Recent SARS-CoV-2 Outlook and Implications in a COVID-19 Vaccination Era
作者机构：Institute of Biological Chemistry“Academia Sinica”TaipeiTaiwanChina Jiangbing HospitalAffiliated to Jiangsu UniversityZhenjiangJiangsuChina University of WindsorWindsorOntarioCanada Taiwan University of Science and TechnologyTaipeiTaiwanChina
出 版 物：《Infectious Microbes & Diseases》 (感染微生物与疾病（英文）)
年 卷 期：2021年第3卷第3期
页 面：125-133页
学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
主 题：breakthrough infections COVID-19 EUA immune response SARS-CoV-2 vaccine
摘 要：While repurposed drugs came in handy earlier in the wake of the coronavirus disease 2019(COVID-19)pandemic,vaccination has been considered a more sustainable *** recent spikes have been linked to“double,“triple,and even multi-mutant variants,thus renewing calls for deeper structural and functional insights of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)as a lead to rationale design of therapeutics,vaccines,and point-of-care *** is a repertoire of findings from the earliest SARS-CoV-2 molecular mimicry to evade host immunity cum host immune responses to the role of the viral glycocalyx in modulating the susceptibility and severity of infection through attraction and repulsive ***,molecular studies of some viral components that aid infection in the face of vaccination seem *** addition,the wave of infections and the attendant case fatality ratios have necessitated the need for emergency use authorizations for COVID-19 vaccines and in vitro *** review provides key updates of SARS-CoV-2,current antigenic and formulation strategies,with emergency use authorizations considerations for future vaccine candidates and *** also premise that despite the difficulty in modeling and analyzing glycans,understanding and exploiting their roles in the SARS-CoV-2 architecture is fundamental to glycan-based COVID-19 vaccines devoid of inconsistent clinical outcomes.
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