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Open journal of Molecular and Integrative Physiology 2015年第3期5卷 37-48页

作者： aaron j. Smith john Oertle Dan Warren Dino Prato Envita Medical Center Scottsdale USA

Ozone therapy has been marred by conventional science for years due to many flawed experimental designs or small sample sizes of the population in which it intends to study. For this reason, many physicians have dismissed ozone therapy and limited funds have been delegated to furthering the knowledge of its therapeutic effects. However, there is evidence that suggests that ozone does have various therapeutic effects that range from disinfection of pathogens, anticancer properties, and treatment of back ailments. In this paper, we have collected the more promising studies that suggest the efficacy and safety of ozone therapy primarily focusing on autohemotherapy. This paper is designed to promote awareness of ozone therapy and to show some supporting evidence of its efficacy. Clinically, ozone therapy is often used adjunctively and combined with other treatment modalities to enhance or encourage a desired mechanism of action. Since the efficacy of ozone alone is still contentious, it is important to note that ozone therapy should be used in conjunction with other various treatments with very few exceptions.

关键词： Ozone Autohemotherapy Cancer Oxidant Lumbar Diabetes Mellitus Lung Disease Metabolome Dentistry Bacterial Infection Viral Infection

Gene variants of the phosphatidylcholine synthesis pathway do not contribute to RDS in the Chinese population

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World journal of Pediatrics 2018年第1期14卷 52-56页

作者： Yu-jun Chen julia Meyer jennifer A.Wambach Kelcey DePass Daniel j.Wegner Xin Fan Qun-Yuan Zhang Heins Hillary F.Sessions Cole aaron Hamvas Neonatology the First Affliated Hospital of GuangxiMedical UniversityNanningChina Division of Newborn Medicine Edward MallinckrodtDepartment of PediatricsWashington University Schoolof MedicineSt.LouisUSA

Background To determine population-based prevalence and disease contribution of phosphatidylcholine synthetic pathway-associated gene variants in a native southern Chinese cohort. Methods We used bloodspots from 2010 that were obtained from the Guangxi Neonatal Screening Center in Nannning China and included the Han (n = 443) and Zhuang (n = 313) ethnic groups. We sequenced the exons of cholinephosphate cytidylyltransferase (PCYT1B) lysophospholipid acyltransferase 1 (LPCAT1), and cholinephosphotransferase (CHPT1) genes, and analyzed both rare and common exonic variants. Results We obtained five mutations (G199D, A299V, G434C, Y490C, L312S) with eight alleles in the three candidate genes. The collapsed minor allele frequency for candidate genes was not significantly different between the Han and Zhuang popula-tions (0.0045 vs. 0.0064, respectively,P = 0.725). The combined Han and Zhuang pool collapsed carrier frequency of rare mutation allele was found to be 1.06%, which is much higher than previously reported for the Missouri population (0.1%). Further, we detected six exonic common variants (three in LPCAT1 and three in CHPT1), with three non-synonymous vari-ants (F162S, F341L, M427K) among them. Two of the non-synonymous exonic variants (F341L, M427K) were not found in CHB;F341L was also not previously reported in exome sequencing project. Conclusions The population-based frequency of mutations in the phosphatidylcholine synthesis pathway-associated genes PCYT1B LPCAT1,CHPT1 is low in southern Chinese newborns and there is no evidence of contribution to population-based disease burden of respiratory distress syndrome. As a population-based study of rare mutations and common variants, this work is valuable in directing future research.

关键词： Genetic epidemiology Human population genetics Neonatal respiratory distress syndrome Pulmonary surfactant

Engineering Microneedle Patches for Improved Penetration:Analysis,Skin Models and Factors Affecting Needle Insertion

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Nano-Micro Letters 2021年第6期13卷 190-230页

作者： Pooyan Makvandi Melissa Kirkby aaron RjHutton Majid Shabani Cynthia K.Y.Yiu Zahra Baghbantaraghdari Rezvan jamaledin Marco Carlotti Barbara Mazzolai Virgilio Mattoli Ryan F.Donnelly Istituto Italiano Di Tecnologia Centre for Materials InterfaceViale Rinaldo Piaggio 3456025 PontederaPisaItaly School of Pharmacy Queen’s University Belfast97 Lisburn RoadBelfast BT97BLUK The BioRobotics Institute Scuola Superiore Sant’AnnaViale Rinaldo Piaggio 3456025 PontederaPisaItaly Paediatric Dentistry and Orthodontics Faculty of DentistryThe University of Hong KongPrince Philip Dental HospitalHong Kong SARChina Department of Chemical Materials and Industrial Production EngineeringUniversity of Naples FedericoⅡ80125 NaplesItaly Center for Advanced Biomaterials for Health Care(iit@CRIB) Italian Institute of Technology80125 NaplesItaly

Transdermal microneedle(MN)patches are a promising tool used to transport a wide variety of active compounds into the *** serve as a substitute for common hypodermic needles,MNs must pierce the human stratum corneum(~10 to 20μm),without rupturing or bending during *** ensures that the cargo is released at the predetermined place and ***,the ability of MN patches to sufficiently pierce the skin is a crucial *** the current review,the pain signal and its management during application of MNs and typical hypodermic needles are presented and *** is followed by a discussion on mechanical analysis and skin models used for insertion tests before application to clinical *** that affect insertion(e.g.,geometry,material composition and cross-linking of MNs),along with recent advancements in developed strategies(e.g.,insertion responsive patches and 3D printed biomimetic MNs using two-photon lithography)to improve the skin penetration are highlighted to provide a backdrop for future research.

关键词： Insertion responsive Implantable microneedles Skin indentation Transdermal microneedles Pain management

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千赫重复率闪灯泵浦Nd:YAG激光器

激光与红外 1975年第4期 229-229,228页

作者： V.j.corcoran 戎瑞

固体脉冲激光器通常有两种工作方式:脉冲闪灯泵浦,振荡重复频率很低（<100赫）,但峰值功率高;连续泵浦脉冲激光器,振荡重复率很高（几千或几兆赫）,但峰值功率低。中等重复率脉冲激光器可用脉冲反射方式或脉冲透射方式Q开关,而高重复率... 详细信息

固体脉冲激光器通常有两种工作方式:脉冲闪灯泵浦,振荡重复频率很低（<100赫）,但峰值功率高;连续泵浦脉冲激光器,振荡重复率很高（几千或几兆赫）,但峰值功率低。中等重复率脉冲激光器可用脉冲反射方式或脉冲透射方式Q开关,而高重复率激光器可以是腔倒空方式或锁模方式工作。许多应用包括搜索雷达在内要求激光器具有高的峰值功率和几千赫的重复频率。本文介绍一种闪灯泵浦Q开关Nd:YAG3+激光器其重复频率几千赫,峰值功率超过500千瓦。

关键词：激光器重复频率 Nd 峰值功率光激射器电子器件泵浦抽运 YAG 重复率重复力

Influence of Amino Acid Supplementations in juvenile Yellow Perch Fed Plant Protein Combinations

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Open journal of Animal Sciences 2019年第2期9卷 183-195页

作者： aaron j. Von Eschen Michael L. Brown Kurt Rosentrater Department of Natural Resource Management South Dakota State University Brookings SD USA U.S. Fish and Wildlife Service Valley City National Fish Hatchery Valley City ND USA Department of Agricultural and Biosystems Engineering Iowa State University Ames IA USA

Distillers dried grains with solubles (DDGS) in combination with soy protein concentrate (SPC) with and without an essential amino acid (EAA) complex were assessed as protein alternatives in juvenile Yellow Perch Perca flavescens diets. Diets contained 5% FM, 40% SPC, and 20% or 40% DDGS each with or without EAA. No mortalities or health assessment differences were observed during the trial and all fish readily accepted the experimental diets. Diets supplemented with EAA produced greater weight gain, improved feed conversion, and apparent protein digestibility. Performance was consistently improved for fish fed diets containing amino acid supplements. Based on these results, Yellow Perch are able to utilize high levels of the plant proteins, accompanied with EAAs, as a FM replacer.

关键词： Yellow Perch Fish Nutrition Distillers Dried Grains with Solubles Soy Protein Concentrate Amino Acids

Mucosal-associated invariant T cells and oral microbiome in persistent apical periodontitis

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International journal of Oral Science 2019年第2期11卷 131-142页

作者： Haleh Davanian Rogier aaron Gaiser Mikael Silfverberg Luisa W. Hugerth Michal j. Sobkowiak Liyan Lu Katie Healy johan K. Sandberg Peggy Nasman jorgen Karlsson Leif jansson Lars Engstrand Margaret Sallberg Chen Department of Dental Medicine Karolinska InstitutetHuddingeSweden Department of Microbiology Tumor and Cell Biology and Science for Life LaboratoryKarolinska InstitutetStockholmSweden Clinical Genomics Facility Science for Life LaboratorySolnaSweden Department of Medicine Karolinska InstitutetHuddingeSweden Clinic of Endodontics and Periodontology Eastman Institute StockholmStockholmSweden

Opportunistic bacteria in apical periodontitis (AP) may pose a risk for systemic ***-associated invariant T (MAIT) cells are innate-like T cells with a broad and potent antimicrobial activity important for gut mucosal *** was recently shown that MAIT cells are present in the oral mucosal tissue,but the involvement of MAIT cells in AP is ***,comparison of surgically resected AP and gingival tissues demonstrated that AP tissues express significantly higher levels of Vα7.2-jα33,Vα7.2- jα20,Vα7.2-jα12,Cα and tumour necrosis factor (TNF),interferon (IFN)-γ and interleukin (IL)-17A transcripts,resembling a MAIT cell ***,in AP tissues the MR1-restricted MAIT cells positive for MR1–5-OP-RU tetramer staining appeared to be of similar levels as in peripheral blood but consisted mainly of CD4^+ *** gingival tissues,the AP microbiome was quantitatively impacted by factors like fistula and high patient age and had a prominent riboflavin-expressing bacterial *** merged in an integrated view,the examined immune and microbiome data in the sparse partial least squares discriminant analysis could identify bacterial relative abundances that negatively correlated with Vα7.2-jα33,Cα,and IL-17A transcript expressions in AP,implying that MAIT cells could play a role in the local defence at the oral tissue *** conclusion,we describe the presence of MAIT cells at the oral site where translocation of oral microbiota could take *** findings have implications for understanding the immune sensing of polymicrobial-related oral diseases.

关键词： apical periodontitis(AP) Mucosal-associated invariant T(MAIT) AP

Strategies towards robust interpretations of in situ zircon oxygen isotopes

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Geoscience Frontiers 2023年第2期14卷 241-255页

作者： janne Liebmann Christopher L.Kirkland john B.Cliff Christopher j.Spencer aaron j.Cavosie Timescales of Mineral Systems Group The Institute for Geoscience Research(TIGeR)School of Earth and Planetary SciencesCurtin UniversityPerthAustralia Pacific Northwest National Laboratory RichlandWashington 99354United States Department of Geological Sciences and Geological Engineering Queen’s UniversityKingstonONCanada Space Science and Technology Centre The Institute for Geoscience Research(TIGeR)School of Earth and Planetary ScienceCurtin UniversityPerthAustralia

Oxygen isotopes are a versatile tool to address a wide range of questions in the Earth *** include geothermometry,paleoclimatology,tracing of geochemical reservoirs,fluid-rock interaction,magmatic petrogenesis,and identification of extra-terrestrial *** arguably provides one of the most robust records of primary magmatic O isotope ratio due to low diffusion rates in crystalline *** ability to correlate zircon O isotopes with temporal and petrogenetic information(e.g.U-Pb geochronology,Lu-Hf isotopes,and trace elements)makes this mineral a key archive for understanding Earth’s crustal ***,zircon O isotope geochemistry has found widespread usage to address fundamental questions across the earth and planetary *** general apparent ease of O isotopic acquisition through the advancement of rapid in situ techniques(*** ion mass spectrometry;SIMS)and associated dedicated national laboratories has led to the generation of large O isotopic data sets of variable quality,highlighting the importance of a coherent workflow for data collection,reduction,and *** paper presents a set of approaches for measurement,assessment,and reporting of zircon O isotope *** focus in this contribution is on in situ analysis via secondary ion mass spectrometry using large geometry instruments,but other commonly used techniques are briefly reviewed for *** work aims to provide an analytical framework necessary for geologically meaningful interpretation of O isotope *** addition,we describe inherent geological(***-induced disturbance of the zircon O isotopic system)and analytical(*** due to sample topography effects)challenges and outline means to identify and avoid such issues as a prerequisite to the generation of robust primary O isotopic signatures for geological interpretation.

关键词： In situ Oxygen isotopes Zircon SIMS Secondary ion mass spectrometry Off-mount standard

British journal of General Practice论文摘要汇编——精神疾病患者使用急诊服务和全科医生服务预测因素的公共卫生调查

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中国全科医学 2020年第9期23卷 1180-1180页

作者： SAINI P MCINTYRE j.corcoran R 本刊编辑部(整理) School of Psychology Faculty of Health Liverpool John Moores University Liverpool. Institute of Population Health Sciences University of Liverpool Liverpool. Institute of Population Health Sciences University of Liverpool NIHR ARC NWC Liverpool. NIHR ARC NWC Liverpool. Cheshire and Wirral NHS Foundation Trust Liverpool. Institute of Public Health Sciences University of Liverpool NIHR ARC NW Liverpool.

【摘要】背景在英国,当前一个重要的问题是人们对卫生服务呈现大量需求,部分体现在精神疾病患者对急诊服务和全科医疗服务的使用率快速增加,而且这些服务的费用不菲。目的探讨精神疾病患者使用卫生服务的社会决定因素。设计与场所本研... 详细信息

【摘要】背景在英国,当前一个重要的问题是人们对卫生服务呈现大量需求,部分体现在精神疾病患者对急诊服务和全科医疗服务的使用率快速增加,而且这些服务的费用不菲。目的探讨精神疾病患者使用卫生服务的社会决定因素。设计与场所本研究在位于英国西北海岸的28个社区开展。每个社区拥有5000~10000例不同贫困程度的人口。方法对研究人群进行全面的公共卫生调查,涉及住房、身体健康、心理健康、生活方式、社会问题、环境、工作和经济等问题。在调整相关社会经济和生活方式因素之后,采用泊松回归模型对精神疾病共病、身体和精神疾病共病和个体心理健康症状对急诊服务和全科医疗服务应用的影响进行分析。

关键词：精神疾病患者卫生服务全科医疗服务全科医生社会决定因素急诊服务公共卫生预测因素

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碳水化合物——蛋白质饮料对运动耐力的影响

食品工业科技 2007年第8期28卷 32-33页

作者： Antonia Rossiter Philip jakeman aaron j. O'Sullivan colum Dunne 爱尔兰利莫理克大学人体教育和运动科学部门人体科学调查组爱尔兰肯尼基尔哥兰比亚创新中心

人在长时间运动后的疲劳和体内存储的肌糖原的消耗密切相关,因此运动后糖原合成的速度是短时间内运动恢复的关键因素。接下来的实验有效地研究了运动后补充的营养成分对于再次运动时耐力表现的影响。

关键词：碳水化合物运动耐力蛋白质饮料恢复过程爱尔兰自行车数据表

Deterministic Dual Control of Phase Competition in Strained BiFeO_(3):A Multiparametric Structural Lithography Approach

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Nanomanufacturing and Metrology 2022年第1期5卷 60-66页

作者： Nathan Black David Edwards Niall Browne joseph G.M.Guy Niyorjyoti Sharma Kristina M・Holsgrove aaron B.Naden Raymond G.P.McQuaid Brian j.Rodriguez Amit Kumar School of Maths and Physics Queen's University BelfastBelfast BT7 INNUK School of Chemistry University of St.AndrewsSt Andrews KY169STUK School of Physics University College DublinBelfieldDublin 4Ireland

The realization of a mixed-phase microstructure in strained BiFeO_(3)(BFO)thin films has led to numerous novel effects derived from the coexistence of the tetragonal-like monoclinic phase(T phase)and rhombohedral-like monoclinic phase(R phase).Strong strain and polarization diiferences between the phases should result in a high level of transformation plasticity,which enables the continuous alteration of the relative proportion of R and T states in response to external *** the potential for utilizing such plasticity to control mixed-phase populations under external stimuli is evident,direct experi・mental evidence backed by equilibrium predictions has not yet been fully *** we demonstrate deterministic control of mixed-phase populations in an epitaxially strained BFO thin film through the application of localized stresses and electric fields in a reversible manne匚The results illustrate and rationalize deterministic control of mixed phases in strained BFO films,which could be crucial in tuning their functional *** findings also highlight a new multiparametric technique in the scanning probe lithography toolbox based on tip-assisted electric and strain field manipulation of functional properties that might find application beyond the ferroelectric domain and structural phase lithography.

关键词： Phase competition Ferroelectric Stress Lithography