Genetic polymorphisms of interleukin 1β gene and sporadic pancreatic neuroendocrine tumors susceptibility

作     者：Dimitrios Karakaxas Anna Sioziou Gerasimos Aravantinos Ahmet Coker Ioannis S Papanikolaou Theodoros Liakakos Christos Dervenis Maria Gazouli 

作者机构：Department of General SurgeryAgia Olga Hospital Department of Basic Medical SciencesLaboratory of BiologyMedical SchoolNational and Kapodistrian University of Athens Second Department of Medical OncologyAgioi Anargiroi Cancer Hospital Department of General SurgeryEge University School of Medicine Hepatogastroenterology Unit2~(nd) Department of Internal Medicine and Research UnitAttikon University General HospitalMedical SchoolNational and Kapodistrian University of Athens 1~(st) Department of SurgeryLaiko Athens General HospitalMedical SchoolNational and Kapodistrian University of Athens 

出 版 物：《World Journal of Gastrointestinal Oncology》 (世界胃肠肿瘤学杂志（英文版）（电子版）)

年 卷 期：2016年第8卷第6期

页      面：520-525页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by Hellenic Society of Medical Oncology No.5839/08--04--2015 

主　　题：Interleukin 1β Neuroendocrine tumors Pancreas 

摘      要：AIM.:To evaluate the association between the interleukin 1β(IL-1β) polymorphisms and the pancreatic neuroendocrine tumor(pN ET) ***.:A case-control study was conducted analyzing IL-1β polymorphisms using germline DNA collected in a population-based case-control study of pancreatic cancer(51 pN ET cases,85 pancreatic ductal adenocarcinoma cases,19 intraductal papillary mucinous neoplasm and 98 healthy controls).RESULTS.:The distribution of genotypes for the-511C/T polymorphism in the pN ET patient groups showed significant difference compared to the control *** is known that the carriers of the IL-1β-511 T allele have increased concentrations of IL-1β.The-511 CT and TT high-expression genotypes were over-represented in pN ET ***.:The findings of this study suggested a possible role of IL-1β-511 C/T genotypes in the pathogenesis of pN ETs since the presence of the IL-1β-511 CT and TT genotypes and the T allele was associated with an increased risk of pN ET only.