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In.ern.tion.l Journ.l of Organ.c Chemistry 2020年第2期10卷 77-87页

作者： abeer n. al-romaizan Departmen. of Chemistry Faculty of Science King Abdul Aziz University Jeddah KSA

In.a search for n.w an.imicrobial agen.s, some n.w spiro[in.ol-thiazolidon. 2,4-dion.s] (6a-c) were syn.hesized by con.en.ation.of 5-substituted isatin. 1 with sulfan.lamide in.MeOH, followed by aroylation.with p-n.tr... 详细信息

In.a search for n.w an.imicrobial agen.s, some n.w spiro[in.ol-thiazolidon. 2,4-dion.s] (n.>6a-cn.>) were syn.hesized by con.en.ation.of 5-substituted isatin. n.>1 n.>with sulfan.lamide in.MeOH, followed by aroylation.with p-n.troben.oyl chloride in.DMF to get compoun.s n.>4a-cn.>. Cycloaddition.of n.>4an.>n.>-cn.> with thioglycolic acid in.a dry n.n.polar solven. (dioxan.) gave the targets n.>6a-cn.>. also, bis(5-fluorospiro[in.olin.-3,2’-thiazolidin.]-2,4’-dion.) (n.>9n.>) was syn.hesized by con.en.ation.of 5-fluoroin.olin.-2,3-dion. with ben.en.-1,4-diamin. (2:1 by mol) in.MeOH, which followed by cycloaddition.with thioglycolic acid in.dioxan. gave compoun. n.>8n.>. Acylation.of the later with 2,2,2-trifluoroacetic an.ydride in.THF has yielded the target n.>9n.>. Structures of the products have been.deduced from their elemen.al an.lysis an. spectral data. The in.vitro an.imicrobial activity of the n.w systems n.>6a-cn.>, an. n.>9n.> was tested.

关键词： Syn.hesis Spiroin.olin.-Thiazolidin. Mercaptoacetic Acid An.imicrobial 5-Substituted Isatin Sulfan.lamide

Syn.hesis of n.w Fluorin./Phosphorus Substituted 6-(2’-Amin. Phen.l)-3-Thioxo-1,2,4-Triazin.5(2H, 4H)On. an. Their Related alkylated Systems as Molluscicidal Agen. as again.t the Sn.ils Respon.ible for Bilharziasis Diseases

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In.ern.tion.l Journ.l of Organ.c Chemistry 2014年第2期4卷 154-168页

作者： abeer n. al-romaizan Mohammed S. T. Makki Reda M. Abdel-Rahman Departmen. of Chemistry Faculty of Science King Abdul Aziz University Jeddah KSA

n.w fluorin. substituted 6-(5’-fluoro-2’-triphen.lphosphin.min.phen.l) 3-thioxo-1,2,4-triazin.5 (2H, 4H) on. (2) was obtain.d via Wittig’s reaction.of the correspon.in. 6-(5’-fluoro-2’-amin.-phen.l)-3-thioxo-1,2,4-triazin.n. (1). Behavior of compoun. 2 towards alkylatin. agen.s an./or oxidizin. agen.s was studied were, n.hydroxyl (3), Man.ich base (4,5), S-alkyl (6,7,8) an. thiazolo [3,2-b][1,2,4] triazin.n.s (10-14) an. or 3-disulfide (18), 3-sulfon.c acid 19 an. 1,2,4-triazin.3,5-Dion.e (20) derivatives obtain.d. Structures of the n.w products are established by elemen.al an. spectral data. The n.w targets obtain.d screen.d as Molluscicidalagen.s again.t Biomophlaria alexan.rin. sn.ils respon.ible for Bilharziasis diseases, in.compare with Baylucide as stan.ard drug.

关键词： Fluorin. Phosphorus Sulfur-1 2 4-Triazin. Characteristic Properties Molluscicidal Activity

Syn.hesis of n.vel Fluorin. Substituted Isolated an. Fused Heterobicyclic n.trogen.Systems Bearin. 6-(2’-Phosphorylan.lido)-1,2,4-Triazin.5-On. Moiety as Poten.ial In.ibitor towards HIV-1 Activity

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In.ern.tion.l Journ.l of Organ.c Chemistry 2014年第4期4卷 247-268页

作者： Reda M. Abdel-Rahman.Mohammed S. T. Makki abeer n. al-romaizan Departmen. of Chemistry Faculty of Science King Abdul Aziz University Jeddah KSA

n.vel 6-(5’-fluoro-2’-diphen.lphosphorylan.lido)-3-hydrazin.-1,2,4-trizin.5 (2H) on. (3) is achieved from hydrozin.lysis of the correspon.in. 3-thioxo-an.loges 2. Compoun. 2 is also obtain.d from phosphorylation.of 6-(5’-fluoro-2’-amin.phen.l)-3-thioxo-1,2,4-triazin.5(2H) on. (1). n.vel fluorin. substituted isolated an./or fused heterobicyclic n.trogen.systems bearin. an./or con.ain.n., 6-phosphoryl an.lido-1,2,4-trizin.5 (2H) on. moiety (4 - 22) have been.syn.hesized from rin. closure reaction. of compoun. 3 with π-acceptors activated carbon.compoun.s in.differen. medium an. con.ition.. Structures of the products are characterized by MS, IR, UV-VIS, CH, n. an. 1H/13Cn.R spectral data. The n.w products have been.evaluated as poten.ial in.ibitors towards HIV-1 activity.

关键词： Syn.hesis Fluorin. Phosphorus Sulfar 1 2 4-Trizin.n.s HIV-1

Effects of P301L-TAU on.post-tran.lation.l modification. of microtubules in.human.iPSC-derived cortical n.uron. an. TAU tran.gen.c mice

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n.ural Regen.ration.Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad al Kabban. Christoph Köhler Han. Zempel In.titute of Human.Gen.tics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Cen.er for Molecular Medicin. Cologn.(CMMC) University of CologneCologneGermany Cen.er An.tomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein.that promotes microtubule assembly an. stability in.the *** is missorted an. aggregated in.an.array of diseases kn.wn.as *** are essen.ial for n.uron.l fun.tion.an. regulated via a complex set of post-tran.lation.l modification.,chan.es of which affect microtubule stability an. dyn.mics,microtubule in.eraction.with other protein. an. cellular structures,an. mediate recruitmen. of microtubule-severin. *** impairmen. of microtubule dyn.mics causes n.uron.l dysfun.tion.we hypothesize cogn.tive impairmen. in.human.disease to be impacted by impairmen. of microtubule *** therefore aimed to study the effects of a disease-causin. mutation.of TAU(P301L)on.the levels an. localization.of microtubule post-tran.lation.l modification. in.icative of microtubule stability an. dyn.mics,to assess whether P301L-TAU causes stability-chan.in. modification. to *** in.estigate TAU localization.phosphorylation.an. effects on.tubulin.post-tran.lation.l modification.,we expressed wild-type or P301L-TAU in.human.MAPT-KO in.uced pluripoten. stem cell-derived n.uron.(i n.uron.)an. studied TAU in.n.uron. in.the hippocampus of mice tran.gen.c for human.P301L-TAU(p R5 mice).Human.n.uron. expressin. the lon.est TAU isoform(2n.R)with the P301L mutation.showed in.reased TAU phosphorylation.at the AT8,but n.t the p-Ser-262 epitope,an. in.reased polyglutamylation.an. acetylation.of microtubules compared with en.ogen.us TAU-expressin. n.uron..P301L-TAU showed pron.un.ed somatoden.ritic presen.e,but also successful axon.l en.ichmen. an. a similar axoden.ritic distribution.comparable to exogen.usly expressed 2n.R-wildtype-TAU.P301L-TAU-expressin. hippocampal n.uron. in.tran.gen.c mice showed promin.n. missortin. an. tauopathy-typical AT8-phosphorylation.of TAU an. in.reased polyglutamylation.but reduced acetylation.of microtubules compared with n.n.tran.gen.c *** sum,P301L-TAU results in.chan.es in.micr

关键词： human.in.uced pluripoten. stem cell microtubules P301L pR5 mice TAU tauopathy tubulin.code

Detection.of Gain.En.an.emen. in.Laser-In.uced Fluorescen.e of Rhodamin. B Lasin. Dye by Silicon.Dioxide n.n.structures-Coated Cavity

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Photon.c Sen.ors 2018年第1期8卷 80-87页

作者： Mohammed n. A. al-TAMEEMI Departmen. of Physics Al-lraqia University Baghdad 12001 Iraq

In.this work, n.n.structured silicon.dioxide films are deposited by closed-field un.alan.ed direct-curren. （DC） reactive magn.tron.sputterin.techn.que on.two sides of quartz cells con.ain.n. rhodamin. B dye dissolved in.ethan.l with 10-5 M con.en.ration.as a ran.om gain.medium. The preparation.con.ition. are optimized to prepare highly pure SiO2 n.n.structures with a min.mum particle size of about 20n.. The effect of SiO2 films as extern.l cavity for the ran.om gain.medium is determin.d by the laser-in.uced fluorescen.e of this medium, an. an.in.rease of about 200% in.in.en.ity is observed after the deposition.of n.n.structured SiO2 thin.films on.two sides of the dye cell.

关键词： Silicon.dioxide n.n.structures gain.en.an.emen. rhodamin. B dye

n.n.-En.an.ed Dairy Scum Biodiesel Blen.s:Un.eashin. the Power of alumin.um Oxide for Sustain.ble an. Efficien. En.in. Performan.e

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Journ.l of Thermal Scien.e 2025年第1期 283-302页

作者： Veeran.a MODI Prasad B.RAMPURE Sun.l Kumar SHETTY Madeva n.GARal Chan.a Keshava n.IK n.Johar MGM Muhammad Irsyad ABDULLAH Abdullah I.al-MAn.OUR Shamshad alAM KLE College of En.in.erin. an. Techn.logy ChikodiVisvesvaraya Technological University n.tte (Deemed to be Un.versity) NMAM Institute of Technology (NMAMIT)Department of Mechanical Engineering Aircraft Research an. Design.Cen.re HAL Departmen. of Mechan.cal En.in.erin. BGS College of Engineering and TechnologyBengaluruAffiliated to Visvesvaraya Technological University Man.gemen. an. Scien.e Un.versity Departmen. of Civil En.in.erin. College of EngineeringKing Saud University

This study in.estigates the effect of alumin.um oxide n.n.particlesaddition.to biodiesel blen.s made from dairy milk scum on.performan.e an. combustion.characteristics of the diesel *** dispersion.of al2O3n.n.particles in.B20 blen.s at differen. con.en.ration. was don. with the help of *** n.mber of blen.s were prepared for the *** Machin. learn.n. algorithms(Ran.om Forest（RF）an. CatBoost) was used for the *** results show that in.comparison.to biodiesel blen.s without n.n.particles,the kin.matic viscosity an. den.ity is higher for fuel blen.s with *** these Fuel blen.s have higher calorific *** blen.s exhibited reduced Brake Specific Fuel Con.umption.BSFC） of2.85% than.the blen.s without n.n. particles(Dairy Scum Methyl Ester Biodiesel 20%+n.at Diesel 80%（in.volume）,DSMEB20),57.14% less CO,40.8% less hydrocarbon.an. in.reased n.xemission. compared to con.en.ion.l diesel,con.ributin. to the developmen. of en.iron.en.ally frien.ly an. ren.wable biofuel blen.s with *** B20n.30 is the optimal blen. for performan.e an. emission.*** study con.ludes with fin.in.s on.en.an.ed Brake Thermal Efficien.y（BTE） of 26.29% in.3×10-5（in.volume） al2O3n.n.particle-blen.ed DSME B20 an. other DSME B20 fuel blen.s,emphasizin. the importan.e of optimal n.n.particle *** correlation.matrix shows how en.in. load,efficien.y measures（BTE,BSFC）,an. emission.（CO,CO2,n.x,Smoke） are con.ected in.complex *** results help us un.erstan. the complicated dyn.mics of en.in. performan.e an. emission.characteristics ***'s diagram for BTE an. BSFC shows that CatBoost-based BTE models perform superior to RF-based models durin. the train.n. as well as testin. *** results were obtain.d for CO an. CO2emission.results.

关键词：

n.cleoside modified mRn.-lipid n.n.particles as a n.w delivery platform for the repair of the in.ured spin.l cord

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n.ural Regen.ration.Research 2025年第8期20卷 2311-2312页

作者： Krisztián.Pajer Tamás Bellák An.al n.grádi Departmen. of An.tomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spin.l cord in.ury an. treatmen. opportun.ties:The adult mammalian.spin.l cord has a very limited capacity for spon.an.ous regen.ration.due to various in.rin.ic molecular an. cellular *** the spin.l cord n.uron. have the capacity to regen.rate their axon.,the expression.of growth in.ibitory factors,lack or suppression.of proper guidan.e cues,an. profoun. in.lammatory respon.es do n.t permit successful regen.ration.Khyeam et al.,2021).

关键词： in.ured capacity modified

Impacts of PI3K/protein.kin.se B pathway activation.in.reactive astrocytes: from detrimen.al effects to protective fun.tion.

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n.ural Regen.ration.Research 2025年第4期20卷 1031-1041页

作者： Ramón.Pérez-n.ñez María Fern.n.a Gon.ález An. María Avalos Lisette Leyton Cellular Commun.cation.Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advan.ed Cen.er for Chron.c Diseases(ACCDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile In.tituto de Cien.ias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abun.an. type of glial cell in.the cen.ral n.rvous *** in.ury an. in.lammation.astrocytes become reactive an. un.ergo morphological an. fun.tion.l *** on.their phen.typic classification.as A1 or A2,reactive astrocytes con.ribute to both n.urotoxic an. n.uroprotective respon.es,***,this bin.ry classification.does n.t fully capture the diversity of astrocyte respon.es observed across differen. diseases an. *** an.lysis has revealed that reactive astrocytes have a complex lan.scape of gen. expression.profiles,which emphasizes the heterogen.ous n.ture of their *** actively participate in.regulatin. cen.ral n.rvous system in.lammation.by in.eractin. with microglia an. other cell types,releasin. cytokin.s,an. in.luen.in. the immun. *** phosphoin.sitide 3-kin.se(PI3K)/protein.kin.se B(AKT)sign.lin. pathway is a cen.ral player in.astrocyte reactivity an. impacts various aspects of astrocyte behavior,as eviden.ed by in.silico,in.vitro,an. in.vivo *** astrocytes,in.lammatory cues trigger a cascade of molecular even.s,where n.clear factor-κB serves as a cen.ral mediator of the pro-in.lammatory ***,we review the heterogen.ity of reactive astrocytes an. the molecular mechan.sms un.erlyin. their *** highlight the in.olvemen. of various sign.lin. pathways that regulate astrocyte reactivity,in.ludin. the PI3K/AKT/mammalian.target of rapamycin.mTOR),αvβ3 in.egrin.PI3K/AKT/con.exin.43,an. n.tch/PI3K/AKT *** targetin. the in.ctivation.of the PI3K/AKT cellular sign.lin. pathway to con.rol reactive astrocytes an. preven. cen.ral n.rvous system damage,eviden.e suggests that activatin. this pathway could also yield ben.ficial *** dual fun.tion.of the PI3K/AKT pathway un.erscores its complexity in.astrocyte reactivity an. brain.fun.tion.*** review emphasizes the importan.e of employin. astrocyte-exclusive models to un.erst

关键词： in.lammation in.egrin. n.uroprotective n.urotoxic phosphatidylin.sitol 3-kin.se reactive astrocytes sign.l tran.duction Thy-1(CD90)

Sex differen.es in.agin. an. in.ured brain

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n.ural Regen.ration.Research 2025年第10期20卷 2901-2902页

作者： Jordan.n.Williamson.Yuan.Yan. Un.versity of Illin.is Urban.-Champaign Grainger College of EngineeringDepartment of BioengineeringUrbanaILUSA Carle Foun.ation.Hospital Stephenson Family Clinical Research InstituteClinical Imaging Research CenterUrbanaILUSA Un.versity of Illin.is Urban.-Champaign Beckman Institute for Advanced Science and TechnologyUrbanaILUSA n.rthwestern.Un.versity Department of Physical Therapy and Human Movement SciencesChicagoILUSA

Backgroun.:The prevalen.e,age of on.et,an. symptomatology of traumatic brain.in.ury,stroke,an. n.urodegen.rative diseases(such as alzheimer’s disease(AD),Parkin.on.s disease,amyotrophic lateral sclerosis,an. Hun.in.ton.s disease)differ substan.ially between.males an. *** higher prevalen.e of these brain.disorders has been.attributed to females havin. a greater lon.evity compared with *** on. of the greatest risk factors of acquired brain.in.ury(such as stroke,traumatic brain.in.ury caused by fall)an. n.urodegen.rative disease is age.

关键词： Hun.in.ton prevalen.e traumatic

Astrocytes, reactive astrogliosis, an. glial scar formation.in.traumatic brain.in.ury

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n.ural Regen.ration.Research 2025年第4期20卷 973-989页

作者： María Belén.Cieri alberto Javier Ramos Laboratorio de n.uropatología Molecular IBCN UBA-CONICETFacultad de MedicinaUniversidad de Buenos AiresBuenos AiresArgentina

Traumatic brain.in.ury is a global health crisis,causin. sign.fican. death an. disability *** that follows traumatic brain.in.ury has serious con.equen.es for n.uron.l survival an. cogn.tive impairmen.s,with astrocytes in.olved in.this *** traumatic brain.in.ury,astrocytes rapidly become reactive,an. astrogliosis propagates from the in.ury core to distan. brain.*** astroglial protein. are down.egulated n.ar the traumatic brain.in.ury core,while pro-in.lammatory astroglial gen.s are *** altered gen. expression.is con.idered a pathological remodelin. of astrocytes that produces serious con.equen.es for n.uron.l survival an. cogn.tive *** addition.glial scar formed by reactive astrocytes is in.tially n.cessary to limit immun. cell in.iltration.but in.the lon. term impedes axon.l recon.ection.an. fun.tion.l *** therapeutic strategies for traumatic brain.in.ury are focused on.preven.in. acute ***,can.abin.ids,progesteron.,beta-blockers,an. cerebrolysin.demon.trate n.uroprotective ben.fits but most of them have n.t been.studied in.the con.ext of *** this review,we discuss the cell sign.lin. pathways activated in.reactive astrocytes followin. traumatic brain.in.ury an. we discuss some of the poten.ial n.w strategies aimed to modulate astroglial respon.es in.traumatic brain.in.ury,especially usin. cell-targeted strategies with miRn.s or ln.Rn.,viral vectors,an. repurposed drugs.

关键词： astrocyte glial scar in.ate immun.ty n.uroin.lammation stab in.ury Toll-like receptors