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World Journal of Engineering and Technology 2014年第3期2卷 85-90页

作者： Mario Fernández arce Daniel Solís Juan Luis Porras Gino González 不详

Role of capsule endoscopy in inflammatory bowel disease:Anything new?

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Artificial Intelligence in Gastrointestinal Endoscopy 2021年第4期2卷 136-148页

作者： Edith Pérez de arce Rodrigo Quera Paulina Núñez F Raúl Araya Department of Gastroenterology Hospital Clínico Universidad de ChileSantiago 8380456Chile Digestive Disease Center Inflammatory Bowel Disease ProgramClínica Universidad de los AndesSantiago 7620157Chile Department of Gastroenterology Hospital San Juan De DiosSantiago 8350488Chile

Capsule endoscopy(CE)is a recently developed diagnostic method for diseases of the small bowel that is non-invasive,safe,and highly *** role in patients with inflammatory bowel disease has been widely validated in suspected and established Crohn’s disease(CD)due to its ability to assess superficial lesions not detected by cross-sectional imaging and proximal lesions of the small bowel not evaluable by *** CE is a highly sensitive but less specific technique,differential diagnoses that can simulate CD must be considered,and its interpretation should be supported by other clinical and laboratory *** use of validated scoring systems to characterize and estimate lesion severity(Lewis score,Capsule Endoscopy Crohn’s Disease Activity Index),as well as the standardization of the language used to define the lesions(Delphi Consensus),have reduced the interobserver variability in CE reading observed in clinical practice,allowing for the optimization of diagnoses and clinical management *** appearance of the panenteric CE,the incorporation of artificial intelligence,magnetically-guided capsules,and tissue biopsies are elements that contribute to CE being a promising,unique diagnostic tool in digestive tract diseases.

关键词： Capsule endoscopy Inflammatory bowel disease Crohn’s disease Artificial intelligence Capsule Endoscopy Crohn’s Disease Activity Index Lewis score

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玻利维亚瓦奴尼矿山的矿物解离度的研究

国外锡工业 1991年第4期19卷 10-19页

作者： arce,O 陈逸明

Phagocytosis: A Practical Approach for Evaluating Neutrophil Function in Health and Disease

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Modern Research in Inflammation 2024年第2期13卷 9-28页

作者： Oscar Rojas-Espinosa Patricia arce-Paredes Sergio Islas-Trujillo Luis Enrique Becerril-Villanueva María Dolores Ponce-Regalado Departamento de Inmunologa Escuela Nacional de Ciencias Biolgicas Instituto Politcnico Nacional Ciudad de Mxico Mxico Laboratorio de Psicoinmunologa Instituto Nacional de Psiquiatra Ramn de la Fuente Ciudad de Mxico Mxico Departamento de Ciencias de la Salud Centro Universitario de los Altos Universidad de Guadalajara Jalisco Mxico

Neutrophils, crucial players in the effector phase of the immune response, are recognized as important mediators of both innate and adaptive immune responses. Through the production of pro- and anti-inflammatory cytokines, they modulate the function of T and other lymphoid cells. Countless reports have highlighted the importance of these cells as efficient antimicrobial agents and annotated their involvement in the pathology of infectious and noninfectious diseases. The development of modern, sophisticated technologies has allowed the study of the functions of these cells in clinical settings. These advanced technologies include fluorescence-activated cell sorters, confocal microscopy, automated cell image analyzers, and live cell analysis instruments. Unfortunately, the cost of these modern instruments, maintenance, reagents, and the need for qualified technicians prohibit their use in low-income laboratories and universities in developing countries. With this in mind, we propose a series of basic tests that can be used in low-input clinical laboratories and universities to evaluate the function of neutrophils in health and disease. Our methodology allows us to assess in a practical and low-cost manner the functions of neutrophils in the phagocytic process, including opsonization, ingestion, ROI production (NBT reduction), myeloperoxidase content, phagosome-lysosome fusion, microbicidal activity, and NET production. Thus, under a disadvantageous ambiance, this may guide physicians in deciding whether a patient’s illness involves phagocytic defects without imposing a heavy financial *** Abstract[-rId13-]

关键词： Phagocytosis Neutrophils Microbicidal Activity Netosis

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玻利维亚瓦努尼矿山矿物解离性的研究

国外稀有金属 1991年第3期 2-10页

作者： arce,O 梁冬云

Pre-hCG variables associated with occurrence of ascites in IVF/ICSI patients at moderate risk of developing OHSS:A pilot investigation

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Open Journal of Obstetrics and Gynecology 2013年第1期3卷 13-20页

作者： Manuel Fernández-Sánchez Per Broberg Goran Pettersson Cristiano Busso Antonio Pellicer Joan-Carles arce Instituto Valenciano de Infertilidad(IVI)Sevilla SevillaSpain Biometrics Global Clinical&Non-Clinical R&DFerring Pharmaceuticals A/SCopenhagenDenmark Reproductive Health Global Clinical&Non-Clinical R&DFerring Pharmaceuticals A/SCopenhagenDenmark International Vaccine Institute(IVI)Valencia ValenciaSpain

Objective: To identify predictors of ascites collected prior to the hCG administration in patients undergoing IVF/ICSI treatment at moderate risk of developing moderate/severe ovarian hyperstimulation syndrome (OHSS), and, based on these predictors, develop a nomogram for estimation of the probability of presence of ascites. Methods and Materials: Data were derived from 53 patients with 20 - 30 follicles ≥10 mmat end of stimulation. All patients received a single dose of hCG (250 mg) to trigger final follicular maturation when ≥2 follicles of ≥18 mmwere observed. Transvaginal ultrasound to measure ascites (total amount of peritoneal fluid ≥9 cm2inlithotomy position) was performed 2, 5 and 8 days after the hCG administration. Associations between clinical, sonographic and endocrinological variables recorded prior to the hCG administration and presence of ascites were analyzed by univariable and multivariable logistic regression. Results: Thirty-four patients (64%) had ultrasonic evidence of ascites. The multivariable analysis identified the total number of follicles [OR 1.29 (95% CI: 1.02 - 1.69, P = 0.043)], the ovarian volume [OR 1.05 (95% CI: 1.00 - 1.11, P = 0.047)] and BMI [OR 0.76 (95% CI: 0.56 - 0.99, P = 0.053)] as predictors of ascites (AUC = 0.825). A nomogram (PROFET) was designed with these three variables for individual prediction of the probability of development of ascites. Conclusions: This pilot investigation indicates that the risk of peritoneal fluid accumulation in IVF/ICSI patients at moderate risk of developing moderate/severe OHSS is influenced by the number of follicles and the ovarian volume on the day of hCG administration as well as the BMI.

关键词： Ascites IVF OHSS Ovarian Stimulation Prediction

Added after Anoxia-Reoxigenation Stress, Genistein Rescues from Death the Rat Embryo Cortical Neurons

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Neuroscience & Medicine 2010年第2期1卷 50-59页

作者： arce Carmen Arteaga José Luis Sánchez-mendoza Eduardo Oset Gasque Ma Jesús González Ma Pilar Centro de Investigaciones Biológicas CSIC Ramiro de Maeztu Madrid Spain Department of Biochemistry and Molecular Biology Faculty of Pharmacy Universidad Complutense Madrid Spain

Estrogens and phytoestrogens have neuroprotective effect against neuronal damage induced by cerebral ischemia /reperfusion (I/R) injury. In preceding studies, the phytoestrogen effects have been assessed by administration previous to the ischemic period, conditions which are unusual to apply to the treatment of human stroke. Here we present a study on neuroprotection afforded by genistein on rat embryo cortical neurons subjected to oxygen and glucose deprivation (OGD) followed by re-oxigenation, when added after the stress stimulus. At 1 and 2 h of OGD times and after 24 h of reperfusion, cell viability, necrotic, apoptotic and autophagic cell death and different parameters related to oxidative stress and mitochondrial dysfunction were measured in the absence and presence of 1 μM genisteine. We found an in-creasing loss of neuronal viability after 1-5 h of OGD which was only reversed in part by 24 h of reperfusion. These changes were preceded by increases in ROS generation, caspase-3 activation, LDH release and increase in LC3B lipi-dation, indicative of autophagia. Treatment with 1 μM genistein during the 24 h reperfusion significantly attenuated neuronal necrosis and autophagia induced by 1 and 2 h of OGD exposure. Genistein also decreased ROS generation and lipid-peroxidation induced by 2 h of OGD. These results suggest an important neuroprotective effect of genistein against transient post-ischemic-like

关键词： Cortical Neurons Oxygen-glucose Deprivation Brain Ischemia Neuronal Death Necrosis Apoptosis Autophagy

Differential Anti-Inflammatory Effects of Three Purified Omega Unsaturated Fatty Acids on Collagen-Induced Arthritis in Mouse

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Modern Research in Inflammation 2016年第3期5卷 31-44页

作者： Pamela Izaret Pérez-Martínez Víctor Gabriel Hernández Oscar Rodríguez-Espinosa Patricia arce-Paredes Oscar Rojas-Espinosa Departamentos de Inmunología Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Ciudad de México México Departamentos de Morfología Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional Ciudad de México México

Background: The Mediterranean Diet (MD) has been linked to a reduced risk of developing degenerative diseases, including atherosclerosis, heart stroke, diabetes, arthritis and cancer. However, only a few scientific investigations have attempted to validate this impression. The ingredients of the MD include significant amounts of omega (ω3, ω6, and ω9) unsaturated fatty acids (UFAs). A few studies of these UFAs in the prevention or treatment of arthritis have yielded controversial results, but a general belief regarding their beneficial effects has prevailed. Objective: To investigate the effects of three relevant UFAs, namely Docosahexaenoic Acid (DHA), Arachidonic Acid (AA), and Oleic Acid (OA) (ω3, ω6, and ω9, respectively), in the development of arthritis using a murine model of Collagen-Induced Arthritis (CIA). Methods: DBA-1 mice were immunized with chicken collagen type II (CII) and were subsequently treated with ω-UFAs for 53 days. Dexamethasone (DEXA) was used as a positive anti-inflammatory agent. The effect of the treatments was evaluated through several parameters: inflammation indices, antibody levels, cell prolifera- tion, and histopathological findings. Results and Conclusion: The anti-inflammatory effect of the tested substances was inversely correlated with the histopathological findings: a greater anti- inflammatory effect was associated with less articular damage. Oleic acid (ω9) was the most efficient anti-inflammatory UFA, followed by DHA and then AA. DEXA completely inhibited the development of arthritis, whereas the untreated CII-immunized mice developed the most severe articular damage. DBA-1 mice with CII-induced arthritis constitute an adequate model for the study of arthritis and its treatment.

关键词： Collagen CIA DBA-1 Mice Omega-UFAs Dexamethasone Anti-Inflammatory

脆性X染色体综合征的临床特征及细胞遗传学研究

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国际遗传学杂志 1985年第4期08卷 187-190页

作者： Miguel De arce ,墙克信

一、脆性X染色体综合征的临床特征根据外表特征鉴别有脆性X染色体的人是十分困难的,即使在智力低下的人群中,也很难决定那一个病例值得进一步研究。目前,筛选的方法:一是研究X-连锁智力低下家系中的成员;二是根据某些临床特征作进一步研... 详细信息

一、脆性X染色体综合征的临床特征根据外表特征鉴别有脆性X染色体的人是十分困难的,即使在智力低下的人群中,也很难决定那一个病例值得进一步研究。目前,筛选的方法:一是研究X-连锁智力低下家系中的成员;二是根据某些临床特征作进一步研究,如像Down综合征那样。脆性X综合征有些临床特征对诊断具有一定价值。与脆性X染色体相关的主要临床特征包括智力低下、巨睾症、特殊面容、语言障碍及行为异常等方面,现分别介绍如下: 智力低下:脆性X综合征智力缺陷的程度变化范围较大。通常,半合子表现较严重

关键词：正常人携带者特殊面容染色体综合征智力低下临床特征

与年龄相关的社区获得性肺炎细菌性病原学危险因素

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中国实用内科杂志 2017年第4期37卷 360-360页

作者： Sahuquillo-arce JM

在感染性疾病中，社区获得性肺炎（CAP）发病率较高，也是导致患者死亡的重要原因。对西班牙一项纳入13所医院的住院CAP患者的前瞻性多中心研究进行二次分析结果显示，在1522例细菌感染患者中，肺炎链球菌933例，嗜肺军团菌110例，铜绿... 详细信息

在感染性疾病中，社区获得性肺炎（CAP）发病率较高，也是导致患者死亡的重要原因。对西班牙一项纳入13所医院的住院CAP患者的前瞻性多中心研究进行二次分析结果显示，在1522例细菌感染患者中，肺炎链球菌933例，嗜肺军团菌110例，铜绿假单胞菌50例，流感嗜血杆菌42例，金黄色葡萄球菌41例，肺炎支原体51例，大肠杆菌31例，伯氏考克斯体51例，肺炎衣原体50例，鹦鹉热衣原体9例和混合感染（其中66％为肺炎链球菌和其他病原体混合感染，

关键词：社区获得性肺炎细菌性危险因素病原体混合感染病原学前瞻性多中心研究金黄色葡萄球菌肺炎链球菌