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New modular platform based on multi-adjuvanted amphiphilic chitosan nanoparticles for efficient lipopeptide vaccine delivery against group A streptococcus

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Asian Journal of Pharmaceutical Sciences 2022年第3期17卷 435-446页

作者： Abdin Shakirin Mohamad Norpi Muhammad Luqman Nordin Nuraziemah ahmad Haliza Katas abdullah al-hadi ahmad fuaad Asif Sukri Nirmal Marasini Fazren Azmi Centre for Drug Delivery Technology Faculty of PharmacyUniversiti Kebangsaan MalaysiaKuala Lumpur 50300Malaysia Faculty Pharmacy and Health Sciences Universiti Kuala LumpurRoyal College of Medicine PerakPerak 30450Malaysia Faculty of Veterinary Medicine Universiti Malaysia KelantanKelantan 16100Malaysia Department of Chemistry Faculty of ScienceUniversiti MalayaKuala Lumpur 50603Malaysia Universiti Teknologi Mara(UiTM) Bandar Puncak AlamIntegrative Pharmacogenomics Institute(iPROMISE)Selangor 43200Malaysia School of Biomedical Sciences The University of QueenslandSt.Lucia QLD 4072Australia

An effective vaccine against group A streptococcus(GAS)is highly desirable for definitive control of GAS *** the present study,two variants of amphiphilic chitosan nanoparticles-based GAS vaccines were *** vaccines were primarily composed of encapsulated KLH protein(a source of T helper cell epitopes)and lipidated M-protein derived B cell peptide epitope(lipoJ14)within the amphiphilic structure of *** only difference between themwas one of the nanoparticles vaccines received additional surface coating with poly(I:C).The formulated vaccines exhibited nanosized particles within the range of 220–240 *** uptake study showed that nanoparticles vaccine without additional poly(I:C)coating has greater uptake by dendritic cells and macrophages compared to nanoparticles vaccine that was functionalized with poly(I:C).Both vaccines were found to be safe in mice and showed negligible cytotoxicity against HEK293 *** immunization in mice,both nanoparticle vaccines produced high antigen-specific antibodies titres that were regulated by a balanced Th1 and Th2 response compared to physical *** antibodies elicited high opsonic activity against the tested GAS ***,our data demonstrated that amphiphilic chitosan nanoparticles platform induced a potent immune response even without additional inclusion of poly(I:C).

关键词： Amphiphilic chitosan nanoparticles Peptide vaccine Lipidation Multi-adjuvanting delivery system Immunogenicity Group A streptococcus

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Manakov model of coupled NLS equation and its optical soliton solutions

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Journal of Ocean Engineering and Science 2024年第4期9卷 364-372页

作者： Esra Unal Yilmaz Farid Samsami Khodad Yesim Saglam Ozkan Reza Abazari A.E.Abouelregal Mayssam Tarighi Shaayesteh hadi Rezazadeh Hijaz ahmad Department of Mathematics Bolu Abant Izzet Baysal UniversityBoluTurkey Faculty of Engineering Technology Amol University of Special Modern TechnologiesAmolIran Department of Mathematics Bursa Uludag UniversityBursaTurkey Department of Mathematics and Applications University of Mohaghegh ArdabiliArdabilIran Department of Mathematics College of Science and ArtsAl-QurayatJouf UniversitySaudi Arabia Basic Sciences Research Unit Jouf UniversitySaudi Arabia Amir Kabir University TehranIran Mathematics in Applied Sciences and Engineering Research Group Scientific Research CenterAl-Ayen UniversityNasiriyah 64001Iraq Section of Mathematics International Telematic University UninettunoCorso Vittorio Emanuele II39Roma 00186Italy

In the field of maritime transport,motion and energy,the dynamics of deep-sea waves is one of the major problems in ocean science.A mathematical modeling of dynamics of solitary waves in deep sea under the two-layer stratification leads to NLS equation,and consequently,the interaction two of them can be formulated by coupled NLS *** this work,extended auxiliary equation and the exp(−ω(χ))-expansion methods are employed to make the optical solutions of the Manakov model of coupled NLS *** methods used in this paper,in addition to providing the analysis of individual wave solutions,also provide general optical *** previously known solutions can be obtained by some special selections of parameters obtained by solving systems of algebraic *** this stage,it is more practical and convenient to apply methods with a symbolic calculation system.

关键词： Manakov model Extended auxiliary equation method Optical solutions Solitons

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Epidemiology and Clinical Characteristics of the First 500 Positive Cases of COVID-19. A Multicenter Retrospective Study across the Najran Region of the Kingdom of Saudi Arabia (KSA)

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Open Journal of Epidemiology 2021年第3期11卷 222-236页

作者： hadi J. al Sulayyim Mohammed Ch al-Noaemi Mohammed M. alyami Shoab ahmad Mohammad H. alyami Hamad S. alyami ali D. al-Swedan Ibraheem S. Banihameem Musallam A. Sedran ali M. al-Zubaidi Obaid M. al Abbas General Directorate of Health Affairs Najran Ministry of Health Najran KSA al-Ghad International College of Applied Medical Sciences Najran KSA Batterjee Medical College Jeddah KSA Najran University Najran KSA

Introduction: Coronavirus Disease 2019 (COVID-19) is a viral infection that was first reported in Wuhan, China on 31 December 2019. This study aimed to clarify the epidemiology and clinical characteristics of 500 first COVID-19 in the Najran region, Saudi Arabia. Material and Methods: A multi-center retrospective study design was employed to study the first 500 confirmed COVID-19 positive cases in Najran province, Kingdom of Saudi Arabia (KSA). Data were collected from 1 March 2020 until 1 July 2020 and provided by the Infection Prevention and Control (IPC) department from the hospitals. Included cases were confirmed using real-time reverse transcriptase-polymerase chain reaction (RT-PCR). Demographic, vital signs, symptoms, incubation period, travel or exposure history medical history, and comorbidities were collected. Logistic regression analysis was used to explore the association between potential risk factors associated with symptoms occurrence of COVID-19. Results: The median age of 500 COVID-19 patients was 31 years;333 (66.6%) males. A total of 34 (6.8%) were Healthcare Workers (HCWs). Out of the 500 patients, 180 (36%) had at least one comorbid disease. The most common symptoms on admission were fever 281 (56.2%), cough 266 (53.2%), shortness of breath 166 (33.2%), and malaise 113 (22.6%). Most of the patients presented with mild disease severity 310 (62%). Nationality, age, and Diabetes Miletus (DM) were independently and significantly associated with being symptomatic (P als, other nationality patients were most likely to have symptoms (β = 2.968, CI = 2.002 - 4.400, P = 0.0010). For every 1 year increase in age, the risk of being symptomatic increased by 5.8% (β = 1.045, CI = 1.033 - 1.058, P = 0.001). Compared with non-DM patients, DM patients had a 4.05 times higher risk (β = 4.05, CI = 2.188 - 7.507, P = 0.0

关键词： Epidemiology Characteristics COVID-19 Najran KSA

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