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Molecular analysis of the sex chromosomes of the platyfish Xiphophorus maculatus: Towards the identification of a new type of master sexual regulator in vertebrates

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Integrative Zoology 2009年第3期4卷 277-284页

作者： astrid bone Christina SCHULTHEIS Delphine GALIANA-ARNOUX Alexander FROSCHAUER Qingchun ZHOU Cornelia SCHMIDT Yvonne SELZ Catherine OZOUF-COSTAZ Agnès DETTAI Béatrice SEGURENS Arnaud COULOUX Sylvie BERNARD-SAMAIN Valérie BARBE Stefan CHILMONCZYK Frédéric BRUNET Amandine DARRAS TOMASZKIEWICZ Marta Marie SEMON Manfred SCHARTL Jean-Nicolas VOLFF Institute of Functional Genomics Ecole Normale Supérieure de Lyon/Universitéde LyonLyonFrance Physiological Chemistry 1 Biozentrum of the University of WürzburgWürzburgGermany Department of Systematics and Evolution Muséum National d’Histoire NaturelleParisFrance CEA/DSV/IG/Genoscope EvryFrance Molecular Virology and Immunology Unit National Institute for Agricultural ResearchJouy-en-JosasFrance

In contrast to mammals and birds,fish display an amazing diversity of genetic sex determination systems,with frequent changes during evolution possibly associated with the emergence of new sex chromosomes and sex-determining *** better understand the molecular and evolutionary mechanisms driving this diversity,several fish models are studied in *** the medaka(Oryzias latipes Temminck and Schlegel,1846)for which the master sex-determination gene has been identified,one of the most advanced models for studying sex determination is the Southern platyfish(Xiphophorus maculatus,Günther 1966).Xiphophorus maculatus belongs to the Poeciliids,a family of live-bearing freshwater fish,including platyfish,swordtails and guppies that perfectly illustrates the diversity of genetic sex-determination mechanisms observed in *** ***,bacterial artificial chro-mosome contigs covering the sex-determination region of the X and Y sex chromosomes have been *** molecular analysis demonstrated that the sex-determination region is very unstable and frequently undergoes duplications,deletions,inversions and other *** gene candidates linked to the master sex-determining gene have been identified,some of them corresponding to *** putative genes are present on both the X and the Y chromosomes,suggesting a poor degree of differentiation and a young evolutionary age for platyfish sex *** compared with other fish and tetrapod genomes,syntenies were detected only with *** observation supports an independent origin of sex chromosomes,not only in different vertebrate lineages but also between different fish species.

关键词： sex chromosomes sex determination fish poeciliid Xiphophorus.

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Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development

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bone Research 2024年第1期12卷 199-214页

作者： Laura J.Brylka Assil-Ramin Alimy Miriam E.A.Tschaffon-Müller Shan Jiang Tobias Malte Ballhause Anke Baranowsky Simon von Kroge Julian Delsmann Eva Pawlus Kian Eghbalian Klaus Püschel astrid Schoppa Melanie Haffner-Luntzer David J.Beech Frank Timo Beil Michael Amling Johannes Keller Anita Ignatius Timur A.Yorgan Tim Rolvien Thorsten Schinke Department of Osteology and Biomechanics University Medical Center Hamburg-Eppendorf20246 HamburgGermany Department of Trauma and Orthopedic Surgery University Medical Center Hamburg-Eppendorf20246 HamburgGermany Institute of Orthopedic Research and Biomechanics University Medical Center UlmBadenWürttemberg89081 UlmGermany Department Legal Medicine University Medical Center Hamburg-Eppendorf20246 HamburgGermany Leeds Institute of Cardiovascular and Metabolic Medicine School of MedicineUniversity of LeedsLS29JT LeedsUK

Piezo proteins are mechanically activated ion channels,which are required for mechanosensing functions in a variety of cell *** we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is essential for boneanabolic processes,there was only suggestive evidence indicating a role of Piezo1 and/or Piezo2 in *** we addressed the question if and how chondrocyte expression of the mechanosensitive proteins Piezo1 or Piezo2 controls physiological endochondral ossification and pathological osteoarthritis(OA)*** with chondrocyte-specific inactivation of Piezo1(Piezo1^(Col2a1Cre)),but not of Piezo2,developed a near absence of trabecular bone below the chondrogenic growth plate ***,all Piezo1^(Col2a1Cre) animals displayed multiple fractures of rib bones at 7 days of age,which were located close to the growth *** skeletal growth was only mildly affected in these mice,OA pathologies were markedly less pronounced compared to littermate controls at 60 weeks of ***,when OA was induced by anterior cruciate ligament transection,only the chondrocyte inactivation of Piezo1,not of Piezo2,resulted in attenuated articular cartilage ***,osteophyte formation and maturation were also reduced in Piezo1^(Col2a1Cre) *** further observed increased Piezo1 protein abundance in cartilaginous zones of human ***,we identified Ptgs2 and Ccn2 as potentially relevant Piezo1 downstream genes in ***,our data do not only demonstrate that Piezo1 is a critical regulator of physiological and pathological endochondral ossification processes,but also suggest that Piezo1 antagonists may be established as a novel approach to limit osteophyte formation in OA.

关键词： Piezo1 markedly ossification

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Stable,dynamic,elastic miniplate osteosynthesis in cranio-maxillofacial surgery:evolution of concepts,biomechanical study and applications

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中国口腔颌面外科杂志 2014年第2期12卷 152-166页

作者： Maxime Champy astrid Wilk Department of Stomatology and Maxillofacial Surgery University of Strasbourg Department of Stomatology Maxillofacial and Aesthetic Plastic Reconstructive SurgeryUniversity of Strasbourg

An osteosynthesis of the mandible should be called stable when this type of treatment does not need to be supported by intermaxillary fixation,without disturbing the healing *** that intention,many techniques of osteosynthesis based on different concepts were proposed during the last century.A classification of these concepts was *** adaptive osteosynthesis which is pragmatically ***,wherein the goal is immobilizing the fracture by bringing the fragments together and fixing them with rigid screwed *** rigid compressive osteosynthesis which is an extrapolation of the ideas of Lane proposed in *** stable dynamic elastic osteosynthesis whose principles,equipment and technique as their applications were developed exclusively through biomechanical *** basic principle was the recovery of mobility by neutralization of detrimental distraction stresses,and reestablishment of favorable compressive stresses providing dynamic physiological *** biomechanical characteristics of the plates and the screws made possible the use of the fixation of all types of fractures or orthognathic procedures in mandibular *** the application of mini or microplates in other facial bones and the skull,the art of fracture treatment and of reconstructive surgery of the craniomaxillofacial skeleton,including orthognathic and reconstructive surgery with or without bone grafting,has profoundly *** the present time,metal plates are sometimes superseded by resorbable plates and ***,the fundamental biomechanical principles of osteosynthesis and bone healing remain unchanged.

关键词：口腔学外科学患者临床治疗

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Calcium phosphate nanoparticles show an effective activation of the innate immune response in vitro and in vivo after functionalization with flagellin

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Virologica Sinica 2014年第1期29卷 33-39页

作者： Diana Kozlova Viktoriya Sokolova Maohua Zhong Ejuan Zhang Jingyi Yang Wei Li Yi Yang Jan Buer astrid Maria Westendorf Matthias Epple Huimin Yan Institute of Inorganic Chemistry and Center for Nanointegration Duisburg-Essen(CeNIDE) University of Duisburg-Essen Mucosal Immunity Research Group State Key Laboratory of VirologyWuhan Institute of VirologyChinese Academy of Sciences Institute of Medical Microbiology University Hospital EssenUniversity of Duisburg-Essen

For subunit vaccines,adjuvants play a key role in shaping the magnitude,persistence and form of targeted antigen-specific immune *** is a potent immune activator by bridging innate inflammatory responses and adaptive immunity and an adjuvant candidate for clinical *** phosphate nanoparticles are efficient carriers for different biomolecules like DNA,RNA,peptides and ***-functionalized calcium phosphate nanoparticles were prepared and their immunostimulatory effect on the innate immune system,*** cytokine production,was *** induced the production of the proinflammatory cytokines IL-8 （Caco-2 cells） and IL-1β（bone marrow-derived macrophages; BMDM） in vitro and IL-6 in vivo after intraperitoneal injection in *** immunostimulation was more pronounced than with free flagellin.

关键词： calcium phosphate nanoparticle immunostimulation innate immune system flagellin adjuvants

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Giant Myositis Ossificans Circumscribed Post Traumatic of Gluteus and Adductor Muscles: Case Report

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Open Journal of Orthopedics 2015年第6期5卷 157-162页

作者： Koné Samba Touré Stanislas Bana Abdoulaye Dogba Eric Doukouré Brahima Ngandeu Nawé astrid Koffi Gérard Vangah Marius Mègné Estelle Allou Sylvain Service de Chirurgie Orthopédique et Traumatologique C.H.U de Cocody Abidjan Ivory Coast Service d’Anatomie Pathologie du C.H.U de Cocody Abidjan Ivory Coast Service de Rhumatologie C.H.U de Cocody Abidjan Ivory Coast Service de Chirurgie Orthopédique et Traumatologique C.H.U de Bouake Bouake Ivory Coast

Myositis ossificans circumscribed is a bone and cartilage heterotopic non neoplastic proliferation inside the soft tissues. It is a benign focal heterotopic ossification process of soft tissues, and a rare disorder that occurs spontaneously or after local trauma. Clinical and radiographic appearances are quite hustler. A careful histological examination of biopsy straightens diagnosis is necessary. There is no consensus in support (surgical or/and medical). From Benign prognosis, evolution of this pathology is usually favorable. The authors report a case of giant myositis ossificans circumscribed post-traumatic localized on gluteus and adductor muscles of the right hip on a 26-year-old man. Through a review of literature the mechanism, the diagnostic methods and therapeutic will be discussed.

关键词： Giant Myositis Ossifying Gluteus and Adductor Muscles Biopsy

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Profile of Knee’s bone and Joint Tuberculosis in Adults: About 33 Cases

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Open Journal of Orthopedics 2015年第7期5卷 189-197页

作者： Touré Stanislas Bana Abdoulaye Koné Samba Soumaro Kanaté Gbané Mariam Sévédé Daouda Ouali Boubacar Megne Estelle Traoré Moriba Ngandeu Nawé astrid Service de Chirurgie Orthopédique et Traumatologique du C.H.U. de Cocody Abidjan Ivory Coast Service de Rhumatologie du C.H.U. de Cocody Abidjan Ivory Coast Service de Bactériologie Institut Pasteur C.H.U. de Cocody Abidjan Ivory Coast

The authors report toward a monocentric retrospective and descriptive study on a 08 year period, 33 cases of knee osteoarticular tuberculosis (OAT) of adult, certified by bacteriologic and/or histolological evidence proof of the sample (synovial biopsy) after a knee arthrotomy. There were 07 cases of arthritis and 26 cases of osteoarthritis. The treatment of knee OAT was medical (anti-tubercular poly-chemotherapy) on one year duration. The surgery was useful in front of some clinical presentations. After a minimum of 18 months, a functional evaluation was done following the Lequesne algo-functionnal index. None had signs of local recurrence testifying the adequacy of medical treatment, even if it is long and binding. The main of our case series is to establish an epidemiological, clinical and biological profile of the knee tuberculosis of adult and to research elements of prognosis through an analysis of results.

关键词： Knee bone and Joint Tuberculosis Adult Prognosis Factors

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