Garlic Essential Oil Attenuates Hepatic Oxidative Stress,Inflammatory Response,and Lipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease
作者单位：National Taiwan University
会议名称：《第十四届全国中药和天然药物学术研讨会》
会议日期：2014年
学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学]
关 键 词：garlic essential oil diallyl disulfide nonalcoholic fatty liver disease metabolites lipid metabolism
摘 要：Garlic（Allium sativum L.） is an important agricultural product,and has variety of dietary and medicinal *** study investigated the protective properties of garlic essential oil（GEO） and its major organosulfur component（diallyl disulfide,DADS） against the development of nonalcoholic fatty liver disease（NAFLD）.C57BL/6J mice were fed a normal diet or high-fat diet（HFD） with/without GEO（25,50,and 100 mg/kg） or DADS（10 and 20mg/kg） for 12 *** significantly increased glucose,insulin,FFA,triglycerides,total cholesterol,AST and ALT serum levels,hepatic triglycerides and total cholesterol levels,and liver steatosis compared to the control *** addition,moderate levels of oxidative stress and inflammation were *** the statistical analysis of metabolomics data,several key metabolites were found to be influenced by HFD *** and DADS dose-dependently exerted antiobesity and antihyperlipidemic effects by reducing HFD-induced body weight gain,adipose tissue weight and serum biochemical *** of 50,100 mg/kg GEO and 20 mg/kg DADS significantly decreased the release of pro-inflammatory cytokines in liver,accompanied by elevated antioxidant capacity via inhibition of cytochrome P450 2E1 expression during NAFLD *** anti-NAFLD effects of GEO and DADS were mediated through down-regulation of sterol regulatory element binding protein-1c,acetyl-CoA carboxylase,fatty acid synthase,and3-hydroxy-3-methylglutaryl-coenzyme A reductase,as well as stimulation of peroxisome proliferator-activated receptor alpha and carnitine *** results demonstrate that GEO and DADS dose-dependently protected obese mice with long-term HFD-induced NAFLD from lipid accumulation,inflammation,and oxidative damage by ameliorating lipid metabolic disorders and oxidative *** dose of 20 mg/kg DADS was equally effective in preventing NAFLD as 50 mg/kg GEO containing the same amount of DADS,which demonstrates that DADS