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Secondary antiviral metabolites from fungi with special reference to coronaviruses

BIOCelL 2022年第8期46卷 1979-1988页

作者： MOHAMED SALEM MOHAMMAD el-METWALLY WESAMelDIN SABER SALLY NEGM attalla el-kott YASSER MAZROUA ABEER MAKHLOUF MAHMOUD MOUSTAFA Department of Chemistry Faculty of Science and ArtKing Khalid UniversityMohailAssirSaudi Arabia Department of Chemistry Faculty of ScienceAl-Azhar UniversityCairoEgypt Botany and Microbiology Department Faculty of ScienceDamanhour UniversityEl-BeheraEgypt Microbial Activity Unit Department of MicrobiologySoilsWater and Environment Research InstituteAgricultural Research CenterGizaEgypt Life Sciences Department College of Science and ArtKing Khalid UniversityMohailAseerSaudi Arabia Unit of Food Bacteriology Central Laboratory of Food HygieneMinistry of HealthSharkiaEgypt Department of Biology College of ScienceKing Khalid UniversityAbhaSaudi Arabia Zoology Department Faculty of ScienceDamanhour UniversityEl-BeheraEgypt Department of Business Administration Community CollegeKing Khalid UniversityAbhaSaudi Arabia Department of Agricultural Economics Faculty of AgricultureTanta UniversityTantaEgypt Department of Botany Faculty of AgricultureMenoufia UniversitySheben El-KomMenoufiaEgypt Botany and Microbiology Department Faculty of ScienceSouth Valley UniversityQenaEgypt

Profound inspection of the life forms on the earth teaches how to be the complexity of interrelationships among the various *** of the emergence of novel viruses all the time and the inadequate of vaccines and antivirals,viral contagions are amongst the most causative diseases affecting people *** exemplify a massive source of bioactive molecules as,many fungal secondary metabolities like Oxoglyantrypine,Carneic acid F,Scedapin C,Asteltoxin E,Phomanolide,Norquinadoline A and Quinadoline B have antiviral *** review deals with how secondary metabolites of fungi can help in the war against viruses in general and especially Coronaviruses moreover several pieces of literature pointed out that many clusters of fungi in different biotopes are waiting to be exploited.

关键词： COVID-19 SARS-CoV-2 Antibiotics Virus Fungi

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Fungal assembly of L-asparaginase using solid-state fermentation:a review

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BIOCelL 2020年第2期44卷 147-155页

作者： SALLY NASER WESAMelDIN SABER MOHAMMAD el-METWALLY MAHMOUD MOUSTAFA attalla el-kott Life Sciences Department College of Science and Literature Mahyel AseerKing Khalid UniversityAbhaSaudi Arabia Unit of Food Bacteriology Central Laboratory of Food HygieneMinistry of HealthBranch in ZagazigSharkiaEgypt Microbial Activity Unit Department of MicrobiologySoilsWater and Environment Research InstituteAgricultural Research CenterGizaEgypt Botany and Microbiology Department Faculty of ScienceDamanhour UniversityEl-BeheraEgypt Biology Department College of ScienceKing Khalid UniversityAbha9004Saudi Arabia Botany and Microbiology Department Faculty of ScienceSouth Valley UniversityQenaEgypt Zoology Department Faculty of ScienceDamanhour UniversityEl-BeheraEgypt

Because of its antitumor therapeutic-activity,as well as its application in food industries to improve the quality,L-asparaginase has attracted considerable attention from several *** recent years,fungi have occupied advanced rank among microorganisms in the production process of the *** review is spotting the light on the advantages of fungal enzyme and its applications in the food industry and *** solid-state fermentation was discussed as the wide alternative and most accepted biosynthesis ***,some lights were also spotted to the statistical experimental design of the fermentation process,mainly on the methodology of the response surface for L-asparaginase biosynthesis by ***,the immobilization of the enzyme and the features of the widely used solid substrates for the maximization of the production process were explored.

关键词： Immobilization Statistical designs Response surface methodology Optimization

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Nanoparticles induce the biosynthesis and activity of the new possible therapeutic proteinase source,Talaromyces purpureogenus KJ584844

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BIOCelL 2021年第1期45卷 119-127页

作者： SALLY NEGM MOHAMMAD el-METWALLY WESAM elDIN SABER SAHAR ABO-NEIMA MAHMOUD MOUSTAFA attalla el-kott Life Sciences Department College of Science and literature Mahyel AseerKing Khalid UniversityAbhaSaudi Arabia Unit of Food Bacteriology Central Laboratory of Food HygieneMinistry of HealthSharkiaEgypt Department of Botany and Microbiology Faculty of ScienceDamanhour UniversityEl-BeheraEgypt Microbial Activity Unit Department of MicrobiologySoilsWater and Environment Research InstituteAgricultural Research CenterGizaEgypt Physics Department Faculty of ScienceDamanhour UniversityDamanhourEgypt Department of Biology College of ScienceKing Khalid University9004AbhaSaudi Arabia Department of Botany and Microbiology Faculty of ScienceSouth Valley UniversityQenaEgypt Zoology Department Faculty of ScienceDamanhour UniversityEl-BeheraEgypt

The need for the bacterial proteinase is rapidly growing,urging to catch a lowcost medium for the microbial fermentation,nanoparticles can play a vital role in this *** proteinase of Talaromyces purpureogenus was produced on the tubers of Helianthus tuberosus that also operated as solid support for the fermentation *** interface amongst nitrogen sources(NH_(4)Cl and yeast extract)was investigated,applying the statistical modeling of central composite design under solid-state *** optimum medium for proteinase secretion was stimulated by 979.82 mg NH_(4)Cl and 437.68 mg yeast extract per 100 g substrate,yielding 108.15 U/g *** Plackett-Burman experimental design,the nanoparticles Co,Ni and Fe were assessed as inducers for proteinase *** nanoparticles(5 ppm)were the greatest in both proteinase production by the fungus as well as an inducer of the proteolysis process by the enzyme when using faba bean straw as a proteinaceous substrate in the reaction mixture,liberating the extreme quantity of amino acids,compared with the lack of the *** findings suggest the incorporation of Co nanoparticles in both the proteinase fabrication process and during the degradation of proteinaceous materials induce proteinase *** approach could be extended to modulate the productivity and activity of similar biomolecules.

关键词： Experimental design Helianthus tuberosus proteolysis solid-state fermentation

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Pterostilbene induces cell apoptosis and inhibits lipogenesis in SKOV3 ovarian cancer cells by activation of AMPK-induced inhibition of Akt/mTOR signaling cascade

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BIOCelL 2021年第1期45卷 89-101页

作者： attalla el-kott EMAN elBEALY FAHMY elSAID HAITHAM el-MEKKAWY ABD-el-KARIM ABD-LATEIF ABDULALI TAWEel HEBA KHALIFA AHMAD KANDEel KAREEM MORSY ESSAM IBRAHIM MASHAel MOHAMMED BIN-MEFERIJ Biology Department College of ScienceKing Khalid UniversityAbha61413Saudi Arabia Zoology Department College of ScienceDamanhour UniversityDamanhour22511Egypt Biology Department College of Science for GirlsKing Khalid UniversityAbha61413Saudi Arabia Zoology Department College of ScienceMansoura UniversityMansoura35511Egypt Zoology Department College of ScienceFayoum UniversityFayoum63511Egypt Zoology Department Faculty of ScienceAl-Zawia UniversityAl-ZawiaLibya Biology Department Faculty of ScienceCairo UniversityCairo12611Egypt Research Center for Advanced Materials Science(RCAMS) King Khalid UniversityAbha61413Saudi Arabia Blood Products Quality Control and Research Department National Organization for Research and Control of BiologicalsCairo12611Egypt Biology Department College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadhSaudi Arabia

This study investigates if the anti-tumor effect of Pterostilbene in the SKOV3 ovarian cancer(OC)cell line involves inhibition of cell metabolism and tested in this effect involves modulating AMPK and Akt-induced regulation of ***,SKOV3 cells were cultured in the humidified conditions in DMEM media for 24 h with or without increasing concentration of ***,the cells were incubated with Pterostilbene(IC_(50)=50μM)under similar conditions with or without pre-incubation with Dorsomorphin,an AMPK *** a dose-dependent manner,Pterostilbene inhibited SKOV3 cell survival and increased their lysate levels of lactate dehydrogenase(LDH)and single-stranded DNA(ssDNA).When SKOV3 cells were treated with 50μM Pterostilbene,Pterostilbene significantly suppressed cell migration and invasion,reduced lysate levels of lactic acid and the optical density of Oil Red O staining,and increased lysate glucose *** also increased levels of malondialdehyde(MDA),reactive oxygen species(ROS),and induced intrinsic cell apoptosis by upregulating protein levels of Bax and cleaved caspase-3 and reducing protein levels of ***,Pterostilbene reduced mRNA levels of sterol regulatory element-binding protein 1(SREBP-1),fatty acid synthase(FAS),acetyl CoA carboxylase-1(ACC-1),and AMP-activated protein kinase(AMPK).Furthermore,Pterostilbene increased the protein levels of p-AMPK,p-p53,p-raptor,p-TSC-2,but significantly decreased protein levels of p-Akt,p-TSC-2,p-mTOR,p-S6K1,and *** with Dorsomorphin(CC)abolished all the anti-tumorigenesis effects afforded by Pterostilbene and prevented Pterostilbene-induced phosphorylation of Akt,p53,and *** conclusion,the tumorsuppressive effect of Pterostilbene in SKOV3 cells involves the induction of ROS and inhibition of dysregulation cell metabolism mainly due to AMPK-induced Akt-dependent or independent suppression of mTOR.

关键词： Pterostilbene Ovarian cancer Lipogenesis Apoptosis AMPK

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Origanum vulgare *** extract alleviates finasteride-induced oxidative stress in mouse liver and kidney

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Asian Pacific Journal of Tropical Biomedicine 2021年第5期11卷 194-204页

作者： Qi-Feng Sun Shi-Xiang Chen Zhang-Feng Tang Xiao-Yi Song Fa Jing Hao-Tian Wu Zhong-Yang Ding attalla el-kott Diaa Massoud Heba Khalifa Department of Hepatobiliary and Vascular Surgery Jinan City People's HospitalJinanShandong Province271100China Department of Hepatology Zhejiang University Ming Zhou HospitalNingboZhejiang Province315199China Department of General Surgery Wuxi Traditional Chinese Medicine Hospital Affiliated to Nanjing University of Traditional Chinese MedicineWuxiJiangsu Province214023China Biology Department College of ScienceKing Khalid UniversityAbhaSaudi Arabia Zoology Department College of ScienceDamanhour UniversityDamanhourEgypt Biology Department College of ScienceJouf UniversityP.O.Box 2014SakakaAl-JoufSaudi Arabia Zoology Department Faculty of ScienceFayoum UniversityFayoumEgypt

Objective:To investigate the hepatorenoprotective effects of Origanum vulgare *** finasteride-induced oxidative injury in the liver and kidney of ***:Liquid chromatography-electrospray ionization-tandem mass spectrometry(LC-ESI/MS)analysis was utilized to yield a fingerprint of Origanum vulgare polyphenolic *** BALB/c mice received 0.5 mL/day distilled water,finasteride(25 mg/kg/day for 10 d),and 100,200,or 400 mg/kg/day finasteride+Origanum vulgare extract with 6 mice per group for five *** day 36,liver and kidney function as well as pro-and antiinflammatory(IFN-γ,IL-12,IL-6,TNF-α,IL-1β,and IL-10)cytokines were *** total antioxidant status,nitric oxide(NO),and malondialdehyde levels as well as the activities of NO synthase and catalase were also *** study was conducted to assess the effect of Origanum vulgare extract on finasteride-induced renal and hepatic ***:Twenty-five major polyphenolic compounds were identified in the Origanum vulgare extract by LC-ESI/*** vulgare extract,especially at 200 and 400 mg/kg/day doses,significantly improved liver and kidney biochemical indices,decreased inflammatory cytokines,increased total antioxidant status and NO synthase and catalase activities,as well as decreased plasma NO and malondialdehyde levels in a dose-dependent manner as compared to the finasteride *** results further confirmed the protective effect of Origanum vulgare ***:Origanum vulgare extract ameliorates finasterideinduced hepatic and renal biochemical and histopathological alterations,and restores antioxidant/oxidant balance.

关键词： Kidney Liver Origanum vulgare L. Inflammation Antioxidant

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Exendin-4 inhibits the survival and invasiveness of two colorectal cancer cell lines via suppressing GS3Kβ/β-catenin/NF-κB axis through activating SIRT1

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BIOCelL 2021年第5期45卷 1337-1353页

作者： attalla F.el-kott AYMAN E.el-KENAWY EMAN R.elBEALY ALI S.ALSHEHRI HEBA S.KHALIFA MASHAel MOHAMMED BIN-MEFERIJ EHAB E.MASSOUD AMIRA M.ALRAMLAWY Biology Department College of ScienceKing Khalid UniversityAbha61413Saudi Arabia Zoology Department College of ScienceDamanhour UniversityDamanhour22511Egypt Pathology Department College of MedicineTaif UniversityTaif11099Saudi Arabia Biology Department College of Science for GirlsKing Khalid UniversityAbha61413Saudi Arabia Biology Department College of SciencePrincess Nourah Bint Abdulrahman UniversityRiyadh84428Saudi Arabia Biology Department Faculty of Science and ArtsDahran AljnoubKing Khalid UniversityAbha61413Saudi Arabia Research Center for Advanced Materials Science King Khalid UniversityAbha61413Saudi Arabia Agriculture Research Centre SoilWater and Environment Research InstituteGiza12619Egypt Mansoura Research Centre for Cord Stem Cell(MARC-CSC) Stem Cells BankChildren’s HospitalMansoura UniversityMansoura35516Egypt

This study examined if the anti-tumorigenesis effect of Exendin-4 in HT29 and HCT116 colorectal cancer(CRC)involves modulation of SIRT1 and Akt/GSR3K/β-catenin/NF-κB ***29 and HCT116 cells were treated either with increasing levels of Exendin-4(0.0-200μM)or with Exendin-4(at its IC50)in the presence or absence of EX-527(10μM/a selective SIRT1 inhibitor)or Exendin-4(9-39)amide(E(9-39)A)(1μM/an Exendin-4 antagonist).In a dose-dependent manner,Exendin-4 inhibited cell survival,but enhanced levels of lactate dehydrogenase(LDH)and single-stranded DNA(ssDNA)in both HT29 and *** both cell lines and at it has an IC50(45μM for HT29 and 35μM for HCT1165),Exendin-4 also significantly reduced cell survival,migration,and invasion of both cell types,with no effect on the expression GLP-1 receptors(GLPRs)nor of the activity of *** these doses,Exendin-4 also increased the expression of SIRT1 but reduced the acetylation of NF-κB and the expression of Bax and cleaved caspase-3 and in both cell ***,protein levels of p-GS3Kβ(Ser9),total and acetylatedβ-catenin,and Anix2 were significantly decreased,but levels of p-GS3Kβ(Ser9)and p-β-catenin(Ser33/37/Thr41)were significantly increased in both HT29 and HCT116-exendin-4 treated *** the effects exerted by Exendin-4 were completely prevented by Ex527 or E(9-39)*** conclusion,Exendin-4 suppresses the tumorigenesis of HT29 and HCT116 CRC cell activation of GS3Kβ-induced inhibition ofβ-catenin and NF-κβin a SIRT1-dependent mechanism.

关键词： Colorectal cancer Exendin-4 SIRT1 GS3Kβ β-catenin NF-κB

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Comparison between seismic analysis of twisting and regular 52-story towers considering soil-structure interaction

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 663-675页

作者： Mohamed Naguib Abouelsaad Mohammed Shaaban Salah el Bagalaty Mohamed E.el Madawy Structural Engineering Department Faculty of EngineeringMansura UniversityMansoura 35511Egypt Faculty of Engineering Delta University for Science and TechnologyGamasa 35712Egypt

A dynamic analysis of both twisting and regular towers is carried out to determine the results of considering soil-structure interaction(SSI)on high-rise *** addition,the difference between the seismic performance of using twisting towers over regular ones is *** twisting tower is a simulation of the Evolution Tower(Moscow).The towers’skeletons consist of RC elements and rest on a reinforced concrete piled-raft *** soil model is considered as multi-layered with the same soil properties as the zone chosen for the analysis(New Mansoura City,Egypt).The only difference between both towers is their shape in *** whole system is modelled and analyzed in a single step as one full 3D model,which is known as the direct approach in *** analyses are carried out using finite-element software(Midas GTS NX).Dynamic output responses due to three records of seismic loads are proposed and presented in some *** on the results,it is concluded that SSI has a considerable effect on the dynamic response of tall buildings mainly because of the foundation flexibility,as it leads to lengthening the vibration period,increasing the story drift and the base shear for both cases.

关键词： soil-structure interaction seismic analysis twisting towers base shear story drift finite element method Midas GTS NX

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Gender-Based Analysis of User Reactions to Facebook Posts

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Big Data Mining and Analytics 2024年第1期7卷 75-86页

作者： Yassine el Moudene Jaafar Idrais Rida el Abassi Abderrahim Sabour Mathematical Engineering and Computer Science Laboratory Faculty of SciencesIbn Zohr UniversityAgadir 8706Morocco Department of Computer Science Mathematical−High School of Technology Ibn Zohr UniversityAgadir 8706Morocco

Online Social Networks(OSNs)are based on the sharing of different types of information and on various interactions(comments,reactions,and sharing).One of these important actions is the emotional reaction to the *** diversity of reaction types available on Facebook(namely FB)enables users to express their feelings,and its traceability creates and enriches the users’emotional identity in the virtual *** paper is based on the analysis of 119875012 FB reactions(Like,Love,Haha,Wow,Sad,Angry,Thankful,and Pride)made at multiple levels(publications,comments,and sub-comments)to study and classify the users’emotional behavior,visualize the distribution of different types of reactions,and analyze the gender impact on emotion *** of these can be achieved by addressing these research questions:who reacts the most?Which emotion is the most expressed?

关键词： profiling knowledge extraction data mining emotion mining social media data crawling Facebook reactions gender

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Stability analysis of a time-delayed Van der Pol–Helmholtz–Duffing oscillator in fractal space with a non-perturbative approach

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Communications in Theoretical Physics 2024年第4期76卷 22-31页

作者： Yusry O el-Dib Department of Mathematics Faculty of EducationAin Shams UniversityRoxyCairoEgypt

The time-delayed fractal Van der Pol–Helmholtz–Duffing(VPHD)oscillator is the subject of this paper,which explores its mechanisms and highlights its stability *** time-delayed technologies are currently garnering significant attention,the focus of this research remains crucially relevant.A non-perturbative approach is employed to refine and set the stage for the system under *** innovative methodologies introduced yield an equivalent linear differential equation,mirroring the inherent nonlinearities of the ***,the incorporation of quadratic nonlinearity into the frequency formula represents a cutting-edge *** analytical solution's validity is corroborated using a numerical *** conditions are ascertained through the residual Galerkin ***,it is observed that the delay parameter,in the context of the fractal system,reverses its stabilizing influence,impacting both the amplitude of delayed velocity and the *** analytical solution's precision is underscored by its close alignment with numerical ***,the study reveals that fractal characteristics emulate damping *** its applicability across diverse nonlinear dynamical systems,this non-perturbative approach emerges as a promising avenue for future research.

关键词： Van der Pol-Helmholtz-Duffing oscillator fractal space time-delay non-perturbative approach stability analysis el-Dib's frequency formula

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Nonlinear wave dispersion in monoatomic chains with lumped and distributed masses:discrete and continuum models

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Applied Mathematics and Mechanics(English Edition) 2024年第4期45卷 633-648页

作者： E.GHAVANLOO S.el-BORGI School of Mechanical Engineering Shiraz UniversityShiraz 71963-16548Iran Mechanical Engineering Program Texas A&M University at QatarDoha 23874Qatar

The main objective of this paper is to investigate the influence of inertia of nonlinear springs on the dispersion behavior of discrete monoatomic chains with lumped and distributed *** developed model can represent the wave propagation problem in a non-homogeneous material consisting of heavy inclusions embedded in a *** inclusions are idealized by lumped masses,and the matrix between adjacent inclusions is modeled by a nonlinear spring with distributed ***,the model is capable of depicting the wave propagation in bi-material bars,wherein the first material is represented by a rigid particle and the second one is represented by a nonlinear spring with distributed *** discrete model of the nonlinear monoatomic chain with lumped and distributed masses is first considered,and a closed-form expression of the dispersion relation is obtained by the second-order Lindstedt-Poincare method(LPM).Next,a continuum model for the nonlinear monoatomic chain is derived directly from its discrete lattice model by a suitable continualization *** subsequent use of the second-order method of multiple scales(MMS)facilitates the derivation of the corresponding nonlinear dispersion relation in a closed *** novelties of the present study consist of(i)considering the inertia of nonlinear springs on the dispersion behavior of the discrete mass-spring chains;(ii)developing the second-order LPM for the wave propagation in the discrete chains;and(iii)deriving a continuum model for the nonlinear monoatomic chains with lumped and distributed ***,a parametric study is conducted to examine the effects of the design parameters and the distributed spring mass on the nonlinear dispersion relations and phase velocities obtained from both the discrete and continuum *** parameters include the ratio of the spring mass to the lumped mass,the nonlinear stiffness coefficient of the spring,and the wave amplitude.

关键词： nonlinear mass-spring chain discrete model continuum model LindstedtPoincare method(LPM) method of multiple scales(MMS) dispersion phase velocity

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