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Characterization and anticancer potential of Withania somnifera fruit bioactives(a native species to Pakistan)using gas chromatography-mass spectrometer,nuclear magnetic resonance and liquid chromatography-mass spectrometry-electrospray ionization

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Journal of Traditional Chinese Medicine 2022年第6期42卷 908-914页

作者： Qudsia Tabassam Tahir Mehmood Sibtain Ahmed Farooq anwar abdul Rauf Raza Institute of Chemistry University of SargodhaSargodha-40100Pakistan Institute of Biochemistry and Biotechnology University of Veterinary and Animal Sciences-UVAS54000-Lahore.Pakistan University of California San Diego 9500 Gilman Drive La JollaCA 92093USA

INTRODUCTION:Withania somnifera(***)is a plant with remarkable pharmacological *** plant has an impressive profile of medicinal uses in the folk medicine system of several ***:This comprehensive study is aimed to characterize phytochemicals in fruit of *** and tested for in vitro anticancer potential to find out active candidate in disease prevention and ***:The bioactive components from *** fruit were extracted with polar and non-polar *** potential of the isolated bioactive was assessed against different cancer cell lines through MTT assay and Incucytes imaging *** extracts were characterized for secondary metabolites using GCMS(gas chromatography-mass spectrometer),LCMS(liquid(electrospray Ionization)and 1H-NMR(electrospray Ionization)***:Both freeze-dried and rotary evaporator condensed extracts exhibited anticancer potential against MDA-MB-231,MCF7-SKOV3 and SKBR3 cell *** tested extracts have cell growth inhibition potential against mammalian cancer cell *** acid purified from n-hexane extract through HPLC was investigated for its cytotoxicity against breast cancer cell line SKBR3 by using Incucytes imaging ***:We found that a variety of bioactive compounds existed in this *** identified compound that was not investigated for cytotoxicity in previous studies was purified and its application showed cytotoxicity on breast cancer cell lines.A number of bioactive identified from *** fruit may have an effective potential for development into chemotherapy drugs.

关键词： phytochemicals plants medicinal anti-cancer activities purification state-of-the-art techniques

Spectral Hole Burning via Kerr Nonlinearity

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Communications in Theoretical Physics 2015年第10期64卷 473-478页

作者： anwar Ali Khan M.S.abdul Jabar M.Jalaluddin Bakht Amin Bacha Iftikhar Ahmad Department of Physics University of Malakand

Spectral hole burning is investigated in an optical medium in the presence of Doppler broadening and Kerr nonlinearity. The Kerr nonlinearity generates coherent hole burning in the absorption spectrum. The higher order Kerr nonlinearity enhances the typical lamb dip of the hole. Normal dispersion in the hole burning region while Steep anomalous dispersion between the two hole burning regions also enhances with higher order Kerr effect. A large phase shift creates large delay or advancement in the pulse propagation while no distortion is observed in the pulse. These results provide significant steps to improve optical memory, telecom devices, preservation of information and image quality.

关键词： spectral hole burning Kerr nonlinearity Doppler br

Detection of Left Ventricular Cavity from Cardiac MRI Images Using Faster R-CNN

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Computers, Materials & Continua 2023年第1期74卷 1819-1835页

作者： Zakarya Farea Shaaf Muhammad Mahadi abdul Jamil Radzi Ambar Ahmed Abdu Alattab anwar Ali Yahya Yousef Asiri Faculty of Electrical and Electronic Engineering Universiti Tun Hussein Onn MalaysiaParit RajaBatu Pahat86400JohorMalaysia Department of Computer Science College of Science and ArtsSharurahNajran UniversityNajran61441Saudi Arabia Department of Computer Science Faculty of Computer Science and Info.SystemsThamar UniversityDhamar87246Yemen Department of Computer Science College of Computer Science and Information SystemsNajran UniversityNajran61441Saudi Arabia

The automatic localization of the left ventricle(LV)in short-axis magnetic resonance(MR)images is a required step to process cardiac images using convolutional neural networks for the extraction of a region of interest(ROI).The precise extraction of the LV’s ROI from cardiac MRI images is crucial for detecting heart disorders via cardiac segmentation or ***,this task appears to be intricate due to the diversities in the size and shape of the LV and the scattering of surrounding tissues across different ***,this study proposed a region-based convolutional network(Faster R-CNN)for the LV localization from short-axis cardiac MRI images using a region proposal network(RPN)integrated with deep feature classification and *** was trained using images with corresponding bounding boxes(labels)around the LV,and various experiments were applied to select the appropriate layers and set the suitable *** experimental findings showthat the proposed modelwas adequate,with accuracy,precision,recall,and F1 score values of 0.91,0.94,0.95,and 0.95,*** model also allows the cropping of the detected area of LV,which is vital in reducing the computational cost and time during segmentation and classification ***,itwould be an ideal model and clinically applicable for diagnosing cardiac diseases.

关键词： Cardiac short-axis MRI images automatic left ventricle localization deep learning models faster R-CNN

Improved Estimation of Rare Sensitive Attribute in a Stratified Sampling Using Poisson Distribution

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Open Journal of Statistics 2016年第1期6卷 85-95页

作者： abdul Wakeel Masood anwar Department of Mathematics COMSATS Institute of Information Technology Islamabad Pakistan

In this study, we propose a two stage randomized response model. Improved unbiased estimators of the mean number of persons possessing a rare sensitive attribute under two different situations are proposed. The proposed estimators are evaluated using a relative efficiency comparison. It is shown that our estimators are efficient as compared to existing estimators when the parameter of rare unrelated attribute is known and in unknown case, depending on the probability of selecting a question.

关键词： Poisson Distribution Rare Sensitive Attribute Rare Unrelated Attribute Stratified Sampling

Indirect Vector Control of Linear Induction Motors Using Space Vector Pulse Width Modulation

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Computers, Materials & Continua 2023年第3期74卷 6263-6287页

作者： Arjmand Khaliq Syed abdul Rahman Kashif Fahad Ahmad Muhammad anwar Qaisar Shaheen Rizwan Akhtar Muhammad Arif Shah Abdelzahir Abdelmaboud Electrical Engineering Department University of Engineering and TechnologyLahore54700Pakistan Department of Basic Sciences Deanship of Common First YearJouf UniversitySakakaAljouf72341Saudi Arabia Department of Information Science Division of Science and TechnologyUniversity of EducationLahore54000Pakistan Department of Computer Science and Information Technology The Islamia University of BahawalpurRahim Yar Khan Sub CampusPakistan Department of IT and Computer Science Pak-Austria Fachhochschule Institute of Applied Sciences and TechnologyHaripurPakistan Department of Information Systems King Khalid UniversityMuhayel Aseer61913Saudi Arabia

Vector control schemes have recently been used to drive linear induction motors(LIM)in high-performance *** trend promotes the development of precise and efficient control schemes for individual *** research aims to present a novel framework for speed and thrust force control of LIM using space vector pulse width modulation(SVPWM)*** framework under consideration is developed in four *** begin,MATLAB Simulink was used to develop a detailed mathematical and electromechanical *** research presents a modified SVPWM inverter control *** tuning the proportional-integral(PI)controller with a transfer function,optimized values for the PI controller are *** the subsystems mentioned above are integrated to create a robust simulation of the LIM’s precise speed and thrust force control *** reference speed values were chosen to evaluate the performance of the respective system,and the developed system’s response was verified using various data *** the low-speed range,a reference value of 10m/s is used,while a reference value of 100 m/s is used for the high-speed *** speed output response indicates that themotor reached reference speed in amatter of seconds,as the delay time is between 8 and 10 *** maximum amplitude of thrust achieved is less than 400N,demonstrating the controller’s capability to control a high-speed LIM with minimal thrust *** to the controlled speed range,the developed system is highly recommended for low-speed and high-speed and heavy-duty traction applications.

关键词： Space vector pulse width modulation linear induction motor proportional-integral controller indirect vector control electromechanical dynamic modeling

Saponins and solvent extracts from Atriplex laciniata L. exhibited high anthelmintic and insecticidal activities

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Journal of Traditional Chinese Medicine 2017年第5期37卷 599-606页

作者： Zul Kamal Farhat Ullah Sajjad Ahmad Muhammad Ayaz abdul Sadiq Muhammad Imran Shujat Ahmad Faiz Ur Rahman anwar Zeb Department of Pharmacy Shaheed Benazir Bhutto University Sheringal Dir Upper 18050Pakistan Department of Pharmacy University of Malakand Chakdara Dir Lower 18000 Pakistan Department of Zoology Shaheed Benazir Bhutto University Sheringal Dir Upper 18050 Pakistan

OBJECTIVE: To investigate saponins and various solvent extracts from Atriplex laciniata(A. laciniata)against human parasites and various ***: The samples from A. laciniata used in the activities were crude saponins(*** F) and solvent samples including methanolic extract(*** F), ethyl acetate(*** F), choloroform(*** F),n-hexane(*** F) and water residual(*** F). Anthelmintic potentials of the samples were analyzed against Pheretima posthuma(earthworms) and Ascaridia galli(round worms) using contact toxicity method. Insecticidal activities were performed against Heterotermes indicola(termite), Monomorium pharaonis(pharaoh ant), Tribolium castaneum(flour beetle) and Rhyzopertha dominica(grain borer) using standard ***: In anthelmintic assay, *** F and *** F were most effective against P. posthuma and A. gal-li with average death times of 25.62 and 29.65 min respectively. Likewise the anthelmintic assay, *** F and *** F were most effective against H. indicola causing 90.36% and 73.24% lethality respectively. Furthermore, in anti-Pharaoh activity *** F, *** F, *** F, *** F and *** F exhibited highest activity with LD50 of 78, 220, 260, 330 and > 800 mg/m L respectively. *** F and *** F were highly effective against R. dominica causing 80.11% and71.30% lethality respectively. *** F was found most active against T. ***: Our findings suggest that the *** F, *** F and *** F extracted from *** *** be the best options for the isolation of anthelmintic and bio-insecticidal compounds.

关键词： Saponins Atriplex Parasites Hetero termes indicola Monomorium pharaonis Rhyzopertha dominica Tribolium castaneum

Treadmill training in Parkinson's disease:possible role of prefrontal modifications in the improved cortical-subcortical network function

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Neural Regeneration Research 2024年第2期19卷 407-408页

作者： Hao Ding Amgad Droby abdul Rauf anwar Jeffrey M.Hausdorff Bahman Nasseroleslami Anat Mirelman Inbal Maidan Muthuraman Muthuraman Department of Neurology University Hospital WürzburgWürzburgGermany Academic Unit of Neurology Trinity College Dublinthe University of DublinDublinIreland Department of Neurology Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Sagol School of Neuroscience Tel Aviv UniversityTel AvivIsrael Biomedical Engineering Centre UET Lahore(KSK Campus)LahorePakistan Laboratory for Early Markers of Neurodegeneration(LEMON) Center for the Study of MovementCognitionand Mobility(CMCM)Neurological InstituteTel Aviv Sourasky Medical CenterTel AvivIsrael Department of Physical Therapy Sackler Faculty of MedicineTel Aviv UniversityTel AvivIsrael Rush Alzheimer’s Disease Center and Department of Orthopaedic Surgery Rush University Medical CenterChicagoILUSA

Parkinson’s disease(PD)is a complex neurodegenerative disorder characterized by a range of motor symptoms such as bradykinesia,resting tremor,rigidity,and postural instability,as well as non-motor symptoms,such as de... 详细信息

关键词： rigidity fatigue

Novel Coronavirus and Emerging Mental Health Issues—A Timely Analysis of Potential Consequences and Legal Policies Perspective

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Fudan Journal of the Humanities and Social Sciences 2021年第1期14卷 87-105页

作者： Mehran Idris Khan Hafiz abdul Rehman Saleem Muhammad Fahad anwar Yen-Chiang Chang School of Law Dalian Maritime UniversityDalian 116026Liaoning ProvinceChina Business Administration Department Faculty of Management SciencesILMA UniversityKarachi 75190Sindh ProvincePakistan Guanghua Law School Zhejiang UniversityHangzhouZhejiang ProvinceChina Department of Law University of SahiwalSahiwal 57000Punjab ProvincePakistan

The present outbreak of coronavirus disease 2019(COVID-19)has swiftly crossed borders,and inflicted the global mental health *** is also affecting peoples’daily behaviours,economics,prevention strategies and decision-making among policymakers,healthcare organisations and medical centres that may unintentionally weaken COVID-19 control strategies and lead to increased morbidity,as well as mental health care needs ***,this outbreak is leading to further health complications worldwide,such as stress,fear of the unknown,anger,anxiety,denial,depression symptoms,and *** all the resources used to counter the spread of the virus,further universal strategies are desirable to address the associated mental health *** present study uses the qualitative means to investigate the potential impact of COVID-19,the consequences and legal aspects,then recommend policy implications,in an attempt to cover any apparent *** presents a unique analysis of its kind on the policy and legal aspects of the ongoing pandemic,as regards mental *** concludes that there is an acute need to prioritising the health care and curative issues,strengthen awareness and address the psychological syndromes or similar complications afflicting members of the general public during this pandemic.

关键词： COVID-19 Mental health Potential consequences Legal aspects

Lipopeptides in promoting signals at surface/interface of micelles:Their roles in repairing cellular and nuclear damages

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Food Bioscience 2022年第2期46卷 73-90页

作者： Sami Saadi Nazamid Saari Hasanah Mohd Ghazali abdulkarim Sabo Mohammed Azizah abdul-Hamid Nor Elhouda Nacer Farooq anwar Institut de la Nutrition de l’Alimentation et des Technologies Agro-alimentaires INATAA 25017Universit´e Fr`eres Mentouri Constantine 1Algeria Faculty of Food Science and Technology University Putra Malaysia43400SerdangSelangorMalaysia Department of Microbiology and Biotechnology Federal University DutseNigeria D´epartement de Biologie Universit´e de Batna 2Algeria Institute of Chemistry University of SargodhaSargodha40100Pakistan

Lipopeptides are recognized as a structurally diverse group of functional *** possess multiple biological,biotechnological and therapeutic applications and are able to affect cell membrane integrity and *** is widely accepted that suppressing the interaction of redooxidation is mainly aimed by inserting functional biopeptides on form alpha-helical peptides or on form *** types of structured biomaterials have great potential in promoting signal transductions to the most organelles having geometrical and spacial structures similar to endogenous liposome forms such as lysosomes,ribosomes,mitochondria and platelets..Thus,inserting radioactive trace-elements along with biopeptides is necessary in tracing the trajectory of those radioactive micelles that are destined in targeting further complicated disease and growth factor *** techniques are important in determining structure-symmetry and asymmetry leading to meso-spherical crystal-packing modes or to copolymer *** main objective of this review is to highlight and elucidate the potential role of lipopeptides in promoting signals at surface/interface of micelles along with their functionalities in repairing cellular and nuclear ***,state-of-the-art scientific knowledge is reviewed regarding bioconjugation and structuring charged-mono-layer and/or bi-layer phospholipidic membranes in adherent to signal-biopeptides using some advanced techniques such as ultra-sound probe based polydispersity of radioactive trace-elements assisted microdialysis as micro-separating techniques in between those miscible and immiscible compounds.

关键词： Lipopeptides Biopeptides Biomaterials Spacial structure Transduction signal