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Chitinase 6 is required for procuticle thickening and organ shape in Drosophila wing

Insect Science 2023年第2期30卷 268-278页

作者： Wei Dong Justin Flaven-Pouchon Ying-Hao Gao Chen-Yang Song abeer El Wakil Jian-Zhen Zhang Bernard Moussian Institute of Applied Biology Shanxi UniversityTaiyuanChina Interfaculty Institute of Cell Biology University of TübingenTübingenGermany College of Life Science Shanxi UniversityTaiyuanChina Faculty of Education Department of Biological and Geological SciencesAlexandria UniversityAlexandriaEgypt INRAE CNRSUniversitéCote d’AzurInstitut Sophia AgrobiotechSophia AntipolisFrance

The polysaccharide chitin is a major scaffolding molecule in the insect *** order to be functional,both chitin amounts and chitin organization have been shown to be important *** great advances in the past decade,the molecular mechanisms of chitin synthesis and organization are not fully ***,we have characterized the function of the Chitinase 6(Cht6)in the formation of the wing,which is a simple flat cuticle organ,in the fruit fly Drosophila *** of Cht6 function by RNA interference during wing development does not affect chitin organization,but entails a thinner cuticle suggesting reduced chitin *** phenotype is opposed to the one reported recently to be caused by reduction of Cht10 *** as a consequence,cuticle permeability to xenobiotics is enhanced in Cht6-less *** also observed massive deformation of these *** addition,the shape of the abdomen is markedly changed upon abdominal suppression of ***,we found that suppression of Cht6 transcript levels influences the expression of genes coding for enzymes of the chitin biosynthesis *** finding indicates that wing epidermal cells respond to activity changes of Cht6 probably trying to adjust chitin ***,in a working model,we propose that Cht6-introduced modifications of chitin are needed for chitin synthesis to proceed *** thickness,according to our hypothesis,is in turn required for correct organ or body part *** molecular mechanisms of this processes shall be characterized in the future.

关键词： abdomen chitin Cht6 Drosophila melanogaster procuticle wing

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Optimization Techniques in University Timetabling Problem:Constraints,Methodologies,Benchmarks,and Open Issues

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Computers, Materials & Continua 2023年第3期74卷 6461-6484页

作者： abeer Bashab Ashraf Osman Ibrahim Ibrahim Abakar Tarigo Hashem Karan Aggarwal Fadhil Mukhlif Fuad A.Ghaleb Abdelzahir Abdelmaboud Faculty of Computer Science&Information Technology Alzaiem Alazhari University13311KhartoumSudan Faculty Computing and Informatics Universiti Malaysia SabahKota Kinabalu88400SabahMalaysia Department of Computer Science University of SharjahSharjah27272United Arab Emirates Electronic and Communication Engineering Department Maharishi Markandeshwar Deemed to be UniversityMullanaAmbala133207HaryanaIndia Information Assurance and Security Research Group(IASRG) School of ComputingFaculty of EngineeringUniversiti Teknologi Malaysia81310JohorMalaysia Department of Information Systems King Khaled UniversityMuhayel61913AseerSaudi Arabia

University timetabling problems are a yearly challenging task and are faced repeatedly each *** problems are considered nonpolynomial time(NP)and combinatorial optimization problems(COP),which means that they can be solved through optimization algorithms to produce the aspired optimal *** techniques have been used to solve university timetabling problems,and most of them use optimization *** paper provides a comprehensive review of the most recent studies dealing with concepts,methodologies,optimization,benchmarks,and open issues of university timetabling *** comprehensive review starts by presenting the essence of university timetabling as NP-COP,defining and clarifying the two formed classes of university timetabling:University Course Timetabling and University Examination Timetabling,illustrating the adopted algorithms for solving such a problem,elaborating the university timetabling constraints to be considered achieving the optimal timetable,and explaining how to analyze and measure the performance of the optimization algorithms by demonstrating the commonly used benchmark datasets for the *** is noted that meta-heuristic methodologies are widely used in the ***,recently,multi-objective optimization has been increasingly used in solving such a problem that can identify robust university timetabling ***,trends and future directions in university timetabling problems are *** paper provides good information for students,researchers,and specialists interested in this area of *** challenges and possibilities for future research prospects are also explored.

关键词： University timetabling timetabling approaches meta-heuristics combinatorial optimization

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Hussein Hassan Okasha,Mahmoud Wahba,Eva Fontagnier,abeer Abdellatef,Hani Haggag,Sameh

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World Journal of Gastrointestinal Endoscopy 2022年第8期14卷 502-507页

作者： Hussein Hassan Okasha Mahmoud Wahba Eva Fontagnier abeer Abdellatef Hani Haggag Sameh AbouElenin Department of Internal Medicine and Hepatogastroenterology Kasr Al-Aini HospitalsCairo UniversityCairo 11451Egypt Department of Internal Medicine and Gastroenterology Tawam HospitalAl-Ain 00000United Arab Emirates Department of Internal Medicine and Gastroenterology Military Medical AcademyCairo 11451Egypt

BACKGROUND Almost half of the patients with colorectal cancer(CRC)will experience localregional recurrence after standard surgical *** local recurrences of colorectal cancer(LRCC)do not grow intraluminally,and some may be covered by a normal mucosa so that they could be missed by *** detection is crucial as it offers a chance to achieve curative *** ultrasound(EUS)is mainly used in CRC staging combined with cross-section imaging *** can provide an accurate assessment of sub-mucosal lesions by demarcating the originating wall layer and evaluating its *** fineneedle aspiration(FNA)provides the required tissue examination and confirms the *** SUMMARY We report a series of five cases referred to surveillance for LRCC with negative colonoscopy and/or negative endoscopic ***-FNA confirmed LRCC implanted deep into the third and fourth wall layer with normal first and second *** Assessment for LCRR is still problematic and may be very *** and EUSFNA may be useful tools to exclude local recurrence.

关键词： Colorectal cancer Endoscopic ultrasound Local recurrence Fine-needle aspiration Deep implanted CRC Case report

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Barriers of Asthma Care among Asthmatic Children in Saudi Arabia: Maternal Perspectives

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Open Journal of Pediatrics 2020年第2期10卷 302-313页

作者： abeer Alatawi Meshaal Alanazi Department of Nursing Faculty of Applied Medical Sciences Tabuk University Tabuk Saudi Arabia Department of Emergency Medical Services Saudi Red Crescent Authority Tabuk Saudi Arabia

Background Bronchial asthma is one of the most common chronic conditions among children. Despite the improvement in asthma treatment regimens, its prevalence and related morbidity are increasing, especially among underserved, minority children. There are barriers in the management of asthma, which may impact the quality of outcomes. The goal of this study is to explore these barriers. Methods A cross-sectional study was conducted on interview data collected through 2019 from mothers of children (aged 6 - 12 years) with asthma visiting, for convenience, a public shopping mall. The interviewees were randomly selected, because they met the inclusion criteria. Participants were considered if the mother answered “yes” to the following questions: Has your child had physician-diagnosed asthma? Is your child currently taking asthma medications of asthma? Two community nurses conducted the interviews. Data was obtained using administrative questionnaires. Data were analyzed using SPSS version 21.0 (IBM Inc., Chicago, IL, USA). Descriptive statistics of percentage, mean, frequency and standard deviation were applied for categorical and continuous variables. Results Three hundred mothers participated in this study. Their average age was 36.8 years, 55% were housekeepers by profession, and 34% had obtained less than high school education. The majority of children (61%) were males, 45% had moderate asthma, and 42% had mild asthma. The most frequent types of barriers identified by parents were environmental factors (67.7%), followed by health care providers (63%),

关键词： Barriers to Asthma Care Mothers Children and Saudi Arabia

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Grape Seed Extract (<i>Vitisvinifera</i>) Alleviate Neurotoxicity and Hepatotoxicity Induced by Lead Acetate in Male Albino Rats

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Journal of Behavioral and Brain Science 2012年第2期2卷 176-184页

作者： abeer M. Waggas Department of Biology (Zoology) Faculty of Girls Education Scientific Department King Abdulaziz University Jeddah Saudi Arabia

Grape seed extracts (GSE) are very potent antioxidant and exhibit numerous interesting pharmacologic activities, including an antioxidant property, and has been suggested to be of use in treatment of several diseases. The present study has been undertaken to investigate the protective and therapeutic effect of GSE against lead-induced neuro and hepatotoxicity in rat. Male albino rats were divided into six groups: the 1st group, rats were injected daily with saline vehicle and served as negative control, the 2nd group (positive control group), the rats were injected (i.p.) with subacute dose (100 mg/kg b·w/day) of lead acetate (LA). The 3rd group (protective group), the rats were injected (i.p.) with LA (100 mg/kg b·w/day) for 7 days after treatment with GSE (100 mg/kg b·w/day) for 3 weeks. The 4th, 5th and 6th groups (therapeutics groups), rats were injected (i.p.) with subacut dose (100 mg/kg b·w/day) of lead acetate for 7 days, then treated with GSE (100 mg/kg b·w/day) for one, two and three weeks, respectively. The level of norepinephrine (NE), dopamine (DA), serotonin (5-HT) and 5-hydroxyindol acetic acid (5-HIAA) were evaluated in brain regions (cerebellum, brainstem, striatum, cerebral cortex, hypothalamus and hippocampus). The result indicated that the administration of subacute dose of LA (100 mg/kg/day, i.p.) induce a significant decrease in NE, DA, 5-HT and 5-HIAA content in all tested brain regions. Also the obtained data showed significant increase in liver enzymes: serum glutamate oxaloacetate transaminase (GOT), serum glutamate pyruvate transaminase (GPT) and Lactate dehydrogenase (LDH) level in group 2 (positive control). There is an improvement in neurotransmitters content. Also the obtained data showed significant in- crease in liver enzymes of protective (G3) and therapeutics groups (G4, G5 and G6) which received GSE compared with animal group that received lead acetate (G2). This is may be the presence of proanthocyanidins and procyanidins which h

关键词： Grape Seed Extract Lead Lead Acetate Antioxidant Norepinephrine Dopamine Serotonin 5-Hydroxyindol Acetic Acid Brain Liver Rat

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Value of duplex doppler ultrasonography in non-invasive assessment of children with chronic liver disease

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World Journal of Gastroenterology 2010年第48期16卷 6139-6144页

作者： Mortada HF El-Shabrawi Maissa El-Raziky Maha Sheiba Hanaa M El-Karaksy Mona El-Raziky Fetouh Hassanin abeer Ramadan Department of Pediatrics Cairo University Department of Tropical Medicine Cairo University Department of Clinical Pharmacy Misr International University

AIM:To investigate the value of duplex Doppler ultrasonography (US) in the assessment of the hemodynamics of the portal and hepatic veins in a cohort of children with chronic liver disease (CLD) and to detect any relationship between the US changes,etiology and severity (or stage) of CLD. METHODS:We prospectively enrolled 25 children with biopsy-proven CLD. Thirteen had cirrhosis (aged 8.9 ± 2.0 years) and 12 had chronic hepatitis (aged 9.3 ± 2.3 years). Gray scale and color-coded duplex Doppler US were performed for all,as well as 30 healthy age and sex-matched controls. Findings were correlated with clinical,laboratory and histopathological characteristics. RESULTS:Prominent caudate lobe was detected in 100% of cirrhotics,but none of the chronic hepatitis or controls. Thickened lesser omentum and loss of the triphasic waveform of the hepatic vein were present in 69.2% and 53.8% of cirrhotics vs 33.3% and 8.3% of chronic hepatitis respectively. Portal vein flow velocity was significantly lower (P < 0.0001) and the congestion index was significantly higher (P < 0.005) in both patient groups compared to controls. Child-Pugh's staging showed a positive correlation with both abnormal hepatic vein waveform and direction of portal blood flow; and a negative correlation with both hepatic and portal vein flow velocities. No correlation with the etiology of CLD could be detected. CONCLUSION:Duplex Doppler added to grayscale US can detect significant morphologic and portal hemodynamic changes that correlate with the severity (stage) of CLD,but not with etiology.

关键词： Chronic hepatitis Chronic liver disease Cirrhosis Doppler Grayscale Pediatrics Ultrasound

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Optimizing the Clinical Decision Support System (CDSS) by Using Recurrent Neural Network (RNN) Language Models for Real-Time Medical Query Processing

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Computers, Materials & Continua 2024年第12期81卷 4787-4832页

作者： Israa Ibraheem Al Barazanchi Wahidah Hashim Reema Thabit Mashary Nawwaf Alrasheedy abeer Aljohan Jongwoon Park Byoungchol Chang College of Computing and Informatics Universiti Tenaga Nasional(UNITEN)Kajang43000Malaysia College of Engineering University ofWarith Al-AnbiyaaKarbala56001Iraq Faculty of Information Science&Technology Universiti Kebangsaan MalaysiaBangi43600Malaysia Department of Computer Science Applied CollegeUniversity of HailHail55424Saudi Arabia Department of Computer Science and Informatics Taibah UniversityMedina42353Saudi Arabia Department of Computer Science Hanyang UniversitySeoul04763Republic of Korea

This research aims to enhance Clinical Decision Support Systems(CDSS)within Wireless Body Area Networks(WBANs)by leveraging advanced machine learning ***,we target the challenges of accurate diagnosis in medical imaging and sequential data analysis using Recurrent Neural Networks(RNNs)with Long Short-Term Memory(LSTM)layers and echo state *** models are tailored to improve diagnostic precision,particularly for conditions like rotator cuff tears in osteoporosis patients and gastrointestinal *** diagnostic methods and existing CDSS frameworks often fall short in managing complex,sequential medical data,struggling with long-term dependencies and data imbalances,resulting in suboptimal accuracy and delayed *** goal is to develop Artificial Intelligence(AI)models that address these shortcomings,offering robust,real-time diagnostic *** propose a hybrid RNN model that integrates SimpleRNN,LSTM layers,and echo state cells to manage long-term dependencies ***,we introduce CG-Net,a novel Convolutional Neural Network(CNN)framework for gastrointestinal disease classification,which outperforms traditional CNN *** further enhance model performance through data augmentation and transfer learning,improving generalization and robustness against data scarcity and *** validation,including 5-fold cross-validation and metrics such as accuracy,precision,recall,F1-score,and Area Under the Curve(AUC),confirms the models’***,SHapley Additive exPlanations(SHAP)and Local Interpretable Model-agnostic Explanations(LIME)are employed to improve model *** findings show that the proposed models significantly enhance diagnostic accuracy and efficiency,offering substantial advancements in WBANs and CDSS.

关键词： Computer science clinical decision support system(CDSS) medical queries healthcare deep learning recurrent neural network(RNN) long short-term memory(LSTM)

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Development of new lateral-flow immunochromatographic strip using colloidal gold and mesoporous silica nanoparticles for rapid diagnosis of active schistosomiasis

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Asian Pacific Journal of Tropical Biomedicine 2019年第8期9卷 315-322页

作者： Manal Kamel Faten Salah Zeinab Demerdash Sara Maher Shimaa Atta abeer Badr Ahmed Afifi Hanan El Baz Immunology Department Theodor Bilharz Research InstituteKornish El Nil streetGizaEgypt Zoology Department Faculty of ScienceCairo University12613GizaEgypt

Objective: To develop a new sandwich based lateral flow immunochromatographic strip for rapid detection of circulating Schistosoma mansoni antigen in serum and urine samples of patients with active schistosomiasis. Methods: This lateral flow immunochromatographic strip was prepared by using anti-Schistosoma mansoni soluble egg antigen monoclonal antibody conjugated gold nanoparticles (MAb-AuNPs) as antigen-detecting antibody, while crystalline material (MCM)-41-MAb bioconjugate was immobilized at the test line as antigen-capturing antibody. Both antigen capturing and detecting antibodies formed sandwich complexes with circulating Schistosoma mansoni antigen in the positive samples. Sandwich complexes immobilized at the test line gave distinct red color. The assay reliability was examined by using urine and serum samples of 60 Schistosoma mansoni infected patients, 20 patients infected with parasites other than Schistosoma, and 20 healthy individuals as negative controls. Results were compared with those obtained via sandwich enzyme linked immunosorbent assay (ELISA). Results: The detection limit of circulating Schistosoma mansoni antigen by lateral flow immunochromatographic strip was lower (3 ng/mL) than the detection limit by ELISA (30 ng/mL). The sensitivity and specificity of lateral flow immunochromatographic strip in urine samples were 98.3% and 97.5%, respectively compared to 93.5% and 90.0% by ELISA. In serum samples, they were 100.0% and 97.5%, respectively compared to 97.0% and 95.0% by ELISA. The strip test took approximately 10 min to complete. Conclusions: This new lateral flow immunochromatographic strip offers a sensitive, rapid, and field applicable technique for diagnosis of active schistosomiasis.

关键词： Schistosomiasis Nanoparticles Immunochromatographic Monoclonal antibodies

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Applying the WHO instead of CDC growth charts may double obesity rates

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Open Journal of Pediatrics 2013年第2期3卷 139-146页

作者： abeer Yasin Guido Filler Department of Paediatrics Division of Paediatric Nephrology Children’s Hospital London Health Sciences Centre London Canada

Aims: This study compares the WHO (2007) and the National Health Examination Survey (NHANES III) reference intervals and investigates the differences when applied on a Canadian cohort of older children and adolescents. Methods: We calculated height, weight and BMI z-scores of 4375 consecutive patients (1993 female, 45.6%) aged 5 - 20 years attending outpatient clinics at a single tertiary care centre using reference data of the latest NHANES (III) survey and the WHO (2007) growth charts. To address age dependency, data was stratified into age groups. Results: Using the NHANES III reference intervals, medians of weight (+0.46), height (+0.29) and BMI z-scores (+0.46) were significantly non-zero. The WHO (2007) growth charts yielded medians of +2.05, +0.32, +0.53 for weight, height and BMI z-scores respectively, all significantly non-zero. When comparing both growth charts, Canadian children had significantly different weight and BMI z-scores (p 95th percentile) doubled from 8.6% to 16.0%. A significant age dependency was observed with higher WHO (2007) weight z-scores (>7 years) and higher BMI z-scores (7 to 13 years) and no significant difference was observed for height z-scores across all age groups. Gender differences were observed for weight z-scores (>9 years) and BMI (males: 9 - 11 years, p = 0.0118;11 - 13 years, p = 0.0069) whereas no significant difference was found in height z-scores across all age groups. Conclusion: Our results reveal substantial differences between both reference populations and thus interpretation needs be done with caution, especially when labelling results as abnormal.

关键词： WHO NHANES Height z-Score Weight z-Score BMI z-Score Bland & Altman Agreement Obesity Rates

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Childhood Poisoning Cases Admitted to Zagazig University Hospitals during the Year 2018: A Retrospective Study

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Occupational Diseases and Environmental Medicine 2019年第4期7卷 115-123页

作者： abeer Ramzy Hussieny Mahmoud Forensic Medicine and Clinical Toxicology Department Faculty of Medicine Zagazig University Zagazig Egypt

Background: Childhood poisoning is considered major socioeconomic and public health problem as there are thousands of children admitted to the emergency departments and millions of calls are made to poison control centers every year. Aim of the Work: Determine the prevalence and pattern of childhood poisoning cases admitted to Zagazig University hospitals. Subjects and Methods: This is a retrospective study on children Results: A total of 624 childhood poisoning cases, more males than females (55.3% versus 44.7% respectively), and more in age group of 3 - 6 years old (40.86%), more in rural than urban communities (65.06% against 34.94% respectively). Oral exposure was the most against other routes (84.94%). Most cases were unintentional (92.8%). The prevalence of childhood poisoning in descending order was;compound therapeutic medications (32.69%) followed by pesticides (26.92%) then corrosives (17.31%), while volatile hydrocarbons (benzene or kerosene) accounted for (15.38%) and carbon monoxide (3.85%) and others (3.85%). Overall, minor cases were the commonest (63%) while only 3.8% of cases were severe. About 88.94% of cases were discharged after completed management while death rate was 0.96%. Conclusion: Most childhood poisoning cases were males, accidentally, mainly by oral route and in rural areas, most commonly in age group of 3 - 6 years. Most cases were due to therapeutic medications then pesticide exposures. Most of cases were completely cured.

关键词： Childhood Poisoning Zagazig

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