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Synergistic effect of picosecond optical and nanosecond electrical pulses on dielectric breakdown in aqueous solutions

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Photonics Research 2021年第3期9卷 416-423页

作者： Zachary N.coker Xiao-Xuan Liang Allen S.Kiester Gary D.Noojin Joel N.Bixler Bennett L.Ibey Alfred Vogel Vladislav V.Yakovlev Department of Physics and Astronomy Texas A&M UniversityCollege StationTexas 77843USA SAIC Ft Sam HoustonTexas 78234USA Institut fur Biomedizinische Optik Universitat zu Lubeck23562 LubeckGermany Air Force Research Laboratory JBSA Fort Sam HoustonTexas 78234USA Department of Biomedical Engineering Texas A&M UniversityCollege StationTexas 77843USA

The combined effect of short(picosecond) optical and(nanosecond) electrical pulses on dielectric breakdown is investigated both theoretically and experimentally. It was demonstrated that nanosecond electrical pulses(nsEPs),being applied simultaneously with picosecond optical pulses, reduce the threshold for optical *** results are discussed with respect to an extended model for opto-electrical-induced *** newly unveiled effect is expected to play a significant role in spatially confined electroporation and further advances in laser-ablation-based processes while also allowing for measurements of ambipolar diffusion constants.

关键词： breakdown optical picosecond

结核病规划应采购二线药治疗耐多药结核病吗?

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国际结核病与肺部疾病杂志 2002年第4期 161-162页

作者：邹级谦 RICHARD coker MSC MD Senior Lecturer Department of Public Health and Policy London School of Hygiene and Tropical Medicine Keppel Street London WC1E 7HT UK

在本刊2001年12月的一期中,Gupta等曾经提出在结核病规划中是否应采购二线药治疗耐多药结核病(MDR—TB)的问题。他们的论文是在“***”(***)网上引发的一场争论后产生的。

关键词：二线 TB MDR 结核病耐多药规划长远计划

Sexual Satisfaction Is Reduced in the Female Patient and Sexually Intimate Partners Following Cancer Therapy

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Advances in Sexual Medicine 2014年第4期4卷 65-70页

作者： Alan M. Martinez Julie M. Sroga Ilana B. Ressler Leslie Ayensu-coker Michael A. Thomas Steven R. Lindheim Department of Obstetrics & Gynecology University of Cincinnati Cincinnati USA New York Fertility Services New York USA Department of Obstetrics & Gynecology University of Kentucky Lexington USA Department of Obstetrics & Gynecology Wright State University Dayton USA

As cancer survival has continued to improve, cancer patients and their sexually intimate partner (SIP) are confronted with a number of issues including sexual function and overall sexual health. Our study objective was to assess changes in sexual function in women undergoing cancer treatment and their SIP, and attempt to identify areas of needed support and improvement. In this questionnaire-based observational study, females (n = 11) completed a Female Sexual Function Index (FSFI) and for SIP’s (n = 11), a Brief Sexual Function Inventory (BSFI). Level of satisfaction prior to and within 3 months following treatment with surgery, chemotherapy and/or radiation was compared. Mean pre-and post-treatment total (30.7 ± 2.7 vs. 23.2 ± 3.7, p < 0.001) and individual FSFI domains were significantly different for desire (4.2 ± 0.6 vs. 2.6 ± 0.6, p < 0.001), arousal (4.9 ± 0.4 vs. 3.5 ± 0.7, p = 0.001), lubrication (5.5 ± 0.4 vs. 4.5 ± 0.8, p = 0.006), orgasm (5.0 ± 0.6 vs. 3.8 ± 0.7, p = 0.001), satisfaction (5.3 ± 0.6 vs. 3.5 ± 0.9, p < 0.001), though no differences were noted with dyspareunia. For SIP’s, BSFI domain scores for level of satisfaction were significantly lower following partner treatment of SIPs (3.5 ± 5.2 vs. 2.5 ± 5.2, p = 0.004). Overall, female sexual dysfunction was identified in 9% of patients prior to cancer treatment and 91% (n = 11, p < 0.001) following treatment. In conclusion, cancer treatment significantly affects sexual function in female cancer patients and their SIPs. While long term effects on sexual dysfunction are still unclear, short-term health care strategies including treatment, counseling, and appropriate referral for cancer patients and their SIPs should not be overlooked.

关键词： Sexuality Sexual Dysfunction Female Cancer Cancer Treatment

高龄女性的社会经济状况和宫颈癌生存率:来自SEER-Medicare连锁资料队列的发现

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世界核心医学期刊文摘（妇产科学分册） 2006年第12期2卷 45-46页

作者： coker A.L. Eggleston K.S. 马超 University of Texas School of Public Health1200 Herman PresslerPOBox 20186HoustonTX 77225United States

Objectives:Tumor stage,age,and cell type are well-characterized predictors for cervical cancer survival; socioeconomic factors may also play an important role. The purpose of this study is to estimate cervical cancer survival by socioeconomic indicators and race/ethnicity among elderly women diagnosed with cervical cancer. Methods:We studied 1251 women with cervical cancer aged 65 or older,identified between 1992 and 1999 from the Surveillance,Epidemiology,and End Results SEER Medicare linked data. All women had similar access to care through Medicare fee-for-services insurance. A composite measure of socioeconomic status was created using census tract level data for poverty,education,and income. Cox proportional hazardmodelingwas used for all-cause and cervical cancer-specific survival analysis. Results:Increased age (P < 0.0001) and advanced tumor stage ( < 0.0001) were associated with poorer all-cause and cervical cancer-specific survival. After adjustment for age,stage,and treatment,increased co-morbidity scores and having non-squamous cervical cancer were associated with poorer all-cause survival (P < 0.001). After adjusting for confounders,women receiving hysterectomy vs. no surgery or any treatment had significantly better all-cause and cervical cancer-specific survival. Socioeconomic factors were not associated with either all-cause (P for trend = 0.79) or cervical cancer-specific (P for trend = 0.81) survival. No racial/ethnic differences in all-cause or cervical cancer-specific survival were observed after adjusting for socioeconomic factors. Conclusion:Among women with similar access to care,neither minority race/ethnicity nor poorer socioeconomic status were associated with poorer survival in this large sample of older women diagnosed with invasive cervical cancer. Presence of co-morbid conditions and treatment were important predictors of cervical cancer survival.

关键词： SEER-Medicare 肿瘤分期生存分析社会经济指标肿瘤特异性细胞类型使用人口子宫切

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血液处理过程中的红细胞溶血

国外医学（输血及血液学分册） 2003年第1期26卷 84-88页

作者： Samuel O.Sowemimo coker 张海琴吕沁风浙江省血液中心

输注的红细胞制品中红细胞发生溶血已有报道,这对于需要输血的病人具有重要的临床意义。因为游离血红蛋白将裂解成二聚体与结合珠蛋白结合,进而通过网状内皮系统清除,一旦超出结合珠蛋白的结合能力,将会发生血红蛋白血症。溶血是指红细... 详细信息

输注的红细胞制品中红细胞发生溶血已有报道,这对于需要输血的病人具有重要的临床意义。因为游离血红蛋白将裂解成二聚体与结合珠蛋白结合,进而通过网状内皮系统清除,一旦超出结合珠蛋白的结合能力,将会发生血红蛋白血症。溶血是指红细胞破坏后释放出血红蛋白并引起血浆颜色改变。红细胞异常溶血由许多因素引起,包括在血液处理过程中操作不当、保存条件不当、细菌性溶血、抗体激活补体的溶血、红细胞膜的缺陷及献血者异常等。溶血的程度常用红细胞比容校正后的整个血红蛋白中游离血红蛋白的百分率来表示。北美尚未建立可被接受的溶血范围,但是1％溶血标准目前用于评估血液贮存材料的生物相容性,而欧洲委员会将标准定为0.8％。本文强调要对全血制备红细胞的全程进行充分的监控,从而减少溶血的发生。仔细评估血液制备过程将降低因溶血而废弃的红细胞量。

关键词：血液处理红细胞溶血输血血液保存

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结核病传播和干预对传染率的影响

国际结核病与肺部疾病杂志 2002年第4期 125-130页

作者： R.Pitman B.Jarman R.coker 邹级谦 Division of Primary Care and Population Health Sciences Imperial College School of Medicine at St. Mary's London London School of Hygiene & Tropical Medicine ECOHOST London United Kingdom

地点:英格兰和威尔士。目的:定量研究英格兰和威尔士在1953-1990年间,菌苗接种、化疗及预防性治疗对减少结核发病的贡献。设计:为了估算接种前的参数,根据1913-1939年的登记资料,拟合了结核病传播的房室模型。化疗及预防性治疗率的最... 详细信息

地点:英格兰和威尔士。目的:定量研究英格兰和威尔士在1953-1990年间,菌苗接种、化疗及预防性治疗对减少结核发病的贡献。设计:为了估算接种前的参数,根据1913-1939年的登记资料,拟合了结核病传播的房室模型。化疗及预防性治疗率的最优估值则是利用1953-1990年的登记资料拟合的模型推算的。还利用了公布的接种率。主要的结果指标:所减少的肺结核病例数。结果:在1953-1990年间,由于应用预防性治疗、菌苗接种和化疗而使呼吸系结核病减少的数量分别为288318,57085和206996。结论:在诸项干预中,预防性治疗对传播的影响最大。由于前期痰菌阳性,传染期长,容易发病。

关键词：模型理论结核病肺流行病学药物治疗接种化学预防卫生政策非线性动力学

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卵巢恶性黑色素瘤:一种罕见的孤立性转移瘤

世界核心医学期刊文摘（妇产科学分册） 2006年第2期2卷 51-52页

作者： Oliver R. Dasgupta C. coker A. 张丽娟 Harold Wood Hospital Gubbins Lane Romford Essex-RM3 0BE United Kingdom

Background. Malignant melanomas of the ovary are rare with unpredictable clinical and biological behavior. We present this case report of a metastatic ovarian malignant melanoma, where the ovary was the first site of relapse after 10 years of remission. Case. A 58-year-old postmenopausal woman was incidentally found to have an abdominal mass, 10 years after removal of a cutaneous malignant melanoma lesion. Ultrasound and CT scan revealed an adnexal mass, which was found to be a solitary ovarian tumor at laparotomy. Histology confirmed malignant melanoma metastasis. Conclusion. Relapse after a prolonged period of remission, presenting, as an isolated ovarian metastasis is an unusual presentation of malignant melanoma. As illustrated by this case report, a differential diagnosis of a metastatic malignant melanoma must be considered.

关键词：卵巢肿瘤卵巢转移瘤组织学检查恶性黑色素瘤附件包块腹部包块鉴别诊断间隔时间

Management of Biohazards and Pandemics: COVID-19 and Its Implications in the Construction Sector

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Computational Water, Energy, and Environmental Engineering 2022年第1期11卷 34-63页

作者： Chiemela Victor Amaechi Ebube Charles Amaechi Sharon Chinyere Amechi Abiodun Kolawole Oyetunji Irish Mpho Kgosiemang Okechukwu John Mgbeoji Adesola Samson Ojo Alejandro Moure Abelenda Mohamed Milad Ibitoye Adelusi Akinwale Oladotun coker Department of Engineering Lancaster University Lancaster UK Standards Organisation of Nigeria (SON) Abuja Nigeria Department of Zoology University of Ilorin Ilorin Kwara State Nigeria School of Health and Social Wellbeing University of the West of England (UWE) Bristol UK Department of Radiography Federal Medical Centre Asaba Delta State Nigeria Lancaster Environment Centre (LEC) Lancaster University Lancaster Lancashire UK Department of Estate Management University of Benin Benin City Edo State Nigeria Department of Business Management University of Central Lancashire (UCLAN) Preston Lancashire UK X-Ray Unit Seventh-Day Adventist Hospital and Motherless Babies’ Home Ogbor Hill Aba Abia State Nigeria Department of Civil Engineering University of Ibadan Ibadan Oyo State Nigeria

This paper investigates the impact of biohazards and pandemics on construction workers’ health and well-being. A proper selection of control methods for biohazards and pandemics like COVID-19 pandemic will result in improved public health conditions. Occupational risks in the construction industry are also examined, with a focus on biohazards and pandemics, their containment, and the implications for health and safety. A safer work environment in the construction industry is encouraged. In this study, some statistical methods were used to analyse the data obtained from sampled questionnaire. According to the findings, fewer people in poor developing countries get routine check-ups compared to developed countries. The construction industries studied have little or no insurance plans for staff. It also demonstrates that personal protective equipment (PPE) such as nasal masks, helmets, hand gloves, and work aprons can assist in the control of biohazards in the construction sector, such as asthma, cancer, and asbestosis. There should be safety awareness programmes, conferences, and seminars, as well as first-aid kits and HSE and qualified health workers on all building sites. In addition, the government should examine the site for the usage of

关键词： Pandemic Biohazard Biological Hazard Biohazard Control Construction COVID19 Corona Virus SARS-CoV Hazard Health and Safety Personal Protective Equipment (PPE)

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有机质成熟程度及生油窗演化的动力学解释

地球与环境 1986年第3期 9-12页

作者： J.E.Ejcdawe ,S.J.L.coker ,陈建平石油部石油勘探开发科学研究院

一、前言有潜力生油岩的种种有机和无机的热成熟度指标,通常用来确定生油窗的位置(Héroux,et,al,1979)。这些有机质成熟度地球化学指标反映了时间和温度的累积效果,用上述指标确定的生油窗门槛值,只提供了一种静态信息,即只确定生油窗... 详细信息

一、前言有潜力生油岩的种种有机和无机的热成熟度指标,通常用来确定生油窗的位置(Héroux,et,al,1979)。这些有机质成熟度地球化学指标反映了时间和温度的累积效果,用上述指标确定的生油窗门槛值,只提供了一种静态信息,即只确定生油窗随时间变化后的目前位置。采用这些指标鉴别有潜力的生油岩时,明显或不明显地要作一些假设,如生油窗的位置应该是

关键词：生油窗烃源岩成熟度纤维性能有机质地温梯度地热增温率沉降速率程度