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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 59-63页

作者： Ayman el Nakeeb ahmed el Gawalby Mahmoud A.Ali ahmed Shehta Hosam Hamed mohamed el Refea ahmed Moneer ahmed abd el Rafee Gastroenterology Surgical Center Mansoura University

Background: The efficacy of octreotide to prevent postoperative pancreatic fistula(POPF) of pancreaticoduodenectomy(PD) is still controversial. This study aimed to evaluate the effect of postoperative use of octreotide on the outcomes after ***: This is a prospective randomized controlled trial for postoperative use of octreotide in patients undergoing PD. Patients with soft pancreas and pancreatic duct elayed gastric emptying(P = 0.472), and early postoperative mortality(P = 0.727).Conclusions: Octreotide did not reduce postoperative morbidities, reoperation and mortality rate. Also, it did not affect the incidence of POPF and its clinically relevant variants.

关键词： Pancreaticoduodenectomy Postoperative pancreatic fistula Octreotide Periampullary tumor

Neoproterozoic Tectonic Events of Egypt

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Acta Geologica Sinica(English Edition) 2021年第4期95卷 1366-1405页

作者： mohamed abd el-WAHED Zakaria HAMIMI Geology Department Faculty of ScienceTanta UniversityTanta 31527Egypt Department of Geology Faulty of ScienceBen ha UniversityBenha 13518Egypt

The Egyptian Nubian Shield(ENS)represents the northwestern part of the Arabian-Nubian Shield and the northern extension of the East African *** ENS is regarded as being formed due to northward-directed escape *** is characterized by mild accretion and suture zones dominated by major strike-slip zones with a commonly sinistral sense of movement;some shear zones display a dextral sense of *** is dominated by gneisses and migmatites in the south,arc volcaniclastic metasediments and highly dismembered ophiolites in the central parts,whereas its northern part is dominated by late-to post-tectonic *** southern Sinai,the Neoproterozoic rocks are grouped into four complexes,namely Feiran–Solaf,Sa’al–Zaghra,Kid and *** ENS ophiolites were formed between 730–750 Ma,mainly in a supra-subduction zone *** ENS has undergone a Neoproterozoic deformation history involving three successive phases:(1)Early N–S shortening phase(D1),(2)Syn-accretionary phase(D2)and(3)Post-accretionary phase(D3).The initial island-arc stage(780–730 Ma)is a N–S shortening phase initiated by collision between the Eastern Desert tectonic terrane to the north with both the Gebeit and Gabgaba terranes to the south(830–720 Ma).During the arc-splitting and back-arc spreading stage(730–620),voluminous syn-tectonic granitoids intruded into the ENS(750–610 Ma).The E–W-directed compressional/transpressional phase(620–450 Ma)led to the overall uplift of the central part of the ENS and consequently the development and exhumation of the core complexes in oblique convergent *** E–W intense shortening deformation resulted also in the formation of NW-and NE-striking sinistral and dextral strike-slip shear zones,*** latest periods of the E–W-directed compressional/transpressional regime were characterized by deposition of the molasse-type Hammamat Sediments unconformably over the Dokhan Volcanics,or interbedded with *** combined thrusting,folding and sin

关键词： Neoproterozoic deformation N–S shortening syn-accretionary phase post-accretionary phase Egyptian Nubian Shield

Human recombinant soluble ACE2(hrsACE2)shows promise for treating severe COVID19

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Signal Transduction and Targeted Therapy 2020年第1期5卷 303-304页

作者： Tarek mohamed abd el-Aziz ahmed Al-Sabi James D.Stockand Department of Cellular and Integrative Physiology University of Texas Health Science Center at San AntonioSan AntonioTX 78229-3900USA Zoology Department Faculty of ScienceMinia UniversityEl-Minia 61519Egypt College of Engineering and Technology American University of the Middle EastKuwaitKuwait

A recent study by Zoufaly et *** in The Lancet Respiratory Medicine describes encouraging data from the first severe COVID-19 patient successfully treated with human recombinant soluble angiotensin-converting enzyme-2(hrsACE2).1 The published data document upon treatment of an adaptive immune response,the disappearance of the virus swiftly from the serum,the nasal cavity and lungs,and a reduction of inflammatory cytokine levels that are critical for COVID-19 ***,the use of hrsACE2 did not impede the generation of neutralizing antibodies,leading to a significant clinical improvement of the treated patient.

关键词： ACE2 al cavity

Induction of sub-G0 arrest and apoptosis by seed extract of Moringa peregrina（Forssk.） Fiori in cervical and prostate cancer cell lines

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Journal of Integrative Medicine 2019年第6期17卷 410-422页

作者： Maged mohamed Maher Abou-Hashem Dina mohamed Abo-elmatty Noha Mostafa Mesbah ahmed mohamed abd el-Mawgoud Faculty of Pharmacy Pharmacognosy DepartmentZagazig UniversityZagazig 44511Egypt Faculty of Pharmacy Biochemistry DepartmentSuez Canal UniversityIsmailia 41522Egypt Egyptian International Pharmaceuticals Industries Company Tenth of Ramadan City 44629Egypt

Objective: This study investigated cytotoxicity and induction of apoptosis in human cervical cancer cells(HelA) and prostate cancer cells(PC-3) using the most active fraction of Moringa peregrina seed ***: Dried and powdered seeds were extracted using 95% ethanol. The total ethanolic extract was further dissolved in distilled water and separated into petroleum ether, chloroform, ethyl acetate and aqueous extracts. Based on the results of in vitro anticancer studies of all extracts, the most highly active extract was selected for evaluation of apoptosis induction and cell cycle analysis on HelA and PC-3 cells at its half maximal inhibitory concentration using flow cytometry;DNA fragmentation by agarose gel electrophoresis and the expression of protein were measured by Western ***: The chloroform fraction from the ethanolic extract of M. peregrina(CFEE) was the most active antitumor fraction. The selectivity index, determined using the normal Vero cell line, indicated that CFEE had a high degree of selectivity against HelA and PC-3 cells. CFEE induced apoptosis, confirmed by cell cycle arrest at sub-G0 phase and DNA fragmentation. CFEE induced an increase in mRNA expression of caspase-3, a decrease in Bcl-2 mRNA expression, and decreased ATP levels. CFEE increased protein expression of caspase-3 and decreased protein expression of poly-ADP-ribose polymerase-1(PARP-1).Flow cytometric analysis showed an appreciable increase in the number of cells in the early apoptotic stage in CFEE-treated HelA and PC-3 cells. CFEE treatment significantly increased lipid peroxidation(malondialdehyde level) in HelA and PC-3 ***: Seed extract of M. peregrina displayed a significant antitumor effect through apoptosis induction in HelA and PC-3 cells.

关键词： Moringa peregrina Fractionation Antiproliferation Apoptosis

Facies Analysis and Biostratigraphy of the Miocene Sequence,Cairo-Suez District,Egypt

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Journal of Earth Science 2017年第1期28卷 1-8页

作者： abdelbaset el-Sorogy mohamed abd-elmoneim ahmed Mowafi Khaled Al-Kahtany Hisham Gahlan Department of Geology and Geophysics College of Science King Saud University Riyadh 11451 Saudi Arabia Geology Department Faculty of Science Zagazig University Zagazig 44519 Egypt

Miocene siliciclastic-carbonate deposits are widely exposed in Cairo-Suez District, Egypt. These deposits are underlain and overlain by continental sediments of Oligocene and post Miocene, respectively. Three stratigraphic sections were investigated at Gabals Geneife, Homeira and Gharra. Lithostrtigraphically, the Miocene sequence could be differentiated into two main rock units representing shallow deposits with relatively intermittent deep marine incursions. These are from base to top, Gharra Formation and Genefe Formation. Detailed macrofossils investigations led to the recognition of four macrofossil zones, namely Alectryonella plicatula-Crassostrea frondosa Range Zone, Echinolampas amplus-Scutella ammonis Range Zone, Chlamys（Macrochlamys） sardoa-Chlamys（Argopecten） submalvinae Range Zone, and Chlamys gentoni-Pecten（Oppenheimopecten） benedictus-Pecten（P.） ziziniae Assemblage Zone. Microfacies analysis and identified taxa indicated that the Miocene sequence was deposited in transgressive-regressive cycles ranged from near shore, warm shallow inner to middle shelf marine environments with storm influence during the accumulation of the oyster banks.

关键词： facies analysis biostratigraphy Miocene Cairo-Suez District Egypt.

Atezolizumab and bevacizumab combination in advanced hepatocellular carcinoma patients:The imperative for safety assessment studies

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World Journal of Clinical Cases 2025年第9期13卷 56-59页

作者： Mina Tharwat ahmed Tawheed mohamed el-Kassas Department of Tropical Medicine and Gastroenterology Faculty of MedicineAswan UniversityAswan 81528Egypt Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt

Hepatocellular carcinoma(HCC)is the most prevalent cancer of the hepatobiliary tract and the third leading cause of cancer-related mortality *** and bevacizumab combination is currently considered among the frontline treatment modalities for advanced unresectable *** studies examining this combination were focused on evaluating its *** numerous case reports documenting some side effects,there is a limited number of large-scale studies assessing these side *** this article,we comment on the case report by Park et al published recently,reporting a fatal intra-tumoral hemorrhage in a patient with HCC who received systemic therapy in the form of the combination of atezolizumab and bevacizumab.

关键词： Hepatocellular carcinoma Atezolizumab Bevacizumab Hemorrhage Side effects

Entropy Generation for Flow and Heat Transfer of Sisko-Fluid Over an Exponentially Stretching Surface

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Computers, Materials & Continua 2020年第1期62卷 37-59页

作者： mohamed abd el-Aziz A.M.Aly Department of Mathematics Faculty of ScienceKing Khalid UniversityAbha61411Saudi Arabia Department of Mathematics Faculty of ScienceHelwan UniversityHelwan-Cairo11795Egypt Department of Mathematics Faculty of ScienceSouth Valley UniversityQena83523Egypt

In the present study,the effects of the magnetic field on the entropy generation during fluid flow and heat transfer of a Sisko-fluid over an exponentially stretching surface are *** similarity transformations are used to transfer the governing partial differential equations into a set of nonlinear-coupled ordinary differential ***-Kutta-Fehlberg method is used to solve the governing *** effects of magnetic field parameter,local slip parameterλ,generalized Biot numberγ,Sisko fluid material parameter,Eckert number Ec,Prandtl number Pr and Brinkman number Br at two values of power law index on the velocity,temperature,local entropy generation number N_(G) and Bejan number Be are ***,the tabular forms for local skin friction coefficient and local Nusselt number under the effects of the physical parameters are *** current results are helpful in checking the entropy generation for *** is found that,an extra magnetic field parameter makes higher Lorentz force that suppresses the *** shear thinning fluids(nelocity *** entropy generation number is more for larger generalized Biot number,magnetic field parameter and Brinkman *** local skin friction coefficient increases as magnetic field parameter and material parameter are increase and it decreases as local slip parameter *** local Nusselt number decreases as magnetic field parameter,local slip parameter and Eckert number are increase,while it increases as material parameter,generalized Biot number and Prandtl number are increase.

关键词： Boundary layer entropy generation exponentially stretching surface magnetic field sisko-fluid

MHD Boundary Layer Flow of a Power-Law Nanofluid Containing Gyrotactic Microorganisms Over an Exponentially Stretching Surface

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Computers, Materials & Continua 2020年第2期62卷 525-549页

This study focusses on the numerical investigations of boundary layer flow for magnetohydrodynamic(MHD)and a power-law nanofluid containing gyrotactic microorganisms on an exponentially stretching surface with zero nanoparticle mass flux and convective *** nonlinear system of the governing equations is transformed and solved by Runge-Kutta-Fehlberg *** impacts of the transverse magnetic field,bioconvection parameters,Lewis number,nanofluid parameters,Prandtl number and power-law index on the velocity,temperature,nanoparticle volume fraction,density of motile microorganism profiles is *** addition,the impacts of these parameters on local skin-friction coefficient,local Nusselt,local Sherwood numbers and local density number of the motile microorganisms are *** results reveal that the power law index is considered an important factor in this *** to neglecting the buoyancy force term,the bioconvection and nanofluid parameters have slight effects on the velocity *** resultant Lorentz force,from increasing the magnetic field parameter,try to decrease the velocity profiles and increase the rescaled density of motile microorganisms,temperature and nanoparticle volume fraction ***,an augmentation of power-law index drops the reduced local skin-friction and reduced Sherwood number,while it increases reduced Nusselt number and reduced local density number of motile microorganisms.

关键词： Bioconvection gyrotactic microorganisms magnetohydrodynamic nanofluid boundary layer power-law

Serum ferritin in neonatal cholestasis: A specific and active molecule or a non-specific bystander marker?

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Hepatobiliary & Pancreatic Diseases International 2019年第2期18卷 173-180页

作者： Behairy el-Sayed Behairy Hatem abd-Alsattar Konswa Hanaa Talaat ahmed Dina Shehata el-Azab Nermin mohamed Adawy Ahmad mohamed Sira Department of Pediatric Hepatology Gastroenterology and Nutrition National Liver Institute Menofiya University Department of Pathology National Liver Institute Menofiya University

Background: Serum ferritin(SF) and consequently hepatic iron have long been considered important in liver fibrosis progression. They have been studied in different liver diseases with no previous reports in neonatal cholestasis(NC). This study aimed to measure SF in different etiologies of NC and investigate its relation to hepatic iron and fibrosis. Methods: SF was measured in 75 infants, including 50 with NC and 25 with sepsis. SF was compared between these two groups. Biochemical parameters, hepatic iron grades, and liver fibrosis and other histopathological characteristics and correlated with SF were assessed in NC group. Finally, a comparison between intrahepatic cholestasis and obstructive etiology was performed. Results: SF was elevated in NC(1598 ± 2405 ng/mL) with no significant difference from those with sepsis( P = 0.445). NC and sepsis constituted augmenting factors leading to more elevation of SF(2589 ± 3511 ng/mL). SF was significantly correlated with hepatic iron grades( r = 0.536, P ell transformation( P = 0.009) and hepatocyte swelling( P = 0.023) than those with obstructive etiology(672 ± 566 ng/mL) and their prevalent pathological findings of ductular proliferation( P = 0.003) and bile plugs( P = 0.002). SF was unrelated to the grade of liver fibrosis( P = 0.058). Conclusions: SF is non-specifically elevated in NC, with positive correlation to hepatic iron grades. SF ≥ 803.5 ng/mL can predict higher grades( ≥ grade 3) of hepatic iron. However, an active role of increased SF and hepatic iron in disease progression remains questionable.

关键词： Biliary atresia Liver fibrosis Hepatic iron grade Intrahepatic cholestasis Iron

Transient elastography compared to liver biopsy and morphometry for predicting fibrosis in pediatric chronic liver disease: Does etiology matter?

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World Journal of Gastroenterology 2016年第16期22卷 4238-4249页

作者： Behairy el-Sayed Behairy Mostafa mohamed Sira Khaled Refat Zalata el-Sayed Ebrahem Salama mohamed ahmed abd-Allah Department of Pediatric Hepatology National Liver Institute Menofiya University Department of Pathology Faculty of Medicine Mansura University

AIM: To evaluate transient elastography (TE) as a noninvasive tool in staging liver fibrosis compared with liver biopsy and morphometry in children with different chronic liver ***: A total of 90 children [50 with chronic hepatitis C virus (HCV), 20 with autoimmune hepatitis (AIH) and 20 with Wilson disease] were included in the study and underwent liver stiffness measurement (LSM) using TE. Liver biopsies were evaluated for fibrosis, qualitatively, by Ishak score and quantitatively by fibrosis area fraction (FAF) using digital image analysis (morphometry). LSM was correlated with fibrosis and other studied variables using spearman correlation. A stepwise multiple regression analysis was also performed to examine independent factors associated with LSM. Different cut-off values of LSM were calculated for predicting individual fibrosis stages using receiver-operating characteristic curve. Cut-off values with optimal clinical performance (optimal sensitivity and specificity simultaneously) were ***: The majority of HCV group had minimal activity (80%) and no/mild fibrosis (72%). On the other hand, the majority of AIH group had mild to moderate activity (70%) and moderate to severe fibrosis (95%) and all Wilson disease group had mild to moderate activity (100%) and moderate to severe fibrosis (100%). LSM correlated significantly with both FAF and Ishak scores and the correlation appeared better with the latter (r = 0.839 vs 0.879, P < 0.0001 for both). LSM discriminated individual stages of fibrosis with high performance. Sensitivity ranged from 81.4% to 100% and specificity ranged from 75.0% to 97.2%. When we compared LSM values for the same stage of fibrosis, they varied according to the different etiologies. Higher values were in AIH (16.15 ± 7.23 kPa) compared to Wilson disease (8.30 ± 0.84 kPa) and HCV groups (7.43 ± 1.73 kPa). Multiple regression analysis revealed that Ishak fibrosis stage was the only ind

关键词： Autoimmune hepatitis Chronic hepatitis C Liver fibrosis Liver stiffness Morphometry Pediatrics Transient elastography Wilson disease