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Nonlinear gallium phosphide nanoscale photonics[Invited]

Photonics Research 2018年第5期6卷 I0068-I0074页

作者： aude martin SYLVAIN COMBRIE ALFREDO DE ROSSI GREGOIRE BEAUDOIN ISABELLE SAGNES FABRICE RAINERI Centre de Nanosciences et de Nanotechnologies CNRSUniversite Paris-SudUniversite Pans-SaclayC2N Marcoussis91460 MarcoussisFrance Thales Research and Technology France 1 avenue Augustin Fresnel91120 PalaiseauFrance Universite Paris Diderot Sorbone Paris Cite75013 ParisFrance

We introduce a nanoscale photonic platform based on gallium phosphide. Owing to the favorable material properties, peak power intensity levels of 50 GW∕cm^2 are safely reached in a suspended membrane. Consequently,the field enhancement is exploited to a far greater extent to achieve efficient and strong light–matter *** an example, parametric interactions are shown to reach a deeply nonlinear regime, revealing cascaded fourwave mixing leading to comb generation and high-order soliton dynamics.

关键词： Invited Nonlinear gallium phosphide nanoscale photonics

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Ballistic tests on hot-rolled Ti-6Al-4V plates:Experiments and numerical approaches

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Defence Technology（防务技术） 2023年第8期26卷 39-53页

作者： Alexander Janda Benjamin James Ralph Yael Demarty Marcel Sorger Stefan Ebenbauer aude Prestl Ingo Siller martin Stockinger Helmut Clemens Department of Materials Science Montanuniversitat LeobenFranz Josef-Straße 188700 LeobenAustria Department Product Engineering Montanuniversitat LeobenFranz Josef-Straße 188700 LeobenAustria French-German Research Institute of Saint-Louis 5 Rue du General Cassagnou68300 Saint-LouisFrance voestalpine BOEHLER Bleche GmbH&Co KG Boehler-Gasse 18680MürzzuschlagAustria

Superior ballistic performance and the lightweight character of Ti alloys are considered as main reasons for their use in armour applications against a broad spectrum of ballistic threats,***,fragment or blast *** dynamic loading caused by typical penetrators is characterized by high strain rates,only specific test methods allow a closer investigation of the respective material *** the present study,quasi-static and dynamic compression tests as well as ballistic tests were conducted on a twophase a+βalloy Ti-6Al-4V(in m%)manufactured by ***-deformation heat treatments,influencing microstructure and mechanical properties were applied in order to compare three different microstructural configurations:as-rolled,mill-annealed and ***,on the one hand,ballistic tests were employed for the determination of the ballistic limit velocity v_(50),compression tests,on the other hand,delivered essential input parameters for the application of the Johnson-Cook constitutive model in a finite element simulation of the impact *** comparison of experimental results to simulation results was supplemented by means of microstructural characterization of tested samples with the focus set on the prevalently observed deformation and damage mechanisms,as for example adiabatic shearing.

关键词： Ti-6Al-4V Ballistic performance Split Hopkinson pressure bar FE simulation Adiabatic shear bands Intermetallic phase

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Complications of Peripartum Cardiomyopathy at the Departmental University Hospital Teaching of Borgou (Benin) in 2022: About 3 Cases

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World Journal of Cardiovascular Diseases 2022年第11期12卷 514-526页

作者： Léopold Houétondji Codjo Serge Hugues Mahougnon Dohou Sèdjro Raoul Atade Fabrice Atika Hamondji Nicolas Amegan Chabi Olaniran Alphonse Biaou Kayivi Murielle Hounkponou Djidjoho Arnaud Sonou Mahouna Philippe Adjagba Marielle Dorine Soude Dominique Sacca Mèdéssè Rolande Quenum aude Sourou Bodjrenou martin Dèdonougbo Houenassi Cardiology Teaching and Research Unit (CNHU-HKM) Faculty of Health Sciences University of Abomey Calavi Cotonou Benin Teaching and Research Unit in Cardiology (CHUD-B/A) Faculty of Medicine University of Parakou Parakou Benin Teaching and Research Department of Gynecology and Obstetric (CHUD-B/A) Faculty of Medicine University of Parakou Parakou Benin Doctoral School of Health Sciences University of Abomey Calavi Cotonou Benin Regional Institute of Public Health University of Abomey Calavi Cotonou Benin Cardiology Teaching and 6 Research Unit (CHU-MEL) Faculty of Health Sciences University of Abomey Calavi Cotonou Benin Cardiology Department of Atacora-Donga Department Hospital Center (CHD-A/D) Natitingou Benin Teaching and Research Unit in Cardiology Faculty of Medicine (CHU-OP) University of Abomey Calavi Cotonou Benin

Introduction: Peripartum cardiomyopathy (PPCM) is a dilated cardiomyopathy occurring in the last month of pregnancy or the first five months postpartum without pre-existing cardiovascular pathology. It is a major cause of pregnancy-related heart failure with high morbidity and mortality. In severe forms (10% to 15% of cases), thrombo-embolic complications are the main cause. The initial hemodynamic evolution is totally unpredictable and sometimes extremely brutal and fatal. The objective of this work was to show the often pejorative evolution of PPCM in our country. Methods: We report in this work three serious clinical cases revealing the complications of this PPCM among patients admitted to the cardiology department of the CHUD-B/A in 2022 for heart failure. The data were collected according to the Declaration of Helsinki. Patients and Observations: The first case was a PPCM with severe left ventricular (LV) systolic dysfunction complicated by spontaneous left intraventricular contrast and right superficial sylvian ischemic stroke. The second case reports a global cardiac decompensation of a PPCM with severe LV systolic dysfunction complicated by an apical thrombus. The third case is that of a state of cardiogenic shock complicating a PPCM with severe LV systolic dysfunction. Among our 03 patients presenting these severe forms of PPCM, the evolution, in spite of the symptomatic and prognostic treatments of the heart failure, and even of the complications, was unfavourable with death in two of them. Conclusion: Complications of PPCM are frequent and fatal in Benin.

关键词： Cardiomyopathy Peripartum Complications Parakou Benin

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Satellite Remote Sensing of Savannas:Current Status and Emerging Opportunities

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Journal of Remote Sensing 2022年第1期2022卷 162-181页

作者： Abdulhakim M.Abdi martin Brandt Christin Abel Rasmus Fensholt Department of Geosciences and Natural Resource Management University of CopenhagenCopenhagenDenmark Centre for Environmental and Climate Science Lund UniversityLundSweden

Savannas cover a wide climatic gradient across large portions of the Earth’s land surface and are an important component of the terrestrial *** have been undergoing changes that alter the composition and structure of their vegetation such as the encroachment of woody vegetation and increasing land-use *** the spatial and temporal dynamics of savanna ecosystem structure(e.g.,partitioning woody and herbaceous vegetation)and function(e.g.,aboveground biomass)is of high *** challenges include misclassification of savannas as forests at the mesic end of their range,disentangling the contribution of woody and herbaceous vegetation to aboveground biomass,and quantifying and mapping fuel ***,we review current(2010–present)research in the application of satellite remote sensing in savannas at regional and global *** identify emerging opportunities in satellite remote sensing that can help overcome existing *** provide recommendations on how these opportunities can be leveraged,specifically(1)the development of a conceptual framework that leads to a consistent definition of savannas in remote sensing;(2)improving mapping of savannas to include ecologically relevant information such as soil properties and fire activity;(3)exploiting high-resolution imagery provided by nanosatellites to better understand the role of landscape structure in ecosystem functioning;and(4)using novel approaches from artificial intelligence and machine learning in combination with multisource satellite observations,e.g.,multi-/hyperspectral,synthetic aperture radar(SAR),and light detection and ranging(lidar),and data on plant traits to infer potentially new relationships between biotic and abiotic components of savannas that can be either proven or disproven with targeted field experiments.

关键词： structure Remote lidar

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通过“生活实验室”和多中心治理设计韧性水景

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景观设计学（中英文） 2019年第3期7卷 12-31页

作者：奥德·赞格拉夫-哈梅德朱丽叶·马丁格尔德·鲁普乔安妮·林内鲁斯-拜耳史蒂文·鲍莱特李慧彦(译) 田晓劼(译) 德国慕尼黑工业大学策略性景观规划与管理系法国图尔大学人文科学学院国际应用系统分析研究所(IIASA) 不详

多中心治理和"生活实验室"概念均基于去中心化的参与式规划、协同设计和决策而建立。尽管"生活实验室"的概念在近几年才刚刚兴起,但于2000~2011年施行的伊萨河计划既已对其进行了开拓性探索。该计划沿德国慕尼黑市伊萨河对多种基于自然... 详细信息

多中心治理和"生活实验室"概念均基于去中心化的参与式规划、协同设计和决策而建立。尽管"生活实验室"的概念在近几年才刚刚兴起,但于2000~2011年施行的伊萨河计划既已对其进行了开拓性探索。该计划沿德国慕尼黑市伊萨河对多种基于自然的解决方案进行了选择、协同设计并予以实施。虽然多个管理部门参与了伊萨河计划的决策过程,但时至今日尚缺乏对促成该项目的多中心治理的研究分析。本文以利益相关者访谈及文献综述为基础,对伊萨河计划的修复规划流程进行了分析。文章阐述了伊萨河计划治理架构的演变,论述了"生活实验室"的协同治理方法,并分析呈现了多中心治理如何增进信任和相互交流,以及韧性水景的协同设计。最终,本文认为,当各具自主权的多层级决策者共同参与政策方案制定时,"生活实验室"可以成为一种实施多中心治理的方法,反之亦然。

关键词：参与式过程社会-生态修复城市研究河流管理水资源治理生活实验室多中心治理

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EGFR Expression Is Unreliable to Decide for Cetuximab Treatment in Patients with Metastatic Colorectal Cancer: Results from “ERBITUX-OUEST”

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Open Journal of Internal Medicine 2016年第2期6卷 56-67页

作者： Jean-Philippe Metges Erick Gamelin Alain Volant Olivier Capitain Jean-François Ramée Jean-Luc Raoul Jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis Roger Faroux Marie-aude Coulon Philippe Deguiral Karine Bideau Nacr Eddine Achour Alain Gourlaouen Corinne Alleaume Annie Wdowik Laurent Miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic Rosenfeld Daniel martin Claire Stampfli Jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome Chettrit Louis-Rémi De Ybarlucea Serge Eloit Pierre Marie Girardot Nathalie Heresbach Christian Laboisse Eric Lavoine Gilles Lemasson Claire Magois Sophie Michalak Norbert Padilla Joseph Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marhuenda Delphine Déniel Lagadec Christian Riché Françoise Grudé Observatoire dédié au Cancer des régions Bretagne et Pays de la Loire France Centre Hospitalier Régional Universitaire (CHRU) Brest France Institut de Cancérologie de l’Ouest (ICO) Paul Papin Angers France Centre Catherine de Sienne Nantes France CRLCC Eugène Marquis Rennes France ICO René Gauducheau Nantes France Centre CARIO-HCPA Plérin France Centre Hospitalier Bretagne Sud (CHBS) Lorient France Clinique Victor Hugo Le Mans France Centre Hospitalier Départemental (CHD) La Roche-sur-Yon France CH Le Mans France Clinique Mutualiste de l’Estuaire Saint-Nazaire France CHIC Quimper France Clinique Pasteur Lanroze Brest France CH MORLAIX France CH Saint-Brieuc France CHBA Vannes France CHP Saint-Grégoire France CHU Nantes France Hopital Privé Océane Vannes France Clinique Saint-Michel et Sainte-Anne Quimper France Pole Santé Sarthe et Loire La Flèche France Polyclinique du Maine Laval France Polyclinique Sud Quimper France CH Laval France Polyclinique Cesson Sévigné France Laboratoire d’anatomie et de cytologie pathologiques Cholet France Cabinet d’anatomie et de cytologie pathologiques Saint-Malo France Laboratoire d’anatomie et de cytologie pathologiques Lorient France Institut d’histopathologie Nantes France Laboratoire de Pathologie Médicale Laval France ARMOR Pathologie Plérin France Laboratoire d’anatomie et de cytologie pathologiques Rennes France Laboratoire d’anatomie et de cytologie pathologiques Angers France Laboratoire Analyses Biologie Glasgow Brest France CHU Angers France Centre d’anatomie et de cytologie pathologiques Le Mans France Cabinet d’anatomie et de cytologie pathologiques Vannes France Laboratoire d’anatomie et de cytologie pathologiques Quimper France CHU Rennes France

Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFR) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCRC). With the objective of improving patient selection, “ERBITUX-OUEST” study aimed at analyzing EGFR status in a large cohort of mCRC patients who received cetuximab without preliminary EGFR screening, and assessing the correlation between EGFR status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EGFR status was assessed using three available immunohistochemistry (IHC) tests and in situ hybridization in case of negativity. Clinical outcomes of EGFR-positive and EGFR-non-detected (or considered as negative with at least one test) patients were compared. Results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFR-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. Regarding results from FDA approved test only, neither objective response rate (ORR), progression-free survival (PFS) nor overall survival (OS) differed significantly between EGFR-negative and EGFR-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to other groups did not show any significant difference in terms of ORR (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: These data strongly argue against mCRC patients selection for Cetuximab treatment based on EGFR expression as measured by currently available IHC technics.

关键词： Metastatic Colorectal Cancer Cetuximab EGFR Expression

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