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Journal of Shanghai University(english edition) 2007年第6期11卷 607-612页

作者：刘强邓瑜衡 ar0wolo e babajide School of environmental and Chemical engineering Shanghai University

A laboratory-scale trickling biofilter column, filled with Raschig rings and inoculated with Pseudomonas putida （ATCC 1785） was used to ＇purify chlorobenzene contained waste gases. Sodium dodecyl sulfonate （SDS） was used to enhance the performance of trickling biofilter. Purification performance of the trickling biofilter was examined for chiorobenzene inlet concentration of 1.20,-5.04 g/m^3 at different eBRTs between 76N153 s. Without SDS addition, with simultaneous increase in chlorobenzene inlet loading rate and gas flow rate, 100% removal efficiency was achieved at eBRT of 109 s and inlet loadings below 5120 mg/m^3. Addition of SDS to nutrient solution led to improvement of trickling biofilter purification performance. By introducing 25 mg/L SDS, the removal efficiency was increased by 21% and elimination capacity up to 234 g/（m^3.h） was achieved at chlorobenzene inlet loading of 241 g/（m^3.h）. Although SDS concentration experienced a low rate reduction after continuous nutrient solution recirculation, this result has period little influence on trickling biofilter＇s removal efficiency in monitoring period.

关键词： trickling biofilter chlorobenzene surfactant sodium dodecyl sulfonate (SDS).

Comparison of air-borne xylene biodegradation between immobilizedcell biofilter and biofilm attached biofilter

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Journal of Shanghai University(english edition) 2007年第5期11卷 514-520页

作者：刘强刘学锦 arOwolo e babajide 安太成傅家谟盛国英 School of environmental and Chemical engineering Shanghai University Shanghai 200072 P. R. China State Key Laboratory of Organic Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences Guangzhou 510640 P. R. China

The Bacillus firmus was immobilized into Ca-alginate beads according to the different initial biomass concentration, calcification time and activation time. Three types of immobilized Bacillus firmus beads were packed respectively in trickling biofilter to purify xylene contained waste gases, and the performance of immobilized-cell biofilter was compared with traditional biofilm attached biofilter packed with two types of ceramic pellets. The results showed that three types of immobilized beads had different capabilities for removing xylene and life-spans. Higher initial biomass in immobilized beads resulted in better performance but shorter life-span. Activation process can remarkably enhance the activity of bacteria, and the removal efficiency of xylene can substantially be improved. Calcification time had influence on life-span of immobilized beads. Without acclimation, the cell-entrapped biofilter can obtain the maximum elimination capacity of 92.4 g/（m^3·h）. However, compared with biofilm attached biofilter, it has a poorer intrinsic drawback in volatile organic compounds （VOCs） removal due to the existence of excess mass transfer resistance.

关键词： immobilized-cell biofilter biofilm attached biofilter xylene biodegradation

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SDS提高生物滴滤床净化氯苯废气的研究

环境科学 2007年第2期28卷 295-299页

作者：刘强陈荣 arowolo e.babajide 安太成傅家谟盛国英上海大学环境与化学工程学院环境污染与健康研究所上海200072 中国科学院广州地球化学研究所有机地球化学国家重点实验室广州510640

以ACOF和陶粒作为生物滤床的填料，利用***净化气相中的氯苯，并将十二烷基磺酸钠（SDS）添加于生物滴滤床的喷淋液中，研究其对滤床处理氯苯废气效果的影响．微生物静态培养结果表明，当培养基中SDS浓度大于35mgL时，对***存在明显抑... 详细信息

以ACOF和陶粒作为生物滤床的填料，利用***净化气相中的氯苯，并将十二烷基磺酸钠（SDS）添加于生物滴滤床的喷淋液中，研究其对滤床处理氯苯废气效果的影响．微生物静态培养结果表明，当培养基中SDS浓度大于35mgL时，对***存在明显抑制作用．在喷淋液中添加25mg/L的SDS，有助于缩短滤床的适应期，并提高稳态下滤床的性能．对于填料为ACOF的情况，喷淋液中的SDS最优添加浓度为25mg／L，此时滤床的最大去除负荷为234．7g，（m^3·h）．喷淋液中的SDS经过5d的运行，会有18％-20％的损失。但对滤床的性能没有明显影响．

关键词：氯苯生物滴滤床十二烷基磺酸钠

A novel hydrogen peroxide-initiated reaction of difluorodiiodomethane with alkynes

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Chinese Journal of Chemistry 1997年第2期15卷 154-159页

作者： Li, ar Chen, QY CHINeSe ACAD SCI SHANGHAI INST ORGAN CHEMSHANGHAI 200032PEOPLES R CHINA

The reaction of difluorodiiodomethane with alkynes (4a-e) in the presence of hydrogen peroxide afforded the corresponding beta-iodo-alpha, beta-unsaturated carboxylic acids. When propargylic alcohol was used as the substrate, beta-iodo-alpha,beta-unsaturated gamma-butyrolactone (5F) was produced. The mechanism of the reaction was suggested.

关键词： difluorodiiodomethane addition alkynes hydrogen peroxide

Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity

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Bone Research 2024年第1期12卷 180-198页

作者： Morten S.Hansen Kaja Madsen Maria Price Kent Søe Yasunori Omata Mario M.Zaiss Caroline M.Gorvin Morten Frost Alexander Rauch Molecular endocrinology Laboratory(KMeB) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Department of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of Metabolism and Systems Research(IMSR)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for Membrane Proteins and Receptors(COMPare) Universities of Birmingham and NottinghamBirmingham B152TTUK Department of Molecular Medicine University of Southern DenmarkDK-5000 Odense CDenmark Department of Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Department of Internal Medicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum Immuntherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of human osteoclastogenesis could help identify potential treatment *** study aimed to provide an overview of transcriptional reprogramming during human osteoclast *** were differentiated from CD14+monocytes from eight female *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight temporal patterns conserved across *** patterns revealed distinct molecular functions associated with postmenopausal osteoporosis susceptibility genes based on RNA from iliac crest biopsies and bone mineral density *** analyses revealed mutual dependencies between temporal expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the monocyte stage,such as filamin B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of mature *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone mineral density SNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exemplified by in vitro pharmacological modulation of complement 5 A receptor 1(C5ar1),somatostatin receptor 2(SSTR2),and free fatty acid receptor 4(FFar4/GPR120).Activating C5ar1 enhanced osteoclast formation,while activating SSTR2 decreased the resorptive activity of mature osteoclasts,and activating FFar4 decreased both the number and resorptive activity of mature *** conclus

关键词： osteoclast programming identif

Growth factor-and cytokine-driven pathways governing liver stemness and differentiation

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World Journal of Gastroenterology 2010年第41期16卷 5148-5161页

作者： aránzazu Sánchez Isabel Fabregat School of Pharmacy Complutense University 28040 Madrid Spain Bellvitge Biomedical Research Institute (IDI- BeLL) and University of Barcelona Molecular Oncology Laboratory Hospital Duran i Reynals. Gran Via de Hospitalet 199 L' Hospitalet 08907 Barcelona Spain

Liver is unique in its capacity to regenerate in response to injury or tissue loss. Hepatocytes and other liver cells are able to proliferate and repopulate the liver. However, when this response is impaired, the contribution of hepatic progenitors becomes very relevant. Here, we present an update of recent studies on growth factors and cytokine-driven intracellular pathways that govern liver stem/pro-genitor cell expansion and differentiation, and the rel-evance of these signals in liver development, regeneration and carcinogenesis. Tyrosine kinase receptor signaling, in particular, c-Met, epidermal growth factor receptors or fibroblast growth factor receptors, contribute to prolifera-tion, survival and differentiation of liver stem/progenitor cells. Different evidence suggests a dual role for the trans-forming growth factor (TGF)-β signaling pathway in liver stemness and differentiation. On the one hand, TGF-βmediates progression of differentiation from a progenitor stage, but on the other hand, it contributes to the expan-sion of liver stem cells. Hedgehog family ligands are nec-essary to promote hepatoblast proliferation but need to be shut off to permit subsequent hepatoblast differentiation. In the same line, the Wnt family and β-catenin/T-cell fac-tor pathway is clearly involved in the maintenance of liver stemness phenotype, and its repression is necessary for liver differentiation during development. Collectively, data indicate that liver stem/progenitor cells follow their own rules and regulations. The same signals that are essential for their activation, expansion and differentiation are good candidates to contribute, under adequate conditions, to the paradigm of transformation from a pro-regenerative to a pro-tumorigenic role. From a clinical perspective, this is a fundamental issue for liver stem/progenitor cell-based therapies.

关键词： Hepatocyte growth factor epidermal growth factor Fibroblast growth factor Transforming growth factor-β Hedgehog and β-catenin Liver Stem cell

Fetal lung growth predicts the risk for early-life respiratory infections and childhood asthma

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World Journal of Pediatrics 2024年第5期20卷 481-495页

作者： Dimitra e.Zazara Olympia Giannou Steven Schepanski Mirja Pagenkemper Anastasios D.Giannou Maike Pincus Ioannis Belios Stefan Bonn Ania C.Muntau Kurt Hecher Anke Diemert Petra Clara arck Division for experimental Feto-Maternal Medicine Department of Obstetrics and Fetal MedicineUniversity Medical Center Hamburg-Eppendorf(UKE)Martinistraße 5220251HamburgGermany University Children’s Hospital UKEHamburgGermany Computer engineering and Informatics Department Polytechnic SchoolUniversity of PatrasPatrasGreece Institute of Developmental Neurophysiology Center for Molecular Neurobiology Hamburg(ZMNH)UKEHamburgGermany Department of Obstetrics and Fetal Medicine UKEHamburgGermany Department of General Visceral and Thoracic SurgeryUKEHamburgGermany Section of Molecular Immunology and Gastroenterology Ⅰ.Department of MedicineUKEHamburgGermany Pediatrics and Pediatric Pneumology Practice BerlinGermany Institute of Medical Systems Biology ZMNHUKEHamburgGermany Hamburg Center for Translational Immunology UKEHamburgGermany

Background early-life respiratory infections and asthma are major health burdens during *** predicting an increased risk for early-life respiratory diseases are ***,we identified the predictive value of ultrasound-monitored fetal lung growth for the risk of early-life respiratory infections and *** Fetal lung size was serially assessed at standardized time points by transabdominal ultrasound in pregnant women participating in a pregnancy *** between fetal lung growth and respiratory infections in infancy or early-onset asthma at five years were ***-learning models relying on extreme gradient boosting regressor or classifier algorithms were developed to predict respiratory infection or asthma risk based on fetal lung *** model development and validation,study participants were randomly divided into a training and a testing group,respectively,by the employed *** enhanced fetal lung growth throughout pregnancy predicted a lower early-life respiratory infection *** sex was associated with a higher risk for respiratory infections in *** lung growth could also predict the risk of asthma at five years of *** designed three machine-learning models to predict the risk and number of infections in infancy as well as the risk of early-onset *** models’R2 values were 0.92,0.90 and 0.93,respectively,underscoring a high accuracy and agreement between the actual and predicted *** variables included known risk factors and novel predictors,such as ultrasound-monitored fetal lung *** Sonographic monitoring of fetal lung growth allows to predict the risk for early-life respiratory infections and asthma.

关键词： Asthma Child risk early-life respiratory infections Prenatal lung development Sexual dimorphism

Chemoprotective activity of aqueous leaf extract of Acalypha wilkesiana against cyclophosphamide-induced toxicity in rats

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Asian Pacific Journal of Tropical Medicine 2019年第9期12卷 409-415页

作者： Chinedu P.Anokwuru God’swill N.Anyasor Olutayo S.Shokunbi babajide Sopekan Oyindamola K.Osinuga Olusola e.Afolabi Olamide B.arojojoye Chibundu N.ezekiel Isaiah DI.Ramaite Department of Basic Sciences School of Science and TechnologyBabcock UnitersiyIlishan RemoOgun StateNgeria Department of Chemistry School of Mathematical and Natural SciencesUnirersity of VendaThohoyandou South Africa Department of Biochenistry Benjamin S.Carson(Snr)Schoo of MedicineCollege of Health and Medical ScienesBabcock Uniters Department of Microbiology School of Science and TchnlogyBabrock Unitersitslishan RemoNigera

Objective:To investigate the protective effect of aqueous leaf extract of Acalypha(A.)wilkesiana ***(euphorbiaceae)against cyclophosphamide-induced toxicity in albino ***:Twenty male albino rats were randomly divided into five groups of four animals *** control group(Ⅰ)was fed with pellets and distilled water,while group Ⅱ was orally administered with only 20 mg/kg *** Ⅲ,Ⅳ and Ⅴ were coadministered with 20 mg/kg body weight cyclophosphamide and 110,220 and 440 mg/kg body weight *** leaf extract,respectively,for 7 *** treatment,liver and kidney function biomarkers,haematological parameters,liver antioxidants,and mitochondrial membrane permeability transition pore opening were ***:*** leaf extract significantly reduced(Pe-induced increase in plasma aspartate aminotransferase,alanine aminotransferase,creatinine,uric acid and *** increased superoxide dismutase,catalase,glutathione-S-transferase activities and reduced glutathione *** also increased packed cell volume count,hemoglobin concentration and white blood cell count while inhibiting the induction of mitochondrial ***:This study demonstrates that aqueous extract of *** leaf protected tissues against cyclophosphamide-induced oxidative damage.

关键词： Medicinal plants Oxidative stress Chemoprotective activity Cyclophosphamide Acalypha wilkesiana

Development of a multicellular 3D-bioprinted microtissue model of human periodontal ligament-alveolar bone biointerface:Towards a pre-clinical model of periodontal diseases and personalized periodontal tissue engineering

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Genes & Diseases 2022年第4期9卷 1008-1023页

作者： Murat Taner Vurat ŞükranŞeker Özge Lalegül-Ülker Mahmut Parmaksiz Ayşe eser elçin Yaşar Murat elçin Tissue engineering Biomaterials and Nanobiotechnology LaboratoryAnkara University Faculty of ScienceAnkara University Stem Cell InstituteAnkara 06100Turkey Biovalda Health Technologies Inc.Ankara 06100Turkey

While periodontal (PD) disease is among principal causes of tooth loss worldwide, regulation of concomitant soft and mineralized PD tissues, and PD pathogenesis have not been completely clarified yet. Besides, relevant pre-clinical models and in vitro platforms have limitations in simulating human physiology. Here, we have harnessed three-dimensional bioprinting (3DBP) technology for developing a multi-cellular microtissue model resembling PD ligament-alveolar bone (PDL-AB) biointerface for the first time. 3DBP parameters were optimized;the physical, chemical, rheological, mechanical, and thermal properties of the constructs were assessed. Constructs containing gelatin methacryloyl (Gel-MA) and hydroxyapatite-magnetic iron oxide nanoparticles showed higher level of compressive strength when compared with that of Gel-MA constructs. Bioprinted self-supporting microtissue was cultured under flow in a microfluidic platform for >10 days without significant loss of shape fidelity. Confocal microscopy analysis indicated that encapsulated cells were homogenously distributed inside the matrix and preserved their viability for >7 days under microfluidic conditions. Immunofluorescence analysis showed the cohesion of stromal cell surface marker-1+ human PDL fibroblasts containing PDL layer with the osteocalcin+ human osteoblasts containing mineralized layer in time, demonstrating some permeability of the printed constructs to cell migration. Preliminary tetracycline interaction study indicated the uptake of model drug by the cells inside the 3D-microtissue. Also, the non-toxic levels of tetracycline were determined for the encapsulated cells. Thus, the effects of tetracyclines on PDL-AB have clinical significance for treating PD diseases. This 3D-bioprinted multi-cellular periodontal/osteoblastic microtissue model has potential as an in vitro platform for studying processes of the human PDL.

关键词： 3D bioprinting Alveolar bone Microtissue model Organ-on-a-chip .Periodontal ligament Periodontal tissue engineering Periodontal-osteoblastic biointer face Periodontium-on-a-chip

Development of an Asynchronous Web Based e-Learning System

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Journal of Computer and Communications 2015年第12期3卷 84-99页

作者： Nathaniel Olufisayo Oluwaniyi babajide Olakunle Afeni Olusegun Olayinka Lawal Department of Computer Science Joseph Ayo Babalola University (JABU) Ikeji-Arakeji Nigeria

Advancements in Information Communication Technology (ICT) have led to several opportunities especially the ones provided by the Internet. Several people are now taking advantage of distance learning courses and in the past few years huge research efforts have been dedicated to the development of distance learning systems. So far, many e-learning systems are proposed and used practically. This paper focused on the development of an asynchronous and interactive Web-based e-learning system. Its primary objective is to develop a fast, reliable, effective and efficient web-based e-learning system that will address the problems associated with the traditional learning system. Succinctly, the paper discusses the design of a system that enhances e-learning where course lecturers can set their courses, tests and quizzes at their convenient time and can track the activities and performance of their students and guide them to acquire knowledge without being obliged to be physically present on the institution campus. The system was designed using PHP as the scripting language, Macromedia Dreamweaver for the web page, MySQL as the database and Apache as the web server. The system was implemented using real data and the result was successful. This system is no doubt a solution to the constraints of the classical learning system and can be used successfully in distance learning, training, and various educational institutions.

关键词： e-Learning Web-Based Asynchronous Information Communication Technology (ICT)