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management of symptomatic neuromas:a narrative review of the most common surgical treatment modalities in amputees

Plastic and Aesthetic Research 2022年第1期9卷 120-132页

作者： Sahand C.Eftekari Peter J.Nicksic Allison J.Seitz D’Andrea T.Donnelly aaron m.dingle Samuel O.Poore Division of Plastic Surgery University of Wisconsin School of Medicine and Public HealthG5-347 Clinical Sciences CenterMadisonWI 53711USA

Symptomatic neuromas are an all-too-common complication following limb amputation or extremity trauma,leading to chronic and debilitating pain for *** resection of symptomatic neuromas has proven to be the superior method of intervention,but traditional methods of neuroma resection do not address the underlying pathophysiology leading to the formation of a future symptomatic neuroma and lead to high reoperation *** approaches employ the physiology of peripheral nerve injury to harness the regeneration of nerves to their *** review explores the underlying pathophysiology of neuroma formation and centralization of pain *** compares the traditional surgical approach for symptomatic neuroma resection and describes three novel surgical strategies that harness this pathophysiology of neuroma formation to their *** traditional resection of symptomatic neuromas is currently the standard of care for amputation patients,but new techniques including the regenerative peripheral nerve interface,targeted muscle reinnervation,and intraosseous transposition have shown promise in improving patient pain outcomes for postamputation pain and residual limb *** neuromas are a chronic and debilitating complication following amputation procedures and trauma,and the current standard of care does not address the underlying pathophysiology leading to the formation of the *** techniques are under development that may provide improved patient pain outcomes and a higher level of care for symptomatic neuroma resection.

关键词： Neuromas regenerative peripheral nerve interface targeted muscle reinnervation osseointegrated neural interface amputation

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A systematic review on embodiment and breast reconstruction:a patient-centered framework for evolving breast outcome measures

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Plastic and Aesthetic Research 2023年第1期10卷 783-796页

作者： madeline G.Chin Sahand C.Eftekari Steven P.moura D’Andrea T.Donnelly Ellen C.Shaffrey Lucas Sears aaron m.dingle Division of Plastic Surgery The Warren Alpert Medical School of Brown UniversityProvidenceRI 02903USA Division of Plastic Surgery University of Wisconsin School of Medicine and Public HealthMadisonWI 53705USA

Embodiment describes the sense of one’s own body,encompassing dimensions of being,having,and using a *** breast reconstruction,embodiment can be understood as how effectively the reconstructed breast replaces the patient’s missing *** there has been increasing attention in recent decades on understanding and measuring embodiment in the prosthetic limb,there is limited literature applying embodiment to the context of breast *** posit that the literature on prosthetic embodiment can be applied to evolving discussions on breast reconstruction outcomes and patient *** breast reconstruction techniques continue to evolve,such as advances in nerve coaptation and reinnervation of the breasts,the concept of embodiment may help broaden the scope of how patient outcomes can be more holistically *** systematic review examines existing literature on embodiment after breast reconstruction,summarizes embodiment and its subcomponents,and discusses how embodiment can be a helpful framework for the future of breast reconstruction outcome measures.

关键词： Embodiment breast reconstruction prosthetic embodiment

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Essential neural anatomy for creating a clinically translatable osseointegrated neural interface for prosthetic control in sheep

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Plastic and Aesthetic Research 2023年第1期10卷 600-614页

作者： Kirsten A.Gunderson Scott K.Odorico Zeeda H.Nkana Lucas Sears Grant Seils Rashea L.minor Weifeng Zeng Samuel O.Poore aaron m.dingle Division of Plastic Surgery University of Wisconsin School of Medicine and Public HealthMadisonWI 53792USA University of Wisconsin-madison School of Veterinary medicine MadisonWI 53706USA

Aim:Ovine models for osseointegrated prosthetics research are well established,but do not consider neural control of advanced *** validity of interfacing technologies,such as the Osseointegrated Neural Interface(ONI),in their ability to provide communication between native nerves and advanced prosthetics is required,necessitating a stable,longitudinal large animal model for *** objective of this study is to provide a detailed anatomic description of the major nerves distal to the carpal and tarsal joints,informing the creation of a chronic ONI for prosthetic control in ***:Six pelvic and six thoracic cadaveric limbs from mature female,non-lactating sheep were *** were obtained to determine average bone length,medullary canal diameter,and cortical bone *** dissection was performed to discern topographical neuroanatomy and average circumferences of the major nerves of the pelvic and thoracic *** analysis was performed.A surgical approach for the creation of ONI was ***:Average metacarpal and metatarsal length was 15.0 cm(±0.0)and 19.7 cm(±1.0),*** intramedullary canal diameter was 12.91 mm(±3.69)for forelimbs and 12.60 mm(±3.69)for *** thoracic limb nerves consisted of one dorsal and three ventral nerves,with an average circumference of 5.14 mm(±2.00)and 5.05 mm(±1.06),*** limb nerves consisted of two dorsal and one ventral nerve with an average circumference of 6.27 mm(±1.79)and 5.40 mm(±0.53),***:These anatomic data inform the surgical approach and manufacture of a sensory ONI for chronic testing in awake,freely ambulating animals for future clinical translation.

关键词： Amputation prosthesis prostheses neural interface clinical translation large animal osseointegration neuroprosthesis

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The role of estradiol in male reproductive function

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Asian Journal of Andrology 2016年第3期18卷 435-440,I0009页

作者： michael Schulster aaron m Bernie Ranjith Ramasamy Department of Urology New York-Presbyterian Hospital Weill Cornell Medical College New York USA Department of Urology Miller School of Medicine University of Miami Miami FL USA.

Traditionally, testosterone and estrogen have been considered to be male and female sex hormones, respectively. However, estradiol, the predominant form of estrogen, also plays a critical role in male sexual function. Estradiol in men is essential for modulating libido, erectile function, and spermatogenesis. Estrogen receptors, as well as aromatase, the enzyme that converts testosterone to estrogen, are abundant in brain, penis, and testis, organs important for sexual function. In the brain, estradiol synthesis is increased in areas related to sexual arousal. In addition, in the penis, estrogen receptors are found throughout the corpus cavernosum with high concentration around neurovascular bundles. Low testosterone and elevated estrogen increase the incidence of erectile dysfunction independently of one another. In the testes, spermatogenesis is modulated at every level by estrogen, starting with the hypothalamus-pituitary-gonadal axis, followed by the Leydig, Sertoli, and germ cells, and finishing with the ductal epithelium, epididymis, and mature sperm. Regulation of testicular cells by estradiol shows both an inhibitory and a stimulatory influence, indicating an intricate symphony of dose-dependent and temporally sensitive modulation. Our goal in this review is to elucidate the overall contribution of estradiol to male sexual function by looking at the hormone＇s effects on erectile function, spermatogenesis, and libido.

关键词： estrogen testosterone spermatogenesis erectile function estrogen receptor aromatase

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Experimental Analysis of Atypically Long Finned Oscillating Heat Pipe for Ventilation Waste Heat Recovery Application

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Journal of Thermal Science 2020年第3期29卷 667-675页

作者： mAHAJAN Govinda CHO Heejin SmITH aaron THOmPSON Scott m. Rheem manufacturing MontgomeryAL 36109USA Department of mechanical Engineering Mississippi State UniversityMsissippi StateMS 39762USA Department of mechanical Engineering Auburn UniversityAubumnAL 36849USA

Oscillating heat pipes(OHP)which are constructed from a serpentine-arranged capillary tube possess a desirable aerodynamic form factor and provide for relatively high heat transfer rates via cyclic evaporation and condensation of an encapsulated working fluid with no internal wicking structure *** last two decades,OHP has been extensively investigated for its potential application in thermal management of various *** study presents an experimental investigation on the heat transfer performance of an atypically long finned *** heat transfer performance of the proposed OHP was analyzed and compared with a bare tube OHP with similar overall *** show that a unit row of finned OHP filled with n-pentane with fill ratio of 70%can recover up to(400±40)W of heat from a typical waste exhaust air *** additional pressure drop due to fins was estimated to be(6.8±2)Pa resulting in an increase of 1–2 W of fan power *** average heat recovery rate via finned OHP was found to be almost 80%more than bare tube OHP filled with same working fluid with same fill ratio.

关键词： oscillating heat pipe waste heat recovery ventilation

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Cytokinin-mediated nuclear shuttling of mYB3R4 regulates cell division

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molecular Plant 2021年第5期14卷 720-721页

作者： m.Arif Ashraf aaron m.Rashotte Department of Biology University of Massachusetts AmherstAmherstMA 01003USA Department of Biological Sciences Auburn UniversityAuburnAL 36849USA

The plant hormone cytokinin,an N6-substituted adenine derivative,was first discovered by Carlos miller and Folke Skoog nearly 70 years ago as being able to promote cell *** then,there have been great advances in our understanding of cytokinin biosynthesis,perception and signaling,and expanded roles across plant growth and development(Schaller et al.,2014).However,the molecular mechanism underlying cytokinin-mediated cell division for which this hormone was first identified is still poorly *** ***-mediated nuclear import of mYB3R4.

关键词： Figure expanded mediated

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Importance of being Nernst: Synaptic activity and functional relevance in stem cell-derived neurons

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World Journal of Stem Cells 2015年第6期7卷 899-921页

作者： aaron B Bradford Patrick m mcNutt Cell/molecular Biology Branch US Army Medical Research Institute of Chemical DefenseAberdeen Proving Grounds-EAMD 21010United States

Functional synaptogenesis and network emergence are signature endpoints of neurogenesis. These behaviors provide higher-order confirmation that biochemical and cellular processes necessary for neurotransmitter release, post-synaptic detection and network propagationof neuronal activity have been properly expressed and coordinated among cells. The development of synaptic neurotransmission can therefore be considered a defining property of neurons. Although dissociated primary neuron cultures readily form functioning synapses and network behaviors in vitro, continuously cultured neurogenic cell lines have historically failed to meet these criteria. Therefore, in vitro-derived neuron models that develop synaptic transmission are critically needed for a wide array of studies, including molecular neuroscience, developmental neurogenesis, disease research and neurotoxicology. Over the last decade, neurons derived from various stem cell lines have shown varying ability to develop into functionally mature neurons. In this review, we will discuss the neurogenic potential of various stem cells populations, addressing strengths and weaknesses of each, with particular attention to the emergence of functional behaviors. We will propose methods to functionally characterize new stem cell-derived neuron(SCN) platforms to improve their reliability as physiological relevant models. Finally, we will review how synaptically active SCNs can be applied to accelerate research in a variety of areas. Ultimately, emphasizing the critical importance of synaptic activity and network responses as a marker of neuronal maturation is anticipated to result in in vitro findings that better translate to efficacious clinical treatments.

关键词： Synapses Neurotransmission In vitrotechniques Induced pluripotent stem cells Neuronalnetworks Neurogenesis Neural stem cells Embryonicstem cells Induced neurons

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Cross-talk between the thyroid and liver:A new target for nonalcoholic fatty liver disease treatment

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World Journal of Gastroenterology 2013年第45期19卷 8238-8246页

作者： Yue-Ye Huang aaron m Gusdon Shen Qu Department of Endocrinology and metabolism Shanghai 10th People’s Hospital School of Medicine Tongji University Department of Neurology and Neuroscience Weill Cornell Medical College New York NY 10065 United States Department of Endocrinology and metabolism Nanjing Medical University

Nonalcoholic fatty liver disease(NAFLD)has been recognized as the most common liver metabolic disease,and it is also a burgeoning health problem that affects one-third of adults and is associated with obesity and insulin resistance *** hormone(TH)and its receptors play a fundamental role in lipid metabolism and lipid accumulation in the *** is found that thyroid receptor and its isoforms exhibit tissue-specific expression with a variety of ***β1 is predominantly expressed in the brain and adipose tissue and TRβ2 is the major isoform in the liver,kidney and *** have different functions and play important roles in lipid ***,there are many studies on the treatment of NAFLD with TH and its *** review here that thyroid hormone and TR are a potential target for pharmacologic *** metabolism and lipid accumulation can be regulated and reversed by TH and its analogues.

关键词： Thyroid hormone Thyroid hormone receptor Nonalcoholic fatty liver disease Obesity

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Equine-assisted interventions for veterans with servicerelated health conditions: a systematic mapping review

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military medical Research 2020年第2期7卷 174-189页

作者： Adam R.Kinney aaron m.Eakman Rebecca Lassell Wendy Woo Department of Occupational Therapy Colorado State UniversityFort CollinsCO 80523USA Temple Grandin Equine Center Department of Animal SciencesColorado State UniversityFort CollinsCO 80523USA

Background:Evidence-based treatments for service-related health conditions such as posttraumatic stress disorder(PTSD),depression,and traumatic brain injury(TBI)are not effective for all ***-assisted interventions are emerging as an additional treatment modality,but little is known regarding the safe and effective delivery of these *** study aimed to describe the following features of the body of literature concerning equineassisted interventions among veterans:1)veterans who have participated in equine-assisted interventions;2)specific characteristics of equine-assisted interventions in veterans;and 3)the specific characteristics of research on equineassisted interventions in ***:We conducted a systematic mapping review of peer-reviewed literature reporting on equine-assisted interventions among veterans between 1980 and *** of nine databases yielded 3336 unique records,six of which met the inclusion criteria and were *** relevant to the study aims were extracted and ***:Equine-assisted interventions among veterans disproportionately targeted psychosocial outcomes and yielded promising *** detailed methods of EAI varied in the reported studies,ranging from communicating with the horse to mounted *** was also great diversity in outcome *** state of theoretical development regarding the mechanisms by which equine-assisted interventions benefit the veteran population is currently *** provided insufficient detail with respect to the description of the intervention,reasons for attrition,and the dose-response ***:Scientific development of equine-assisted interventions targeting psychosocial outcomes among veterans is warranted to establish their *** outcomes should be expanded,including outcomes more closely aligned with the nature of polytraumatic *** research must also emphasize the theoretical develo

关键词： Veterans Service-related injuries Equine-assisted interventions Posttraumatic stress disorder Systematic mapping review

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Critical minimum temperature limits xylogenesis and maintains treelines on the southeastern Tibetan Plateau

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Science Bulletin 2017年第11期62卷 804-812页

作者： Xiaoxia Li Eryuan Liang Jozica Gricar Sergio Rossi Katarina Cufar aaron m. Ellison Key Laboratory of Alpine Ecology and Biodiversity Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau Research Chinese Academy of Sciences Beijing 100101 China CAS Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101 China Sloven ian Forestry Institute Department of Yield and Silviculture Vecna pot 2 S1-1000 Ljubljana Slovenia University of Quebec in Chicoutimi Departement des Sciences Fondamentales 555 Boulevard de l'Universite Chicoutimi (QC) G7H2B1 Canada Key Laboratory of Vegetation Restoration and management of Degraded Ecosystems Guangdong Provincial Key Laboratory of Applied Botany South China Botanical Garden Chinese Academy of Sciences Guangzhou 510650 China University of Ljubljana Biotechnical Faculty Department of Wood Science and Technology Jamnikarjeva 101 S1-1000 Ljubljana Slovenia Harvard Forest Harvard University 324 North Main St. Petersham MA 01366 USA

Physiological and ecological mechanisms that define treelines are still debated. It has been suggested that the absence of trees above the treeline is caused by low temperatures that limit growth. Thus, we hypothesized that there is a critical minimum temperature （CTmin） preventing xylogenesis at treeline. We tested this hypothesis by examining weekly xylogenesis across three and four growing seasons in two natural Smith fir （Abies georgei var. srnithii） treeline sites on the southeastern Tibetan Plateau. Despite differences in the timing of cell differentiation among years, minimum air temperature was the dominant climatic variable associated with xylem growth; the critical minimum temperature （CTmin） for the onset and end of xylogenesis occurred at 0.7 ±0.4 ℃. A process-based modelling chronology of tree-ring formation using this CTmin was consistent with actual tree-ring data. This extremely low CTmin permits Smith fir growing at treeline to complete annual xylem production and maturation and provides both support and a mechanism for treeline formation.

关键词： Cambial activity Critical minimum temperature Timberline Xylem Vaganov-Shashldn model

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