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Pterostilbene induces cell apoptosis and inhibits lipogenesis in SKOV3 ovarian cancer cells by activation of AMPK-induced inhibition of Akt/mTOR signaling cascade

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BIOCelL 2021年第1期45卷 89-101页

作者： ATTALLA el-KOTT EMAN elBEALY FAHMY elSAID HAITHAM el-MEKKAWY abd-el-KARIM abd-LATEIF abdULALI TAWEel HEBA KHALIFA AHMAD KANDEel KAREEM MORSY ESSAM IBRAHIM MASHAel mohammed BIN-MEFERIJ Biology Department College of ScienceKing Khalid UniversityAbha61413Saudi Arabia Zoology Department College of ScienceDamanhour UniversityDamanhour22511Egypt Biology Department College of Science for GirlsKing Khalid UniversityAbha61413Saudi Arabia Zoology Department College of ScienceMansoura UniversityMansoura35511Egypt Zoology Department College of ScienceFayoum UniversityFayoum63511Egypt Zoology Department Faculty of ScienceAl-Zawia UniversityAl-ZawiaLibya Biology Department Faculty of ScienceCairo UniversityCairo12611Egypt Research Center for Advanced Materials Science(RCAMS) King Khalid UniversityAbha61413Saudi Arabia Blood Products Quality Control and Research Department National Organization for Research and Control of BiologicalsCairo12611Egypt Biology Department College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadhSaudi Arabia

This study investigates if the anti-tumor effect of Pterostilbene in the SKOV3 ovarian cancer(OC)cell line involves inhibition of cell metabolism and tested in this effect involves modulating AMPK and Akt-induced regulation of ***,SKOV3 cells were cultured in the humidified conditions in DMEM media for 24 h with or without increasing concentration of ***,the cells were incubated with Pterostilbene(IC_(50)=50μM)under similar conditions with or without pre-incubation with Dorsomorphin,an AMPK *** a dose-dependent manner,Pterostilbene inhibited SKOV3 cell survival and increased their lysate levels of lactate dehydrogenase(LDH)and single-stranded DNA(ssDNA).When SKOV3 cells were treated with 50μM Pterostilbene,Pterostilbene significantly suppressed cell migration and invasion,reduced lysate levels of lactic acid and the optical density of Oil Red O staining,and increased lysate glucose *** also increased levels of malondialdehyde(MDA),reactive oxygen species(ROS),and induced intrinsic cell apoptosis by upregulating protein levels of Bax and cleaved caspase-3 and reducing protein levels of ***,Pterostilbene reduced mRNA levels of sterol regulatory element-binding protein 1(SREBP-1),fatty acid synthase(FAS),acetyl CoA carboxylase-1(ACC-1),and AMP-activated protein kinase(AMPK).Furthermore,Pterostilbene increased the protein levels of p-AMPK,p-p53,p-raptor,p-TSC-2,but significantly decreased protein levels of p-Akt,p-TSC-2,p-mTOR,p-S6K1,and *** with Dorsomorphin(CC)abolished all the anti-tumorigenesis effects afforded by Pterostilbene and prevented Pterostilbene-induced phosphorylation of Akt,p53,and *** conclusion,the tumorsuppressive effect of Pterostilbene in SKOV3 cells involves the induction of ROS and inhibition of dysregulation cell metabolism mainly due to AMPK-induced Akt-dependent or independent suppression of mTOR.

关键词： Pterostilbene Ovarian cancer Lipogenesis Apoptosis AMPK

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Agrobacterium-Mediated Transformation of Rice: Constraints and Possible Solutions

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Rice science 2019年第3期26卷 133-146页

作者： Sulaiman mohammed Azman abd SAMAD Zaidah RAHMAT Department of Biotechnology and Medical Engineering Faculty of Biosciences and Medical Engineering Universiti Teknologi Malaysia Department of Biological Sciences Faculty of Science Gombe State University

Genetic transformation of rice(Oryza sativa L.) by introducing beneficial traits is now a central research instrument in plant physiology and a practical tool for plant improvement. Many approaches are verified for stable introduction of foreign genes into the plant genome. The review examined the different constraints that limit the success of rice genetic transformation via Agrobacterium-mediated approach and suggested possible solutions. Explant identification, gene transfer technique and construct to tailor the integration, transgene expression without collateral to genetic damage and transformant selection are among the technical challenges affecting the rice transformation. Despite the contests, Agrobacteriummediated transformation system has been a better option for producing transgenic rice varieties because of its exact T-DNA processing and simple integration of low copy-number transgene. This information is necessary for improving the transformation system for recalcitrant rice varieties.

关键词： rice Agrobacterium-mediated transformation tissue culture gene transfer T-DNA integration

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Impact of referral pattern and timing of repair on surgical outcome after reconstruction of post-cholecystectomy bile duct injury:A multicenter study

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Hepatobiliary & Pancreatic Diseases International 2021年第1期20卷 53-60页

作者： Ayman el Nakeeb Ahmad Sultan Helmy Ezzat Mohamed Attia Mohamed abd elWahab Taha Kayed Ayman Hassanen Ahmad AlMalki Ahmed Alqarni mohammed M mohammed Gastrointestinal Surgical Center Mansoura UniversityMansouraEgypt Minia University Hospital MiniaEgypt Aseer Central Hospital Aseer regionSaudi Arabia

Background:Bile duct injury(BDI)after cholecystectomy remains a significant surgical *** guideline exists to guide the timing of repair,while few studies compare early versus late repair *** study aimed to analyze the outcomes in patients undergoing immediate,intermediate,and delayed repair of ***:We retrospectively analyzed 412 patients with BDI from March 2015 to January *** patients were divided into three groups based on the time of BDI *** 1 underwent an immediate reconstruction(within the first 72 hours post-cholecystectomy,n=156);group 2 underwent an intermediate reconstruction(from 4 days to 6 weeks post-cholecystectomy,n=75),and group 3 underwent delayed reconstruction(after 6 weeks post-cholecystectomy,n=181).Results:Patients in group 2 had significantly more early complications including anastomotic leakage and intra-abdominal collection and late complications including anastomotic stricture and secondary liver cirrhosis compared with groups 1 and *** outcome was observed in 111(71.2%)patients in group 1,31(41.3%)patients in group 2,and 157(86.7%)patients in group 3(P=0.0001).Multivariate analysis identified that complete ligation of the bile duct,level E1 BDI and the use of external stent were independent factors of favorable outcome in group 1,the use of external stent was an independent factor of favorable outcome in group 2,and level E4 BDI was an independent factor of unfavorable outcome in group *** BDI and level E4 BDI were independent factors of unfavorable ***:Favorable outcomes were more frequently observed in the immediate and delayed reconstruction of post-cholecystectomy *** ligation of the bile duct,level E1 BDI and the use of external stent were independent factors of a favorable outcome.

关键词： Bile duct injury Hepaticojejunostomy Anastomotic stricture Biloma Biliary peritonitis

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A Lightweight Approach for Skin Lesion Detection Through Optimal Features Fusion

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Computers, Materials & Continua 2022年第1期70卷 1617-1630页

作者： Khadija Manzoor Fiaz Majeed Ansar Siddique Talha Meraj Hafiz Tayyab Rauf mohammed A.el-Meligy Mohamed Sharaf abd elatty E.abd elgawad Department of Information Technology University of GujratGujrat50700Pakistan Department of Software Engineering University of GujratGujrat50700Pakistan Department of Computer Science COMSATS University Islamabad-Wah CampusWah Cantt47040Pakistan Centre for Smart Systems AI and CybersecurityStaffordshire UniversityStoke-on-TrentUK Advanced Manufacturing Institute King Saud UniversityRiyadh11421Saudi Arabia Department of Industrial Engineering College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia

Skin diseases effectively influence all parts of *** and accurate detection of skin cancer is necessary to avoid significant *** manual detection of skin diseases by dermatologists leads to misclassification due to the same intensity and color ***,an automated system to identify these skin diseases is *** studies on skin disease classification using different techniques have been ***,previous techniques failed to identify multi-class skin disease images due to their similar *** the proposed study,a computer-aided framework for automatic skin disease detection is *** the proposed research,we collected and normalized the datasets from two databases(ISIC archive,Mendeley)based on six Basal Cell Carcinoma(BCC),Actinic Keratosis(AK),Seborrheic Keratosis(SK),Nevus(N),Squamous Cell Carcinoma(SCC),and Melanoma(M)common skin ***,segmentation is performed using deep Convolutional Neural Networks(CNN).Furthermore,three types of features are extracted from segmented skin lesions:ABCD rule,GLCM,and in-depth *** transfer learning is used for deep feature extraction,while a support vector machine(SVM)is used for *** results show that SVM outperformed other studies in terms of accuracy,as AK disease achieved 100%accuracy,BCC 92.7%,M 95.1%,N 97.8%,SK 93.1%,SCC 91.4%with a global accuracy of 95.4%.

关键词： AlexNet CNN GLCM SVMs skin disease

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Radionuclides measurements and mineralogical studies on beach sands, East Rosetta Estuary, Egypt

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Chinese Journal Of Geochemistry 2013年第2期32卷 146-156页

作者： abd el Wahab M. el Nahas H.A. Physics Department Faculty of Women for Arts Science and Education Ain Shams University Cairo P.O 11757 Egypt Nuclear Materials Authority Cairo P.O. Box 530 Egypt

Radiometric measurements were carried out for the beach sands from East Rosetta estuary to determine the activity concentrations of 238 U, 226 Ra, 232 Th, and 40 K, using a Hyper Pure Germanium spectrometer, to estimate the dose rates and radiation hazard indices. The average specific activities are 778.20 Bq/kg for 238 U; 646.89 Bq/kg for 226 Ra; 621.92 and 627.85 Bq/kg for the 222 Rn daughters 214 Pb and 214 Bi respectively. The average specific activity of 232 Th is 1510.25 Bq/kg, while the calculated specific activity for 40 K has an average of 8.41 Bq/kg. The average specific activity of 235 U is 38.61 Bq/kg. The average absorbed dose rate is 1211.36 nGy/h, 20 times higher than the estimated average global primordial radiation of 60 nGy/h and 6 times higher than that of the world range (10-200 nGy/h). The radium equivalent (Ra eq ) values are from 6 to 9 times the recommended value. The internal and external hazard indices (H int , H ex ) indicate that their values are from 6 to 11 times the permissible values of these indices. These higher values may be due to the presence of economic heavy minerals containing radionuclides as zircon and monazite as well as some trace minerals, thorite and uranothorite. The mineralogical study indicates the beach sands contain heavy minerals, zircon, monazite, rutile, ilmenite, leucoxene, magnetite and garnet. The average abundance of zircon is 0.175 wt% ranging from 0.125 wt% to 0.239 wt%, while it is 0.004wt% ranging from 0.001 wt% to 0.007 wt% for monazite. The average abundance is 0.087 wt% for rutile; 2.029 wt% for ilmenite; 1.084 wt% for magnetite; 0.384 wt% for leucoxene and 0.295 wt% for garnet.

关键词：放射性核素海滩砂矿物学核素测量河口平均丰度埃及辐射测量

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A Pilot Study of Gemcitabine and Epirubicin Combination Chemotherapy as a Salvage Regimen for Recurrent Platinum Resistant and/or Refractory Epithelial Ovarian Cancer

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Journal of Cancer Therapy 2011年第4期2卷 490-496页

作者： abd el halim Abu-Hamar 不详

BACKGROUND AND OBJECTIVES: The objective of this study was to assess the antitumor activity and toxicity profile of gemcitabine combined with epirubicin in patients with recurrent platinum refractory ovarian epithelial cancer. PATIENTS AND METHODS: Patients with recurrent platinum refractory ovarian cancer and with adequate hematologic, renal and hepatic function and an Eastern Cooperative Oncology Group (ECOG) performance status of 0 - 2 were enrolled. The regimen was Gemcitabine 1000 mg/m2 (day 1, 8) and Epirubicin 60 mg/m2 (day 1), the cycle was repeated at interval of 21 days. RESULTS: Twenty eight patients were recruited and received 156 cycles of gemcitabine-epirubicin combination chemotherapy (median 6 cycles). Overall response rate was 42.9% (95% CI equal 24.5 to 62.7) and tumor control rate was 75% (95% CI equal 55.1 to 89.3). No complete responses were observed. Median progression-free and median overall survival times were 7 and 15 months, respectively. The most common grade 3/4 hematological toxicities were neutropenia (57.1%), anemia (10.7%), and thrombocytopenia (7.1%), while the most common grade 3/4 non-hematological toxicities were mucositis (14.3%) and vomiting (3.6%). No treatment related deaths were observed. CONCLUSION: Gemcitabine combined with epirubicin regimen appeared to offer an acceptable clinical profile in patients with recurrent platinum-refractory epithelial ovarian cancer.

关键词： Platinum-Refractory/Resistant Ovarian Cancer Gemcitabine Anthracyclines

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Comparison of bacterial community structures in two systems of a sewage treatment plant using PCR-DGGE analysis

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Journal of Environmental Sciences 2011年第12期23卷 2049-2054页

作者： abd el-Latif Hesham Rong Qi Min Yang State Key Laboratory of Environmental Aquatic Chemistry Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China Genetics Department Faculty of Agriculture Assiut University Assiut Egypt

The combination of PCR amplification of 16S rRNA genes with denaturing gradient gel electrophoresis （DGGE） analysis was used to reveal the compositions and dynamics of bacterial communities in a sewage treatment plant with two systems, i.e., an anoxic- anaerobic-aerobic system （inverted A2O） and an anaerobic-anoxic-aerobic one （conventional A2O） over a period from February to July 2009, during which both systems experienced serious sludge bulking problems. The DGGE patterns showed that there were many common bands in both systems, suggesting the high similarity of bacterial communities of the two systems. Meanwhile, the moving window correlation analysis showed that the two systems experienced different microbial community structure changes during the period, which might be related with the different situations of the occurrence and disappearance of sludge bulking, as being reflected by sludge volume index （SVI） values. Major bands of DGGE patterns of sludge samples were further sequenced. Phylogenetic affiliation indicated that the majority of the sequences obtained were affiliated with Actinobacteria, Firmicutes, Bacteroidetes/Chlorobi group and α- and β-Proteobacteria. Two sequences showed high similarities to typical filamentous bacteria Microthrix parvicella and Nostocoida limicola I, indicating that these bacterial species have been involved in the sludge bulking problems.

关键词： PCR-DGGE bacterial community activated sludge sludge bulking sewage treatment plant

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Automatic PV Grid Fault Detection System with IoT and LabVIEW as Data Logger

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Computers, Materials & Continua 2021年第11期69卷 1709-1723页

作者： Rohit Samkria mohammed abd-elnaby Rajesh Singh Anita Gehlot Mamoon Rashid Moustafa H.Aly Walid el-Shafai Project Engineer NWTFIndian Institute of TechnologyKanpurIndia Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia School of electronics and electrical Engineering Lovely Professional UniversityJalandharIndia School of Computer Science and Engineering Lovely Professional UniversityJalandharIndia Department of electronics and Communications Engineering College of Engineering and TechnologyArab Academy for ScienceTechnology and Maritime TransportAlexandria 1029Egypt Department electronics and electrical Communications Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt

Fault detection of the photovoltaic(PV)grid is necessary to detect serious output power reduction to avoid PV modules’*** identify the fault of the PV arrays,there is a necessity to implement an automatic *** this IoT and LabVIEW-based automatic fault detection of 3×3 solar array,a PV system is proposed to control and monitor Internet connectivity *** component to automatically reconfigure the solar PV array from the series-parallel(SP)to the complete cross-linked array underneath partial shading conditions(PSC)is centered on the Atmega328 system to achieve maximum *** the LabVIEW environment,an automated monitoring system is *** automatic monitoring system assesses the voltage drop losses present in the DC side of the PV generator and generates a decimal weighted value depending on the defective solar panels and transmits this value to the remote station through an RF modem,and provides an indicator of the faulty solar panel over the built-in Interface *** managing of this GUI indicator helps the monitoring system to generate a panel alert for damaged panels in the PV *** MCU in the receiver section enables transmission of the fault status of PV arrays via Internet *** IoT-based Blynk app is employed for visualizing the fault status of the 3×3 PV *** dashboard of Blynk visualizes every array with the status.

关键词： Blynk app IoT LabVIEW node MCU PV array RF modem WSN

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Effect of Doum Fruit (Hyphaene Thebaica) Extract on Some Biochemical Parameters, Enzyme Activities and Histopathological Changes of Pancreas in Alloxan Induced Diabetic Rats

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Food and Nutrition Sciences 2020年第3期11卷 207-219页

作者： Naglaa abd Fattah abd el halim Hassan Department of Home Economics Faculty of Agriculture Alexandria University Alexandria Egypt

Medicinal plants have been used in the treatment of some diseases like diabetes. One of them is doum fruit extract. The study was conducted to evaluate effect of doum fruit extract on some biochemical parameters, including enzyme activities and histopathological changes of pancreas in alloxan induced diabetic rats. Animals were allocated into five groups of rats, two groups, several as control (one normal and one diabetic rats) and the other three groups were induced diabetic with doum extract (0.5, 1 and 2 g/kg b·wt) which were given every other day by stomach tube for 6 weeks. Evaluation was made for glucose, insulin, lipid profile, enzyme activities, antioxidant activity and histopathological changes of pancreas. The results showed that doum fruit extract decreased blood glucose, insulin, total cholesterol (TC), triglyceride (TG), total lipid (TL), low-density lipoprotein cholesterol (LDL-C), lactate dyhadreygenase (LDH), alanine and aspartate amino transferase (ALT, AST), alkaline phosphatase (ALP) and Malondialdehyde (MDA) while plasma catalase activity and high density lipoprotein cholesterol (HDL-C) were significantly (p 0.05) increased. Therefore, the results of this study demonstrated that the active compounds present in the doum extract have a positive effect on the biochemical parameters of diabetic rats.

关键词： Doum Fruit Extract Alloxan Histopathological MDA Biochemical Parameters

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Entropy Generation for Flow and Heat Transfer of Sisko-Fluid Over an Exponentially Stretching Surface

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Computers, Materials & Continua 2020年第1期62卷 37-59页

作者： Mohamed abd el-Aziz A.M.Aly Department of Mathematics Faculty of ScienceKing Khalid UniversityAbha61411Saudi Arabia Department of Mathematics Faculty of ScienceHelwan UniversityHelwan-Cairo11795Egypt Department of Mathematics Faculty of ScienceSouth Valley UniversityQena83523Egypt

In the present study,the effects of the magnetic field on the entropy generation during fluid flow and heat transfer of a Sisko-fluid over an exponentially stretching surface are *** similarity transformations are used to transfer the governing partial differential equations into a set of nonlinear-coupled ordinary differential ***-Kutta-Fehlberg method is used to solve the governing *** effects of magnetic field parameter,local slip parameterλ,generalized Biot numberγ,Sisko fluid material parameter,Eckert number Ec,Prandtl number Pr and Brinkman number Br at two values of power law index on the velocity,temperature,local entropy generation number N_(G) and Bejan number Be are ***,the tabular forms for local skin friction coefficient and local Nusselt number under the effects of the physical parameters are *** current results are helpful in checking the entropy generation for *** is found that,an extra magnetic field parameter makes higher Lorentz force that suppresses the *** shear thinning fluids(nelocity *** entropy generation number is more for larger generalized Biot number,magnetic field parameter and Brinkman *** local skin friction coefficient increases as magnetic field parameter and material parameter are increase and it decreases as local slip parameter *** local Nusselt number decreases as magnetic field parameter,local slip parameter and Eckert number are increase,while it increases as material parameter,generalized Biot number and Prandtl number are increase.

关键词： Boundary layer entropy generation exponentially stretching surface magnetic field sisko-fluid

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