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Paracentesis following intravitreal drug injections in maintaining physiologic ocular perfusion pressure

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1925-1927页

作者： Austin Bach Artur Filipowic aaron S. gold Azeema Latiff Timothy G. Murray Bascom Palmer Eye Institute University of MiamiMiamiFL 33136USA Des Moines University College of Osteopathic Medicine Des MoinesIA 50312USA Murray Ocular Oncology&Retina MiamiFL 33143USA

A retrospective analysis was performed of patients who received a paracentesis immediately following an intravitreal injection of bevacizumab or triamcinolone *** patients were previously diagnosed as having glaucoma,ocular hypertension,or had responded previously with sustained elevated intraocular *** 1661 procedures were *** 219（13%） of the injections were on phakic patients.A median（SD） of 210 μL（40 μL） of aqueous was removed during each *** were no reported incidences of any *** propose performing a paracentesis immediately following intravitreal injections for patients at risk for ocular hypertension,glaucoma,and retinal vein or artery occlusion.

关键词： anterior chamber paracentesis intravitreal injection intraocular pressure ocular perfusion pressure

Axial length development in children

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International Journal of Ophthalmology(English edition) 2019年第5期12卷 815-819页

作者： Austin Bach Victor M.Villegas aaron S.gold Wei Shi Timothy G.Murray Larkin Eye Institute Bascom Palmer Eye Institute Murray Ocular Oncology & Retina

AIM: To study ocular axial lengths in pediatric subjects without intraocular pathology. METHODS: An Institutional Review Board-approved consecutive retrospective chart review of axial lengths measured in pediatric subjects who underwent examination under anesthesia due to positive family history of retinoblastoma or other inherited ocular disease. Only subjects without any intraocular pathology in either eye were included. Subjects were stratified into age groups. An axial length model using a logarithmic regression algorithm was ***: Data from 330 eyes of 165 subjects were included in the study. The mean age at the time of examination was 30.62(SD 18.04)mo. The steepest increase in axial length was present during the first 10 mo of life. After 36 mo, there was no statistically significant axial length growth. CONCLUSION: This study presents the biggest series of pediatric axial lengths in healthy eyes. The axial length model developed with these data may assist in the diagnosis and management of a wide variety of pediatric ophthalmic diseases.

关键词： pediatric axial length model biometry eye development

Spontaneous exudative retinal detachment in a patient with sturge-weber syndrome after taking arginine, a supplement for erectile dysfunction

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Eye and Vision 2014年第1期1卷 46-50页

作者： Austin Bach aaron S gold Victor M Villegas Andrea C Wildner Fiona J Ehlies Timothy G Murray Larkin Community Hospital 7031 SW 62nd AvenueSouth MiamiFlorida 33143USA Murray Ocular Oncology&Retina 6705 Red RoadSuite 412MiamiFlorida 33143USA.

Background:Patients with Sturge-Weber syndrome can have ipsilateral diffuse or circumscribed choroidal *** hemangiomas have been seen to undergo spontaneous exudative or hemorrhagic retinal *** is no definitive treatment for these types of retinal detachments,but radiotherapy,photodynamic therapy,oral propranolol,pegaptinib and bevacizumab have been *** presentation:A 26-year-old male with Sturge-Weber Syndrome developed an exudative retinal detachment that occurred immediately after taking a supplement containing *** patient was treated with intravitreal bevacizumab 1.25 mg in 0.05 ml *** of the retinal detachment was seen after 4 treatments over a six-month ***:Arginine and other medications that cause a release of nitric oxide may lead to intravascular leakage and exudative retinal detachments in patients who have a choroidal hemangioma.

关键词： Sturge-Weber Syndrome Exudative retinal detachment Choroidal hemangioma Nitric oxide arginine

Suppressing tawny crazy ant (Nylanderia fulva) by RNAi technology

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Insect Science 2020年第1期27卷 113-121页

作者： Jia Meng Jiaxin Lei Andrew Davitt Jocelyn RHolt Jian Huang Roger gold Edward L Vargo aaron MTarone Keyan Zhu-Salzman College of Plant Protection Fujian Agricultural and Forestry UniversityFuzhouFujianChina Department of Entomology Texas A&M UniversityCollege StationTexasUSA Institute for Plant Genomics&Biotechnology Texas A&M UniversityCollege StationTexasUSA

A bstract The tawny crazy ant(Nylanderia fulva)is a new invasive pest in the United *** present,its management mainly relies on the use of synthetic insecticides,which are generally ineffective at producing lasting control of the pest,necessitating alternative environmentally friendly *** this study,we evaluated the feasibility of gene silencing to control this ant *** housekeeping genes encoding actin(NfActin),coatomer subunit β (NfCOPP),arginine kinase(NfArgK),and V-type proton ATPase subunits A(NfvATPaseA),B(NfvATPaseB)and E(NfvATPaseE)were *** analysis revealed high sequence similarity to homologs from other ant species,particularly the Florida carpenter ant(Camponotus floridanus).To silence these genes,vector L4440 was used to generate six specific RNAi constructs for bacterial ***-inactivated,dsRNA-expressing Escherichia coli were incorporated into artificial *** ants exhibited reduced endogenous gene expression after feeding on such diet for 9 ***,only ingestion of dsRNAs of NfCOPfi(a gene involved in protein trafficking)and NfArgK(a cellular energy reserve regulatory gene in invertebrates)caused modest but significantly higher ant mortality than the *** results suggest that bacterially expressed dsRNA can be orally delivered to ant cells as a mean to target its *** efficacy is necessary for the RNAi-based approach to be useful in tawny crazy ant management.

关键词： artificial diet gene silencing housekeeping gene Nylanderia fulva RNAi survival rate

Invasion genetics： Lessons from a ubiquitous bird, the house sparrow Passer domesticus

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Current Zoology 2015年第3期61卷 465-476页

作者： Andrea L. LIEBL aaron W. SCHREY samuel C. ANDREW Elizabeth L.SHELDON Simon C. GRIFFITH University of Exeter ComwaU Campus Penryn Cornwall TR10 9EZ UK Department of Biology Armstrong State University Savannah GA31419 USA Department of Biological Sciences Macquarie University Sydney NSW 2109 Australia

Following an introduction, non-native species are exposed to environments that differ from those found in their native range; further, as these non-native species expand beyond the site of introduction, they must constantly adapt to novel environ- ments. Although introduced species are present across most ecosystems, few species have successfully established themselves on a truly global scale. One such species, the house sparrow Passer domesticus, is now one of the world＇s most broadly distributed vertebrate species and has been introduced to a great part of its current range. To date, work on four continents suggests both ge- netic and phenotypic variation exists between native and introduced ranges. As such, house sparrows represent an excellent op- portunity to study adaptations to novel environments and how these adaptations are derived. The global distribution of this spe- cies and the multiple independent introductions to geographically isolated sites allow researchers to ask questions regarding ge- netic variation and adaptation on a global scale. Here, we summarize the molecular studies of invasive house sparrows from the earliest work using allozymes through more recent work on epigenetics; using these studies, we discuss patterns of dispersal of this species. We then discuss future directions in techniques （e.g. next generation sequencing） and how they will provide new in- sight into questions that are fundamental to invasion biology. Finally, we discuss how continued research on the house sparrow in light of these genetic changes and adaptations will elucidate answers of adaptation, invasion biology, range expansion, and resi- lience in vertebrate systems generally

关键词： House sparrow Invasive Passer domesticus

Management of symptomatic neuromas:a narrative review of the most common surgical treatment modalities in amputees

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Plastic and Aesthetic Research 2022年第1期9卷 120-132页

作者： Sahand C.Eftekari Peter J.Nicksic Allison J.Seitz D’Andrea T.Donnelly aaron M.Dingle samuel O.Poore Division of Plastic Surgery University of Wisconsin School of Medicine and Public HealthG5-347 Clinical Sciences CenterMadisonWI 53711USA

Symptomatic neuromas are an all-too-common complication following limb amputation or extremity trauma,leading to chronic and debilitating pain for *** resection of symptomatic neuromas has proven to be the superior method of intervention,but traditional methods of neuroma resection do not address the underlying pathophysiology leading to the formation of a future symptomatic neuroma and lead to high reoperation *** approaches employ the physiology of peripheral nerve injury to harness the regeneration of nerves to their *** review explores the underlying pathophysiology of neuroma formation and centralization of pain *** compares the traditional surgical approach for symptomatic neuroma resection and describes three novel surgical strategies that harness this pathophysiology of neuroma formation to their *** traditional resection of symptomatic neuromas is currently the standard of care for amputation patients,but new techniques including the regenerative peripheral nerve interface,targeted muscle reinnervation,and intraosseous transposition have shown promise in improving patient pain outcomes for postamputation pain and residual limb *** neuromas are a chronic and debilitating complication following amputation procedures and trauma,and the current standard of care does not address the underlying pathophysiology leading to the formation of the *** techniques are under development that may provide improved patient pain outcomes and a higher level of care for symptomatic neuroma resection.

关键词： Neuromas regenerative peripheral nerve interface targeted muscle reinnervation osseointegrated neural interface amputation

Essential neural anatomy for creating a clinically translatable osseointegrated neural interface for prosthetic control in sheep

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Plastic and Aesthetic Research 2023年第1期10卷 600-614页

作者： Kirsten A.Gunderson Scott K.Odorico Zeeda H.Nkana Lucas Sears Grant Seils Rashea L.Minor Weifeng Zeng samuel O.Poore aaron M.Dingle Division of Plastic Surgery University of Wisconsin School of Medicine and Public HealthMadisonWI 53792USA University of Wisconsin-Madison School of Veterinary Medicine MadisonWI 53706USA

Aim:Ovine models for osseointegrated prosthetics research are well established,but do not consider neural control of advanced *** validity of interfacing technologies,such as the Osseointegrated Neural Interface(ONI),in their ability to provide communication between native nerves and advanced prosthetics is required,necessitating a stable,longitudinal large animal model for *** objective of this study is to provide a detailed anatomic description of the major nerves distal to the carpal and tarsal joints,informing the creation of a chronic ONI for prosthetic control in ***:Six pelvic and six thoracic cadaveric limbs from mature female,non-lactating sheep were *** were obtained to determine average bone length,medullary canal diameter,and cortical bone *** dissection was performed to discern topographical neuroanatomy and average circumferences of the major nerves of the pelvic and thoracic *** analysis was performed.A surgical approach for the creation of ONI was ***:Average metacarpal and metatarsal length was 15.0 cm(±0.0)and 19.7 cm(±1.0),*** intramedullary canal diameter was 12.91 mm(±3.69)for forelimbs and 12.60 mm(±3.69)for *** thoracic limb nerves consisted of one dorsal and three ventral nerves,with an average circumference of 5.14 mm(±2.00)and 5.05 mm(±1.06),*** limb nerves consisted of two dorsal and one ventral nerve with an average circumference of 6.27 mm(±1.79)and 5.40 mm(±0.53),***:These anatomic data inform the surgical approach and manufacture of a sensory ONI for chronic testing in awake,freely ambulating animals for future clinical translation.

关键词： Amputation prosthesis prostheses neural interface clinical translation large animal osseointegration neuroprosthesis

Artificial intelligence using advanced imaging techniques and cholangiocarcinoma: Recent advances and future direction

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Artificial Intelligence in Gastroenterology 2022年第3期3卷 88-95页

作者： aaron R Brenner Passisd Laoveeravat Patrick J Carey Danielle Joiner samuel H Mardini Manol Jovani Department of Internal Medicine University of Kentucky College of MedicineLexingtonKY 40536United States Division of Digestive Diseases and Nutrition University of Kentucky College of MedicineLexingtonKY 40536United States Division of Digestive Diseases and Nutrition University of Kentucky College of MedicineLexingtonKENTUCKY 40536United States Digestive Diseases and Nutrition University of Kentucky Albert B.Chandler HospitalLexingtonKY 40536United States

While cholangiocarcinoma represents only about 3%of all gastrointestinal tumors,it has a dismal survival rate,usually because it is diagnosed at a late *** utilization of Artificial Intelligence(AI)in medicine in general,and in gastroenterology has made gigantic ***,the application of AI for biliary disease,in particular for cholangiocarcinoma,has been *** use of AI in combination with clinical data,cross-sectional imaging(computed tomography,magnetic resonance imaging)and endoscopy(endoscopic ultrasound and cholangioscopy)has the potential to significantly improve early diagnosis and the choice of optimal therapeutic options,leading to a transformation in the prognosis of this feared *** this review we summarize the current knowledge on the use of AI for the diagnosis and management of cholangiocarcinoma and point to future directions in the field.

关键词： Cholangiocarcinoma Artificial intelligence Cholangioscopy Artificial neural network Machine learning Therapeutic endoscopy Endoscopic ultrasound

Microsurgical epididymal sperm aspiration： indications, techniques and outcomes

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Asian Journal of Andrology 2013年第1期15卷 40-43页

作者： aaron M Bernie Ranjith Ramasamy Doron S Stember Peter J Stahl Weill Cornell Medical College New York-Presbyterian Hospital New York NY 10021 USA Beth Israel Medical Center of Albert Einstein College of Medicine of YeshivaUniversity New York NY 10003 USA Columbia University College of Physicians & Surgeons New York-Presbyterian Hospital New York NY 10032 USA

Microsurgical epididymal sperm aspiration （MESA） refers to retrieval of sperm-containing fluid from optimal areas of the epididymis that are selected and sampled using high-power optical magnification provided by an operating microscope. Retrieved sperm are subsequently used for intracytoplasmic sperm injection （ICSI） to induce fertilization and pregnancy. MESA is considered by many experts to be the gold standard technique for sperm retrieval in men with obstructive azoospermia given its high yield of quality sperm, excellent reported fertilization and pregnancy rates, and low risk of complications. However, MESA must be performed in an operating room, requires microsurgical skills and is only useful for reproduction using ICSI. Herein we present an overview of the evaluation of candidate patients for MESA, the technical performance of the procedure and the outcomes that have been reported.

关键词： azoospermia ICSI infertility male MESA microsurgical epididymal sperm aspiration microsurgery sperm retrieval