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Cancer Biology & Medicine 2014年第4期11卷 277-280页

作者： Mohan Hingorani Sanjay dixit Fahim Bashir Mohammad Butt Simon Hawkyard Richard Khafagy Andrew Robertson Department of Clinical Oncology Castle Hill Hospital Department of Urology Scarborough General Hospital

＂Ihe management of castrate-resistant prostate cancer progressing after maximum androgen blockade （MAB） has evolved in the last decade with the development of several novel therapeutic options. However, the initial therapeutic strategy in these patients usually involves withdrawal of anti-androgen that can be associated with biochemical response in approximately 20% of patients. Notably; we have observed evidence of sustained biochemical response in two patients following second- and third-line MAB using rechallenge schedule of previously administered anti-androgen after latent interval. The possibility of response following sequential MAB using the same anti-androgen agent has not yet been reported.

关键词： Prostate cancer castrate resistance maximum androgen blockade (MAB)

Pseudomonas fluorescens-like bacteria from the stomach:A microbiological and molecular study

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World Journal of Gastroenterology 2013年第7期19卷 1056-1067页

作者： Saurabh Kumar Patel Chandra Bhan Pratap Ajay Kumar Verma Ashok Kumar Jain Vinod Kumar dixit Gopal Nath Department of Microbiology Institute of Medical SciencesBanaras Hindu UniversityVaranasi UP 221005India Department of Gastroenterology Institute of Medical SciencesBanaras Hindu UniversityVaranasi UP 221005India

AIM:To characterize oxidase-and urease-producing bacterial isolates,grown aerobically,that originated from antral biopsies of patients suffering from acid peptic ***:A total of 258 antral biopsy specimens were subjected to isolation of bacteria followed by tests for oxidase and urease production,acid tolerance and aerobic *** selected isolates were further characterized by molecular techniques *** for 16S rRNA using universal eubacterial and HSP60 gene specific *** amplicons were subjected to restriction analysis and partial sequencing.A phylogenetic tree was generated using unweighted pair group method with arithmetic mean(UPGMA) from evolutionary distance computed with bootstrap test of *** of acidity tolerance of bacteria isolated from antrum was performed using hydrochloric acid from 10-7 mol/L to 10-1 mol/***:Of the 258 antral biopsy specimens collected from patients,179(69.4%) were positive for urease production by rapid urease test and 31%(80/258) yielded typical Helicobacter pylori(***) after 5-7 d of incubation under a microaerophilic environment.A total of 240(93%) antral biopsies yielded homogeneous semi-translucent and small colonies after overnight *** partial 16S rRNA sequences revealed that the isolates had 99% similarity with Pseudomonas species.A phylogenetic tree on the basis of 16S rRNA sequences denoted that JQ927226 and JQ927227 were likely to be related to Pseudomonas fluorescens(***).On the basis ofHSP60 sequences applied to the UPGMA phylogenetic tree,it was observed that isolated strains in an aerobic environment were likely to be ***,and HSP60 sequences had more discriminatory potential rather than 16S rRNA ***,this bacterium was acid tolerant for hours at low ***,a total of 250(96.9%) genomic DNA samples of 258 biopsy specimens and DNA from 240 bacterial isolates were positive for the 613 bp amplicons by targetin

关键词： Antral biopsy Helicobacter pylori Pseudomonas fluorescens HSP60 Nested polymerase chain reaction Acid-tolerant bacteria

Morphological and mechanical characterization of a PMMA/CdS nanocomposite

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Frontiers of Chemical Science and Engineering 2011年第2期5卷 258-263页

作者： Vishal MATHUR Manasvi dixit K.S.RATHORE N.S.SAXENA K.B.SHARMA Semi-conductor&Polymer Science Laboratory 5-6Vigyan BhawanUniversity of RajasthanRajasthan 302004India

Thickﬁlm of poly(methyl methacrylate)(PMMA)/CdS nanocomposite have been synthesized by the solution casting *** nanostructure of the CdS particles has been ascertained through the small angle X-ray scattering(SAXS)*** surface morpholo-gical characterization of the PMMA/CdS nanocomposite has been done through scanning electron microscopy(SEM)*** variation of mechanical loss factor(Tanδ)with temperature and tensile properties of prepared samples have been studied using Dynamic Mechanical Analyzer(DMA).This study reveals that the glass transition temperature(Tg),Young’s modulus,and fracture energy of the PMMA/CdS nanocomposite are greatly inﬂuenced by the existence of interfacial energetic interaction between dispersed CdS nanoparticles and the matrix of PMMA.

关键词： poly(methyl methacrylate)(PMMA) ﬁller nanoparticles polymer semiconducting nanocomposite tensile properties glass transition temperature

Development and Evaluation of Self-propelled Cabbage/Cauliflower Harvester

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NASS Journal of Agricultural Sciences 2022年第1期4卷 56-63页

作者： Jagvir dixit Naieam Jan Rawat Division of Farm Machinery and Power Engineering College of Agricultural Engineering&TechnologySKUAST-KSrinagar(J&K)India

In the present study,self-propelled cabbage/cauliflower harvester was designed,developed and *** machine consisted of different components like engine,frame,shearing(cutting)unit and power transmission *** power transmission unit consisted of main clutch,shearing blade operating clutch,belt drive unit,chain and sprocket drive,universal joint and cutter blade *** main working principle of harvester is based on shearing of crop stem against high-speed rotating *** power from the engine is transmitted by belt-pulley drive unit to transmission shaft on which chain and sprocket is mounted on one side and then power is transmitted to shearing blade coupling with the help of a stationary pulley and fixed *** mean head diameter of the selected cabbage and cauliflower was 89.5±15.24 mm and 107.5±15.24 mm,*** mean stem(plant)diameter of the selected cabbage and cauliflower was 18±4.85 mm and 21.5±3.08 mm,*** shearing force increased with increase in diameter of *** optimum performance of the machine was achieved when it was operated at 1.5 km/h forward speed and the shearing blade moving at speed of 147 *** mean field capacity for developed prototype was observed as 0.063 ha/h and 0.053 in case of cabbage and cauliflower,respectively with field efficiency of 91.97 and 90.48%.The average head damage was negligible(0.15%)for both the *** average untrimmed percentage with developed harvester was 3.2 and 3.0%in case of cabbage and cauliflower crop,*** developed machine helps to increase the field capacity in cabbage/cauliflower harvesting due to 7-times more capacity and 50%cheaper compared to traditional method of cabbage/cauliflower *** the operating condition of forward speed(1.5 km/h)and shearing blade speed(147 rpm),the machine could harvest 0.5 ha of cabbage and 0.42 ha of cauliflower farm per day of *** same task would have required between 15 labour per day if

关键词： Self-propelled Harvester Cabbage/cauliflower Field capacity Field efficiency Untrimmed percentage

Advances in Oligoprotection

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Neuroscience & Medicine 2011年第2期2卷 93-103页

作者： Hong Liao dixit Sanjaya Mani 不详

Oligodendrocytes, the myelinating glial cells of the nervous system, in various disease states display great vulnerability to excitotoxic damage, oxidative stress, and inflammatory cytokines. Besides demyelinating diseases where oligoden-drocyte injury is primarily implicated, damage to them also occurs secondarily in various neuropathies. Oligoprotec-tion should, therefore, be looked into something not just as a means for protecting oligodendrocytes alone but also as a common target of protecting neurons and the neurogliovascular unit as a whole. In this review, we provide a descrip-tion on oligodendrocytes, the reasons for their vulnerability, the evolving new concepts of protecting neurovascular unit and recently neurogliovascular unit;the various diseases where oligodendrocyte injury is implicated with a brief idea on different injury mechanisms of oligodendrocytes. Finally, we present the summary of the drugs that have shown promising results in protecting oligodendrocytes or in protecting white matter as a whole in different in-vivo and in-vitro models.

关键词： Oligodendrocytes neurovascular unit oxidative stress excitotoxicity demyelinating diseases stroke spinal cord injury neuropharmacology

Antioxidant Potential Some Medicinal Plants of Central India

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Journal of Cancer Therapy 2010年第2期1卷 87-90页

作者： Savita dixit Huma Ali Maulana Azad National Institute of Technology Bhopal Bhopal India Maulana Azad National Institute of Technology Bhopal Bhopal India.

Cellular damage or oxidative injury arising from free radicals or reactive oxygen species (ROS) now appears the fun-damental mechanism underlying a number of human neurodegenerative disorder, diabetes, inflammation, viral infec-tions, autoimmune pathologies and digestive system disorders. Free radicals are generated through normal metabolism of drugs, environmental chemicals and other xenobiotics as well as endogenous chemicals, especially stress hormones (adrenalin and noradrenalin). Accumulated evidence suggests that ROS can be scavenged through chemoprevention utilizing natural antioxidant compounds present in foods and medicinal plants. In this review, research on the antioxi-dant potential of some medicinal plants of origin of Central India is considered.

关键词： Medicinal Plants Antioxidant Activity Chemoprevention Neurodegenerative Diseases Central India

An Experimental Study of Microstructure through SEM and AFM by Interaction from High Power Femtosecond Laser Wave with BaTiO₃

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Journal of Modern Physics 2016年第10期7卷 1068-1081页

作者： Shivani Saxena Sanjay dixit Sanjay Srivastava Department of Physics Government Motilal Vigyan Mahavidyalaya College Barkatullah University Bhopal India Department of Material Science & Metallurgical Engineering Maulana Azad National Institute of Technology Bhopal India

This paper deals with the interaction of femtosecond laser with strain dependent high dielectric material. For this investigation, ferroelectric material like BaTiO3 has been chosen because of centrosymmetric structure. Due to irradiation of laser light, the micro-structure of BaTiO3 is found to change along the direction of heat propagation. SEM and AFM tools have been used to detect the morphology and roughness of the femotosecond laser treated BaTiO3. The change of morphology and surface behavior depends upon the laser fluence and intensity of laser light. The maximum change in morphology has been observed at a higher laser fluence.

关键词： BaTiO3 Femtosecond Laser Laser Fluence Ablated Areas

High level of soluble expression and purification of catalytically active native UDP-galactose 4-epimerase of <i>Aeromonas hydrophila</i>in <i>E. coli</i>

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Advances in Bioscience and Biotechnology 2011年第6期2卷 397-403页

作者： Keshav Gopal Shivani Agarwal Aparna dixit 不详

The ubiquitous Aeromonas hydrophila is responsible for several pathological conditions in fish and human. Like most gram negative bacteria, its virulence relies on outer membrane lipopolysachharide (LPS). The Leloir pathway enzyme UDP-galactose 4-epimerase (GalE), plays an important role in the LPS biosynthesis, and therefore is a potential drug target. We have earlier carried out extensive biochemical and biophysical studies with histidine-tagged recombinant GalE. However, for effective drug design it is desirable to understand the structure-function relation of a protein in its native form without any additional sequences or tags. In the present study, we report the high level expression, purification and characterization of recombinant GalE (rGalE) of Aeromonas hydrophila in its native form in E coli. The rGalE expressed as a soluble protein was purified to near homogeneity. From 1 L of shake flask culture ~15 mg of purified rGalE was obtained. The purified protein was biologically active with Km and Kcat values of 0.7 mM and 28.8 s–1, respectively. The enzyme exhibited a temperature and pH optima of 37。C and 7 - 9, respectively. Thus, the present study employed for soluble expression and purification of functionally active rGalE without any tag bypasses the need for cumbersome strategies associated with removal of tag from purified protein.

关键词： Tag-Less GalE Aeromonas hydrophila Recombinant Expression Kcat

Assessment of compatibility of rhlGF-1/rhlGFBP-3 with neonatal intravenous medications

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World Journal of Pediatrics 2023年第1期19卷 58-67页

作者： Nazila Salamat-Miller Mark A.Turner Amey Bandekar Nitin dixit Emily Jochim Barry Mangum Christopher McPherson Srini Tenjarla Sukhjeet Singh You Seok Hwang Norman Barton Takeda 200 Shire WayLexingtonMA 02421USA Institute of Translational Medicine University of LiverpoolLiverpoolUK Paidion Research DurhamNCUSA Washington University St.LouisMOUSA

Background Recombinant human(rh)IGF-1/IGFBP-3 protein complex,administered as a continuous intravenous infusion in preterm infants,is being studied for the prevention of complications of *** We conducted in vitro studies to evaluate the physical and chemical compatibility of rhIGF-1/IGFBP-3 with medications routinely administered to preterm *** vitro mixing of rhIGF-1/IGFBP-3 drug product with small-molecule test medications plus corresponding controls was *** compatibility was defined as no color change,precipitation,turbidity,gas evolution,no clinically relevant change in pH/osmolality or loss in medication *** compatibility of small molecules was assessed using liquid chromatography(e.g.,reverse-phase HPLC and ion chromatography),with incompatibility defined as loss of concentration of≥10%.A risk evaluation was conducted for each medication based on in vitro compatibility data and potential for chemical *** In vitro physical compatibility was established for 11/19 medications:caffeine citrate,fentanyl,fluconazole,gen-tamicin,insulin,intravenous fat emulsion,midazolam,morphine sulfate,custom-mixed parenteral nutrition solution(with/without electrolytes),parenteral nutrition solution+intravenous fat emulsion,and vancomycin(dosed from a 5 mg/mL solu-tion),but not for 8/19 medications:amikacin,ampicillin,dopamine,dobutamine,furosemide,meropenem,norepinephrine,and penicillin G,largely owing to changes in pH after ***-molecule compatibility was unaffected post-mixing,with no loss of small-molecule *** physically compatible medications,risk analyses confirmed low probability and severity of a risk *** Co-administration of rhIGF-1/rhIGFBP-3 drug product with various medications was assessed by in vitro studies using case-by-case risk analyses to determine the suitability of the products for co-administration.

关键词： Chemical compatibility Intravenous Neonatal Physical compatibility rhIGF-1/rhIGFBP-3

Fatigue life of machined components

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Advances in Manufacturing 2017年第1期5卷 59-76页

作者： A. Pramanik A. R. dixit S. Chattopadhyaya M. S. Uddin Yu Dong A. K. Basak G. Littlefair Department of Mechanical Engineering Curtin UniversityBentley WA 6102 Australia Department of Mechanical Engineering Indian School ofMines Dhanbad 826004 India School of Engineering University of South AustraliaMawson Lakes SA 5095 Australia Adelaide Microscopy The University of Adelaide AdelaideSA Australia School of Engineering Deakin University Waurn PondsVIC Australia

A correlation between machining process and fatigue strength of machined components clearly exists. However, a complete picture of the knowledge on this is not readily available for practical applications. This study addresses this issue by investigating the effects of machining methods on fatigue life of commonly used materials, such as titanium alloys, steel, aluminium alloys and nickel alloys from previous literature. Effects of turning, milling, grinding and different non-conventional machining processes on fatigue strength of above-mentioned materials have been investigated in detail with correlated information. It is found that the effect of materials is not significant except steel in which phase change causes volume expansion, resulting in compressive/tensile residual stresses based on the amounts of white layers. It is very complex to identify the influence of surface roughness on the fatigue strength of machined components in the presence of residual stresses. The polishing process improves the surface roughness, but removes the surface layers that contain compressive residual stresses to decrease the fatigue strength of polished specimens. The compressive and tensile residual stresses improve and reduce fatigue strength, respectively. Grinding process induces tensile residual stresses on the machined surfaces due to high temperature generation. On the other hand, milling and turning processes induce compressive residual stresses. High temperature non-conventional machining generates a network of microcracks on the surfaces in addition to tensile residual stresses to subsequently reduce fatigue strength of machined components. Embedded grits of abrasive water jet machining degrade the fatigue performance of components machined by this method.

关键词： Traditional machining Non-traditionalmachining Fatigue strength Surface roughness Residualstress Phase change