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Quality of life assessment in patients with chronic pancreatitis receiving antioxidant therapy

World journal of Gastroenterology 2010年第32期16卷 4066-4071页

作者： Nehal S Shah Alistair j Makin aali j sheen Ajith K Siriwardena Hepatobiliary Surgery Unit Manchester Royal InfirmaryManchester M13 9WLUnited Kingdom Department of Gastroenterology Manchester Royal InfirmaryManchester M13 9WLUnited Kingdom

AIM:To undertake a baseline study comparing quality of life(QoL) in patients with chronic pancreatitis(CP) on Antox to those with CP,matched for disease duration,who were not on this ***:CP was defined according to the Zurich *** eight consecutive patients with CP who were taking Antox(antioxidants) were compared with 69 consecutive control CP patients not on *** Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core questions 30 and Pancreatic Modification(28 questions) were used to assess *** of a total of 137 patients 28 in each group were matched for disease duration(within 12 mo).Median disease duration was 8(1-22) years in the Antox group and 7(1-23) years in the Non-Antox cohort(P = NS,Mann-Whitney U-test).Other parameters(age,gender,etiology,endocrine and exocrine insufficiency) were similar between ***:Median visual analogue pain score in the Antox group was 3(0-8) compared with 6(0-8) in the Non-Antox group(P < 0.01).Perceptions of cognitive,emotional,social,physical and role function were impaired in the Non-Antox group compared to Antox patients(P < 0.0001,P = 0.0007,P = 0.0032 and P < 0.005 and P < 0.001,respectively).Analgesics and opiate usage was significantly lower in the Antox group(P < 0.01).Overall physical health and global QoL was better in the Antox group(P < 0.0001,95% CI:1.5-3).CONCLUSION:Contemporary quality of life assessments show that after correction for disease duration and cigarette smoking,patients with CP taking antox had better scores than non-antox controls.

关键词： Chronic pancreatitis Antioxidants Quality of life Assessment Management

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Non-operative management of pancreatic trauma in adults

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 605-606页

作者： Nadia Matias a Santhalingam jegatheeswaran a Vinotha Nadarajah aali j.sheen Saurabh jamdar Ajith K.Siriwardena Regional Hepato-Pancreato-Biliary Surgery Unit Manchester Royal InfirmaryOxford RoadManchester M139WLUK Department of Radiology Manchester Royal InfirmaryManchesterUK Faculty of Biology Medicine and HealthUniversity of ManchesterManchesterUK Manchester Metropolitan University ManchesterUK

To the Editor:Pancreatic trauma accounts for 0.4%-2.0%of all trauma-related injuries worldwide[1-3].The American Association for the Surgery of Trauma(AAST)categorizes pancreatic injury according to the severity[4].Pancreatic injury involving transection of the gland(grades III to V)typically requires surgical management[4].However,pancreatic trauma,especially in children and young adults,can be managed without surgery[5].This study reports the outcome of a policy of preferential non-operative management of pancreatic trauma in adults.

关键词： trauma operative Surgery

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Garlic Essential Oil Attenuates Hepatic Oxidative Stress,Inflammatory Response,and Lipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease

Garlic Essential Oil Attenuates Hepatic Oxidative Stress,Inf...

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第十四届全国中药和天然药物学术研讨会

作者： Yi-Syuan Lai Lee-Yan sheen National Taiwan University

Garlic（Allium sativum L.） is an important agricultural product,and has variety of dietary and medicinal *** study investigated the protective properties of garlic essential oil（GEO） and its major organosulfur component（diallyl disulfide,DADS） against the development of nonalcoholic fatty liver disease（NAFLD）.C57BL/6j mice were fed a normal diet or high-fat diet（HFD） with/without GEO（25,50,and 100 mg/kg） or DADS（10 and 20mg/kg） for 12 *** significantly increased glucose,insulin,FFA,triglycerides,total cholesterol,AST and ALT serum levels,hepatic triglycerides and total cholesterol levels,and liver steatosis compared to the control *** addition,moderate levels of oxidative stress and inflammation were *** the statistical analysis of metabolomics data,several key metabolites were found to be influenced by HFD *** and DADS dose-dependently exerted antiobesity and antihyperlipidemic effects by reducing HFD-induced body weight gain,adipose tissue weight and serum biochemical *** of 50,100 mg/kg GEO and 20 mg/kg DADS significantly decreased the release of pro-inflammatory cytokines in liver,accompanied by elevated antioxidant capacity via inhibition of cytochrome P450 2E1 expression during NAFLD *** anti-NAFLD effects of GEO and DADS were mediated through down-regulation of sterol regulatory element binding protein-1c,acetyl-CoA carboxylase,fatty acid synthase,and3-hydroxy-3-methylglutaryl-coenzyme A reductase,as well as stimulation of peroxisome proliferator-activated receptor alpha and carnitine *** results demonstrate that GEO and DADS dose-dependently protected obese mice with long-term HFD-induced NAFLD from lipid accumulation,inflammation,and oxidative damage by ameliorating lipid metabolic disorders and oxidative *** dose of 20 mg/kg DADS was equally effective in preventing NAFLD as 50 mg/kg GEO containing the same amount of DADS,which demonstrates that DADS

关键词： garlic essential oil diallyl disulfide nonalcoholic fatty liver disease metabolites lipid metabolism

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数字化立体成像分析用于辨别青光眼视神经病变

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世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 57-58页

作者： Morgan j.E. sheen N.j.L. North R.V. 吴琼 Cardiff University Sch. of Optom. and Vision Sciences Redwood Building Kind Edward VII Avenue Cathays Park CF10 3NB Cardiff United Kingdom Dr.

Purpose: To evaluate the diagnostic power of a novel digital stereoscopic imaging system in the diagnosis of glaucomatous optic neuropathy. Design: Prospective cross-sectional analysis of the diagnostic accuracy of digital stereoscopic optic disc analysis in the diagnosis of glaucomatous optic neuropathy exhibiting mild to moderate field loss. Participants: Fifty-two patients with open-angle glaucoma and 54 normal individuals were recruited. The presence of a reproducible visual field loss characteristic of glaucoma was used as the reference standard for the presence of glaucoma independent of the optic nerve head appearance. Patients were excluded if the optic disc, fundus, or visual field indicated other disease. One eye from each patient and individual was included in the study, the eye with the least field loss and a randomly designated normal eye, respectively. Methods: Simultaneous stereoscopic optic disc photography was performed on each specified eye. Three experienced observers viewed the resultant stereoscopic image of each nerve head using a Z screen, recorded a subjective clinical diagnosis, and undertook digital stereoscopic planimetry. Separate linear regression analysis was performed, post hoc, from the planimetric results for each observer of the logarithm of neuroretinal rim (NRR) against optic disc area derived from each normal eye. Eyes with NRR areas below the 95th prediction interval of the normal cohort were then classified as glaucomatous. Main Outcome Measures: Sensitivity and specificity for the detection of glaucomatous optic neuropathy. Results: With subjective stereoscopic analysis, sensitivity for glaucoma detection among the 3 observers was 80.8%, 76.9%, and 90.4%, with respective specificities of 94.4%, 79.6%, and 79.6%. Regression analysis of the NRR in 30°segments gave sensitivities between 69.2%and 80.8%and specificities between 83.3%and 90.7%. A combination of the subjective and quantitative analysis did not significantly improve d

关键词：立体成像视野缺损开角型青光眼视野检查视盘面积主观分析视神经乳头面积测量立体图像神经视网膜

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A Novel Urine Method for the Diagnosis of Active Tuberculosis by Immunoassay for the Detection of ESAT-6 Using Hydrogel Nanoparticles in HIV Patients

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journal of Tuberculosis Research 2021年第2期9卷 73-84页

作者： Luz Huaroto Raquel Mugruza Marinelly Roca Ricardo Antiparra César Ticona Patricia sheen Eduardo Ticona Robert H. Gillman Alessandra Luchini Lance Liotta Major National University of San Marcos Lima Peru Dos de Mayo National Hospital Lima Peru Universidad Peruana Cayetano Heredia Lima Peru johns Hopkins Bloomerg School of Public Health Baltimore USA Center for Applied Proteomic and Molecular Medicine George Mason University North Virginia USA

Background: In patients with HIV, conventional tests are of low sensitivity;therefore, a new diagnostic test with hydrogel nanoparticles with reactive blue dye is proposed, which allows the capture, conservation and concentration of ESAT-6 in urine. NIPAs are copolymers that capture low molecular weight proteins and protect against enzymatic degradation. Using an immunoassay, it is possible to detect and quantify ESAT-6 present in urine as a possible marker of active TB. Design/Methods: Study in Lima, Peru, HIV+ participants, ≥18 years with and without tuberculosis (TB). Smear microscopy, culture in solid medium and urine immunoassay were performed. The reference was the diagnosis of TB by radiological or clinical microbiological criteria (indication for TB treatment). There were 2 preanalytical processes: untreated and treated urine (centrifuged, heated), then incubation with NIPAm. After washing, elution, sonication, heat and centrifugation, the final eluate was obtained. This was placed on nitrocellulose membranes, which by means of fixation and incubation processes with anti-ESAT-6 and anti-IgG antibodies, revelation with C-DiGit® Blot Scanner and FluorChem R FR0001. Calibration curves were included in the membranes, density was measured using Image j software. ROC curves, sensitivity and specificity were obtained. Results: The result by groups was HIV+ patient: ROC: 0.75,

关键词： Tuberculosis HIV+ Hydrogel Nanoparticles and ESAT-6

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手术前给予加巴喷丁可防治骨科手术后椎管内注射吗啡引起的瘙痒

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麻醉与镇痛 2009年第5期5卷 29-33页

作者： Michael j. sheen Shung-Tai Ho Chian-Her Lee Yu-Chi Tsung Fang-Lin Chang 邱必军(译) 王振猛(校) 俞卫锋(校) Departments of Anesthesiology and Orthopedic Surgery Tri-Service General Hospital National Defense Medical Center Taipei Taiwan 不详

背景瘙痒是椎管内注射吗啡后最常见的副作用。据报道加巴喷丁做为一种抗惊厥药物可以改善一些慢性瘙痒的症状，但关于加巴喷丁对椎管内注射吗啡；1起瘙痒的作用还没有研究。方法将86例腰麻下择期行下肢手术的患者随机分为相同的两组，... 详细信息

背景瘙痒是椎管内注射吗啡后最常见的副作用。据报道加巴喷丁做为一种抗惊厥药物可以改善一些慢性瘙痒的症状，但关于加巴喷丁对椎管内注射吗啡；1起瘙痒的作用还没有研究。方法将86例腰麻下择期行下肢手术的患者随机分为相同的两组，分别在手术前2小时服用1200mg加巴喷丁和安慰剂，进行前瞻、双盲研究。所有患者均予椎管内注射0．5％等比重的布比卡因15mg和不含防腐剂的吗啡0．2mg。椎管内注射吗啡后3、6、9、12和24小时评估瘙痒情况。结果与加巴喷丁组相比，对照组瘙痒的发生率显著增高（77．5％与47．5％；P=0．01）；与对照组（3．1±0．8小时）相比，加巴喷丁组（6．2±1．8小时）瘙痒的起始时间显著延迟（P〈0．0001）；与加巴喷丁组相比，对照组在椎管内注射吗啡后3小时和6小时的瘙痒程度更重。结论腰麻下行下肢手术的患者手术前给予加巴喷丁可以防治椎管内注射吗啡引起的瘙痒。

关键词：椎管内注射加巴喷丁手术前骨科手术后瘙痒吗啡防治下肢手术

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春玉米密植定额和种植方式研究

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作物学报 1964年第3期 229-245页

作者：许章全黄炳生沈仲茂江苏省淮阴专区农业科学研究所

本文综合分析了淮阴地区历年来有关春玉米密植定额和种植方式的试验资料。在密植定额问题上,研究了密度与产量、品种、生产水平间的关系,并从田间小气候、植株生长发育、光能利用、群体与个体关系等方面探索了密植增产的原因;在种植方... 详细信息

本文综合分析了淮阴地区历年来有关春玉米密植定额和种植方式的试验资料。在密植定额问题上,研究了密度与产量、品种、生产水平间的关系,并从田间小气候、植株生长发育、光能利用、群体与个体关系等方面探索了密植增产的原因;在种植方式问题上,比较了不同生产水平和不同密度下,宽窄行和等行距的效果,并从根系发育、植株性状、田间小气候、光能利用等方面分析了宽窄行减产的原因。

关键词：玉米窄行等行距宽窄行种植生物产量杂交种杂交品种籽粒产量种植方式栽培方式净同化率光合生产率叶面积指数叶面积系数每穗粒数光合势密度个体生产力玉米产量

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水平及垂直英文文本阅读中的眼动控制

水平及垂直英文文本阅读中的眼动控制

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第二十届全国心理学学术会议--心理学与国民心理健康

作者：李莎 Maryam A.Al jassmi Kayleigh L.Warrington Sarah j.White Mercedes sheen Timothy R.jordan Kevin B.Paterson 王敬欣天津师范大学心理与行为研究院扎耶德大学莱斯特大学

在英文阅读中,文本通常是从左到右水平排列,并且对这种水平排列文本阅读的眼动控制已经有较好的了解。但是,在现实生活中英文文本有时候会以垂直排列的方式呈现。已有的研究表明,垂直呈现条件下文本的阅读速度要显著慢于水平呈现条件,... 详细信息

在英文阅读中,文本通常是从左到右水平排列,并且对这种水平排列文本阅读的眼动控制已经有较好的了解。但是,在现实生活中英文文本有时候会以垂直排列的方式呈现。已有的研究表明,垂直呈现条件下文本的阅读速度要显著慢于水平呈现条件,但是这种阅读速度的降低到底是由于词汇识别过程受损还是眼跳目标选择所致目前却还不清楚。因此,本研究通过两个实验,分别控制句子中目标词的词长(长词:10字母词;短词:4字母词)和词频(高频词和低频词),考查不同文本阅读方向对英文阅读眼动控制的影响。实验过程中,要求读者阅读四种呈现方式的文本:正?K匠氏帧⑺呈闭胄呈现、逆时针旋转90°呈现以及每个字母垂直排列呈现,并记录他们阅读中的眼动。与前人的研究结果一致,本研究发现垂直呈现条件下文本的阅读速度慢于水平呈现条件。另外,在所有呈现方式上都发现了稳定的词长效应(对短词的加工快于对长词的加工)以及词频效应(对高频词的加工快于对低频词的加工),并且垂直呈现条件下的词长效应以及词频效应都显著大于水平阅读条件。表明,垂直呈现条件下文本的词汇识别过程受损。而对注视位置的分析发现,文本呈现方向并不影响对目标词的首次注视位置。表明,垂直文本阅读中的眼跳目标选择并为受损。本研究对阅读的眼动控制模型的完善有重要意义。

关键词：眼动垂直阅读词长效应词频效应

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Nanostructured fibers as a versatile photonic platform: radiative cooling and waveguiding through transverse Anderson localization

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Light(Science & Applications) 2018年第1期7卷 690-698页

作者： Norman Nan Shi Cheng-Chia Tsai Michael j.Carter jyotirmoy Mandal Adam C.Overvig Matthew Y.Sfeir Ming Lu Catherine L.Craig Gary D.Bernard Yuan Yang Nanfang Yu Department of Applied Physics and Applied Mathematics Columbia UniversityNew YorkNY 10027USA Center for Functional Nanomaterials Brookhaven National LaboratoryUptonNY 11973USA Museum of Comparative Zoology Harvard UniversityCambridgeMA 02138USA Department of Electrical Engineering University of WashingtonSeattleWA 98195USA

Broadband high reflectance in nature is often the result of randomly,three-dimensionally structured *** study explores unique optical properties associated with one-dimensional nanostructures discovered in silk cocoon fibers of the comet moth,Argema *** fibers are populated with a high density of air voids randomly distributed across the fiber cross-section but are invariant along the *** filamentary air voids strongly scatter light in the solar spectrum.A single silk fiber measuring~50μm thick can reflect 66%of incoming solar radiation,and this,together with the fibers’high emissivity of 0.88 in the mid-infrared range,allows the cocoon to act as an efficient radiative-cooling *** inspiration from these natural radiative-cooling fibers,biomimetic nanostructured fibers based on both regenerated silk fibroin and polyvinylidene difluoride are fabricated through wet *** characterization shows that these fibers exhibit exceptional optical properties for radiative-cooling applications:nanostructured regenerated silk fibers provide a solar reflectivity of 0.73 and a thermal emissivity of 0.90,and nanostructured polyvinylidene difluoride fibers provide a solar reflectivity of 0.93 and a thermal emissivity of *** filamentary air voids lead to highly directional scattering,giving the fibers a highly reflective sheen,but more interestingly,they enable guided optical modes to propagate along the fibers through transverse Anderson *** discovery opens up the possibility of using wild silkmoth fibers as a biocompatible and bioresorbable material for optical signal and image transport.

关键词： fibers radiative transverse

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