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Current interventional options for palliative care for patients with advanced-stage cholangiocarcinoma

World Journal of Clinical Oncology 2024年第3期15卷 381-390页

作者： Maryam Makki Malak Bentaleb Mohammed Abdulrahman Amal abdulla Suhool Salem al Harthi Marcelo AF Ribeiro Jr Department of Surgery Division of TraumaCritical Care and Acute Care SurgerySheikh Shakhbout Medical CityAbu Dhabi 11001United Arab Emirates Department of Surgery College of Medicine and Health SciencesKhalifa UniversityAbu Dhabi 11001United Arab Emirates Department of Surgery Division of Hepato-Pancreato-Biliary(HPB)SurgerySheikh Shakhbout Medical CityAbu Dhabi 91888United Arab Emirates

Primary biliary tract tumors are malignancies that originate in the liver,bile ducts,or *** tumors often present with jaundice of unknown etiology,leading to delayed diagnosis and advanced ***,several palliative treatment options are available for primary biliary tract *** include percutaneous transhepatic biliary drainage(PTBD),biliary stenting,and surgical interventions such as biliary *** therapy is also commonly used for the palliative treatment of primary biliary tract *** involves the administration of chemotherapy drugs,such as gemcitabine and cisplatin,which have shown promising results in improving overall survival in patients with advanced biliary tract *** is another palliative treatment option for patients with unresectable or inoperable malignant biliary *** stenting can also be used as a palliative treatment option to alleviate symptoms in patients with unresectable or inoperable malignant biliary *** interventions,such as biliary diversion,have traditionally been used as palliative options for primary biliary tract ***,biliary diversion only provides temporary relief and does not remove the *** biliary tract tumors often present in advanced stages,making palliative treatment the primary option for improving the quality of life of patients.

关键词： Cholangiocarcinoma Palliative care Endoscopic treatment Surgery Complications Interventional radiology

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QT Dispersion and QTc Interval in Patients with Adult Sickle Cell Disease: Electrocardiographic (EKG) and Echocardiographic Evaluation

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International Journal of Clinical Medicine 2014年第10期5卷 550-557页

作者： Taysir S. Garadah Adla B. Hassan Mohamed al alwai Ahmed A. Jaradat Fathia Qurishi abdulla alajmi Colleges of Medicine and Medical Sciences Arabian Gulf University Manama Kingdom of Bahrain Salmaniya Medical Complex Ministry of Health Manama Kingdom of Bahrain Salmaniya Medical Complex Ministry of Health Manama Kingdom of Bahrain Colleges of Medicine and Medical Sciences Arabian Gulf University Manama Kingdom of Bahrain

Background: QT dispersion (QTd) varies according to heterogeneity of recovery time in the myocardium, and the impact of iron overload on the QTd in adult patients with Sickle Cell Disease (SCD) is not clear. Aim: This cross-sectional study was designed to evaluate corrected QTc interval and QTd on 12 leads ECG in patients with SCD, and assess the LV systolic and diastolic function using Pulsed Doppler Echocardiogram. Method: all patients were evaluated clinically with pulse Doppler echocardiography. Twelve leads ECG were taken to measure QTd and QTc. Blood samples withdrawn to assess the blood level of ferritin and hemoglobin. Pearson correlation coefficient was used to measure the linear relationship between serum ferritin and QTd. Results: The study included patients with SCD (n = 70, age 15.7 ± 8.9 years), compared with age-matched healthy control group (n = 70, age 15.9 ± 8.9 years). In patients with SCD compared with healthy control group the QTc (msec) 416 ± 23.21 ms vs. 401 ± 24.12 (p = 0.75), and the QTd were slightly longer in SCD compared with the control of 43 ± 22.1 vs. 38 ± 20.16 msec, (p = 0.071) with no significant difference. M mode echo showed that SCD patients compared with control had higher LVMI gm/M2 of 105 ± 10.3 vs. 83 ± 7.1, P = 0.001, larger LV end diastolic dimension (cm) of 5.5 ± 0.32 vs. 4.72 ± 0.35, p = 0.03, RV diameter (cm) of 2.8 ± 0.42 vs. 2.4 ± 0.31, (p = 0.041) and RV wall thickness (mm) of 0.31 ± 0.06 vs. 0.28 ± 0.03, (p = 0.024). Pulsed Doppler showed high LV transmitral E wave velocity of 85.23 ± 1.92 vs. 62.43 ± 1.67 m/s (p = 0.001), A wave (msec) 46.26 ± 4.7 vs. 56.24 ± 3.2 m/s, p = 0.032, with E/A ratio of 1.86 ± 0.01 vs. 1.10 ± 0.03, (p = 0.024) and DT of E wave (msec) of 156.43 ± 23.5 vs. 189.87 ± 19.5, (p = 0.031). Left ventricle ejection fraction percentage was similar between both groups, but SCD had significantly higher right ventricle tricuspid annular plane systolic excursion TAPSE (cm) of 1.23 ± 0.21 vs. 1.11 ± 0.23

关键词： Sickle Cell Anemia Tissue Doppler QT Dispersion Bahrain

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Extra-Oral Digital Panoramic Radiographic Interpretation and Clinical Findings of Stage IV Periodontitis among Some Samples Concerning Saudi/Non-Saudi Nationality

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Open Journal of Stomatology 2022年第2期12卷 42-61页

作者： Mohammed M. A. abdulla al-Abdaly Amer Hassan alasmari Saeed J. alqahtani Ahmed Abdulrahman alzahrani Jawaher Moshabab A. al Ahmari Ghadeer Mohammed Mohammed al-Abdaly Ibrahim Hassan Ibrahim alqaysi Mohammed Dhafer Mohammed al-Shamrani Periodontics and Community Dental Sciences Department College of Dentistry King Khalid University Abha Saudi Arabia College of Dentistry King Khalid University Abha Saudi Arabia Faculty of Dentistry Sana’a University Sana’a Republic of Yemen

Background: There are associations between the severity of periodontal diseases and some predisposing factors, such as age, race, and income rate. Therefore, the present study was designed to evaluate the extra-oral digital panoramic radiographic interpretation and clinical findings of stage IV periodontitis among some samples concerning Saudi/non-Saudi nationality. Material and Methods: The study comprised a random sample of 298 residents in Saudi Arabia referred to the internship program clinics at the College of Dentistry, King Khalid University. They were according to the age of participants as follows: youth (15 - 24 years), adults (25 - 64 years), and seniors (65 years and over) within two groups according to nationality (Saudi and non-Saudi). Clinical periodontal examination and radiographic extra oral digital panoramic radiographs were done, and then the periodontal parameters, the percentage of bone loss, and the pattern of bone loss were recorded. The data was collected, and the statistical analysis was performed with ANOVA test, Tukey’s test, Chi-square test, and T-test and considered a P-value at (p Results: The samples included 62 (20%) youth participants with mean of age (21.806 ± 3.390), 182 (57%) adults’ participants with mean age (42.802 ± 9.094), and 54 (23%) seniors participants with a mean age (69.074 ± 6.810). There were highly statistically significant differences in the comparison between the participants’ ages (P 0.05). Conclusion: At the end of this study, we concluded that there are alterations in clinical and radiographic and clinical findings of stage IV periodontitis with the alteration of participants’ ages and nationality.

关键词： Extra-Oral Digital Panoramic Radiographs Nationality Stage IV Periodontitis

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沙特阿拉伯水资源利用的有关问题与政策雏议

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环境科学与管理 1991年第4期23卷 21-30页

作者： abdulla ali al-Ibrahim 张旭东郑彤

沙特阿拉伯国家干燥少雨,潜在着严重缺水的危机。目前需水量正在大幅度增长,而原本不足的供水量相对于需水量来讲,供需逆差日益增大。这种日趋严重的水资源供需矛盾主要靠增加供水量来应付,需水量的管理问题却被忽视了。本文论述的是如... 详细信息

沙特阿拉伯国家干燥少雨,潜在着严重缺水的危机。目前需水量正在大幅度增长,而原本不足的供水量相对于需水量来讲,供需逆差日益增大。这种日趋严重的水资源供需矛盾主要靠增加供水量来应付,需水量的管理问题却被忽视了。本文论述的是如何保持水资源供需平衡的问题,并着重强调了急需采取的解决措施和需水量的规划管理,以求达到缓解水资源供需平衡的这一日趋尖锐的矛盾。作者针对各个部门提高用水效率方面有其独特的见解。文章指出沙特阿拉伯政府必须将其重点从开发水资源增加其供水量方面转移到水资源的合理利用方面上来,以避免在已到极限且不能再生的水资源白白地浪费和低效率的利用。该文还描述了这个国家的水资源现状,探讨了水资源如何合理有效利用的有关问题,并建议其重点要放在农业,这个用水量最大且效率最低的部门上,以便尽快采取一些具有可行性的水资源保护措施。

关键词：水资源利用水资源供需平衡水资源保护用水效率需水量开发水资源地下水储量再生水资源水资源合理利用水资源量

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Nutritional management and autism spectrum disorder:A systematic review

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World Journal of Clinical Pediatrics 2024年第4期13卷 65-101页

作者： Mohammed al-Beltagi Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671Bahrain

BACKGROUND Autism spectrum disorder(ASD)presents unique challenges related to feeding and nutritional *** with ASD often experience feeding difficulties,including food selectivity,refusal,and gastrointestinal *** interventions have been explored to address these challenges,including dietary modifications,vitamin supplementation,feeding therapy,and behavioral *** To provide a comprehensive overview of the current evidence on nutritional management in *** examine the effectiveness of dietary interventions,vitamin supplements,feeding therapy,behavioral interventions,and mealtime practices in addressing the feeding challenges and nutritional needs of children with *** We systematically searched relevant literature up to June 2024,using databases such as PubMed,PsycINFO,and *** were included if they investigated dietary interventions,nutritional supplements,or behavioral strategies to improve feeding behaviors in children with *** assessed the quality of the studies and synthesized findings on the impact of various interventions on feeding difficulties and nutritional *** extraction focused on intervention types,study designs,participant characteristics,outcomes measured,and intervention *** The review identified 316 studies that met the inclusion *** evidence indicates that while dietary interventions and nutritional supplements may offer benefits in managing specific symptoms or deficiencies,the effectiveness of these approaches *** therapy and behavioral interventions,including gradual exposure and positive reinforcement,promise to improve food acceptance and mealtime *** findings also highlight the importance of creating supportive mealtime environments tailored to the sensory and behavioral needs of children with *** Nutritional management for children with ASD requires a multifaceted approach that includes dietary modifications,supp

关键词： Feeding therapy Behavioral interventions Mealtime practices Autism spectrum disorder Children High-dose methyl cobalamine

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Autism medical comorbidities

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World Journal of Clinical Pediatrics 2021年第3期10卷 15-28页

作者： Mohammed al-Beltagi Department of Pediatrics University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama P.O.Box 26671BahrainBahrain Department of Pediatrics Faculty of MedicineTanta UniversityTanta 0000000Al GharbiaEgypt

Medical comorbidities are more common in children with autism spectrum disorders(ASD)than in the general *** genetic disorders are more common in children with ASD such as Fragile X syndrome,Down syndrome,Duchenne muscular dystrophy,neurofibromatosis type I,and tuberous sclerosis *** with autism are also more prone to a variety of neurological disorders,including epilepsy,macrocephaly,hydrocephalus,cerebral palsy,migraine/headaches,and congenital abnormalities of the nervous ***,sleep disorders are a significant problem in individuals with autism,occurring in about 80%of ***(GI)disorders are significantly more common in children with ASD;they occur in 46%to 84%of *** most common GI problems observed in children with ASD are chronic constipation,chronic diarrhoea,gastroesophageal reflux and/or disease,nausea and/or vomiting,flatulence,chronic bloating,abdominal discomfort,ulcers,colitis,inflammatory bowel disease,food intolerance,and/or failure to *** categories of inborn-errors of metabolism have been observed in some patients with autism including mitochondrial disorders,disorders of creatine metabolism,selected amino acid disorders,disorders of folate or B12 metabolism,and selected lysosomal storage disorders.A significant proportion of children with ASD have evidence of persistent neuroinflammation,altered inflammatory responses,and immune ***-brain antibodies may play an important pathoplastic mechanism in *** disorders are significantly more common in individuals with ASD from all age *** influence the development and severity of *** could cause problematic behaviours in at least a significant subset of affected ***,it is important to consider the child with autism as a whole and not overlook possible symptoms as part of *** physician should rule out the presence of a medical condition before moving on to other interventions o

关键词： Autism Children Medical comorbidity Epilepsy Sleep disorders allergy Gastrointestinal diseases

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Pre-autism:What a paediatrician should know about early diagnosis of autism

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World Journal of Clinical Pediatrics 2023年第5期12卷 273-294页

作者： Mohammed al-Beltagi Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511AlgahrbiaEgypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityDr.Sulaiman Al Habib Medical GroupManama 26671ManamaBahrain

Autism,also known as an autism spectrum disorder,is a complex neurodevelopmental disorder usually diagnosed in the first three years of a child's life.A range of symptoms characterizes it and can be diagnosed at any age,including adolescence and ***,early diagnosis is crucial for effective management,prognosis,and ***,there are no established fetal,prenatal,or newborn screening programs for autism,making early detection *** review aims to shed light on the early detection of autism prenatally,natally,and early in life,during a stage we call as“pre-autism”when typical symptoms are not yet *** fetal,neonatal,and infant biomarkers may predict an increased risk of autism in the coming *** developing a biomarker array,we can create an objective diagnostic tool to diagnose and rank the severity of autism for each *** biomarkers could be genetic,immunological,hormonal,metabolic,amino acids,acute phase reactants,neonatal brainstem function biophysical activity,behavioral profile,body measurements,or radiological ***,every biomarker has its accuracy and *** factors can make early detection of autism a real *** improve early detection,we need to overcome various challenges,such as raising community awareness of early signs of autism,improving access to diagnostic tools,reducing the stigma attached to the diagnosis of autism,and addressing various culturally sensitive concepts related to the disorder.

关键词： Autism Pre-autism Biomarkers Autism spectrum disorder Biophysical profile Neurodevelopment Antenatal Neonatal

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Unveiling the impact:COVID-19's influence on bacterial resistance in the Kingdom of Bahrain

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World Journal of Virology 2025年第1期14卷 83-98页

作者： Nermin K Saeed Safiya K almusawi Noor A albalooshi Mohammed al-Beltagi Medical Microbiology Section Department of PathologySalmaniya Medical ComplexGovernmental HospitalsManama 12Bahrain Medical Microbiology Section Department of PathologyRoyal College of Surgeons in Ireland-Medical University of BahrainBusaiteen 15503MuharraqBahrain Department of Paediatrics Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671AlgharbiaBahrain

BACKGROUND Antibiotic resistance is a growing global health threat,and understanding local trends in bacterial isolates and their susceptibility patterns is crucial for effective infection control and antimicrobial *** coronavirus disease 2019(COVID-19)pandemic has introduced additional complexities,potentially influencing these *** To analyze trends in bacterial isolates and their antibiotic susceptibility patterns at Salmaniya Medical Complex from 2018 to 2023,with a specific focus on the impact of the COVID-19 pandemic on these *** A retrospective analysis of microbiological data was conducted,covering the period from 2018 to *** study included key bacterial pathogens such as Escherichia coli(***),Klebsiella pneumoniae,Acinetobacter baumannii,Pseudomonas aeruginosa,and Staphylococcus aureus,among *** antibiotic susceptibility profiles of these isolates were assessed using standard laboratory *** contextualize the findings,the findings were compared with similar studies from other regions,including China,India,Romania,Saudi Arabia,the United Arab Emirates,Malaysia,and United *** The study revealed fluctuating trends in the prevalence of bacterial isolates,with notable changes during the COVID-19 *** example,a significant increase in the prevalence of Staphylococcus aureus was observed during the pandemic years,while the prevalence of *** showed a more variable *** resistance rates varied among the different pathogens,with a concerning rise in resistance to commonly used antibiotics,particularly among Klebsiella pneumoniae and ***,the study identified an alarming increase in the prevalence of multidrug-resistant(MDR)strains,especially within Klebsiella pneumoniae and *** *** impact of the COVID-19 pandemic on these trends was evident,with shifts in the frequency,resistance patterns,and the emergence of MDR bacteria among several key ***

关键词： Multidrug-resistant organisms Antibiotic susceptibility COVID-19 pandemic Antimicrobial stewardship Bacterial isolates Salmaniya Medical Complex Bahrain

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Fabrication and Characteristics of Fast Photo Response ZnO/Porous Silicon UV Photoconductive Detector

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Advances in Materials Physics and Chemistry 2011年第3期1卷 70-77页

作者： Hanan A. Thjeel abdulla. M. Suhail Asama N. Naji Qahtan G. al-zaidi Ghaida S. Muhammed Faten A. Naum 不详

Fast response time UV photoconductive detector was fabricated based on ZnO film prepared by thermal chemical spray pyrolysis technique. The ZnO nanofilms are grown on the porous silicon (PS) nanosurface which has drastically reduced the response time of the ZnO UV detector from few seconds to few hundreds of microseconds. The surface functionalization of the ZnO film deposited on porous silicon (PS) layer by polyamide nylon has highly improved the photoresponsivity of the detector to 0.8 A/W. The normalized de-tectivity (D*) of the fabricated ZnO UV detector at wavelength of 385 nm is found to be about 2.12 × 1011 cm Hz1/2 W–1. The ZnO film grown on the porous silicon layer was oriented in the c-axis and it is found to be a p-type semiconductor, which is referred to the compensation of the excess charge carriers in the ZnO film by the nanospikes silicon layer.

关键词： Porous Silicon P-ZnO/PSi Junction Nanostructure Materials Photoconductive Detectors Recombination and Trapping

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Diabetes-inducing effects of bronchial asthma

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World Journal of Diabetes 2025年第1期16卷 121-139页

作者： Mohammed al-Beltagi Adel Salah Bediwy Nermin Kamal Saeed Hosameldin A Bediwy Reem Elbeltagi Department of Pediatric Faculty of MedicineTanta UniversityTanta 31511AlghrabiaEgypt Department of Pediatric University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671ManamaBahrain Department of Pulmonology Faculty of MedicineTanta UniversityTanta 31527AlghrabiaEgypt Department of Pulmonology University Medical CenterKing Abdulla Medical CityArabian Gulf UniversityManama 26671ManamaBahrain Medical Microbiology Section Department of PathologySalmaniya Medical ComplexMinistry of HealthKingdom of BahrainManama 26671ManamaBahrain Medical Microbiology Section Department of PathologyIrish Royal College of SurgeonBusaiteen 15503MuharraqBahrain Faculty of Medicine Tanta UniversityTanta 31527AlgharbiaEgypt Department of Medicine The Royal College of Surgeons in Ireland-BahrainBusiateen 15503MuharraqBahrain

BACKGROUND The relationship between diabetes mellitus(DM)and asthma is complex and can impact disease *** To explore the bidirectional influences between the two conditions on clinical outcomes and disease *** We systematically reviewed the literature on the relationship between DM and asthma,focusing on their impacts,mechanisms,and therapeutic *** studies were assessed,which investigated the effect of glycemic control on asthma outcomes,lung function,and *** study highlighted the role of specific diabetes medications in managing *** The results showed that poor glycemic control in diabetes can exacerbate asthma,increase hospitalizations,and reduce lung ***,severe asthma,especially in obese individuals,can complicate diabetes management and make glycemic control more *** diabetes-associated mechanisms,such as inflammation,microangiopathy,and oxidative stress,can exacerbate asthma and decrease lung *** diabetes medications exhibit anti-inflammatory effects that show promise in mitigating asthma *** The complex interrelationship between diabetes and asthma suggests bidirectional influences that affect disease course and *** and microvascular complications associated with diabetes may worsen asthma outcomes,while asthma severity,especially in obese individuals,complicates diabetes ***,the current research has limitations,and more diverse longitudinal studies are required to establish causal relationships and identify effective treatment strategies for individuals with both conditions.

关键词： Diabetes mellitus Bronchial asthma Glycemic control Lung function Asthma exacerbation Disease interaction Microangiopathy

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