in Enzyme Research 2023年第2期11卷 34-57页

作者： abhishek Kumar tripathi Ravi Kant Upadhyay Department of Zoology Deen Dayal Upadhyaya Gorakhpur University Gorakhpur India

In the present investigation, various bioassays were conducted to evaluate the alteration in levels of various enzymes i.e. alkaline phosphatase, acid phosphatase, glutamate oxaloacetate transaminase, glutamate pyruvate transaminase and acetylcholinesterase. For this purpose worker termites were treated with sub-lethal doses of 40% and 80% of 24 hrs LD50 of latex-based combinatorial formulations and observations were taken at 4 hours intervals up to 24 hours. Ficus benghalensis crude latex and its combinatorial mixtures, like C-MLT-A, CU-MLT-A, AQ-MLT, P-MLT and EA-MLT significantly altered the level of enzymes in Odontotermes obesus and this effect found time and dose-dependent. Reduction or increase in enzymes was calculated by using the corresponding control. The maximum decrease in acid phosphatase level was observed at 16 h when termites were treated with 80% of LD50 of B-MLT-B and P-MLT i.e. 82.84% at 16 h of treatment. A similar dose caused a very slight decrease in glutamate pyruvate transaminase at 4 h of treatment but with the increase in time. Further decrease was noted in other successive treatments that were significant at p > 0.05. Similarly, 40% and 80% of LD50 of the C-MLT-B mixture caused significant (p > 0.05) decrease in alkaline phosphatase and acid phosphatase level at 16 h treatment i.e. 93.42%, 89.46% and 95.89%, 88.17% respectively. The level of acetylcholinesterase was also found to be decreased when termites were treated with 40% and 80% of LD50 of C-MLT-B mixture i.e. 92.72% and 97.27% respectively. All the above alterations noted in levels of various enzymes confirm the action of latex ingredients on worker termites that were anti-feedant or deterrent types. These ingredients can be used to control not only termites but also other phytophagous insects.

关键词： Ficus benghalensis Enzymes Alteration Odontotermes obesus Latexes Anti-Feedant Termiticides

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Nanomaterial Based Biosensors for Detection of Viruses Including SARS-CoV-2:A Review

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Journal of Analysis and Testing 2021年第4期5卷 327-340页

作者： Ayushi Bisht abhishek Mishra Harender Bisht R.M.tripathi Amity Institute of Biotechnology Amity UniversityNoida 201303India Amity Institute of Nanotechnology Amity UniversityNoida 201303India Reliance Industries Limited MotikhavdiJamnagar 361140India

The COVID-19 outbreak led to an uncontrollable situation and was later declared a global ***-PCR is one of the reliable methods for the detection of COVID-19,but it requires transporting samples to sophisticated laboratories and takes a significant amount of time to amplify the viral ***,there is an urgent need for a large-scale,rapid,specific,and portable detection *** nanomaterials-based detection technology has been developed and it showed advancement over the conventional methods in selectivity and *** review aims at summarising some of the most promising nanomaterial-based sensing technologies for detecting *** possess unique physical,chemical,electrical and optical properties,which can be exploited for the application in ***,nanomaterials work on the same scale as biological processes and can be easily functionalized with substrates of *** devices do not require extraordinary sophistication and are suitable for use by common individuals without high-tech *** and colorimetric methods similar to glucometer and pregnancy test kits are discussed and reviewed as potential diagnostic devices for *** devices working on the principle of immune response and microarrays are also discussed as possible *** such as metal nanoparticles,graphene,quantum dots,and CNTs enhance the limit of detection and accuracy of the biosensors to give spontaneous *** challenges of industrial-scale production of these devices are also *** mass production is successfully developed,these sensors can ramp up the testing to provide the accurate number of people aff ected by the virus,which is extremely critical in today’s scenario.

关键词： SARS-CoV-2 Electrochemical sensors Nanomaterials Colorimetric detection Microarray-based sensors Impedimetric biosensors

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A novel slot scheduling technique for duty-cycle based data transmission for wireless sensor network

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Digital Communications and Networks 2022年第3期8卷 351-358页

作者： Yogesh tripathi Arun Prakash Rajeev tripathi Department of Electronics and Communication Engineering Motilal Nehru National Institute of Technology AllahabadPrayagraj211004India

The duty cycling process involves turning a radio into an active and dormant state for conserving energy. It is a promising approach for designing routing protocols for a resource-constrained Wireless Sensor Networks (WSNs). In the duty cycle-based WSNs, the network lifetime is improved and the network transmission is increased as compared to conventional routing protocols. In this study, the active period of the duty cycle is divided into slots that can minimize the idle listening problem. The slot scheduling technique helps determine the most efficient node that uses the active period. The proposed routing protocol uses the opportunistic concept to minimize the sender waiting problem. Therefore, the forwarder set will be selected according to the node's residual active time and energy. Further, the optimum routing path is selected to achieve the minimum forwarding delay from the source to the destination. Simulation analysis reveals that the proposed routing scheme outperforms existing schemes in terms of the average transmission delay, energy consumption, and network throughput.

关键词： Duty cycle Energy model Wireless sensor network Slot scheduling technique

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A Mathematical Study on Three Layered Oscillatory Blood Flow Through Stenosed Arteries

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Journal of Bionic Engineering 2012年第1期9卷 119-131页

作者： Dharmendra tripathi Department of Mathematics Indian Institute of Technology Ropar Punjab-140001 India

A mathematical model is constructed to examine the characteristics of three layered blood flow through the oscillatory cylindrical tube （stenosed arteries）. The proposed model basically consists three layers of blood （viscous fluids with different viscosities） named as core layer （red blood cells）, intermediate layer （platelets/white blood cells） and peripheral layer （plasma）. The analysis was restricted to propagation of small-amplitude harmonic waves, generated due to blood flow whose wave length is larger compared to the radius of the arterial segment. The impacts of viscosity of fluid in peripheral layer and intermediate layer on the interfaces, average flow rate, mechanical efficiency, trapping and reflux are discussed with the help of numerical and computational results. This model is the generalized form of the preceding models. On the basis of present discussion, it is found that the size of intermediate and peripheral layers reduces in expanded region and enhances in contracted region with the increasing viscosity of fluid in peripheral layer, whereas, opposite effect is observed for viscosity of fluid in intermediate layer. Final conclusion is that the average flow rate and mechanical efficiency increase with the increasing viscosity of fluid in both layers, however, the effects of the viscosity of fluid in both layers on trapping and reflux are opposite to each other.

关键词： mathematical model three layered oscillatory blood flow stenosed arteries mechanical efficiency trapping reflux

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A two-dimensional analytical model for channel potential and threshold voltage of short channel dual material gate lightly doped drain MOSFET

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Chinese Physics B 2014年第11期23卷 620-625页

作者： Shweta tripathi Department of Electronics & Communication Engineering Motilal Nehru National Institute of Technology

An analytical model for the channel potential and the threshold voltage of the short channel dual-material-gate lightly doped drain （DMG-LDD） metal-oxide-semiconductor field-effect transistor （MOSFET） is presented using the parabolic approximation method. The proposed model takes into account the effects of the LDD region length, the LDD region doping, the lengths of the gate materials and their respective work functions, along with all the major geometrical parameters of the MOSFET. The impact of the LDD region length, the LDD region doping, and the channel length on the channel potential is studied in detail. Furthermore, the threshold voltage of the device is calculated using the minimum middle channel potential, and the result obtained is compared with the DMG MOSFET threshold voltage to show the improvement in the threshold voltage roll-off. It is shown that the DMG-LDD MOSFET structure alleviates the problem of short channel effects （SCEs） and the drain induced barrier lowering （DIBL） more efficiently. The proposed model is verified by comparing the theoretical results with the simulated data obtained by using the commercially available ATLASTM 2D device simulator.

关键词： dual-material-gate MOSFET lightly doped drain short channel effect threshold voltage

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A two-dimensional analytical modeling for channel potential and threshold voltage of short channel triple material symmetrical gate Stack(TMGS) DG-MOSFET

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Chinese Physics B 2016年第10期25卷 518-524页

作者： Shweta tripathi Department of Electronics & Communication Engineering Motilal Nehru National Institute of Technology

In the present work, a two-dimensional（2D） analytical framework of triple material symmetrical gate stack（TMGS）DG-MOSFET is presented in order to subdue the short channel effects. A lightly doped channel along with triple material gate having different work functions and symmetrical gate stack structure, showcases substantial betterment in quashing short channel effects to a good extent. The device functioning amends in terms of improved exemption to threshold voltage roll-off, thereby suppressing the short channel effects. The encroachments of respective device arguments on the threshold voltage of the proposed structure are examined in detail. The significant outcomes are compared with the numerical simulation data obtained by using 2D ATLAS;device simulator to affirm and formalize the proposed device structure.

关键词： triple material symmetrical gate stack(TMGS) DG MOSFET gate stack short channel effect drain induced barrier lowering threshold voltage

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