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Malignant eccrine acrospiroma with nodal and bone metastasis

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 255-258页

作者： Burhan Wani Shiekh Aejaz Aziz Mohmad Hussain Mir Gull Mohammad Bhat abdul rashid lone Department of Medical Oncology Sher-i-Kashmir Institute of Medical SciencesSrinagar 190011KashmirIndia

Acrospiromas are cutaneous tumors of sweat duct *** various eccrine sweat gland tumours including benign acrospiroma are widely reviewed,malignant acrospiroma is rarely ***,they resemble other cutaneous lesions and the primary treatment is wide local excision with or without lymph node *** efficacy of adjuvant chemotherapy and radiation therapy requires further investigation.

关键词： Acrospiroma metastasis chemotherapy radiotherapy

Extracellular vesicles as tools and targets in therapy for diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 872-912页

作者： Mudasir A.Kumar Sadaf K.Baba Hana Q.Sadida Sara Al.Marzooqi Jayakumar Jerobin Faisal H.Altemani Naseh Algehainy Mohammad A.Alanazi abdul-Badi Abou-Samra Rakesh Kumar Ammira S.Al-Shabeeb Akil Muzafar A.Macha rashid Mir Ajaz A.Bhat Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaKashmir 192122India Department of Human Genetics-Precision Medicine in Diabetes Obesity and Cancer ProgramSidra MedicineDohaQatar Qatar Metabolic Institute Academic Health SystemHamad Medical CorporationDohaQatar Department of Medical Laboratory Technology Prince Fahad Bin Sultan Chair for Biomedical ResearchFaculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia School of Biotechnology Shri Mata Vaishno Devi UniversityKatraIndia

Extracellular vesicles(EVs)are nano-sized,membranous structures secreted into the extracellular *** exhibit diverse sizes,contents,and surface markers and are ubiquitously released from cells under normal and pathological *** serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses *** vesicles transport various cellular components such as proteins,mRNAs,miRNAs,DNA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents,drug delivery systems,and disease *** in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic ***,various EV subtypes are emerging as targeted drug delivery tools,highlighting their potential clinical *** need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains *** into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the *** this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck,lung,gastric,breast,and hepatocellular carcinoma),neurodegenerative disorders,diabetes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

关键词： diseases sized sizes

National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma

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World Journal of Gastroenterology 2024年第9期30卷 1018-1042页

作者： Faisal Saud Dar Zaigham Abbas Irfan Ahmed Muhammad Atique Usman Iqbal Aujla Muhammad Azeemuddin Zeba Aziz Abu Bakar Hafeez Bhatti Tariq Ali Bangash Amna Subhan Butt Osama Tariq Butt abdul Wahab Dogar Javed Iqbal Farooqi Faisal Hanif Jahanzaib Haider Siraj Haider Syed Mujahid Hassan Adnan abdul Jabbar Aman Nawaz Khan Muhammad Shoaib Khan Muhammad Yasir Khan Amer Latif Nasir Hassan Luck Ahmad Karim Malik Kamran rashid Sohail rashid Mohammad Salih abdullah Saeed Amjad Salamat Ghias-un-Nabi Tayyab Aasim Yusuf Haseeb Haider Zia Ammara Naveed Department of Hepatopancreatic Biliary Surgery&Liver Transplant Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Hepatogastroenterology and Liver Transplantation Dr.Ziauddin University HospitalKarachi 75600SindhPakistan University of Aberdeen Aberdeen B243FXUnited Kingdom Department of Pathology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Gastroenterology&Hepatology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Radiology Aga Khan UniversityKarachi 74800Pakistan Department of Oncology Hameed Latif HospitalLahore 54000Pakistan Division of Hepatopancreatic Biliary Surgery&Liver Transplantation Shifa International HospitalIslamabad 44000Pakistan Department of Hepatopancreatic Biliary Surgery&Liver Transplant Shaikh Zayed Hospital and Post Graduate Medical InstituteLahore 54000Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan Department of Liver Transplant Pir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Medicine&Gastroenterology Lifecare Hospital and Research CentrePeshawar 25000Khyber PakhtunkhwaPakistan Department of Hepatopancreatobiliary&Liver Transplant Bahria International HospitalLahore 54000Pakistan Department of Surgery Hepatopancreatobiliary&Liver TransplantDow University of Health SciencesKarachi 74800Pakistan Department of Gastroenterology Hepatology&NutritionPir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Oncology Dr.Ziauddin HospitalKarachi 74800Pakistan Department of Radiology Rehman Medical InstitutePeshawar 25000Pakistan Army Liver Transplant Unit Pak Emirates Military HospitalRawalpindi 46000Pakistan Department of Gastroenterology Sindh Institute of Urology and TransplantationKarachi 75500Pakistan rashid Nursing Home and Cancer Clinic Rashid Nursing Home and Cancer ClinicRawalpindi 46000Pakistan Department of Gastroentero

A consensus meeting of national experts from all major national hepatobiliary centres in the country was held on May 26,2023,at the Pakistan Kidney and Liver Institute&Research Centre(PKLI&RC)after initial consultations with the *** Pakistan Society for the Study of Liver Diseases(PSSLD)and PKLI&RC jointly organised this *** effort was based on a comprehensive literature review to establish national practice guidelines for hilar cholangiocarcinoma(hCCA).The consensus was that hCCA is a complex disease and requires a multidisciplinary team approach to best manage these *** coordinated effort can minimise delays and give patients a chance for curative treatment and effective *** diagnostic and staging workup includes high-quality computed tomography,magnetic resonance imaging,and magnetic resonance *** cytology or biopsy utilizing endoscopic retrograde cholangiopancreatography is a mainstay for ***,histopathologic confirmation is not always required before *** ultrasound with fine needle aspiration of regional lymph nodes and positron emission tomography scan are valuable adjuncts for *** only curative treatment is the surgical resection of the biliary tree based on the Bismuth-Corlette *** patients with unresectable hCCA can be considered for liver *** chemotherapy should be offered to patients with a high risk of *** use of preoperative biliary drainage and the need for portal vein embolisation should be based on local multidisciplinary *** with acute cholangitis can be drained with endoscopic or percutaneous biliary *** chemotherapy with cisplatin and gemcitabine has shown improved survival in patients with irresectable and recurrent hCCA.

关键词： Hilar cholangiocarcinoma Bismuth-Corlette classification Memorial Sloan Kettering Cancer Centre Staging Preoperative biliary drainage Portal vein embolisation Surgical resection Hepatectomy

卵巢移行细胞癌:一例报道与文献复习(英文)

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The Chinese-German Journal of Clinical Oncology 2013年第9期12卷 454-456页

作者： Sheikh Aijaz Aziz abdul rashid lone Mohmad Hussain Mir Sumyra Khursheed Qadri Arif Nabi Bhat Farhana Siraj Bagdadi Mir Muzaffar Bashir Sanjeed Ahmed Department of Medical Oncology Sheri Kashmir Instiute of Medical Sciences Department of Pathology Sheri Kashmir Instiute of Medical Sciences Department of Internal Medicine Sheri Kashmir Instiute of Medical Sciences Department of Radio Diagnosis Sheri Kashmir Instiute of Medical Sciences

Transitional cell carcinoma(TCC)of the ovary is a rare and recently recognized subtype of ovarian epithelial *** presented the first case report from our Institute(Sheri Kashmir Instiute of Medical Sciences,Srinagar,India),which was initially misdiagnosed as stromal cell carcinoma(granulosa cell tumour),and on review of histopathology with immunohistochemistry,the diagnosis of TCC of the ovary was *** aim of this article was to describe the typical case of primary TCC of the ovary and to review the literature for information on TCC management.

关键词：卵巢颗粒细胞病例报告文献移行癌复习组织病理学克什米尔

Radiative capture of proton by ^(9)Be(p,γ)^(10)B at low energy

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Communications in Theoretical Physics 2022年第2期74卷 78-82页

作者： abdul Kabir Jameel-Un Nabi Sumair Sagheer Laiba rashid Department of Space Science Institute of Space TechnologyIslamabadPakistan University of Wah Quaid AvenueWah Cantt 47040PunjabPakistan Faculty of Engineering Sciences GIK Institute of Engineering Sciences and TechnologyTopi 23640SwabiKhyber PakhtunkhwaPakistan

Radiative capture p+^(9)Be→^(10)B+γ at energies bearing astrophysical importance is a key process for the spectroscopic study of ^(10)*** this work,we consider the radiative capture cross-section for the ^(9)Be(p,γ)^(10)B within the framework of the potential model and the R-matrix method for the multi-entrance channel *** certain cases,when the potential fails,therefore,the R-matrix approach is better to use for the description of partial components of the cross-section that have sharp or broad *** all possible electric and magnetic dipole transitions,partial components of the astrophysical S-factor are *** computed value of the total S-factor at zero energy is consistent with the reported results.

关键词： potential model R-matrix approach E1 transitions M1 transitions cross-section astrophysical S-factor

Infra-tentorial brain tumor subtypes in children and adults--surgical outcome in an ethnic population with a single regional tertiary center

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Chinese Neurosurgical Journal 2022年第3期8卷 160-168页

作者： abdul rashid Bhat Muhammed Afzal Wani Altaf Rehman Kirmani Department of Neurosurgery Sher-i-Kashmir Institute of Medical Sciences(SKIMS)SrinagarKashmirIndia

Background:To analyze clinically and radiologically the surgical outcome like residual disease,progression of disease,recurrence,disabilities,event-free survival(EFS),and mortality of different infra-tentorial tumor subtypes in children and adults of a strictly non-migratory and ethnic ***:The 410 histologically proved,out of 589,infra-tentorial brain tumor patients were analyzed clinically and by the imaging post-surgically in a single tertiary center for an ethnic *** this analytico-observational study,retrospectively postoperative records of 589 infra-tentorial brain tumors from November 1998 to December 2018(20 years)were retrieved,scrutinized,and *** post-operative clinic-radiological records of 410 patients with proved histopathological examination results were *** law of variance was applied where-ever ***:The 63.2%of the all 410 operated infra-tentorial brain tumors were males while females predominated in meningiomas and *** 31.7%infra-tentorial tumors were children(below 18 years).About 54.1%cases were histologically *** residual tumors comprised 40.2%and symptoms of disease-progression occurred in 10.9%.The tumor recurrence occurred in 14.3%while 6.0%patients developed severe *** overall mortality was 11.4%but 18.9%in malignant *** event-free survival(EFS)for all the patients was 66.0%,patients with malignancies had 47.7%and benign group had 87.7%.Conclusion:The study,surgical outcome of infra-tentorial brain tumor subtypes in children and adults(approx.1/3rd of patients being children),conducted in a tertiary center at a remote land-locked location with non-migratory ethnic population as its catchment area,has a significant epidemiological value for the community and the region.

关键词： Infra-tentorial brain tumors Histological subtypes Ethnic population Surgical outcome

Zinc oxide nanoparticles accelerate the healing of methicillin-resistant Staphylococcus aureus(MRSA)-infected wounds in rabbits

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Asian Pacific Journal of Tropical Biomedicine 2023年第11期13卷 488-496,I0002页

作者： Muhammad Asif Ayesha Safdar Chaudhry Ambreen Ashar Hamad Bin rashid Muhammad Hassan Saleem Hassaan Bin Aslam abdul Aziz Department of Veterinary Surgery University of Veterinary and Animal SciencesLahorePunjabPakistan TECS Department Wilson College of TextilesNC State UniversityRaleigh 27606USA Department of Veterinary Medicine University of Veterinary and Animal SciencesLahorePunjabPakistan Institute of Microbiology University of Veterinary and Animal SciencesLahorePunjabPakistan Department of Veterinary Clinical Sciences University of PoonchRawalakot 12350Pakistan

Objective:To synthesize zinc oxide nanoparticles(ZnONPs)and evaluate their antibacterial and wound healing effects against wounds infected with methicillin-resistant Staphylococcus aureus(MRSA).Methods:ZnONPs were prepared by sol-gel method and characterized by X-ray diffraction(XRD)analysis and scanning electron microscopy(SEM).A total of 18 rabbits were divided into three groups:the ZnONPs group,the gentamicin group and the control group.A wound of 3 cm^(2) was inflicted on each rabbit and contaminated with MRSA *** was started from the fourth day *** healing,microbiological analysis,and histopathological analysis were performed to assess the efficacy of ZnONPs ***:XRD analysis confirmed the hexagonal wurtzite structure of the ZnONPs with an average crystallite size of 29.23 *** revealed discoid-shaped ZnONPs with a rough surface and an average size of 48.36 ***-dispersive X-ray analysis confirmed the purity of ***,the particle size ranged from 100-700 nm with a high agglomeration *** with ZnONPs promoted MRSA-infected wound *** addition,ZnONPs showed a good antibacterial effect as evidenced by a dose-dependent increase in the zone of ***:ZnONPs accelerate the healing of MRSA-infected ***,it can be explored for the treatment of MRSA infection.

关键词： MRSA Wound healing ZnO Nanoparticles Ointment

Rare earth element geochemistry of the Permo-Carboniferous clastic sedimentary rocks from the Spiti Region,Tethys Himalaya:significance of Eu and Ce anomalies

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Chinese Journal Of Geochemistry 2015年第2期34卷 252-264页

作者： Javid Ahmad Ganai Shaik abdul rashid Department of Geology Aligarh Muslim University

包括沙岩和联系页岩， Siliciclastic 沉积岩石 NW Tethys Himalaya 从 Permo 含碳的 Kanawar 组织， Spiti 区域，印度 geochemically 被检验在 Himalaya 在上面的大陆人外壳中监视进化变化。岩石被一致稀土元素元素(REE ) 描绘有轻 R... 详细信息

包括沙岩和联系页岩， Siliciclastic 沉积岩石 NW Tethys Himalaya 从 Permo 含碳的 Kanawar 组织， Spiti 区域，印度 geochemically 被检验在 Himalaya 在上面的大陆人外壳中监视进化变化。岩石被一致稀土元素元素(REE ) 描绘有轻 REE 丰富的模式(La N /Yb N ?=?5.328.2) 和完全重的 REE 模式。REE 价值高(多达 281 ? ppm ) 与大否定 Eu 异例(avg。Eu/Eu *?=? 0.57 ) 。沉积的 REE 特征类似于 Archean 以后澳大利亚人页岩和北美的页岩的那些合成。La/Th 价值(avg。2.34 ) 对应于一相对陆上的火的岩石标准的 felsic 作文(G-1 的 La/Th ?=? 2.3 ) 。沉积的发展 felsic 作文可能在来源联系到普遍酸的活动。REE 模式和 Th/U 价值似乎被沉积环境以及由起源影响了。在一些沉积的积极 Ce 异例的存在可以是 post-depositional 过程的结果。而且， Permo 含碳的沉积显示甚至在短运输距离上，水力的排序能够集中足够的附件阶段影响 REE 作文并且开发否定 Eu 异例。高 REE， La/Yb，和 Th/U 内容和大否定 Eu 异例表明沉积在氧化环境被扔，建议地表的环境变得在在印度 craton 的含碳二叠的边界附近氧化。

关键词：稀土元素地球化学特提斯喜马拉雅石炭二叠系 Ce异常碎屑沉积岩 Eu 氧化环境硅质沉积岩

A Coprocessor Architecture for 80/112-bit Security Related Applications

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Computers, Materials & Continua 2023年第3期74卷 6849-6865页

作者： Muhammad rashid Majid Alotaibi Department of Computer Engineering Umm Al-Qura UniversityMakkah21955Saudi Arabia

We have proposed a flexible coprocessor key-authentication architecture for 80/112-bit security-related applications over GF(2m)field by employing Elliptic-curve Diffie Hellman(ECDH)*** flexibility,a serial input/output interface is used to load/produce secret,public,and shared keys ***,to reduce the hardware resources and to achieve a reasonable time for cryptographic computations,we have proposed a finite field digit-serial multiplier architecture using combined shift and accumulate ***,two finite-statemachine controllers are used to perform efficient control *** proposed coprocessor architecture over GF(2^(163))and GF(2^(233))is programmed using Verilog and then implemented on Xilinx Virtex-7 FPGA(field-programmable-gate-array)*** GF(2^(163))and GF(2^(233)),the proposed flexible coprocessor use 1351 and 1789 slices,the achieved clock frequency is 250 and 235MHz,time for one public key computation is 40.50 and 79.20μs and time for one shared key generation is 81.00 and 158.40μ***,the consumed power over GF(2^(163))and GF(2^(233))is 0.91 and 1.37mW,*** proposed coprocessor architecture outperforms state-of-the-art ECDH designs in terms of hardware resources.

关键词： Coprocessor design key-authentication wireless sensor nodes RFID ECDH FPGA