检索结果-南通市图书馆

Aerosol jet printing of surface acoustic wave microfluidic devices

Microsystems & Nanoengineering 2024年第1期10卷 231-242页

作者： Joseph Rich Brian Cole Teng Li Brandon Lu Hanyu Fu Brittany N.Smith Jianping Xia Shujie Yang Ruoyu Zhong James L.doherty Kanji Kaneko Hiroaki Suzuki Zhenhua Tian aaron d.franklin Tony Jun Huang department of Biomedical Engineering Duke UniversityDurhamNC 27708USA department of Electrical and Computer Engineering Duke UniversityDurhamNC 27708USA department of Mechanical Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA 24061USA Thomas Lord department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC 27708USA deptartment of Precision Mechanics Faculty of Science and EngineeringChuo UniversityTokyo 112-8551Japan department of Chemistry Duke UniversityDurhamNC 27708USA

The addition of surface acoustic wave(SAW)technologies to microfluidics has greatly advanced lab-on-a-chip applications due to their unique and powerful attributes,including high-precision manipulation,versatility,integrability,biocompatibility,contactless nature,and rapid ***,the development of SAW microfluidic devices is limited by complex and time-consuming micro/nanofabrication techniques and access to cleanroom facilities for multistep photolithography and vacuum-based *** simplify the fabrication of SAW microfluidic devices with customizable dimensions and functions,we utilized the additive manufacturing technique of aerosol jet *** successfully fabricated customized SAW microfluidic devices of varying materials,including silver nanowires,graphene,and poly(3,4-ethylenedioxythiophene)polystyrene sulfonate(PEdOT:PSS).To characterize and compare the acoustic actuation performance of these aerosol jet printed SAW microfluidic devices with their cleanroom-fabricated counterparts,the wave displacements and resonant frequencies of the different fabricated devices were directly measured through scanning laser doppler ***,to exhibit the capability of the aerosol jet printed devices for lab-on-a-chip applications,we successfully conducted acoustic streaming and particle concentration ***,we demonstrated a novel solution-based,direct-write,single-step,cleanroom-free additive manufacturing technique to rapidly develop SAW microfluidic devices that shows viability for applications in the fields of biology,chemistry,engineering,and medicine.

关键词： printing wave fluid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

determining minimum sample size for the conditioned Latin hypercube sampling algorithm

引用

Pedosphere 2024年第3期34卷 530-539页

作者： daniel d.SAURETTE Asim BISWAS Richard J.HECK Adam W.GILLESPIE aaron A.BERG School of Environmental Sciences University of Guelph50 Stone Rd EastGuelph ON N1G 2W1(Canada) Ontario Ministry of Agriculture Food and Rural Affairs1 Stone Rd WestGuelph ON N1G 2Y4(Canada) Geography Environment&GeomaticsUniversity of Guelph50 Stone Rd EastGuelph ON N1G 2W1(Canada)

In digital soil mapping(dSM),a fundamental assumption is that the spatial variability of the target variable can be explained by the predictors or environmental *** to adequately sample the predictors have been well documented,with the conditioned Latin hypercube sampling(cLHS)algorithm receiving the most attention in the dSM *** advances in sampling design,a critical gap remains in determining the number of samples required for dSM *** propose a simple workflow and function coded in R language to determine the minimum sample size for the cLHS algorithm based on histograms of the predictor variables using the Freedman-diaconis rule for determining optimal bin *** preprocessing was included to correct for multimodal and non-normally distributed data,as these can affect sample size determination from the *** on a user-selected quantile range(QR)for the sample plan,the densities of the histogram bins at the upper and lower bounds of the QR were used as a scaling factor to determine minimum sample *** technique was applied to a field-scale set of environmental covariates for a well-sampled agricultural study site near Guelph,Ontario,Canada,and tested across a range of *** results showed increasing minimum sample size with an increase in the QR *** sample size increased from 44 to 83 when the QR increased from 50% to 95% and then increased exponentially to 194 for the 99%*** technique provides an estimate of minimum sample size that can be used as an input to the cLHS algorithm.

关键词： bin width digital soil mapping normal distribution quantile range sampling design

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

PETG:Applications in Modern Medicine

引用

Engineered Regeneration 2024年第1期5卷 45-55页

作者： Catherine Yan Corinne Kleiner aaron Tabigue Veer Shah Gregory Sacks darshi Shah Vincent deStefano Renaissance School of Medicine at Stony Brook University Stony BrookNYUSA department of Biology Niagara UniversityLewistonNYUSA Stony Brook University Stony BrookNYUSA department of Mechanical and Industrial Engineering Northeastern UniversityBostonMAUSA

Polyethylene terephthalate glycol,PETG,is a miscible,transparent thermoplastic known to have strong tensile properties,high ductility,as well as resistance to heat and chemical *** may be manufactured in several ways,most notably 3d printing *** such,PETG has emerged as a viable biomaterial for a variety of medical applications such as tissue engineering,dentistry,optometry,vascular health,cardiology,orthopedics,neurology,gynecology,and *** also serves a valuable role in biomedical research and engineering by offering improvements in cell studies,drug carriers,and anti-bacterial *** medical research and innovation utilizing PETG will better characterize its value as an inexpensive and versatile biomaterial.

关键词： Polyethylene terephthalate glycol Tissue Engineering 3d Printing Clinical Applications Biomedical Research

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Integrated proteomic profiling identifies amino acids selectively cytotoxic to pancreatic cancer cells

引用

The Innovation 2024年第3期5卷 138-145页

作者： Alfred Akinlalu Zachariah Flaten Komila Rasuleva Md Saimon Mia aaron Bauer Santhalingam Elamurugan Nega Ejjigu Sudipa Maity Amara Arshad Min Wu Wenjie Xia Jia Fan Ang Guo Sijo Mathew dali Sun department of Electrical and Computer Engineering University of Denver2155 E Wesley AvenueDenverCO 80210USA Biomedical Engineering Program North Dakota State University1401 Centennial BoulevardEngineering AdministrationRoom 203FargoND 58102USA department of Pharmaceutical Sciences School of PharmacyNorth Dakota State University1001 S.1401 Albrecht Boulevard Sudro HallFargoND 58102USA Materials and Nanotechnology Program North Dakota State University1410 North 14th AvenueCIE 201FargoND 58102USA Wenzhou Institute University of Chinese Academy of SciencesWenzhouZhejiang 325000China department of Aerospace Engineering Iowa State UniversityAmesIA 50011USA Center for Cellular and Molecular diagnostics Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA department of Biochemistry and Molecular Biology Tulane University School of Medicine1430 Tulane AvenueNew OrleansLA 70112USA Knoebel Institute for Healthy Aging University of Denver2155 E Wesley AvenueDenverCO 80210USA

Pancreatic adenocarcinoma(PdAC)is one of the most deadly cancers,characterized by extremely limited therapeutic options and a poor prognosis,as it is often diagnosed during late disease *** and selective treatments are urgently needed,since current therapies have limited efficacy and significant side *** proteomics analysis of extracellular vesicles,we discovered an imbalanced distribution of amino acids secreted by PdAC tumor *** findings revealed that PdAC cells preferentially excrete proteins with certain preferential amino acids,including isoleucine and histidine,via extracellular *** amino acids are associated with disease progression and can be targeted to elicit selective toxicity to PdAC tumor *** in vitro and in vivo experiments demonstrated that supplementation with these specific amino acids effectively eradicated PdAC ***,we also identified XRN1 as a potential target for these amino *** high selectivity of this treatment method allows for specific targeting of tumor metabolism with very low toxicity to normal ***,we found this treatment approach is easy-to-administer and with sustained tumor-killing ***,our findings reveal that exocytosed amino acids may serve as therapeutic targets for designing treatments of intractable PdAC and potentially offer alternative treatments for other types of cancers.

关键词： finding identif selectivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Modeling Common-Mode Current due to Asymmetric Aging of Machine Winding Insulation

引用

Complex System Modeling and Simulation 2023年第2期3卷 118-128页

作者： Jin Zhao aaron d.Brovont department of Electrical and Computer Engineering The University of AlabamaTuscaloosaAL 35487USA the PC Krause and Associates West LafayetteIN 47906USA

Machine stator winding insulation degradation is one of the main results of machine *** is non-negligible once this degradation process becomes asymmetric between *** traditional way to determine the insulation state of health is a partial discharge ***,this method requires the system offline,which causes production loss and extra administrative *** paper presents an idea for better characterizing the insulation machine’s state of health using common-mode(CM)behavior in the machine-drive *** the help of circuit decomposition methods and modeling tools,the CM quantities due to asymmetric aging show a unique characteristic that distinguishes itself from other differential-mode(dM)quantities in the equivalent *** is shown effective to represent the asymmetric aging effect from the detection of system leakage *** paper provides an analytical method to quantify this characteristic from mathematical approaches,and a proper approximation has been made on the CM equivalent model(CEM)such that the CM behavior is accurately *** proposed method will serve the purpose of predicting machine abnormal behavior using the simple RLC *** can adapt this method to quantify and characterize the machine insulation state of health(SOH).

关键词： common-mode equivalent circuit machine decomposition machine stator winding insulation health model approximation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chiral carbon dots:synthesis,optical properties,and emerging applications

引用

Light(Science & Applications) 2022年第4期11卷 542-564页

作者： aaron doring Elena Ushakova Andrey L.Rogach department of Materials Science and Engineering and Centre for Functional Photonics(CFP)City University of Hong Kong83 Tat Chee AvenueKowloonHong Kong SARChina. Center of Information Optical Technologies ITMO UniversitySaint Petersburg 197101Russia. Shenzhen Research Institute City University of Hong Kong518057 ShenzhenChina

Carbon dots are luminescent carbonaceous nanoparticles that can be endowed with chiral properties,making them particularly interesting for biomedical applications due to their low cytotoxicity and facile *** recent years,synthetic efforts leading to chiral carbon dots with other attractive optical properties such as two-photon absorption and circularly polarized light emission have *** start this review by introducing examples of molecular chirality and its origins and providing a summary of chiroptical spectroscopy used for its *** approaches used to induce chirality in nanomaterials are *** the main part of this review we focus on chiral carbon dots,introducing their fabrication techniques such as bottom-up and top-down chemical syntheses,their morphology,and optical/chiroptical *** then consider emerging applications of chiral carbon dots in sensing,bioimaging,and catalysis,and conclude this review with a summary and future challenges.

关键词： properties synthesis chiral

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Temporally resolving premixed turbulent flame structures using self-supervised adversarial reconstruction of CH-PLIF

引用

能源与人工智能(英文) 2023年第1期11卷 51-62页

作者： Ji-Hun Oh aaron W.Skiba Stephen d.Hammack Constandinos M.Mitsingas Campbell d.Carter Tonghun Lee department of Mechanical Science and Engineering University of Illinois at Urbana-ChampaignIL61801United States U.S.Air Force Research Laboratory Wright-Patterson Air Force BaseOH45433United States Army Research Lab Aberdeen Proving GroundMD21005United States

Understanding the turbulence-flame interaction is crucial to model the low-emission combustors developed for energy and propulsion applications. To this end, a novel frame interpolation (FI) method is proposed to better resolve the spatiotemporal evolution of premixed turbulent flame structures. The framework is completely selfsupervised, agnostic to optical flow, and driven by leveraging transferrable feature knowledge at lower speeds and adversarial learning to statistically map the flame dynamics across frames. The method is successfully applied on a 10 kHz CH planar laser-induced fluorescence (PLIF) dataset of highly wrinkled premixed flames with turbulent Reynolds numbers (ReT ) of 1100, 1400, and 7900, by down-sampling the image sequence to 5 kHz and restoring the sequence back to 10 kHz via FI. All reconstructions recovered important flame events and displayed excellent resemblance of the corrugated CH-layer geometries to that of the ground truths, with average intersection over union (IoU) and structural similarity index (SSIM) scores of 0.49 and 0.82, which are above the high-similarity baselines of 0.36 and 0.75, respectively. The wrinkling parameters (WP) of the flames also matched the ground truths, wherein R2 was roughly 0.95 for ReT = 1100 and 1400 and 0.85 for ReT = 7900 (lower due to the turbulence-induced uncertainties). The FI is further iteratively repeated to 40 kHz on the ReT = 7900 flames to facilitate pocket analysis by confidently linking their origin of formation, thus, enabling distinction from 3d tunnels, and improving statistical characterization of their consumption speeds. Given that the object features do not exhibit highly turbulent motions with regard to the initial time step, the proposed FI method is shown to be highly accurate and useful to analyzing finite-resolution experimental image sets including, but not restricted to, CH-PLIF.

关键词： Self-supervised frame interpolation Premixed turbulent flames Planar laser-induced fluorescence Generative adversarial networks Pocket behavior

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Viral hepatitis in 2021:The challenges remaining and how we should tackle them

引用

World Journal of Gastroenterology 2022年第1期28卷 76-95页

作者： Rebecca dunn aaron Wetten Stuart McPherson Mhairi C donnelly Gastroenterology University Hospital of North TeesStockton on Tees TS198PEUnited Kingdom Liver Unit Freeman HospitalNewcastle NE77DNUnited Kingdom Translational and Clinical Research Institute Newcastle UniversityNewcastle NE17RUUnited Kingdom

Viral hepatitis results in 1.4 million deaths *** World Health Organization(WHO)set an ambitious target to eliminate viral hepatitis by 2030,but significant challenges *** include inequalities in access to healthcare,reaching at risk populations and providing access to screening and effective *** around viral hepatitis persists and must be *** WHO goal of global elimination by 2030 is a worthy aim,but remains ambitious and the coronavirus 2019 pandemic undoubtedly has set back *** review article will focus on hepatitis A to E,highlighting problems that have been resolved in the field over the past decade,those that remain to be resolved and suggest directions for future problem solving and research.

关键词： Hepatitis A Hepatitis B Hepatitis C Hepatitis d Hepatitis E COVId-19

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A comparison of three surface roughness characterization techniques:photogrammetry,pin profiler,and smartphone-based LidAR

引用

International Journal of digital Earth 2022年第1期15卷 2422-2439页

作者： Zohreh Alijani Julien Meloche Alexander McLaren John Lindsay Alexandre Roy aaron Berg department of Geography Environment and GeomaticsUniversity of GuelphGuelphCanada département de Géomatique Appliquée Université de SherbrookeSherbrookeCanada département des Sciences de l’Environment Université du Québec à Trois-RivièresTrois-RivièresCanada

Surface roughness plays an important role in microwave remote *** the agricultural domain,surface roughness is crucial for soil moisture retrieval methods that use electromagnetic surface scattering or microwave radiative transfer ***,improved characterization of Soil Surface Roughness(SSR)is of considerable *** this study,three approaches,including a standard pin profiler,a LidAR point cloud generated from an iPhone 12 Pro,and a Structure from Motion(SfM)photogrammetric point cloud,were applied over 24 surface profiles with different roughness variations to measure surface *** objective of this study was to evaluate the capability of smartphone-based LidAR technology to measure surface roughness parameters and compare the results of this technique with the more common *** showed that the iPhone LidAR technology,when point cloud data is captured in a fine-resolution mode,has a significant correlation with SfM photogrammetry(R2=0.70)and a relatively close agreement with pin profiler(R2=0.60).However,this accuracy tends to be greater for random surfaces and rough profiles with row structure *** results of this study confirm that smartphone-based LidAR can be used as a cost-effective,fast,and time-efficient alternative tool for measuring surface roughness,especially for rough,wide,and inaccessible areas.

关键词： LidAR surface roughness structure from motion iPhone pin profiler

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

神经退行性疾病“不可成药”靶点的小分子靶向策略

引用

Science Bulletin 2023年第16期68卷 1715-1718页

作者：卢俊梅李朝阳 aaron d.Gitler 鲁伯埙 Neurology department at Huashan Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceNew Cornerstone Science LaboratorySchool of Life SciencesFudan UniversityShanghai 200438China department of Genetics Stanford UniversityStanfordCA 94305USA Chan Zuckerberg Biohub-San Francisco San FranciscoCA 94158USA

As our population continues to age,neurodegenerative diseases are increasing in prevalence and taking a greater toll on *** devastating diseases are disparate in their clinical presentationÐsome affect memory while others affect *** despite those differences,a common theme uniting most neurodegenerative disorders is that misfolded proteins accumulate in the brains of patients afflicted with these *** genetics discoveries have strongly implicated the accumulation of misfolded proteins as drivers of disease ***,making drugs to target these disease proteins has been challenging,owing to them being‘‘misfoldedºand thus their lack of classic activity‘‘pocketsº,whose occupancy by small molecules influences a protein’s biochemical function.

关键词：神经退行性疾病 diseases drugs

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：