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中国毒理学会第九次全国青年科技大会暨第二届生物技术药物毒理与安全评价委员会学术会议

作者：唐雪琪 Rekha C.Balachandran michael Aschner aaron B.Bowman School of Health Sciences Purdue University Department of molecular Pharmacology Albert Einstein College of Medicine

目的胰岛素/胰岛素样生长因子(IGF)信号通路(IIS)是神经细胞对过量锰的反应中的重要一环,且通路中多个信号转导激酶利用锰离子作为催化反应辅助因子。目前,尚不清楚IIS信号通路活性在锰的神经毒性发生发展过程中如何变化。本课题组研究... 详细信息

目的胰岛素/胰岛素样生长因子(IGF)信号通路(IIS)是神经细胞对过量锰的反应中的重要一环,且通路中多个信号转导激酶利用锰离子作为催化反应辅助因子。目前,尚不清楚IIS信号通路活性在锰的神经毒性发生发展过程中如何变化。本课题组研究表明,生理水平IGF与高剂量锰共同刺激能够协同增强IIS通路中的激酶活性,表现为蛋白激酶B (PKB,又称AKT)磷酸化水平显著升高。AKT磷酸化是IIS活性的一个关键指标,同时,为哺乳动物雷帕霉素靶蛋白复合体1(mTORC1)及其下游靶蛋白核糖体蛋白S6 (S6)提供激活信号。然而,大剂量急性暴露并不能完整反映锰的神经毒性在人体中的形成机制。锰暴露引起的人脑神经退行是在低剂量阈值水平长期积累的结果。因此,为了更好地确定低剂量锰暴露对IIS功能的影响,我们评估了IIS通路中各激酶活性在系列锰暴露剂量和时间下的变化。材料方法及结果在神经元细胞系STHdh中,短期(3-30小时)低剂量锰和生理剂量IGF共同处理可诱导S6 Ser235/236位点磷酸化,且在5μm浓度下即有显著升高。同时,S6相比于其上游调节因子AKT对于低浓度急性锰暴露更为敏感,表明亚毒性水平的锰对IIS和mTORC1信号转导有协同激活作用。在此基础上,我们在人源SH-SY5Y细胞系中进行了长期(40天)低剂量锰暴露实验,并通过RNA测序分析信号通路的改变。mRNA表达和通路分析结果证实,在长期暴露条件下,亚毒性浓度的锰(5ιm)仍可以显著改变AKT信号通路的mRNA表达水平。结论:综合以上结果,我们认为在低剂量锰暴露中,IIS通路是神经细胞中过量锰累积的高度敏感靶标,该通路在环境浓度相关的锰暴露引起的神经毒理机制中发挥核心作用。

关键词：锰神经毒性胰岛素样生长因子信号通路

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中国成人棕色脂肪阳性率及其相关因素分析

中国成人棕色脂肪阳性率及其相关因素分析

中华医学会第十二次全国内分泌学学术会议

作者：苗青 aaron m.Cypess 张朝云叶红英张琼月左传涛管一晖李益明复旦大学上海医学院附属华山医院内分泌科复旦大学上海医学院附属华山医院PET中心美国哈佛大学JOSLIN糖尿病中心

目的:既往的研究显示成人体内存在着活性棕色脂肪组织(aBAT),对调节人体的能量平衡起着重要作用。目前有关中国成人aBAT阳性率的研究很少,并且国内外几乎所有的研究对象均为肿瘤患者,不能代表健康人群。我们

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前海19单元03街坊城市设计

城市建筑 2017年第33期14卷 75-79页

作者：冯果川张春亮 aaron 李昂泰何桂华吴欣荣无不详筑博设计(集团)股份有限公司

深圳前海具有极佳的区位条件、完善的交通网络、高品质的景观资源。03街坊位于前海妈湾片区19单元的核心位置,紧临地铁站及中央绿轴,基地用地面积6.42 hm2,可开发建设面积4.78 hm2。19单元03街坊是前海地区首个由多家开发主体共同参与... 详细信息

深圳前海具有极佳的区位条件、完善的交通网络、高品质的景观资源。03街坊位于前海妈湾片区19单元的核心位置,紧临地铁站及中央绿轴,基地用地面积6.42 hm2,可开发建设面积4.78 hm2。19单元03街坊是前海地区首个由多家开发主体共同参与、同步整体式开发的典型项目。城市设计提出了一体化街坊开发的整体目标,其中二层步行体系整体开发和地下室整体开发系统性最强、难度最大。1.街坊形象一体化——集群造型过去国际商务区争相建设标志性塔楼,使得城市建设毫无秩序,独立塔楼已经无法在城市中凸显。本街坊由6个高度在100~200 m的“背景”塔楼和一个330 m高的标志性塔楼组成完整的组团。地标成为街坊集群的核心,在富有动感的城市天际线中脱颖而出。

关键词：城市设计街坊单元开发系统城市天际线区位条件交通网络景观资源

VEGF-B prevents excessive angiogenesis by inhibiting FGF2/FGFR1 pathway

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Signal Transduction and Targeted Therapy 2023年第9期8卷 4380-4393页

作者： Chunsik Lee Rongyuan Chen Guangli Sun Xialin Liu Xianchai Lin Chang He Liying Xing Lixian Liu Lasse DJensen Anil Kumar Harald FLanger Xiangrong Ren Jianing Zhang Lijuan Huang Xiangke Yin JongKyong Kim Juanhua Zhu Guanqun Huang Jiani Li Weiwei Lu Wei Chen Juanxi Liu Jiaxin Hu Qihang Sun Weisi Lu Lekun Fang Shasha Wang Haiqing Kuang Yihan Zhang Geng Tian Jia mi Bi-Ang Kang masashi Narazaki aaron Prodeus Luc Schoonjans David mOrnitz Jean Gariepy Guy Eelen mieke Dewerchin Yunlong Yang Jing-Song Ou Antonio mora Jin Yao Chen Zhao Yizhi Liu Peter Carmeliet Yihai Cao Xuri Li State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen University and Guangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060P.R.China Affiliated Eye Hospital of Nanjing medical University Nanjing 210000China Department of Obstetrics and Gynecology Guangdong Provincial Key Laboratory of Major Obstetric DiseasesGuangdong Provincial Clinical Research Center for Obstetrics and GynecologyThe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhenChina Department of Health Medical and Caring SciencesDivision of Diagnostics and Specialist MedicineLinköping University58183 LinköpingSweden Department of Cardiology AngiologyHaemostaseology and Medical Intensive CareUniversity Medical Centre MannheimMedical Faculty MannheimHeidelberg UniversityMannheimGermany DZHK(German Research Centre for Cardiovascular Research) partner site Mannheim/HeidelbergMannheimGermany European Center for Angioscience Medical Faculty MannheimHeidelberg UniversityMannheimGermany Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease Guangdong Research Institute of GastroenterologyDepartment of Colorectal SurgeryThe Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouChina Eye Institute Eye and ENT HospitalShanghai Medical CollegeFudan UniversityKey Laboratory of Myopia of State Health Ministry(Fudan University)and Shanghai Key Laboratory of Visual Impairment and Restoration200031 ShanghaiChina Shandong Technology Innovation Center of molecular Targeting and Intelligent Diagnosis and Treatment Binzhou Medical UniversityYantai 264003P.R.China Division of Cardiac Surgery National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular DiseasesNHC key Laboratory of Assisted Circulation(Sun Yat-sen University)The First Affiliated HospitalSun Yat-sen UniversityGuangzhouChina Department of Respiratory medicine and Clinical Imm

Although VEGF-B was discovered as a VEGF-A homolog a long time ago,the angiogenic effect of VEGF-B remains poorly understood with limited and diverse findings from different ***,drugs that inhibit VEGF-B together with other VEGF family members are being used to treat patients with various neovascular *** is therefore critical to have a better understanding of the angiogenic effect of VEGF-B and the underlying *** comprehensive in vitro and in vivo methods and models,we reveal here for the first time an unexpected and surprising function of VEGF-B as an endogenous inhibitor of angiogenesis by inhibiting the FGF2/FGFR1 pathway when the latter is abundantly ***,we unveil that VEGF-B binds to FGFR1,induces FGFR1/VEGFR1 complex formation,and suppresses FGF2-induced Erk activation,and inhibits FGF2-driven angiogenesis and tumor *** work uncovers a previously unrecognized novel function of VEGF-B in tethering the FGF2/FGFR1 *** the anti-angiogenic nature of VEGF-B under conditions of high FGF2/FGFR1 levels,caution is warranted when modulating VEGF-B activity to treat neovascular diseases.

关键词： FGFR1 FGF2 drugs

AB034. Knowledge and understanding of eye disease among older adults with vision impairment

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Annals of Eye Science 2019年第1期 209-209页

作者： Caitlin murphy Stephanie Pietrangelo Sophie Hallot Jonah Toulch aaron Johnson Department of Psychology Concordia UniversityMontrealQCCanada School of Optometry Universitéde MontréalMontrealQCCanada CRIR/Centre de réadaptation mAB-mackay du CIUSSS du Centre-Ouest-de-l’Île-de-montréal MontrealQCCanada

Background:By 2026,projections indicate that 1/5 Canadians will be over the age of *** shift in demographics will be accompanied by an increase in age-related eye *** studies have reported vision loss as a major medical concern among older adults,but there is little information on older adults’awareness and knowledge of age-related eye diseases.A lack of knowledge can lead to missed or delayed treatment and/or lifestyle *** study aims to assess the knowledge and understanding older adults have of their own eye disease and its ***:Participants over the age of 50 with a visual impairment were recruited from the mAB-mackay Rehabilitation Centre,the Low Vision Self-Help Association(LVSHA)of the West Island and through word of *** acuity and contrast sensitivity were measured using the ETDRS charts and mars Charts,*** coherence tomography(OCT)/scanning laser ophthalmoscopy was used to take cross-sectional images of participant *** were asked to name their visual diagnoses and describe them in their own *** diagnoses were compared to diagnoses determined by an optometrist or ***:To date,this study has recruited 26 participants(7m,19F)over the age of 50 years(range,51-95 years).many participants(73%)were able to name their visual diagnoses,articulate their symptoms,and discuss their treatment and *** majority of these individuals(67%)were clients of the mAB-mackay or participants in the *** the 27%(4m,4F)who were unclear or had misunderstood their diagnoses,half were participants in a low vision support group,but they had multiple visual diagnoses and it was the congenital or trauma-related visual impairments acquired before joining the mAB-mackay or LVSHA that remained *** other 4 individuals who misunderstood their diagnoses were not involved with any low vision or rehabilitation ***:Visual impairment is some

关键词： Low vision low vision rehabilitation aging awareness

*** impact of visual impairment on the montreal Cognitive Assessment

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Annals of Eye Science 2019年第1期 208-208页

作者： Elliott morrice Zoey Stark Caitlin murphy Walter Wittich aaron Johnson Department of Psychology Concordia UniversityMontrealQCCanada CRIR/Centre de Réadaptation mAB-mackay du CIUSSS du Centre Ouest del’Île de montréal QCCanada Optometry University of MontrealQCCanada

Background:Cognitive assessments,such as the montreal Cognitive Assessment(moCA),use components that assume intact sensory abilities,however,adults show concomitant decreases in visual acuity with increasing *** on cognitive assessments are typically lower for individuals with visual impairments compared to individuals with normal/corrected to normal *** it is not clear if lowers scores on cognitive assessments are due to the assessments relying on visual stimuli,or if individuals with visual impairments are actually more likely to have cognitive *** we simulated visual impairments,i.e.,reduced visual acuity and contrast sensitivity,in young healthy adults to determine how this impacts their scores on a measure of cognitive ability,i.e.,the ***:Participants(n=19)completed one of the three version of the moCA under three conditions(20/20,simulated 20/80,simulated 20/200).The moCA was administered following the clinical *** participants that scored>26(i.e.,normal cognitive function)at 20/20 were included in the *** comparison,we included moCA data from a sample of older adults with normal vision(n=19,mage=74,Acuity m=0.04 logmAR,SD=0.16)or visual impairment(n=19,mage=79,Acuity m=0.35 logmAR,SD=0.3).Results:Acuity of participants at 20/20(m=0.06 LogmAR,SD=0.1),simulated 20/80(m=0.63,SD=0.18)and simulated 20/200(m=0.88,SD=0.19)showed that the participants experienced simulated acuity loss with the *** the moCA scores,we found a main effect of acuity(F=16.22,Pmparisons showed a significant difference between scores with a 20/20 acuity(m=27.26,SD=0.93)and 20/80(m=24.74,SD=1.66,t=5.62,ptukeym=25.63,SD=1.46,t=3.63,ptukey=0.002,Cohen’s d=1.33).However,no difference was observed between 20/80 and 20/200(t=−1.99,ptukey=0.125,d=0.572).The moCA scores in older adults with normal vision(m=27.32,SD=2.41)and with visual impa

关键词： Visual impairment cognitive assessment simulated visual impairment montreal Cognitive Assessment(moCA)

室外空气污染、早产和低出生体重：世界卫生组织孕产妇和围产期保健全球调查分析

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环境与职业医学 2014年第12期31卷 988-993页

作者： Nancy L.Fleischer mario merialdi aaron van Donkelaar Felipe Vadillo-Ortega Randall V.martin Ana Pilar Betran Jo?o Paulo Souza marie S.O'Neill 王晓宇汪源金泰廙 University of South Carolina Arnold School of Public Health Department of Reproductive Health and Research World Health Organization Department of Physics and Atmospheric Science Dalhousie University School of medicine Universidad NacionalA utónoma de México Instituto Nacional de medicina Genomica Harvard-Smithsonian Center for Astrophysics Cambridge University of michigan School of Public Health

[背景]吸入细颗粒物（颗粒物直径≤2.5μm,Pm2.5）能诱发氧化应激和炎症反应,并有可能导致早产和其他不良的围产期结局。[目的]检测2004—2008年,世界卫生组织在全球22个国家中进行的孕产妇和围产期保健调查中,室外Pm2.5是否与不良妊娠... 详细信息

[背景]吸入细颗粒物（颗粒物直径≤2.5μm,Pm2.5）能诱发氧化应激和炎症反应,并有可能导致早产和其他不良的围产期结局。[目的]检测2004—2008年,世界卫生组织在全球22个国家中进行的孕产妇和围产期保健调查中,室外Pm2.5是否与不良妊娠结局相关。[方法]以有新生儿出生的各医疗诊所周围50 km为半径的圆弧缓冲区计算室外Pm2.5的长期均值（2001—2006年）。应用广义估计方程确定诊所的Pm2.5水平与个体的早产和低出生体重之间的相关性,调整个人、诊所和国家水平的季节性因素及潜在的混杂因素。另外还对各国中的相关性进行了研究。[结果]在所有国家中,调整季节性因素后,Pm2.5与早产无关联,但是与低出生体重相关[Pm2.5的第四个四分位数段（〉20.2μg/m3）与第一个四分位数（〈6.3μg/m3）相比,比值比（OR）=1.22;95%CI：1.07-1.39]。中国是Pm2.5测量值范围最大的国家,早产和低出生体重均仅与Pm2.5的最高四分位数段相关,提示可能存在阈值效应（Pm2.5≥36.5μg/m3与Pm2.5〈12.5μg/m3相比,早产和低出生体重比值比分别为：OR=2.54;CI：1.42-4.55和OR=1.99;CI：1.06-3.72）。[结论]室外Pm2.5浓度与低出生体重相关,但与早产不相关。在快速发展的国家中,例如中国,最高的空气污染水平可能与两个结局都相关。

关键词：低出生体重世界卫生组织围产期保健空气污染保健调查孕产妇早产室外

饲粮中钙离子浓度对肉鸡各肠段内营养物质消化的影响

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饲料博览 2014年第11期24卷 23-23页

作者： Ruvini K m Velmurugu R Ganesharanee R aaron J C

文章旨在评价饲粮中钙(Ca)的浓度对肉仔鸡肠道内Ca、磷(P)、氮(N)、脂肪和淀粉消化的影响。在3周龄肉仔鸡饲粮中添加Ca 6、9和12 g·kg-(1Ca:P分别为1:1、1.4:1和2:1),试验共进行6周,并且分别收集十二指肠、空肠、回肠上部和回肠下部的... 详细信息

文章旨在评价饲粮中钙(Ca)的浓度对肉仔鸡肠道内Ca、磷(P)、氮(N)、脂肪和淀粉消化的影响。在3周龄肉仔鸡饲粮中添加Ca 6、9和12 g·kg-(1Ca:P分别为1:1、1.4:1和2:1),试验共进行6周,并且分别收集十二指肠、空肠、回肠上部和回肠下部的食糜。根据饲粮和食糜中标记物的比例来计算P、N、脂肪和淀粉在不同肠断内的表观消化率。在十二指肠内P和Ca的表观消化率均表现出负面效应。随着Ca浓度的增加,P的表观消化率显著降低(P0.05),Ca的主要吸收部位在空肠。随着Ca浓度的增加,N和脂肪的消化率显著降低(P<0.05)。N的消化率方面,饲粮中的Ca与肠道部位有显著的互作。当饲粮中Ca浓度适量或偏低时,N的主要吸收部位在空肠末端。但当Ca浓度偏高时,N的吸收部位为空肠和回肠上端。所有处理组中,脂肪主要消化部位是空肠和回肠,并且其一直持续到回肠末端。饲粮中Ca的浓度对淀粉的表观消化率物影响显著(P<0.05)。大部分的淀粉是在空肠的末端完成的。研究结果表明,P和N的消化部位取决于膳食Ca的浓度。增加饲粮中Ca浓度对P、N和脂肪的消化产生不利影响,但对Ca和淀粉消化无影响。

关键词：肉鸡钙消化肠段磷

*** the link between reduced reading ability and cognitive decline in older adults with acquired vision impairment:a feasibility study

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Annals of Eye Science 2019年第1期 204-204页

作者： Swaathi Balaji Karine Elalouf Andrea Urqueta-Alfaro Julie-Andrée marinier aaron Johnson Natalie Phillips Eva Kehayia m.Kathy Pichora-Fuller Walter Wittich École d'Optométrie Universitéde MontréalMontréalQCCanada Centre de recherche interdisciplinaire en réadaptation du montréal métropolitain MontrealQCCanada Department of Psychology Concordia UniversityMontréalQCCanada School of Physical and Occupational Therapy McGill UniveristyMontréalQCCanada Department of Psychology University of Toronto at MississaugaMississaugaOntarioCanada

Background:Reading enables us to obtain information,to engage in leisure,educational,business and other activities,and fosters cognitive *** vision loss can have a negative effect on an individual’s ability to read,and,by extension,reduce overall quality of *** addition,a growing body of research on the association between reading and cognition has linked a decrease in reading ability with negative changes in cognitive ***,the purpose of the current study is to test the feasibility of a research protocol that will be used to study the association between reduced reading ability and cognitive impairment,specifically in older adults with acquired vision ***:Seven participants(age range,27-60 years,mage=44,4 males)completed a series of questionnaires and assessments that measured their cognitive,hearing,and reading *** participants had normal hearing,vision and cognition,with the exception of one(two pre-existing hearing conditions).Cognition was tested using the Rey Auditory Verbal Learning Test(RAVLT),the RAVLT 50-word Recognition test,the Verbal Fluency Test,an auditory Trail-making task,and an auditory 1-N-back memory *** was used to assess ear health,and hearing was measured with self-administered computerized audiometry(Home Hearing Test)and a speech-in-noise test(Canadian Digit Triplet Test).Questionnaires included the Hearing Handicap Inventory for the Elderly,and a multiple-choice questionnaire on subjective reading ability and reading ***,reading acuity,speed and comprehension were assessed using the International Reading Speed Texts and the ***:In testing the feasibility of this protocol,the uninterrupted length of testing time,including obtaining consent,was determined to be between 60-90 *** of the assessments and tests(RAVLT,mNRead,audiogram)were reported to be mentally ***,all pilot participants were able to complete all *** the exception of s

关键词： Cognition vision impairment reading rehabilitation