检索结果-南通市图书馆

Asian Pacific Journal of Tropical Medicine 2010年第11期3卷 866-870页

作者： N Mirzaie Damabi aa.Moazedi SM Seyyednejad School of Science Department of BiologyShahid Chamran UniversityAhwazIran School of Science Department of Biology Shahid Chamran University Ahwaz Iran

Objective:To investigate Petroselinum crispum Latifolum(parsley) for treating stomach and intestinal disorders in ***:An 80%ethanol extract was prepared from parsley seeds, and its antispasmodic activity assessed by measuring contractions of isolated ilea induced by 60 mM potassium chloride(KG).A piece of ileum from an adult male Wistar rat was dissected and mounted in an organ bath containing Tyrode’s solution,and ileum contractions were recorded by an isotonic transducer under one gram resting *** effect of parsley extract was measured in the presence of two antagonists’ of a - and(***:These experiments showed that parsley extract inhibited the response to 60 mM KC1 in a concentration-dependent manner(P<0.01,n=7).The spasmolytic effect of parsley extract was unaffected by 1μM phentolamine or 1μM ***:This study shows that parsley seed extract is a relaxant of isolated rat ileum and the relaxation effect of extract does not involved adrenergic receptors.

关键词： Petroselinum crispum Latifolum Adrenergic receptors Relaxation Ileum

Surface modified solid lipid microparticles based on homolipids and Softisan 142:preliminary characterization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2010年第3期3卷 205-210页

作者： Nnamani PO Ibezim EC Attama aa.Adikwu MU Drug Delivery Research Unit Department of PharmaceuticsFaculty of Pharmaceutical SciencesUniversity of Nigeria ICS-UNIDO International Center for High Technology and New Materials AREA Science Park Science and Technology Education Post-Basic(STEP-B) Abuja Nigeria

ObjectiveTo preliminarily investigate three different lipid matrices consisting of two natural homolipids from Capra hircus (goat fat) and Bovine Spp. (tallow fat) and one semi-synthetic lipid (Softisan? 142) separately structured with Phospholipon? 90G (P90G) as potential delivery systems for poorly water soluble drugs.MethodsThe structured lipid matrices were characterized by differential scanning calorimetry (DSC) and employed to prepare solid lipid microparticles (SLMs) by the melt homogenization method using gradient concentrations of polysorbate 80 and at different emulsification times of 2, 5 and 10 min using a Silverson mixer. The SLMs were analyzed for morphology and particle size, thermal properties, stability studies and determination of injectability.ResultsThe results showed that SLM production was optimum at 5 % of lipid matrices, 1.5 % of polysorbate 80 and emulsification time of 5 min. Increase in polysorbate 80 concentrations decreased the particle size of the SLMs. The SLMs were well formed, spherical, smooth and non-porous with particle sizes in the ranges of (13.90 ± 2.10) μm - (0.09 ± 0.01) μm for SLMs produced from the structured - tallow fat; (13.40 ± 1.30) μm - (0.10 ± 0.01) μm for the structured - goat fat and (13.40±2.00) μm - (2.10± 1.00)μm for the structured Softisan? 142 lipid matrices. DSC traces showed that Softisan? 142 was the most crystalline of all three bulk matrices due to its high enthalpy (?7.962 mW/mg) while tallow fat was the least (?5.067 mW/mg) but addition of P90G to the matrices lowered their enthalpies mostly in the structured goat fat matrices. The SLMs when stored at 4-6 ° were most stable and syringeable with 27 G needle.ConclusionsThis suggests that structured goat fat matrices with the enthalpy of ?2.813 mW/mg will mostly favour drug loading of some poorly soluble drugs more than tallow fat (?4.892 mW/mg) and Softisan? 142 (?5.501 mW/mg).

关键词： Phospholipon? 90G Solid lipid microparticle Goat fat tallow fat Softisan? 142 Characterization

Atypical pathogens in community acquired pneumonia of Egyptian children

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2009年第2期2卷 1-8页

作者： Deraz TE El Sahriggy SA Shaheen MA Motawea aa.Gomaa.HE Fawzy SH Mohamed aa Pediatric Department Ain Shams Faculty of Medicine Pediatric Department National Research Center Clinical Pathology Department National Research Center Microbiology Department Ain Shams Faculty of Medicine Cairo 11371 Egypt

Objective:Diagnosis of atypical pathogens as an aetiology for community-acquired pneumonia(CAP) in children is a challenge world *** aim of this study was to detect the frequency of atypical pathogens as a cause of community-acquired pneumonia(CAP) in Egyptian ***:From 50 children(with age ranged from 2 months to 12 years) hospitalized for community-acquired pneumonia;respiratory sputum samples were collected by induction or *** samples were subjected to conventional cultures and Polymerase Chain Reaction(PCR) technique DNA extraction for identification of Mycoplasma,Chlamydia pneumoniae and Legionella ***;A definite pathogen was identified in 78%of the studied children;30% typical bacteria,8%Candida albicans and atypical bacteria in 40%of the pneumonic *** pneumoniae was isolated from 26%of the children while Mycoplasma pneumoniae was isolated from 14%, whereas Legionella pneumophilla was not isolated at ***;Atypical pathogens are evident as a potential aetiology for community-acquired pneumonia in(13.3%) of young and(80%) of older Egyptian children.

关键词： Atypical pathogens Community-acquired pneumonia Children Egypt

Plasma antioxidant capacity, sexual and thyroid hormones levels, sperm quantity and quality parameters in stressed male rats received nano-particle of selenium

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian pacific Journal of Reproduction 2017年第1期6卷 32-37页

作者： Rezaeian-tabrizi M Sadeghi aa Department of Animal Science Science and Research BranchIslamic Azad UniversityTehranIran

Objective:To evaluate the effects of nano-particle of selenium (nSe) on plasma antioxidant capacity, sexual and thyroid hormones and spermatogenesis in male rats exposed to oxidative ***:Forty rats were randomly divided into four treatments with ten replicates. Treatment groups were: C, the control group received normal saline as gavage and injection (i.p.);OS, received tert-butyl hydroperoxide (0.2 mmol/kg body weight) for inducing oxidative stress;nSe, received nSe (0.3 mg/kg body weight) as gavage, and OS+nSe, received tert-butyl hydroperoxide and nSe. All groups were treated for 28 d and administrations were done each 48 ***:Oxidative stress decreased and gavage of nSe to stressed rats increased the antioxidant capacity and activities (P0.05) between rats exposed to oxidative stress and those in the control group for sperm quantity and quality. Gavage of nSe to stressed rats had no effect (P>0.05) on the sperm parameters, except increased viability and progressive ***:Nano-particle of Selenium administration in stressed rats could ameliorate the negative effects of oxidative stress on the antioxidant capacity and activities, but not on the quantity and quality parameters of sperm.

关键词： Antioxidant capacity Oxidative stress Nano-selenium Sperm parameters Hormone Rat

Hospital-based care for people living with HIV/AIDS in Ibadan,South Western Nigeria

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2009年第2期2卷 68-71页

作者： Olwookere SA Fatiregun aa.Fayemi AF Department of Medicine State HospitalAsubiaroOsogboNigeria Department of Epidemiology Medical Statistics and Environmental HealthFaculty of Public HealthCollege of MedicineUniversity of IbadanIbadanNigeria Department of Medicine University College HospitalIbadanNigeria

Objective:To describe the pattern of admission-defining ailments and outcomes of care among people living with human immunodeficiency virus(HIV) /acquired immune deficiency syndrome(AIDS)(PLWHA) who presented for treatment at a tertiary health care institution in ***:We reviewed the hospital records of all patients admitted for AIDS and AIDS-related illnesses at the University College Hospital,Ibadan, Nigeria,from January 2005 to January ***:Seventy-two PLWHA were admitted during the study *** were 39 females(54.2%) and 33(45.8%) ***-seven(95%) PLWHA presented with *** 12(17%) were already receiving highly active antiretroviral therapy before *** -three patients(60%) commenced antiretroviral(ARV) therapy on ***-three patients(46%) had pulmonary tuberculosis,10(14%) had extrapulmonary tuberculosis,21(29.1%) had diarrhoea-related illnesses,20(28%) had anaemia,and nine(12.5%) presented with ***-nine patients(40.3%) were discharged home,and 43(59.7%) died before ***-nine patients(95.6%) were judged to be indigent,and required financial *** contributory causes of death included pulmonary tuberculosis in 21(48.8%),diarrhoeal diseases in five(11.6%),anaemia in five(11.6%),coma in nine(20.9%), and pneumonia in three(7.1%).Conclusion:Tuberculosis was the major admission-defining ailment among PLWHA.

关键词： Hospital Care Tuberculosis PLWHA

Small-scale outbreak of measles in the Irewole local government area of Osun State in Nigeria

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2009年第6期2卷 33-36页

作者： Fatiregun aa.Olowookere SA Abubakar O Aderibigbe A Department of Epidemiology Medical Statistics and Environmental HealthFaculty of Public HealthCollege of MedicineUniversity of IbadanIbadan Osun State Hospital Management Board State Hospital AsubiaroOsogbo Osun State Ministry of Health Epidemiology UnitAbereOsogbo Department of Primary Health Care Disease Surveillance UnitIrewole Local Government AreaIkire

Objective:An investigation of an outbreak of measles in a district in Nigeria was initiated following confirmation of the *** objectives of the study were to assess the size and determine the cause of the outbreak. Methods:Visits were made to health facilities and affected *** were line-listed using specified forms and descriptive epidemiology carried out on collected ***:A total of 18 cases and 0 deaths were identified over a period of six *** of the cases(11%) were < 9 months of *** proportion of zero-dose children was 39%.Conclusion:Low herd immunity was suggested as the cause of the outbreak.

关键词： Measles Measles outbreak Outbreak investigation Nigeria

达立通颗粒主要活性成分在正常及功能性消化不良模型大鼠胃肠道组织中差异分布研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

药物评价研究 2024年第5期47卷 1017-1029页

作者：苏艳康安赵岩王晓霞邝振英盛先杰王广基阿基业南京中医药大学药学院江苏南京210023 南昌弘益药业有限公司江西南昌330096 中国药科大学江苏省药物代谢动力学重点实验室江苏南京210009

目的研究达立通颗粒主要活性成分在正常和功能性消化不良(FD)模型大鼠胃肠道组织中的分布差异。方法采用夹尾刺激结合不规律饮食双因素干预方法建立FD模型。12只大鼠(对照、模型各6只)用于FD模型验证,进行胃、小肠排空实验,HE染色后进... 详细信息

目的研究达立通颗粒主要活性成分在正常和功能性消化不良(FD)模型大鼠胃肠道组织中的分布差异。方法采用夹尾刺激结合不规律饮食双因素干预方法建立FD模型。12只大鼠(对照、模型各6只)用于FD模型验证,进行胃、小肠排空实验,HE染色后进行胃肠组织病理学观察;36只大鼠(对照、模型各18只)用于胃肠道组织差异分布研究,禁食不禁水18 h,按22.4 g‧kg^(−1)剂量(8倍临床等效剂量)ig给予达立通颗粒1次,于给药后1、3、6 h收集各组大鼠的胃、十二指肠、空肠、回肠和结肠。应用超高效液相色谱-串联四级杆/线性离子阱质谱(UPLC-QTRAP-MS/MS)法检测各组织牡荆素-4''-O-葡糖苷、原阿片碱、黄连碱、小檗碱、甜橙黄酮、川陈皮素、桔皮素、去甲基川陈皮素、木香烃内酯、去氢木香内酯、原儿茶酸、伞形花内酯、木犀草苷、橙皮苷、木犀草素、柚皮素、橙皮素、白杨素含量,采用ACQUITY HPLCTM HSS T3(50 mm×2.1 mm,1.8μm)色谱柱,柱温为40℃,0.1%甲酸水-乙腈为流动相,梯度洗脱,体积流量为0.3 mL‧min^(−1),进样量为2μL。结果与对照组比较,模型组大鼠体质量显著降低(P<0.001),胃、小肠排空率显著降低(P<0.001),十二指肠肠黏膜的紧密连接被破坏,但未出现胃肠组织的器质性病变,符合FD的病理特征。建立的UPLC-QTRAP-MS/MS方法中,各化合物线性关系良好,R^(2)≥0.9900。对建立的检测方法进行专属性、精密度与准确度、提取回收率、稳定性和基质效应等方面的考察,均符合要求。各成分在对照和模型组大鼠胃肠道组织中浓度差异明显,且在各组织中达到最高浓度的时间点差异较大,模型组出现达峰时间延后的现象;与对照组比较,模型组大鼠胃组织中化合物的暴露水平降低,可能与FD引起胃肠道蠕动减慢有关。橙皮苷、橙皮素、柚皮素、原儿茶酸、去氢木香内酯、川陈皮素、去甲基川陈皮素、小檗碱和桔皮素在胃、十二指肠、空肠、回肠和结肠中暴露水平较高,且在对照组和模型组中各时间点下的浓度差异较显著。结论经方法学验证,所建立的UPLC-QTRAP-MS/MS法灵敏、专属性强、准确性高,适用于大鼠胃肠道组织中达立通颗粒主要活性成分的胃肠组织分布研究。达立通颗粒主要活性成分在正常和FD模型大鼠胃肠组织分布具有显著性差异。

关键词：达立通颗粒功能性消化不良 UPLC-QTRAP-MS/MS 橙皮苷橙皮素柚皮素原儿茶酸去氢木香内酯川陈皮素去甲基川陈皮素小檗碱桔皮素

Anti-ulcer potentials of phylum mollusca(tropical snail)slime

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2009年第3期2卷 23-28页

作者： Nwodo NJ Okonta J M Ezugwu CO Attama aa Faculty of Pharmaceutical Sciences University of NigeriaNsukka410001Enugu State

Objective:The effectiveness of the slimy substance in snail to regenerate and repair damaged areas on it body/shell lead to this ***:The anti-ulcer’property of snail slime extracted from phylur mollusca(tropical snail) from the giant African snail Archachatina marginata(***) was investi gated using histamine,stress and indomethacin-induced *** solubility profile of extract was investiga ted in different solvents and at different *** analysis was carried out to determine the type of constituents present in the slim,while acute toxicity test was carried out to evaluate its profile of toxicity The effect of the snail slim on gastrointestinal motility was investigated in mice,while the guinea pig ileum wa used to study the effect of the extract on contraction produced by acetylcholine and *** snail slim contained copious quantity of protein,with varying amounts of simple sugars,carbohydrates and *** slime was not soluble in most common solvents and increases in temperature,did not appear to increase its sol ***:The result further indicated that although the snail slime exhibited significant(Ptamine,it was most potent against ulcer induced by *** snai slime potently inhibited gastrointestinal movement in mice in a dose-dependent manner;however,it was not a ble to inhibit contraction induced by acetylcholine and histamine in guinea pig ***:The snai mucin possesses potent antiulcer properties without any toxic *** mechanism responsible for the anti-ul cer property may not be postulated with certainty but cytoprotective and anti-spasmodic activities are most likel to be involved.

关键词： Anti-ulcer activity Phylum moliusca Snail slime

Burden and outcome of human influenza in a tertiary care hospital of Bangladesh

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2011年第6期4卷 478-481页

作者： Rasul CH Bakar MA Mamun aa.Siraz MS Zaman RU Department of Paediatrics Khulna Medical College & HospitalKhulnaBangladesh Department of Medicine Khulna Medical College & HospitalKhulnaBangladesh International Center for Diarrhoeal Disease Research Bangladesh

Objective:To determine the magnitude and outcome of influenza in southern part of Bangladesh and also to identify intrusion of novel influenza ***:This study was conducted for two years(2008-2009) in outpatient and inpatient department of both paediatrics and medicine discipline of Khulna Medical College *** and throat swab specimens were collected from each influenza like illness(ILI) case and kept together in a virus transport media and transported to international centre for diarrhoeal disease and research,Bangladesh laboratory. Influenza virus was detected by rRT-PCR including types and ***:A total of 526 patients were enrolled during the study period with the mean(SD) age of 19(17) years. Identification of influenza virus was 14%and positive cases were mostly found in under-five children(24%).The vast majority(88%) of influenza cases were found during April to September. Virus detection rate was higher in inpatient department(IPD)(21%) than in outpatient department (12%).The dominant virus type and subtype was influenza A(87%) and H3(49%),respectively. Type A was significantly higher than type B in causing severe illness compared to ILI(0R=7.04, 95%CI:2.76-18.7,Ptalized cases majority(77%) recovered completely except two cases that needed referral for additional ***: Influenza mostly affected under-five children and young *** peak season here was late summer and rainy season.

关键词： Influenza Burden Outcome Bangladesh

Thermal characterisation of PEGylated mucin

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Medicine 2010年第6期3卷 458-460页

作者： Momoh MA Adikwu MU Ibezim CE Ofokansi KC Attama aa Department of Pharmaceutics University Nigeria of NsukkaEnugu State

Objective:To investigate the characteristics of PEGylated mucin and its potential usage. Methods:Mucin was extracted from giant African land snails and PECylated mucin was prepared with different ratios of PEG 2000-Mwt and mucin（1:1,0:1,2:1,1:3 and 3:1 to form batch A-E） using solvent *** physicochemical properties of mucin were identified and the solubility of mucin was *** thermal properties of PEGylated mucin were measured by differential scanning calorimetry（DSC）.Results:Carbohydrates,proteins and trace amounts of fats were present in snail *** mucin powder was water-soluble at 30℃and more water-soluble at 35℃but not soluble;in acetone,ethanol,0.1 M NaOH,0.1M H2SO4 and 0.1 NH4OH was *** melting point Tm ranged from 58.58℃to 61.17℃, crystallization temperature Tc 37.08℃to 39.83℃,and glass transition temperature Tg 126.85℃to 138.39℃.The variation in Tm,Tc,and Tg with the composition in the PEGylaton showed that an interaction between PEG and mucin ***:This result can serve as a basis for further evaluation of the PEGylation method and be used for drug delivery.

关键词： PEGylation Mucin Matrices DSC