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Macrocyclic Nonapeptides Incorporating Uncharacterized Amino Acids with Inhibitory Effects on Th17 Differentiation

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CCS Chemistry 2021年第2期3卷 844-858页

作者： Kai-Long Ji Yao-Yue Fan hio.Ha Kuok Qun-Fang Liu Ting Li Jian-Min Yue State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203 State Key Laboratory of Quality Research in Chinese Medicines Macao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyMacao 999078

Four unprecedented macrocyclic nonapeptides,orberryamides A–D(1–4),were isolated from Glycosmis pentaphylla(orangeberry)and structurally characterized by obtaining solid data from numerous analytical *** 1 incorporated a new amino acid residue,named orangeberrine(Orgb),compounds 2 and 3 integrated the rare,nonproteinogenic amino acid residues(Kyn and Dioia,respectively),and compound 4 existed as two major conformational isomers in solution at ambient *** biosynthetic pathways proposed for compounds 1–4 are of considerable biological significance for the modification and metabolism of tryptophan(Trp)and/or Trp containing proteins in ***,compounds 1–4 suppressed Th17 differentiation significantly,and the effects of 1–3 was achieved through targeting the ligand-binding domain(LBD)of the retinoic acid-related orphan receptor gamma t(RORγt).

关键词： natural products Glycosmis pentaphylla,cyclopeptides Th17 differentiation inhibitors RORγt LBD blockers

Clinical results of radical prostatectomy for patients with prostate cancer in Macao

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Chinese Medical Journal 2008年第4期121卷 295-298页

作者： Ho Son-fat Lao hio.fai Li Kin Tse Men-kin Department of Urology Centro Hospitalar Conde de Sáo Januário Macao Special Administrative Region China

Background Incidence of prostate cancer has been increasing in recent decades. In the year 2005, prostate cancer became the second most common cancer in males in Macao. The purpose of this report was to review and summarize the clinical features and prognosis of the 54 patients undergoing radical prostatectomy in Macao Special Administrative Region （SAR）, China.Methods From November 2000 to November 2006, retropubic radical prostatectomy were performed in 54 cases for the treatment of prostate cancer. The mean age of patients was 69.8 years （range from 54 to 79）. The preoperative prostate specific antigen （PSA） level, postoperative pathologic stage and Gleason＇s score, operation duration, intraoperative bleeding and intraoperative and postoperative complications were reported. The follow-up duration was 3 months to 6.25 years with a mean of 2.1 years. Postoperative parameters including PSA alteration, biochemical recurrence, local recurrence, distant metastasis and mortality were observed.Results Most of the patients in our study were diagnosed as localized prostate cancer. The patients＇ preoperative serum PSA was 0-4.0 ng/ml （16.7%）, 4.0-10.0 ng/ml （51.8%）, 10.1-20.0 ng/ml （24.1%） and above 20.0 ng/ml （7.4%）. The TNM stage T1a ＋ T1b comprised 7.6% of patients, stage T2a ＋ T2b comprised 20.3%, stage T2c 38.9%, stage T3a 20.3% and over T3a only 12.9%. There were 9.5% cases with Gleason scores of 2-4, 41.5% with scores of 5-6, 30.2% with scores of 7 and 18.8% with scores of 8-10. The average operative duration was 216 minutes and the average intraoperative bleeding was 760 ml. Intraoperative complications included one massive hemorrhage （1.9%）, one rectal injury （1.9%） and one obturator nerve injury （1.9%）. Early postoperative complications consisted of urinary incontinence （14 cases, 25.9%）, bladder neck stricture （5 cases, 9.3%）, acute urinary retention （4 cases, 7.4%）, pelvic effusion （2 cases, 3.8%）, lymphocele （1 case, 1.9%） and vesicorectal fistula （only 1 c

关键词： prostate cancer prostate specific antigen radical prostatectomy

Synthesis and structure of a praseodymium (Ⅲ) complex with carboxylate ligand：A thermal and spectroscopic study

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Journal of Rare Earths 2018年第10期36卷 1090-1097页

作者： Kátia Veronica Tenório José Augusto Teixeira Leandro Moreira de Campos Pinto Flávio Júnior Caires Oswaldo Treu-Filho Fáhio.Alencar dos Santos Tiago André Denck Colman Alexandre Cuin Cláudio Teodoro de Carvalho Federal University of Grande Dourados CP 364 79804-970 Dourados MS Brazil Institute of Chemistry State University of Sao Paulo 14.801-970 Araraquara SP Brazil Chemistry Institute Federal University of Mato Grosso do Sul 79074-460 Campo Grande MS Brazil Chemistry Department State University of Sao Paulo 17033-360 Bauru SR Brazil Federal University of Juiz de Fore 36036-330 Juiz de Fora MG Brazil

One Pr（Ⅲ） lanthanide ion complex was initially synthesized and characterized by TGA-DSC in air atmosphere, as well as characterized by CHN elemental analysis, defining the stoichio.etric ratio as Pr（DMBz）3. The gaseous products evolved during the thermal decomposition were also monitored in N2 atmosphere employing TGA/FT-IR system. A crystal structure is obtained by state-of-the-art powder X-rays diffraction methods measured in conventional laboratory equipment and refined by the Rietveld method, which defined it as a monoclinic system of the space group P21/C with a polymeric crystal structure, [Pr（DMBZ）3]n. FT-IR theoretical spectrum and time-dependent density functional theory（TD-DFT） were calculated from TGA-DSC and crystalline system data. The experimental and theoretical FT-IR spectra present a high correlation degree when the main stretching bands are compared, while the energy transfer（HOMO - LUMO） in their neighborhoods suggests the main contributions of the light-emitting states.

关键词： Complex Thermal analysis Powder diffraction state-of-art Polymeric structure Theoretical calculation Rare earths

Familial gastric cancers with Li-Fraumeni Syndrome: A case repast

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World Journal of Gastroenterology 2005年第26期11卷 4124-4126页

作者： Il-Jin Kim hio.Chung Kang Yong Shin Byong Chul Yoo Han-Kwang Yang Jae-Gahb Park Korean Hereditary Tumor Registry Cancer Research Institute and Cancer Research Center Seoul National UniversitySeoulSouth Korea Research Institute and Hospital National Cancer Center Goyang Gyeonggi South Korea

TO THE EDITORAlthough the incidence of gastric cancer has declined somewhat in recent years, it remains one of the most common cancers worldwide[1], and is the most common cancer in East Asian countries such as Korea and Japan[2].In terms of the genetics of gastric cancer, mutations in CDH1 (E-cadberin) have been associated with hereditary diffuse gastric cancer (HDGC). The first germline mutation in CDH1 was reported in a large Maori HDGC family[1],with subsequent corroborations in Western and Asian HDGC families[3-5], CDH1 mutations are believed to be associated with up to 50% of HDGC families[5], but have not been linked with sporadic or intestinal types of gastric cancer[5].

关键词： Familial gastric cancers Li-Fraumeni syndrome TP53 mutation

Analysis of microsatellite instability in stool DNA of patients with colorectal cancer using denaturing high performance liquid chromatography

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World Journal of Gastroenterology 2006年第41期12卷 6689-6692页

作者： Seok-Byung Lim Seung-Yong Jeong Il-Jin Kim Dae Yong Kim Kyung Hae Jung Hee Jin Chang Hyo Seong Choi Dae Kyung Sohn hio.Chung Kang Yong Shin Sang-Geun Jang Jae-Hyun Park Jae-Gahb Park Research Institute and Hospital National Cancer CenterGoyangKorea Cancer Research Institute and Cancer Research Center Seoul National UniversitySeoulKorea

AIM： To evaluate the usefulness of denaturing high performance liquid chromatography （DHPLC） for analyzing microsatellite instability （MSI） status in stool DNA of patients with colorectal cancer. METHODS： A total of 80 cancer tissues from patients with primary sporadic colorectal tumor （proximal cancer： 27, distal cancer： 53） and matched stool （which were employed for comparison with the tissues） were analyzed for MSI status in BAT 26. DNA samples extracted from stool were evaluated by nested polymerase chain reaction （PCR） and DHPLC for MSI analysis. RESULTS： Six cases （7.5%） of MSI were identified in BAT 26 from 80 cancer tissues. All the stool DNA samples from patients whose cancer tissue showed IVlSI also displayed MSI in BAT 26. CONCLUSION： As MSI is one of the established fecal DNA markers to screen colorectal cancer, we propose to use DHPLC for the IVlSI analysis in fecal DNA.

关键词： Colorectal cancer Denaturing high performance liquid chromatography Fecal DNA MicrosateUite instability Stool

船用柴油机循环废气对燃油经济性和废气排放的影响

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柴油机 2002年第3期24卷 28-35,38页

作者： Myung-whan BAE hio.jung JEON Jae-sung CHOI 李翼龙

为测试循环废气对燃油耗率、NOx和碳烟排放的影响,在一台8缸4冲程直喷式水冷船用柴油机上对不同的负荷和转速进行了试验。不管试验工况如何,试验中燃油喷射正时固定为上止点前38℃A。进气氧气浓度通过进气空气流量和废气再循环中的氧气... 详细信息

为测试循环废气对燃油耗率、NOx和碳烟排放的影响,在一台8缸4冲程直喷式水冷船用柴油机上对不同的负荷和转速进行了试验。不管试验工况如何,试验中燃油喷射正时固定为上止点前38℃A。进气氧气浓度通过进气空气流量和废气再循环中的氧气浓度测定,废气氧气浓度在排气歧管上测定。由进气氧气与燃油耗率的比值计算的平均当量比,被用来分析评价废气再循环率（EGR）对NOx和碳烟排放的影响。结果发现比油耗受废气再循环率的影响较小,由于进气和排气氧气浓度下降以及当废气再循环率增大时当量比增大,NOx排放明显降低,而在某一给定负荷和转速下,特别是较高负荷时,碳烟排放随着EGR率的增大而加剧。基于NOx和碳烟排放这种关联关系,在不增加比油耗的条件下,在韩国重载柴油机排放标准范围内,不同的柴油机工况的最佳EGR率可以粗略估计。

关键词：船舶颗粒排放氮氧化物柴油机废气燃油经济性废气排放

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澳門地区部份居民眼病情況的調查研究

镜湖医学 1995年第1期 13-18页

作者：林琼芳幸曉華镜湖医院眼睛健康普查小組中国澳门

1993年對9683名澳門地区居民眼病調查結果分析,眼病的患病率為:屈光不ghd 42.23%、白内障40.73%、結膜病13.02%、眼底病9.03%、角膜病2.61%、眼瞼病2.38%、眼肌病1.05%、青光眼0.83%、玻璃體病0.80%及色素膜病0.34%。眼病患病率按年齡... 详细信息

1993年對9683名澳門地区居民眼病調查結果分析,眼病的患病率為:屈光不ghd 42.23%、白内障40.73%、結膜病13.02%、眼底病9.03%、角膜病2.61%、眼瞼病2.38%、眼肌病1.05%、青光眼0.83%、玻璃體病0.80%及色素膜病0.34%。眼病患病率按年齡順位第一位:屈光不正是15-24歲組;眼肌病是7〜14歲組;其余眼病是50额及以上的老人組。按職業分組:農民、漁民、退休、家務及小販的首位眼病是白内障;技術員、學生、職員、教師、専業人員、服務人員及商人的首位眼病是屈光不正,漁民的首位眼疾是結膜病。

关键词：調查眼病患病率

ASL技術診斷線粒體腦病1例報告及文獻複習

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镜湖医学 2022年第2期22卷 74-75,F0004页

作者：彭靜嫻朱海珊柯曉北陳景南澳門鏡湖醫院影像科中国澳门

線粒體腦病,乳酸性酸中毒和中風樣發作綜合症(Mitochondrial Encephalomyopathy,Lactic Acidosis,and Stroke-like Episodes,MELAS)屬於影響多系統的一種疾病,多發生在兒童期,患者多於2歲~10歲期間發病,初期常見的臨床症狀包括有全身性... 详细信息

線粒體腦病,乳酸性酸中毒和中風樣發作綜合症(Mitochondrial Encephalomyopathy,Lactic Acidosis,and Stroke-like Episodes,MELAS)屬於影響多系統的一種疾病,多發生在兒童期,患者多於2歲~10歲期間發病,初期常見的臨床症狀包括有全身性僵直陣攣型發作、復發性頭痛、復發性嘔吐、食欲減退、運動耐力不佳或近端肢體無力。癲癇症狀通常伴隨着瞬間偏癱或眼盲之類中風症狀[1]。

关键词：乳酸性酸中毒 MELAS 眼盲 Mitochondrial myopathy

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正常成人全身磁共振彌散加權成像的初步研究

镜湖医学 2016年第1期16卷 21-23,17页

作者：伍玲鄭偉基柯曉北謝學斌澳門鏡湖醫院影像科中國

目的探討成人全身磁共振彌散加權成像(WB-DWI)的正常表現。方法採用背景信號抑制全身彌散加權成像(DWIBS)序列在自由呼吸狀態下對159例正常成人進行全身掃描,經最大密度投影(MIP)重建獲得三維WB-DWI影像,並按部位或系統總結歸納人體主... 详细信息

目的探討成人全身磁共振彌散加權成像(WB-DWI)的正常表現。方法採用背景信號抑制全身彌散加權成像(DWIBS)序列在自由呼吸狀態下對159例正常成人進行全身掃描,經最大密度投影(MIP)重建獲得三維WB-DWI影像,並按部位或系統總結歸納人體主要器官或組織的正常信號表現。結果腦實質、脊髓、外周神經、會厭、面頸部腺體、脾臟、腎臟、膽囊、生殖器官、淋巴結及椎間盤呈中等~高信號;肺部呈現極低信號;血管、肌肉、脂肪等背景組織呈低信號。結論通過研究正常成人各主要臟器的DWI信號,為WB-DWI圖像評價及臨床應用提供了參考依據。

关键词：磁共振彌散加權成像全身成像