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Frequency of Cardiovascular Risk Factors in Systemic Lupus Erythematosus: A Case-Control Study in a Department of Internal Medicine in Sub-Saharan Africa

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Open Journal of Internal Medicine 2020年第1期10卷 1-12页

作者： Maï mouna sow Baï dy Sy Kane Abdourahmane Samba Awa Cheikh Ndao Nafissatou Diagne Boundia Djiba Mouhamed Dieng Atoumane Faye abdoulaye Pouye Internal Medicine Department Aristide Le Dantec Teaching Hospital Dakar Senegal Biochemistry Department Aristide Le Dantec Teaching Hospital Dakar Senegal

Background: The morbidity and mortality of systemic lupus erythematosus are largely due to accelerated atherosclerosis. This is partly related to the high prevalence of traditional cardiovascular risk factors. The aim of our study was to determine the frequency of these factors in lupus patients compared to a control population in a department of internal medicine. Methods: We realized a case-control study in patients with systemic lupus erythematosus according to ACR criteria in 1997. Patients were matched by age and gender with controls subjects without autoimmune disease. We studied the frequency of traditional cardiovascular risk factors in both populations. The study was done in the department of internal medicine of Aristide Le Dantec teaching Hospital, in Senegal, during the period from August 2017 to December 2018. The statistical analysis was performed with SPSS 23.0 software and the level of significance was retained for a p-value Results: We recruited 100 subjects including 50 patients and 50 controls. The mean age was 33.5 ± 11.3 years in cases and 33.3 ± 11.3 years in controls. Dyslipidemia was significantly associated with systemic lupus erythematosus (p = 0.009). Levels of triglycerides (p Conclusion: Traditional cardiovascular risk factors including dyslipidemia and hyperuricemia were more common in patients. Similarly, renal failure was associated with lupus.

关键词： Cardiovascular Risk Factors Systemic Lupus Erythematosus Sub-Saharan Africa

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Seronegative Myasthenia Gravis and a Biermer’s Anemia:A Rare Association

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Open Journal of Internal Medicine 2017年第4期7卷 160-164页

作者： Boundia Djiba Baidy Sy Kane Awa Cheikh Ndao Michel Assane Ndour Nafissatou Diagne Atoumane Faye Mohamed Dieng Maimouna sow abdoulaye Pouye Department of Internal Medicine Center Hospital Aristide Le DantecDakarSenegal

We report a rare association of seronegative myasthenia gravis and a Biermer’s anemia (or pernicious anemia). A Senegalese patient of 31 years has been followed for a vitamin B12 deficiency anemia, 12 months before his hospitalization in our department. She has been admitted for an intense and invalidating fatigability in spite of the correction of anemia, associated to a right ptosis. This clinical picture has electively been improved to the prostigmine test. The electromyography had revealed a compatible decrement with a diagnosis of myasthenia. The positivity of the antibodies anti gastric parietal cells and the twice negativity of the antibody against acetylcholine receptor (AChR) and muscle-specific kinase (MuSK) had permitted to deduct a diagnosis of seronegative myasthenia and Biermer’s anemia. The evolution was favorable under substitutive B12 vitamin therapy associated to corticotherapy and azathioprine. We insist on the research and the early treatment of a myasthenia, in a context of Biermer’s anemia, before suggestive clinical signs in spite of the negativity of the anti-Rach antibodies and anti-Musk.

关键词： Myasthenia Gravis Pernicious Anemia Seronegative

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Contribution of High Sensible C-Reactive Protein (hsCRP) in the Assessment of the Risk of Onset of Type 2 Diabetes and Its Cardiovascular Complications

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Journal of Diabetes Mellitus 2024年第2期14卷 95-107页

作者： Maïmouna Touré Léopold Ngor Sène Jean Pierre Diagne Demba Diédhiou Souleymane Thiam Abdou Khadir sow Mor Diaw Aïssatou Seck Salimata Diagne Houndjo abdoulaye Ba abdoulaye Samb Fatou Diallo-Agne Modou Oumy Kane Laboratoire de Physiologie et d’ Explorations Fonctionnelles Physiologiques Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal IRL3189 &#8220Environnement Sant&#233 Soci&#233t&#233&#8221 CNRS CNRST Bamako-UCAD Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal Laboratoire Privé de Biologie General Kaolack S&#233n&#233gal Centre Hospitalier Universitaire (CHU) Abasse Ndao Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal Laboratoire de Biochimie et de Biologie molé culaire Facult&#233 de M&#233decine de Pharmacie et d&#8217OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal Laboratoire de Physiologie Pharmaceutique Facult&#233 de M&#233decine de Pharmacie et d'OdontoStomatologie (FMPOS) Universit&#233 Cheikh Anta Diop (UCAD) Dakar S&#233n&#233gal

Background: Type 2 diabetes is a metabolic disease characterized by chronic hyperglycemia. The latter plays an essential role in inflammation by stimulating the production of pro-inflammatory cytokines or by increasing their secretion by an oxidative mechanism. These cytokines control the hepatic synthesis of an inflammatory protein called C-Reactive Protein (CRP). High or average values of CRP would have a predictive value of cardiovascular diseases and type 2 diabetes. The relationship between low CRP values and the risk of developing type 2 diabetes and its cardiovascular complications is not sufficiently studied. The hsCRP could serve as a predictive biomarker of risk of onset, follow-up and prognosis for type 2 diabetes and its cardiovascular complications. To answer this problem, we conducted this study, the aim of which was to study the predictive role of hsCRP in the risk of occurrence of type 2 diabetes and its cardiovascular complications. Materials and Methods: This is a prospective and cross-sectional case-control study involving 200 participants including 100 control women and 100 women with type 2 diabetes (mean age was respectively 49.89 years ± 8.26 & 51.92 years ± 7.18;p = 0.066). The interviews were conducted on the basis of a questionnaire. Physical examination collected biometric data and cardiovascular constants. The biochemical parameters such as hsCRP were analyzed by an automated Abbott device. Results: We noted that hsCRP was significantly higher in type 2 diabetic subjects compared to control subjects (p (rho = 0.40, p systolic blood pressure (rho = 0.30, p = 0.003), diastolic blood pressure (rho = 0.28, p = 0.006), total body fat (rho = 0.48, p Conclusion: hsCRP has a prognostic value in the evaluation of cardiovascular risk. It seems to play an important role in the pathogenesis of type 2 diabetes mellitus and its cardiovascular complications. It could thus be considered as a biomarker for the screening, monitoring and prognosis of type 2

关键词： hsCRP Biomarker Inflammation Type 2 Diabetes

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Empty Sella Turcica Syndrome: About a Case Revealed by Adrenal Insufficiency

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Open Journal of Internal Medicine 2021年第2期11卷 68-72页

作者： sow Maïmouna Diagne Nafissatou Ndao Awa Cheikh Thiam Mbaye Faye Atoumane Dieng Mouhamed Kane Baïdy Sy Djiba Boundia Pouye abdoulaye Internal Medicine Department Aristide Le Dantec Teaching Hospital Dakar Senegal Radiology Department FANN Teaching Hospital Dakar Senegal

Background: Empty sella turcica corresponds to an arachnocele which may be complete or partial, primary or secondary. The primary form is rarer. Its cause is unknown, but etiological factors have been identified. The prevalence of this condition is variable, depending on techniques of diagnosis. It may be detected fortuitously on imaging or in the presence of neurological, ocular or endocrine manifestations. Aim: We aim to report a case of empty sella turcica syndrome revealed by adrenal insufficiency in a young African black woman. Case presentation: It was an overweight young woman with signs of intracranial hypertension associated with central adrenal insufficiency. The diagnosis of empty sella was confirmed by magnetic resonance imaging. Secondarily, she developed a hypo metabolism syndrome and biology confirmed central hypothyroidism. After correction of the adrenal cortical deficit, the treatment of the thyroid deficit was administered. Evolution was favourable clinically and biologically. Conclusion: The empty sella turcica is rare and its revelation by a central adrenal insufficiency is even more. The case we report is a perfect illustration.

关键词： Empty Sella Turcica Adrenal Insufficiency Intracranial Hypertension

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Predictors of Clostridium difficile infection severity in patients hospitalised in medical intensive care

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World Journal of Gastroenterology 2013年第44期19卷 8034-8041页

作者： Nagham Khanafer abdoulaye Touré Cécile Chambrier Martin Cour Marie-Elisabeth Reverdy Laurent Argaud Philippe Vanhems Laboratory of Epidemiology and Public Health CNRS UMR 5558 University of Lyon 69 373 Lyon France Epidemiology and Infection Control Unit Edouard Herriot Hospital Hospices Civils of Lyon 69437 Lyon France Clinical Nutrition Intensive Care Unit Croix Rousse Hospital Hospices Civils of Lyon69317 Lyon France INSERM Unit 1060 INRA 1235 University of Lyon 69921 Oullins France Medical Intensive Care Unit Edouard Herriot Hospital Hospices Civils of Lyon 69437 LyonFrance Microbiology Laboratory Hospices Civils of Lyon 69677 Bron France

AIM:To describe and analyse factors associated with Clostridium difficile infection(CDI)severity in hospitalised medical intensive care unit ***:We performed a retrospective cohort study of 40 patients with CDI in a medical intensive care unit(MICU)at a French university *** include patients hospitalised between January 1,2007and December 31,*** on demographics characteristics,past medical history,CDI description was *** to risk factors associated with CDI within 8 wk before CDI was recorded,including previous hospitalisation,nursing home residency,antibiotics,antisecretory drugs,and surgical ***:All included cases had their first episode of *** mean incidence rate was 12.94 cases/1000admitted patients,and 14.93,8.52,13.24,19.70,and8.31 respectively per 1000 admitted patients annually from 2007 to *** age was 62.9[interquartile range(IQR)55.4-72.40]years,and 13(32.5%)were *** length of MICU stay was 14.0d(IQR 5.0-22.8).In addition to diarrhoea,the clinical symptoms of CDI were fever(>38℃)in 23 patients,abdominal pain in 15 patients,and ileus in 1 *** duration of diarrhoea was 13.0(8.0-19.5)*** addition to diarrhoea,the clinical symptoms of CDI were fever(>38℃)in 23 patients,abdominal pain in 15 patients,and ileus in 1 *** to CDI,38patients(95.0%)were exposed to antibiotics,and 12(30%)received at least 4 ***,3rdgeneration cephalosporins,coamoxiclav and tazocillin were prescribed most frequently(65%,55%,40%and 37.5%,respectively).The majority of cases were hospital-acquired(n=36,90%),with 5 cases(13.9%)being *** patients had severe *** crude mortality rate within 30 d after diagnosis was 40%(n=16),with 9 deaths(9 over 16;56.3%)related to *** our 40 patients,15(37.5%)had severe *** logistic regression showed that male gender[odds ratio(OR):8.45;95%CI:1.06-67.16,P=0.044],rising serum C-reactive protein levels(OR=

关键词： Clostridium difficile Health-care associated infection Hospital-acquired infection Intensive care unit Nosocomial infection Severe Clostridium difficile infection

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Fusarivirus accessory helicases present an evolutionary link for viruses infecting plants and fungi

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Virologica Sinica 2022年第3期37卷 427-436页

作者： Assane Hamidou abdoulaye Jichun Jia Aqleem Abbas Du Hai Jiasen Cheng Yanping Fu Yang Lin Daohong Jiang Jiatao Xie State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhan430070China Hubei Key Laboratory of Plant Pathology College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan430070China Hubei Hongshan Laboratory Wuhan430070China

A significant number of mycoviruses have been identified that are related to plant viruses,but their evolutionary relationships are largely unexplored.A fusarivirus,Rhizoctonia solani fusarivirus 4(RsFV4),was identified in phytopathogenic fungus Rhizoctonia solani(***)strain XY74 co-infected by an ***4 had a genome of 10,833 nt(excluding the poly-A tail),and consisted of four non-overlapping open reading frames(ORFs).ORF1 encodes an 825 aa protein containing a conserved helicase domain(Hel1).ORF3 encodes 1550 aa protein with two conserved domains,namely an RNA-dependent RNA polymerase(RdRp)and another helicase(Hel2).The ORF2 and ORF4 likely encode two hypothetical proteins(520 and 542 aa)with unknown *** phylogenetic analysis based on Hel2 and RdRp suggest that RsFV4 was positioned within the fusarivirus group,but formed an independent branch with three previously reported fusariviruses of ***,the Hel1 and its relatives were phylogenetically closer to helicases of potyviruses and hypoviruses than fusariviruses,suggesting fusarivirus Hel1 formed an evolutionary link between these three virus *** finding provides evidence of the occurrence of a horizontal gene transfer or recombination event between mycoviruses and plant viruses or between *** findings are likely to enhance the understanding of virus evolution and diversity.

关键词： Fusarivirus Potyvirus Hypovirus Helicase Horizontal gene transfer(HGT)

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Study on the Safety and Prevention Technology of Coal Mining under the River in Xingyuan Coal Mine

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Open Journal of Geology 2024年第3期14卷 339-402页

作者： abdoulaye Sylla Wenbing Guo School of Energy Science and Engineering Henan Polytechnic University Jiaozuo China

Coal mining-induced surface subsidence poses significant ecological and infrastructural challenges, necessitating a comprehensive study to ensure safe mining practices, particularly in underwater conditions. This project aims to address the extensive impact of coal mining on the environment, infrastructure, and overall safety, focusing on the Shigong River area above the working face. The study employs qualitative and quantitative analyses, along with on-site engineering measurements, to gather data on crucial parameters such as coal seam characteristics, roof rock lithology, thickness, water resistance, and structural damage degree. The research encompasses a multidisciplinary approach, involving mining, geology, hydrogeology, geophysical exploration, rock mechanics, mine surveying, and computational mathematics. The importance of effective safety measures and prevention techniques is emphasized, laying the foundation for research focused on the Xingyun coal mine. The brief concludes by highlighting the potential economic and social benefits of this project and its contribution to valuable experience for future subsea coal mining.

关键词： Coal Mining-Induced Surface Subsidence Ecological and Infrastructural Challenges Safe Mining Practices Underwater Conditions Multidisciplinary Approach Safety Measures Prevention Techniques

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Ankle-Brachial Index in Systemic Lupus Erythematosus:A Senegalese Case-Control Study

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World Journal of Cardiovascular Diseases 2019年第12期9卷 958-968页

作者： Baidy Sy Kane Maimouna sow Fatou Aw Abdourahmane Samba Ahmed Tall Lemrabott Awa Cheikh Ndao Souhaibou Ndongo Mouhamadou Bamba Ndiaye Maboury Diao abdoulaye Pouye Department of Internal Medicine Le Dantec Teaching HospitalCheikh Anta DIOP UniversityDakarSenegal Department of Cardiology Le Dantec Teaching HospitalCheikh Anta DIOP UniversityDakarSenegal Biochemistry Laboratory Le Dantec Teaching HospitalCheikh Anta DIOP UniversityDakarSenegal Department of Nephrology Le Dantec Teaching HospitalCheikh Anta DIOP UniversityDakarSenegal

Systemic lupus erythematosus (SLE) is associated with accelerated atherosclerosis and increasing cardiovascular risk which is recognized as a major cause of morbidity and death. Whether subclinical atherosclerosis has been evaluated by several methods, there are very limited data about Ankle-Brachial Index (ABI) in patients with systemic lupus erythematosus. The aim of the present study was to compare this index, between SLE patients and controls. We conducted a case-control study in the Department of Internal Medicine of our institution during the period from August 1, 2017 to December 31, 2018. We included 100 subjects, including 50 SLE patients and 50 control cases. This included 44 women and 6 men in patients with an identical distribution in controls. The mean age was 33.5 ± 11.3 years for cases and 33.3 ± 11.3 years (p-value: 0.93) for controls subjects. There was higher frequency of cardiovascular risk factors such as dyslipidemia (p-value at 0.009), low level of serum HDL-cholesterol (p-value??0.001), hypertriglyceridemia (p-value at 0.000) and hyperuricemia (p-value at 0.000) in patients with SLE. Overweight/obesity was higher in controls subjects (p-value at 0.028). There was no statistically significant difference in the frequency of diabetes-mellitus, smoking and high blood pressure. The abnormally ABI was recorded in 19 patients with SLE (38%) and 8 controls (16%) with a p-value: 0.01 and odds ratio: 3.22. Eight patients (16%) and four controls (8%) had low ABI without significant difference (p-value: 0.11 but odds-ratio at 2.98). Eleven patients with SLE (22%) and five controls (10%) had high ABI (p-value: 0.05 and odds-ratio: 3.24). In patients with SLE only disease activity (cSLEDAI) at the inclusion of the study was correlated?to abnormal ABI.?Conclusion:?This study showed an increasing prevalence of abnormal ABI in black African patients with SLE compared to controls with a correlation between disease activity and abnormal ABI.

关键词： Systemic Lupus Erythematosus Subclinical Atherosclerosis Peripheral Arterial Disease Ankle-Brachial Index Africa South of the Sahara

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Infectious ENT Emergencies: A One-Year Experience at the ENT Department of Mamou Regional Hospital

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International Journal of Otolaryngology and Head & Neck Surgery 2024年第5期13卷 359-372页

作者： Mamadou Mouctar Ramata Diallo Ibrahima Diallo Oumou Amadou Diallo Alsény Cisse Mamadou Bailo sow Raphan Madi Kaba Keita abdoulaye Keita Alpha Oumar Diallo ENT Department Mamou Regional Hospital Mamou Guinea Faculty of Health Sciences and Techniques Gamal Abdel Nasser University of Conakry Conakry Guinea ENT Department Donka National Hospital Conakry Guinea ENT Department Ignace Deen National Hospital Conakry Guinea ENT Department Lab Regional Hospital Lab Guinea ENT Department NZrkor Regional Hospital NZrkor Guinea

Introduction: ENT infectious emergencies encompass all infectious pathologies affecting the ear, nose, sinuses, throat, and neck. A good understanding of these emergencies is essential for organizing appropriate care. In Guinea, few studies have described ENT infectious pathologies in rural areas. Objective: To study ENT infectious emergencies in the Otorhinolaryngology department of the Mamou Regional Hospital. Materials and Methods: This is a retrospective and prospective descriptive study, conducted from August 1, 2021, to July 31, 2022. All patients admitted to the ENT department of the Mamou Regional Hospital for an infectious emergency were included. Results: Among the 1854 recorded consultations, 261 cases involved ENT infectious emergencies, representing a prevalence of 14.07%. The most represented age group was 0 to 10 years (31.03%), with a majority of female patients (59%) and a predominantly urban origin (81.61%). Students accounted for 32.18% of the cases. The main reasons for consultation were odynophagia/dysphagia (32.42%) and otalgia (22.94%). The primary etiologies were tonsillitis (28.73%) and otitis (27.20%). Treatments administered included probabilistic antibiotic therapy (38.80%), analgesics (32.03%), and corticosteroid therapy (10.47%). The outcome was favorable in 98.85% of cases, with only 0.38% lost to follow-up. Conclusion: The results of our study confirm the frequency of ENT infectious pathologies. Their management requires joint actions for population awareness, staff training, and services equipment, particularly in rural areas.

关键词： ENT Infection Emergency Mamou Regional Hospital

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Connective Tissue Diseases on the Elderly Population in Dakar Hospital Setting

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Open Journal of Internal Medicine 2022年第2期12卷 103-111页

作者： Ndao Awa Cheikh Atoumane Faye Amadou Diop Dia Nafissatou Diagne Diatou Gueye Dia Birame Codou Fall Michel Assane Ndour Mouhamed Dieng Maïmouna sow abdoulaye Pouye Department of Internal Medicine Aristide Le Dantec Hospital Cheikh Anta Diop University Dakar Senegal Department of Internal Medicine Regional Hospital of Saint-Louis Gaston Berger University Saint-Louis Senegal Department of Internal Medicine DalalJamm Hospital Cheikh Anta Diop University Dakar Senegal Department of Internal Medicine Abass Ndao Hospital Cheikh Anta Diop University Dakar Senegal Department of Internal Medicine Aristide Le Dantec Hospital Dakar Senegal

Introduction: Immunosenescence contributes to the development of auto-antibodies. However, while the prevalence of some autoantibodies increases with age, the incidence of connective tissue diseases decreases with age. This study aims to determine the clinical and paraclinical characteristics of connective tissue diseases in the elderly population. Materials and Methods: We conducted a retrospective and descriptive study, from March 2010 to March 2021, in the Internal Medicine Department of Aristide Le Dantec Hospital, including all the medical records of patients followed up for connective tissue disease and whose symptomatology began at an age greater than or equal to 65 years. Epidemiological, clinical, paraclinical, therapeutic and evolutionary data were collected from a pre-established survey form and then processed using SPSS software. Results: Overall, 22 cases were collected out of 275 seen on consultation. They involved 16 women and 6 men, aged between 65 and 85 years with a median of 70 years. The mean duration of the clinical picture was 15.7 months with extremes of 1 and 96 months. The clinical symptoms were joint pain in 21 patients associated with dry eye and mouth syndrome in seven cases and one patient underwent isolated dry eye and mouth syndrome. Joint involvement was deforming in 13 patients. Poor general condition was noted in 20 patients. Biology showed anemia in 14 patients, hyperleukocytosis (2 patients) and thrombocytosis (5 patients). The sedimentation rate (SR) was accelerated in 9 patients and the C-reactive protein (CRP) was positive in 12 patients. Immunology showed a positive Latex test (3 patients/6), Waaler-Rose reaction (8 patients/13), anti-cyclic citrullinated peptides (anti-CCP) antibodies (11 patients/11), anti-nuclear antibodies (2 patients/4). Anti-extractable nuclear antigens (anti-ENA) antibody testing in 4 patients showed positive anti-U1RNP (1 case), anti-SSA and anti-SSB (1 case). Plain X-Rays of the hands, wrists and feet

关键词： Connective Tissue Disease Elderly Rheumatoïd Polyarthritis Sjögren’s Syndrome Dakar

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