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Liver transplantation in patients with incidental hepatocellular carcinoma/cholangiocarcinoma and intrahepatic cholangiocarcinoma： a single-center experience

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Hepatobiliary & Pancreatic Diseases International 2017年第3期16卷 264-270页

作者： Mohammed Elshamy Naftali Presser abdulrahman Y Hammad Daniel J Firl Christopher Coppa John Fung Federico N Aucejo Hepatobiliary and Transplant Surgery Digestive Disease and Surgery Institute Cleveland Clinic Cleveland OH USA Imaging Institute Cleveland Clinic Cleveland OH USA

BACKGROUND： Reports of fiver transplantation （LT） in patients with mixed hepatocellular carcinoma/cholangiocarcinoma （HCC/CC） and intrahepatic cholangiocarcinoma （ICC） are modest and have been mostly retrospective after pathological categorization in the setting of presumed HCC. Some studies suggest that patients undergoing LT with small and unifocal ICC or mixed HCC/CC can achieve about 40%-60% 5-year post-transplant survival. The study aimed to report our experience in patients undergoing LT with explant pathology revealing HCC/CC and ICC. METHODS： From a prospectively maintained database, we performed cohort analysis. We identified 13 patients who underwent LT with explant pathology revealing HCC/CC or ICC. RESULTS： The observed recurrence rate post-LT was 31% （4/13） and overall survival was 85%, 51%, and 51% at 1, 3 and 5 years, respectively. Disease-free survival was 68%, 51%, and 41% at 1, 3 and 5 years, respectively. In our cohort, four patients would have qualified for exception points based on updated HCC Organ Procurement and Transplantation Network imaging guidelines. CONCLUSIONS： Lesions which lack complete imaging characteristics of HCC may warrant pre-LT biopsy to fully elucidate their pathology. Identified patients with early HCC/CC or ICC may benefit from LT if unresectable. Additionally, incorporating adjunctive perioperative therapies such as in the case of patients undergoing LT with hilar cholangiocarcinoma may improve outcomes but this warrants further investigation.

关键词： mixed hepatocellular carcinoma/ cholangiocarcinoma liver transplantation survival outcomes

Awareness of the Potential Threat of Cyberterrorism to the National Security

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Journal of Information Security 2014年第4期5卷 137-146页

作者： abdulrahman Alqahtani School of Politics Philosophy & International Studies The University of Hull Hull UK

The revolution of computing and networks could revolutionise terrorism in the same way that it has brought about changes in other aspects of life. The modern technological era has faced countries with a new set of security challenges. There are many states and potential adversaries, who have the potential and capacity in cyberspace, which makes them able to carry out cyber-attacks in the future. Some of them are currently conducting surveillance, gathering and analysis of technical information, and mapping of networks and nodes and infrastructure of opponents, which may be exploited in future conflicts. This paper uses qualitative data to develop a conceptual framework for awareness of cyberterrorism threat from the viewpoint of experts and security officials in critical infrastructure. Empirical data collected from in-depth interviews were analysed using grounded theory approach. This study applied to Saudi Arabia as a case study.

关键词： Cyberterrorism Terrorism National Security Critical Infrastructure Conceptual Framework

Visibility Enhancement of Scene Images Degraded by Foggy Weather Condition: An Application to Video Surveillance

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Computers, Materials & Continua 2021年第9期68卷 3465-3481页

作者： Ghulfam Zahra Muhammad Imran abdulrahman M.Qahtani Abdulmajeed Alsufyani Omar Almutiry Awais Mahmood Fayez Eid Alazemi Department of Computer Science Shaheed Zulfikar Ali Bhutto Institute of Science and TechnologyIslamabad44000Pakistan Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia College of Applied Computer Science King Saud University(Almuzahmiyah Campus)Riyadh11543Saudi Arabia Department of Computer Science and Information Systems College of Business StudiesPAAET12062Kuwait

:In recent years,video surveillance application played a significant role in our daily *** taken during foggy and haze weather conditions for video surveillance application lose their authenticity and hence reduces the *** reason behind visibility enhancement of foggy and haze images is to help numerous computer and machine vision applications such as satellite imagery,object detection,target killing,and *** remove fog and enhance visibility,a number of visibility enhancement algorithms and methods have been proposed in the ***,these techniques suffer from several limitations that place strong obstacles to the real world outdoor computer vision *** existing techniques do not perform well when images contain heavy fog,large white region and strong atmospheric *** research work proposed a new framework to defog and dehaze the image in order to enhance the visibility of foggy and haze *** proposed framework is based on a Conditional generative adversarial network(CGAN)with two networks;generator and discriminator,each having distinct *** generator network generates fog-free images from foggy images and discriminator network distinguishes between the restored image and the original fog-free *** are conducted on FRIDA dataset and haze *** assess the performance of the proposed method on fog dataset,we use PSNR and SSIM,and for Haze dataset use e,r−,andσas performance *** results shows that the proposed method achieved higher values of PSNR and SSIM which is 18.23,0.823 and lower values produced by the compared method which are 13.94,0.791 and so *** results demonstrated that the proposed framework Has removed fog and enhanced the visibility of foggy and hazy images.

关键词： Video surveillance degraded images image restoration transmission map visibility enhancement

Chemical composition of essential oil of Thymus vulgaris collected from Saudi Arabian market

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Asian Pacific Journal of Tropical Biomedicine 2017年第2期7卷 147-150页

作者： abdulrahman Khazim Al-Asmari Md Tanwir Athar Ahmed Abdullah Al-Faraidy Mohammed Salim Almuhaiza Department of Research Center Prince Sultan Military Medical CityRiyadhSaudi Arabia Department of Psychiatry Prince Sultan Military Medical CityRiyadhSaudi Arabia Department of Dentistry Prince Sattam Bin Abdulaziz UniversityAl-KharjSaudi Arabia

Objective: To focus on the analysis of chemical constituents of the Thymus vulgaris L.(locally known as "Zaitra" or "Za'atar"; Family: Lamiaceae) which is available in the market of Saudi ***: The Zaitra oil was analyzed by gas chromatography-mass spectrometry. The mass spectra were compared with the standard spectra available in National Institute Standard and Technique ***: The results indicated that the Thymus oil is composed of many chemical compounds including a pinene, thymol and caryophyllene which are biologically active and also used in various ***: It can be concluded that the Thymus vulgaris due to presence of many bioactive compounds can be used as a new potential source of medicine for the treatment of various types of illness.

关键词： Essential oil GC–MS Saudi Arabian herbs Thymus vulgaris

Recent SARS-CoV-2 Outlook and Implications in a COVID-19 Vaccination Era

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Infectious Microbes & Diseases 2021年第3期3卷 125-133页

作者： Teddy Ehianeta Said abdulrahman Salim Mzee Muslimat Kehinde Adebisi Oluwayemisi Ehianeta Institute of Biological Chemistry “Academia Sinica”TaipeiTaiwanChina Jiangbing Hospital Affiliated to Jiangsu UniversityZhenjiangJiangsuChina University of Windsor WindsorOntarioCanada Taiwan University of Science and Technology TaipeiTaiwanChina

While repurposed drugs came in handy earlier in the wake of the coronavirus disease 2019(COVID-19)pandemic,vaccination has been considered a more sustainable *** recent spikes have been linked to“double,”“triple,”and even multi-mutant variants,thus renewing calls for deeper structural and functional insights of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)as a lead to rationale design of therapeutics,vaccines,and point-of-care *** is a repertoire of findings from the earliest SARS-CoV-2 molecular mimicry to evade host immunity cum host immune responses to the role of the viral glycocalyx in modulating the susceptibility and severity of infection through attraction and repulsive ***,molecular studies of some viral components that aid infection in the face of vaccination seem *** addition,the wave of infections and the attendant case fatality ratios have necessitated the need for emergency use authorizations for COVID-19 vaccines and in vitro *** review provides key updates of SARS-CoV-2,current antigenic and formulation strategies,with emergency use authorizations considerations for future vaccine candidates and *** also premise that despite the difficulty in modeling and analyzing glycans,understanding and exploiting their roles in the SARS-CoV-2 architecture is fundamental to glycan-based COVID-19 vaccines devoid of inconsistent clinical outcomes.

关键词： breakthrough infections COVID-19 EUA immune response SARS-CoV-2 vaccine

The SARS-CoV-2 pandemic course in Saudi Arabia:A dynamic epidemiological model

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Infectious Disease Modelling 2020年第1期5卷 766-771页

作者： Abdullah Murhaf Al-Khani Mohamed Abdelghafour Khalifa abdulrahman Almazrou Nazmus Saquib College of Medicine Sulaiman Al Rajhi UniversityP.O.Box 777BukairyahAl-Qassim51941Saudi Arabia

Objective:Saudi Arabia ranks second in the number of coronavirus disease 2019(COVID-19)cases in the Eastern Mediterranean *** houses the two most sacred religious places for Muslims:Mecca and *** is important to know what the trend in case numbers will be in the next 4e6 months,especially during the Hajj pilgrimage ***:Epidemiological data on COVID-19 were obtained from the Saudi Arabian Ministry of Health.A susceptible-exposed-infectious-recovered(SEIR)prediction model was constructed to predict the trend in COVID-19 in Saudi Arabia in the next 6 ***:The model predicts that the number of active cases will peak by 22 May *** cumulative infected cases are predicted to reach 70,321 at that *** total number of infected individuals is estimated reach to 114,580 by the end of the ***:Our estimates show that by the time the Hajj season commences in Saudi Arabia,the pandemic will be in the midst of its deceleration phase(phase 3).This information will likely be useful to policymakers in their management of the outbreak.

关键词： Epidemiology Infectious disease Outbreaks Surveillance Modelling

Dietary betaine activates hepatic VTGⅡexpression in laying hens associated with hypomethylation of GR gene promoter and enhanced GR expression

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Journal of Animal Science and Biotechnology 2018年第2期9卷 381-390页

作者： Nagmeldin A.Omer Yun Hu Yan Hu abdulrahman A.Idriss Halima Abobaker Zhen Hou Haibo Dong Ruqian Zhao MOE Joint International Research Laboratory of Animal Health&Food Safety Nanjing Agricultural UniversityNanjing 210095People’s Republic of China Key Laboratory of Animal Physiology&Biochemistry Nanjing Agricultural UniversityNanjing 210095People’s Republic of China Jiangsu Collaborative Innovation Centre of Meat Production and Processing Quality and Safety ControlNanjing 210095People’s Republic of China Poultry Institute Chinese Academy of Agriculture SciencesYangzhouJiangsuChina

Background: Vitellogenin(VTG) is a precursor of egg yolk proteins synthesized within the liver of oviparous vertebrates. Betaine is an important methyl donor that is reported to improve egg production of laying hens with an unclear mechanism. In the present study, we fed betaine-supplemented diet(0.5%) to laying hens for 4 wk and investigated its effect on VTGII expression in the ***: Betaine did not affect chicken weight, but significantly(P < 0.05) increased egg laying rate accompanied with a significant(P < 0.05) increase in hepatic concentration and plasma level of VTGI. Plasma estrogen level did not change,but the hepatic expression of estrogen receptor α(ERα) mR NA was significantly(P < 0.05) up-regulated. Betaine did not affect the protein content of ERα, but significantly(P < 0.05) increased hepatic expression of glucocorticoid receptor(GR)at both mR NA and protein levels. Also, ERα/GR interaction tended to be enhanced in the liver nuclear lysates of betainesupplemented hens as determined by co-immunoprecipitation. Furthermore, dietary betaine supplementation significantly increased(P < 0.05) the hepatic expression of methyl-transfer enzymes, such as BHMT, GNMT, and DNMT1,which was associated with higher SAM/SAH ratio and hypomethylation of GR promoter ***: Betaine activates hepatic VTGII expression in association with modified DNA methylation of GR gene promoter, GR expression and ERα/GR interaction. Activation of hepatic VTGII expression may contribute, at least partly, to improved egg production in betaine-supplemented hens.

关键词： Betaine Glucocorticoid receptor Hypomethylation Laying hens Vitellogenin

Global research production pertaining to gastrointestinal involvement in COVID-19:A bibliometric and visualised study

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World Journal of Gastrointestinal Surgery 2022年第5期14卷 494-505页

作者： Sa'ed H Zyoud Samah W Al-Jabi Moyad Jamal Shahwan Ammar abdulrahman Jairoun Department of Clinical and Community Pharmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Poison Control and Drug Information Center College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Clinical Research Centre An-Najah National University HospitalNablus 44839Palestine Department of Clinical Sciences College of Pharmacy and Health SciencesAjman UniversityAjman 346United Arab Emirates Centre of Medical and Bio-allied Health Sciences Research Ajman UniversityAjman 346United Arab Emirates Department of Health and Safety Dubai MunicipalityDubai 67United Arab Emirates

BACKGROUND Coronavirus disease 2019(COVID-19)is a global pandemic that can cause diarrhoea,nausea/vomiting,and abdominal pain,among other gastrointestinal(GI)*** To perform a bibliometric analysis of the global research production pertaining to GI involvement in *** The Scopus database was used to search the global literature on GI involvement in COVID-19 during 2020.A bibliometric review of these publications was also performed using *** Scopus had published 95615 documents on COVID-19 in all areas of research at the time of data *** total,1267 publications on the topic of GI and COVID-19 were *** articles(n=606;47.83%),letters(293;23.13%),and reviews(186;14.68%)were the most popular types of *** most productive countries and institutions in this field were the United States and Huazhong University of Science and *** most cited paper was Xiao et al,which was published in Gastroenterology as a brief communication,with 798 *** paper provides evidence for GI infection of COVID-19 and its possible faecal–oral transmission *** the term cluster analysis,there were two frontiers in this field:GI manifestations among COVID-19 patients and the implications of COVID-19 for the *** GI manifestations among COVID-19 patients and implications of COVID-19 for gastroenterologists were of interest,especially in the early stages of the pandemic.

关键词： COVID-19 Gastrointestinal Symptoms Bibliometric Scopus

Cyclooxygenase-2 expression as a predictor of outcome in colorectal carcinoma

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World Journal of Gastroenterology 2012年第15期18卷 1793-1799页

作者： Jaudah Al-Maghrabi Abdelbaset Buhmeida Eman Emam Kari Syrjnen abdulrahman Sibiany Mohmmad Al-Qahtani Mahmoud Al-Ahwal Department of Pathology King Abdulaziz UniversityJeddah 21589Saudi Arabia Center of Excellence in Genomic Medicine Research King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Oncology and Radiotherapy Turku University HospitalT-Hospital(Administration)FIN20521 TurkuFinland Department of Surgery King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Medicine Scientific Chair for Colorectal CancerKing Abdulaziz UniversityJeddah 21589Saudi Arabia

AIM:To correlate cyclooxygenase-2(COX-2)expression profile with clinical and pathological variables to assess their prognostic/predictive value in colorectal carcinoma(CRC).METHODS:Archival tumor samples were analyzed using immunohistochemistry for COX-2 expression in 94 patients with *** were diagnosed and treatedat the Departments of Surgery and Oncology,King Abdulaziz University Hospital,Saudi ***:Fifty-six percent of the tumors showed positive cytoplasmic COX-2 expression,whereas 44%of cases were completely *** were no significant correlations between COX-2 expression and sex,age,grade or tumor ***,COX-2 expression revealed a significant correlation with tumor stage(P=0.01)and distant metastasis(P=0.02),and a borderline association with lymph node involvement(P =0.07).Tumors with high COX-2 expression showed a higher recurrence rate than tumors with no expression(P<0.009).In univariate Kaplan-Meier survival analysis,there was a significant(P=0.026)difference in disease-free survival between COX-2-positive and negative tumors in favor of the ***-2 expression did not significantly predict disease-specific survival,which was much shorter for COX-2-positive *** multivariate(COX)models,COX-2 did not appear among the independent predictors of disease-free survival or disease-specific ***:COX-2 expression seems to provide useful prognostic information in CRC,while predicting the patients at high risk for recurrent disease.

关键词： Colorectal carcinoma Cyclooxygenase-2 Immunohistochemistry Disease outcome Adjuvant therapy