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Plasma chitinase 3-like 1 is persistently elevated during first month after minimally invasive colorectal cancer resection

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World Journal of Gastrointestinal Oncology 2016年第8期8卷 607-614页

作者： HMC Shantha Kumara David Gaita hiromichi Miyagaki Xiaohong Yan Sonali AC Hearth Linda Njoh Vesna Cekic Richard L Whelan Division of Colon and Rectal Surgery Department of Surgery Mount Sinai West Hospital Department of Gastroenterological Surgery Osaka University

AIM: To assess blood chitinase 3-like 1(CHi3L1) levels for 2 mo after minimally invasive colorectal resection(MICR) for colorectal cancer(CRC). METHODS: CRC patients in an Institutional Review Board approved data/plasma bank who underwent elective MICR for whom preoperative(PreO p), early postoperative(PostO p), and 1 or more late PostO p samples [postoperative day(POD) 7-27] available were included. Plasma CHi3L1 levels(ng/m L) were determined in duplicate by enzyme linked immunosorbent assay. RESULTS: PreOp and PostOp plasma sample were available for 80 MICR cancer patients for the study. The median PreOp CHi3L1 level was 56.8 CI: 41.9-78.6 ng/mL(n = 80). Significantly elevated(P < 0.001) median plasma levels(ng/mL) over PreOp levels were detected on POD1(667.7 CI: 495.7, 771.7; n = 79), POD 3(132.6 CI: 95.5, 173.7; n = 76), POD7-13(96.4 CI: 67.7, 136.9; n = 62), POD14-20(101.4 CI: 80.7, 287.4; n = 22), and POD 21-27(98.1 CI: 66.8, 137.4; n = 20, P = 0.001). No significant difference in plasma levels were noted on POD27-41. CONCLUSION: Plasma CHi3L1 levels were significantly elevated for one month after MICR. Persistently elevated plasma CHi3L1 may support the growth of residual tumor and metastasis.

关键词： Colorectal cancer Recurrence Minimally inasive colorectal resection Chitinase 3-like 1 Metastasis

Attention-Deficit/Hyperactivity Disorder in Adults with High-Functioning Pervasive Developmental Disorders in Japan

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Open Journal of Psychiatry 2014年第4期4卷 372-380页

作者： Yasuko Takanashi Hirobumi Mashiko Hirohide Yokokawa Yoko Kawasaki Shuntaro Itagaki hiromichi Ishikawa Norihiro Miyashita Yasuaki Hayashi Asako Kudo Kentaro Oga Rieko Matsuura Shin-Ichi Niwa Department of Neuropsychiatry Fukushima Medical University School of Medicine Fukushima Japan Fukushima General Health and Welfare Center Fukushima Japan Department of Public Health Fukushima Medical University School of Medicine Fukushima Japan Department of General Medicine Juntendo University School of Medicine Tokyo Japan Musasino Child Development Clinic Tokyo Japan Hanawakousei Hospital Fukushima Japan Landic Nihonbashi Clinic Tokyo Japan Hoshigaoka Hospital Fukushima Japan Surugadai Nihon University Hospital Tokyo Japan Shiba Clinic Tokyo Japan

Aims: This study was designed to verify the proportion of Japanese adults with pervasive developmental disorder (PDD) who met the diagnostic criteria (other than E) for attention-deficit/hyperactivity disorder (ADHD) in the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR). Furthermore, we examined to what extent adults with PDD think that they exhibit ADHD symptoms. Methods: We developed an original Japanese self-report questionnaire to determine the presence or absence of 18 symptoms from the diagnostic criteria for ADHD in the DSM-IV-TR. We administered the questionnaire to 64 adults with high-functioning PDD (45 men and 19 women) and 21 adults with ADHD (10 men and 11 women), aged 18 to 59 years, with a full-scale intelligence quotient ≥75. Target patients were evaluated for ADHD by their psychiatrists. Results: Twenty-nine (45.3%) adults with PDD also had ADHD. The percentage of these adults who had over six perceived inattention symptoms from the DSM-IV-TR was 96.6%. The percentage of these adults who had over six perceived hyperactivity-impulsivity symptoms was 65.5%. Thirty-five (55.6%) adults with PDD responded that they were aware of having ADHD symptoms at the level of the relevant diagnostic criteria. Conclusions: The present study is the first to examine the frequency of objective and perceived ADHD symptoms in adults with PDD in Japan. Our results show that both objective and perceived ADHD symptoms frequently appear in a large number of adults with PDD. This suggests that it is necessary to attend to concomitant ADHD symptoms in the medical care of adults with PDD.

关键词： Adults Attention-Deficit/Hyperactivity Disorder (ADHD) High-Functioning Pervasive Developmental Disorders (PDD) Self-Report

True left-sided gallbladder with variations of bile duct and cholecystic vein

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World Journal of Gastroenterology 2015年第21期21卷 6754-6758页

作者： hiromichi Ishii Akinori Noguchi Mie Onishi Koji Takao Takahiro Maruyama Hiroaki Taiyoh Yasunobu Araki Takeshi Shimizu Hiroyuki Izumi Naoki Tani Masahide Yamaguchi Tetsuro Yamane Department of Surgery Matsushita Memorial Hospital

A left-sided gallbladder without a right-sided round ligament,which is called a true left-sided gallbladder,is extremely rare.A 71-year-old woman was referred to our hospital due to a gallbladder *** tomography(CT) revealed not only a gallbladder polyp but also the gallbladder located to the left of the round ligament connected to the left umbilical *** portography revealed that the main portal vein diverged into the right posterior portal vein and the common trunk of the left portal vein and right anterior portal *** cholangiography revealed that the infraportal bile duct of segment 2 joined the common bile *** cholecystectomy was performed for a gallbladder polyp,and the intraoperative finding showed that the cholecystic veins joined the round ligament.A true left-sided gallbladder is closely associated with several anomalies; therefore,surgeons encountering a true left-sided gallbladder should be aware of the potential for these anomalies.

关键词： True left-sided gallbladder Infraportal bileduct of segment 2 Anomaly of the cholecystic vein Anomaly of the portal vein Laparoscopic cholecystectomy

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二磷酸盐的长期治疗与骨微损伤的积聚

二磷酸盐的长期治疗与骨微损伤的积聚

Clinical significance of monocyte-derived dendritic cell activation in patients with acute coronary syndrome

中华医学会第四次全国骨质疏松和骨矿盐疾病学术会议

作者：曹永平 Satoshi Mori Tasuku Mashiba hiromichi Norimatsu 北京大学第一医院骨科日本香川大学医学部整形外科

背景在力学负荷的不断作用下骨基质内发生的微裂隙(mcriocrack)称之为骨的微损伤(micro- damage),在生理范围内微损伤主要通过骨的改建(remodeling)来修复。如果微损伤产生过多或是微损伤的修复能力减弱将导致微损伤积聚,从而影响骨的...

背景在力学负荷的不断作用下骨基质内发生的微裂隙(mcriocrack)称之为骨的微损伤(micro- damage),在生理范围内微损伤主要通过骨的改建(remodeling)来修复。如果微损伤产生过多或是微损伤的修复能力减弱将导致微损伤积聚,从而影响骨的生物力学特性而发生疲劳骨折。目前临床查常用的二磷酸盐通过抑制改建可以增加骨量和降低骨折发生率,这有可能抑制骨微损伤的修复从而导致微损伤的积聚,并且可能进一步影响骨的生物力学特性。研究目的本实验的目的在于评估三年的二磷酸盐治疗对骨微损伤和骨生物力学特性的影响。材料和方法29只一岁龄犬(雌性14只,雄性15只)按体重

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World Journal of Cardiovascular Diseases 2012年第2期2卷 74-81页

作者： Yasue Takahashi Kazunori Shimada Katsuhiko Sumiyoshi Takashi Kiyanagi Makoto Hiki Kosuke Fukao Kuniaki Hirose Rie Matsumori hiromichi Ohsaka Atsumi Kume Tetsuro Miyazaki Hiroaki Miyajima Isao Nagaoka Hiroyuki Daida Department of Cardiovascular Medicine Juntendo University School of Medicine Tokyo Japan Department of Host Defense and Biochemical Research Juntendo University Graduate School of Medicine Tokyo Japan Division of Cell Biology Juntendo University Graduate School of Medicine Tokyo Japan

Background: Acute coronary syndrome (ACS) is an amplified state of inflammation and immune reaction. Dendritic cells (DCs) expressing various Toll-like receptors (TLRs) have been observed in atherosclerotic lesions, however, the clinical significance of DCs in pathogenesis of ACS has not been completely investigated. Methods: Ten patients with ACS and 10 patients with stable angina pectoris (SAP) were enrolled in this study. Monocyte-derived DCs were generated from CD14+ cells by culturing with granulocyte macrophage colony-stimulating factor and interleukin (IL)-4 for 6 days. Expression of cell surface CD86 and CD83 were measured by flowcytometry. Expression of genes, including CD86, CD83, CCL19, CCR7, TLR2, TLR4, TLR5, TLR8, and TLR9, were measured by real-time PCR. Plasma IL-6 and tumor necrosis factor (TNF)-α levels were also measured. Results: The number of CD86+CD83+DCs in the ACS group was significantly higher than that in the SAP group (P P P +CD83+ cells and plasma levels of IL-6 (P = 0.88, P +CD83+ cells TNF-α levels (r = 0.78, P < 0.0001). Conclusions: These results demonstrated that mono-cyte-derived DCs are activated in patients with ACS, suggesting that activated DCs may play an important role in the pathogenesis of ACS.

关键词： Acute Coronary Syndrome (ACS) Dendritic Cells (DCs) Toll-Like Receptors (TLRs)

四川盆地中侏罗世石柱叶肢介及其个体发育暗示

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四川盆地中侏罗世石柱叶肢介及其个体发育暗示

Clinical and prognostic features in asymptomatic and symptomatic patients with arteriosclerosis obliterans

中国古生物学会第十次全国会员代表大会暨第25届学术年会——纪念中国古生物学会成立80周年

作者：李罡 HIRANO hiromichi KOZAI Takeshi SAKAI Takashi 泮艳红现代古生物学和地层学国家重点实验室中国科学院南京地质古生物研究所 Department of Earth Sciences School of EducationWaseda University Laboratory Geosciences Faculty of ScienceNaruto University of Education Department of Earth and Planetary Sciences Kyushu University

目前叶肢介的分类位置为甲壳纲腮足亚纲双甲目,具有两个几丁质外壳。叶肢介的地质记录可追溯到古生代的泥盆纪。中生代是它的大发展时期,分异度提高,在陆相地层中扮演着地层划分对比的重要角色。到新生代该类动物全面衰退,目前仅存少数... 详细信息

目前叶肢介的分类位置为甲壳纲腮足亚纲双甲目,具有两个几丁质外壳。叶肢介的地质记录可追溯到古生代的泥盆纪。中生代是它的大发展时期,分异度提高,在陆相地层中扮演着地层划分对比的重要角色。到新生代该类动物全面衰退,目前仅存少数种属。本文通过扫描电镜研究重新描述了四川盆地重庆地区中侏罗世的石柱叶肢介(Shizhuestheria)属。该属最早描述于重庆市石柱县沿溪中侏罗统新田沟组。最近通

关键词：叶肢介个体发育中侏罗世四川盆地

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World Journal of Cardiovascular Diseases 2012年第1期2卷 1-7页

作者： hiromichi Ohsaka Kazunori Shimada Kosuke Fukao Eiryu Sai Yoshifumi Fukushima Hiroshi Masuda Kuniaki Hirose Takuma Yoshihara Rie Matsumori Makoto Hiki Takashi Kiyanagi Atsumi Kume Haruyo Yamashita Tetsuro Miyazaki Hiroyuki Daida 不详

Background: Patients with arteriosclerosis obliterans (ASO) often have co-existing atherosclerotic diseases. The purpose of this study was to examine the clinical features of patients with ASO, including the overlap of atherosclerotic risk factors, characteristics of car-diovascular events, and clinical prognosis. Method: We enrolled 205 consecutive patients who had ankle brachial index (ABI) of ?0.9 between January 2008 and December 2009. Fontaine (F) classification and clinical background were evaluated and clinical events including mortality and major adverse cardiocerebro-vascular events (MACCEs) were determined. Results: There was a high prevalence of each risk factor. Sixty- five percent of subjects had three or more of the four overlapping risk factors, including hypertension, dia- betes, dyslipidemia, and smoking. After a maximum follow-up of 800 days, the incidence of MACCEs and mortality was 46% and 10%, respectively. We divided the patients into two groups according to the presence of ASO symptoms (F1 and F2-4) and compared the incidence of events. The incidence of MACCEs and mortality in the F2-4 group was significantly higher than that in the F1 group (P = 0.048, P = 0.044, respectively). After excluding lower extremity revascularization, coronary artery disease was a common cause of MACCEs, and the mortality rates after MACCEs increased in a stepwise manner according to F classification severity (P = 0.028). Conclusion: Patients with ASO had overlapping coronary risk factors and a high incidence rate of cardiovascular events. The incidence of coronary events was common, especially in symptomatic patients, and the mortality rates after MACCEs were high in accordance with F classification severity.

关键词： Arteriosclerosis Obliterans Fontaine Classification Risk Factor Mortality Cardiocerebrovascular Event

Granular cell tumor of the pancreas:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2010年第2期2卷 121-124页

作者： Atsushi Kanno Kennichi Satoh Morihisa Hirota Shin Hamada Jun Umino hiromichi Itoh Atsushi Masamune Shinichi Egawa Fuyuhiko Motoi Michiaki Unno Kazuyuki Ishida Tooru Shimosegawa Division of Gastroenterology Tohoku University Graduate School of Medicine Department of Hepatobiliary-pancreatic surgery Tohoku University Graduate School of Medicine Department of Pathology Tohoku University Graduate School of Medicine

Granular cell tumors,also called Abrikossof's tumors,were originally described by Abrikossof A in *** f irst case of a pancreatic granular cell tumor was described in 1975 and only 6 cases have been *** describe a case of granular cell tumor in the pancreas showing pancreatic duct *** imaging studies showed f indings compatible with those of pancreatic carcinoma,the patient underwent distal *** examination showed that the tumor consisted of a nested growth of large tumor cells with ample granular cytoplasm and small round *** tumor cells expressed S-100 protein and were stained with neuron-specific enolase and periodic acid-Schiff,but were negative for desmin,vimentin,and *** resected tumor was diagnosed as a granular cell *** our knowledge,this is the seventh case of Granular cell tumor of the pancreas to be reported.

关键词： Granular cell tumor Pancreas Diagnosis Distal pancreatectomy

Is there diversity among UGT1A1 polymorphism in Japan?

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World Journal of Gastrointestinal Oncology 2012年第7期4卷 170-175页

作者： Michiya Kobayashi Shoichi Hazama Kenichi Takahashi Koji Oba Naoko Okayama Mitsuaki Nishioka Yuji Hinoda Masaaki Oka Ken Okamoto hiromichi Maeda Daisuke Nakamura Junichi Sakamoto Hideyuki Mishima Department of Human Health and Medical Sciences Kochi Medical School Nankoku 783-8505 Japan Department of Digestive Surgery and Surgical Oncology (Surgery Ⅱ) Yamaguchi University Graduate School of Medicine Ube Yamaguchi 755-8505 Japan Department of Surgery Aomori Prefectural Central Hospital Aomori 030-8553 Japan Translational Research and Clinical Trial Center Hok-kaido University Hospital Sapporo 060-8638 Japan Division of Laboratory Yamaguchi University Hospital Ube Yamaguchi 755-8505 Japan Department of Oncology and Laboratory Medicine Yamaguchi University Graduate School of Medicine Ube Yama-guchi 755-8505 Japan Tokai University School of Medicine Is-ehara Kanagawa 259-1131 Japan Young Leaders Program in Healthcare Administration Nagoya University Graduate School of Medicine Nagoya 466-8550 Japan Department of Surgery Osaka National Hos-pital Osaka 565-0871 Japan

AIM: To investigate into the diversity of UGT1A1 polymorphism across three different districts in Japan and highlight genetic differences among the population in Japan. METHODS: We enrolled 50 healthy volunteers from each of the Yamaguchi (western part of Japan), Kochi(southern part of Japan) and Akita (northern part of Japan) prefectures. Blood samples (7 mL) were collected from each participant and stored in EDTA for subsequent genotyping by fragment size analysis, direct sequencing and TaqMan assay of UGT1A1*28, UGT1A7*3/UGT1A9*22 and UGT1A1*93/UGT1A1*6/ UGT1A1*27/UGT1A1*60/UGT1A7 (-57), respectively. RESULTS: The only statistically significant differences in allele polymorphisms among the group examined were for UGT1A1*6. The Akita population showed more UGT1A1*6 heterozygosity (P = 0.0496). CONCLUSION: Our study revealed no regional diversity among UGT1A1, UGT1A7 or UGT1A9 polymorphisms in Japan.

关键词： UGT1A1 gene Polymorphism Diversity