检索结果-南通市图书馆

Two sides to colon cancer: mice mimic human anatomical region disparity in colon cancer development and progression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Cancer Metastasis and Treatment 2018年第1期4卷 606-614页

作者： Jessica Felton Kunrong Cheng aaron C.Shang Shien Hu Shannon M.Larabee Cinthia b.Drachenberg Jean-Pierre Raufman Department of Surgery University of Maryland School of MedicineBaltimoreMD 21201USA Department of Medicine University of Maryland School of MedicineBaltimoreMD 21201USA Department of Pathology University of Maryland School of MedicineBaltimoreMD 21201USA

Aim:Strong evidence reveals important differences between cancers in the proximal *** *** models of metastatic colon cancer are available but with varying degrees of reproducibility and several important *** explored whether there were regional differences in the location of murine colon cancers and assessed the utility of murine models to explore the biological basis for such ***:We re-analyzed data from our previous studies to assess the regional distribution of murine colon *** survival surgery experiments,we injected HT-29 human colon cancer cells into the wall of the cecum or distal colon of Nu(NCr)-Foxn1 nu or ***-Prkdc scid Il2rg Tim1Wji/SzJ mice and compared the development of primary tumors and ***:Within 7-17 weeks after intramural cecal injection of HT-29 cells,eight mice failed to develop solid primary tumors or *** contrast,within four weeks after cell injection into the distal colon,13 mice developed metastases-12 mice developed subcutaneous metastases;of these,four developed liver metastases and one developed both liver and lung *** mouse developed liver metastases *** examination confirmed these lesions were ***:Our findings reveal the preferential growth of murine colon neoplasia and invasive human orthotopic xenografts in the distal mouse *** new approach of injecting cells into the distal colon wall results in a pattern of colon cancer development that closely mimics the progression of metastatic colon cancer in *** novel model of colon neoplasia has great potential for exploring anatomical differences in colon cancer and testing novel therapeutics.

关键词： Colorectal cancer orthotopic tumor model mouse model HT-29 cells colon

Numerical Study of Solid Iron Carburization in a Carbon Monoxide Atmosphere

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

材料科学与工程（中英文b版） 2013年第9期3卷 582-585页

作者： Miguel Angel barron Meza G. Plascencia aaron Almaraz Departamento de Materiales Universidad Autonoma Metropolitana Azcapotzalco Av. San Pablo 180 Col. Reynosa-TamaulipasMexico D.F. 02200 Mexico CIITEC-IPN Cerrada Cecati s/n Col. Sta. Catarina Mexico D.F. 02250 Mexico

The diffusion step during the high temperature carburization of a spherical iron particle in a carbon monoxide atmosphere is mathematically modeled and numerically simulated in this work. The continuity equation is numerically solved using a forward finite-differences scheme, and a temperature range of 1,486-1,664 K is considered. An integration time during which the solid iron particle is not yet melted is assumed. The programming code was verified using experimental results previously reported by other authors. Radial carbon concentration is determined for several temperatures, and the average carbon concentration in the particle is obtained by numerical integration.

关键词：一氧化碳固体渗碳铁颗粒数值研究气氛温度范围连续性方程数值模拟

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

情绪管理-管理情绪.而不是被情绪管理

情绪管理-管理情绪.而不是被情绪管理

2020年

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

无限多样性的基因工程面料

中国制衣 2015年第7期 8-8页

作者： aaron Tilley

由三位博士科学家在六年前成立的公司bolt Threads堪称是一项长期的科学实验。这家公司在发酵桶中制造基因工程面料。但现在,该公司需要把自己的科研成果转化成商业运营。近期,这家位于加州埃默里维尔的初创公司宣布获得了3230万美元的... 详细信息

由三位博士科学家在六年前成立的公司bolt Threads堪称是一项长期的科学实验。这家公司在发酵桶中制造基因工程面料。但现在,该公司需要把自己的科研成果转化成商业运营。近期,这家位于加州埃默里维尔的初创公司宣布获得了3230万美元的b轮融资。相关调研数据显示,这轮融资对bolt Threads的投资后估值为1.0012亿

关键词：面料蜘蛛丝初创公司基因工程

第二代佳洁士电动牙刷与手动牙刷对牙菌斑去除功效的比较

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

牙体牙髓牙周病学杂志 2003年第7期13卷 400-403页

作者： Jan Haun Karen Williams Lynn Friesen Anita Ferrante Patricia A. Walters Robert D. bartizek aaron R. biesbrok 王漪涛密苏里州大学堪萨斯市牙科学院宝洁公司健康护理研究中心北京宝洁公司佳洁士口腔护理研究院北京100084

目的 :研究新一代电动牙刷 -佳洁士SpinbrushProTM与两种先进设计的手动牙刷 -欧乐 -bCrossAction和高露洁Navigator的去除菌斑功效。方法 :本研究采用随机对照、检查者单盲、九循环交叉设计 ,为期 2个月。受试者分别使用电动牙刷和两... 详细信息

目的 :研究新一代电动牙刷 -佳洁士SpinbrushProTM与两种先进设计的手动牙刷 -欧乐 -bCrossAction和高露洁Navigator的去除菌斑功效。方法 :本研究采用随机对照、检查者单盲、九循环交叉设计 ,为期 2个月。受试者分别使用电动牙刷和两种对照牙刷各 3次。使用Turesky等改良的Quigley -Hein指数 ,在刷牙前后记录菌斑值。结果 :共 12 7名受试者完成实验。佳洁士SpinbrushProTM的菌斑去除值较高露洁Navigator和欧乐 -bCrossAction分别高 4 9%和 2 8% ,结果具有统计学意义 (P brushProTM的菌斑去除功效优于高露洁Narigator和欧乐 -b -CrossAction的菌斑去除功效。

关键词：电动牙刷手动牙刷菌斑去除

对于非酒精性脂肪肝病的认识——基于亚洲人群的研究

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gastroenterology Report 2016年第2期4卷 131-135,I0002页

作者： George b.b.Goh Clarence Kwan Sze Ying Lim Nanda KK Venkatanarasimha Rafidah Abu-bakar Thinesh L Krishnamoorthy Hang Hock Shim Kiang Hiong Tay Wan Cheng Chow Department of Gastroenterology&Hepatology Singapore General HospitalSingapore Duke-NUS Graduate Medical School Singapore Department of Diagnostic Radiology Singapore General HospitalSingapore

背景和目的:非酒性脂肪肝病(NAFLD)是最常见的慢性肝病,同时也是代谢综合征的一项危险因素。NAFLD在全球范围内的患病率基于地域差异在5%~30%不等。尽管流行病学资料显示代谢相关性疾病的患病率在新加坡呈快速增长,但对于该地区NAFLD的... 详细信息

背景和目的:非酒性脂肪肝病(NAFLD)是最常见的慢性肝病,同时也是代谢综合征的一项危险因素。NAFLD在全球范围内的患病率基于地域差异在5%~30%不等。尽管流行病学资料显示代谢相关性疾病的患病率在新加坡呈快速增长,但对于该地区NAFLD的数据却十分有限。本研究旨在了解新加坡NAFLD的患病率及公众对该病的认识。方法:本研究是一项横断面观察研究,旨在评估NAFLD患者的人口统计学、人体测量学及临床资料,研究对象来自于一项胃肠公众论坛的参会者。NAFLD的诊断基于超声学标准;代谢综合征的诊断则基于国际糖尿病联盟的指南。通过自行设计的调查问卷来了解大家对NAFLD这种疾病的看法。结果:共有227名研究对象纳入研究,其中40%被诊断为NAFLD。相对于那些非NAFLD人群,NAFLD者男性居多,年龄更大,体质指数更高,腰围更宽,患代谢性综合征的比例更高(均P0.05)。值得注意的是,75.6%的具有代谢危险因素者,并不认为自己存在NAFLD风险。结论:我们的研究显示NAFLD在新加坡具有较高的患病率,包括在那些非肥胖人群中。考虑到人们对NAFLD的发生风险认识不足,有必要加强公众教育,以提高人们对NAFLD的认识。

关键词：非酒精性脂肪肝病流行病学认识新加坡

Treatment of early stage(T1) esophageal adenocarcinoma:Personalizing the best therapy choice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Meta-Analysis 2019年第9期7卷 406-417页

作者： Lindsay Danielle Kumble Elisabeth Silver aaron Oh Julian A Abrams Joshua R Sonett Chin Hur General Medicine Columbia University Medical CenterNew YorkNY 10032United States Department of Medicine Columbia University Medical CenterNew YorkNY 10032United States

Esophagectomy is considered the primary form of management for esophageal adenocarcinoma(EAC);however,the surgery is associated with high rates of morbidity and *** patients with early-stage EAC,endoscopic resection(ER)presents a potential curative treatment option that is less invasive and carries fewer risks procedure related risks,but it is associated with higher rates of cancer recurrence following the *** some patients,age and comorbidities may prevent them from having esophagectomy as a treatment option,while other patients may be operative candidates but do not wish to undergo esophagectomy for a variety of reasons related to their values and ***,while anxiety of cancer recurrence following ER may significantly diminish a patient’s quality of life(QOL),so might the morbidity surrounding *** addition to considering health status,patient preferences,and impacts on QOL,physicians and patients must also consider what treatments would be both beneficial and available to the patient,considering esophagectomy methods-minimally invasive vs open-or the use of chemoradiotherapy in addition to *** article reviews and summarizes available treatment options for patients with early EAC and their potential effects on the health and wellbeing of patients based on the current *** conclude with a request for more research of available options for early EAC patients,the conditions that determine when each option should be employed,and their effects not only on patient health but also QOL.

关键词： Esophageal cancer Adenocarcinoma T1b Esophagectomy Endoscopic resection Chemoradiotherapy Quality of life

胆固醇下降与非疾病死亡率:随机对照试验的汇总分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

英国医学杂志中文版 2001年第3期4卷 168-168页

作者： Matthew F Muldoon Stephen b Manuck aaron b Mendelsohn Jay R Kaplan Steven H belle 崔会娣

目的：调查降胆固醇治疗与自杀、意外事故或外伤致死（非疾病死亡率）危险性之间的关系。设计：降胆固醇治疗的大型随机对照试验中非疾病死亡率结果的汇总分析。研究回顾：21组入选试验中19组提供了非疾病死亡率的可用数据。干预回顾：... 详细信息

目的：调查降胆固醇治疗与自杀、意外事故或外伤致死（非疾病死亡率）危险性之间的关系。设计：降胆固醇治疗的大型随机对照试验中非疾病死亡率结果的汇总分析。研究回顾：21组入选试验中19组提供了非疾病死亡率的可用数据。干预回顾：过去1~10年间采取饮食调节、药物治疗或行部分回肠旁路手术。主要结果测定指标：治疗组与对照组间自杀、意外事故和暴力致死的比较。结果：汇集所有试验，治疗组非疾病死亡率与对照组的比数比为1.18（95%可信区间0.91~1.52； P=0.20）。初级预防试验的比数比为1.28（0.94~1.74 P = 0.12），二级预防试验为1.0（0.65~1.55 P = 0.98）。使用他汀类药物的随机对照试验表明，治疗与非疾病死亡率升高无关（0.84，0.50~1.41： P = 0.50）。相反，试验显示，饮食干预及非他汀类药物有增加自杀及暴力致死的趋势（1.32，0.98~1.77； P =0.06）。已发现胆固醇降低数值与非疾病死亡率之间并无关系（ P = 0.23）。结论目前尚无证据表明降胆固醇治疗使非疾病死亡率明显上升，而饮食调节及非他汀类药物可使非疾病死亡率轻度增加。

关键词：胆固醇下降非疾病死亡率降胆固醇治疗

肺表面活性物质相关基因变异在中国人群的研究

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

肺表面活性物质相关基因变异在中国人群的研究