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Alternative feedstock for the production of activated carbon with ZnCl_(2):Forestry residue biomass and waste wood

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Carbon Resources Conversion 2022年第4期5卷 299-309页

作者： Dominik Bosch Jan OBack David Gurtner Sara Giberti angela Hofmann Anke Bockreis Josef Ressel Centre for Production of Activated Carbon from Municipal Residues Department of EnvironmentalProcess and Energy EngineeringMCI–The Entrepreneurial SchoolUniversitaetsstrasse 156020 InnsbruckAustria Unit of Environmental Engineering Department for InfrastructureUniversity of InnsbruckTechnikerstrasse 136020 InnsbruckAustria Department of Environmental Process and Energy EngineeringMCI–The Entrepreneurial SchoolUniversitaetsstrasse 156020 InnsbruckAustria Institute for Chemical and Energy Engineering BOKU-University of Natural Resources and Life ScienceGregor-Mendel-Strasse 331160 ViennaAustria Department of Civil ChemicalEnvironmentaland Materials EngineeringUniversit`a di BolognaVia Zamboni 3340126 BolognaItaly

In order to substitute fossil resources in activated carbon(AC)production,recent efforts have focused on the utilization of renewable raw *** with important wood industries offer two potentially underestimated resource types:forestry residue biomass(FRB)and waste wood(WW).Although these materials are widely available(approx.130 mio.m3a-1 FRB,approx.50 ***^(-1) WW in the EU),they are mostly valorised through energy production,as they are high in ashes and may be contaminated with organics and heavy *** this study,both FRB and WW were treated via one-step pyrolysis for AC ***_(2) was applied as activating agent at pyrolysis temperatures varying from 400 to 600℃ and residence times between 1 and 3 ***,76 samples were prepared and characterized thoroughly via elemental analysis,N_(2)/CO_(2) ad/-desorption,thermogravimetric analysis(TGA),scanning electron microscopy(SEM),and infrared spectroscopy(FTIR).The produced carbons showed specific surface areas of up to 1430 m2g􀀀1 and a pore size distribution with a micropore share of up to 80%.The presence of oxygen-containing functional groups was confirmed via *** feedstock contamination can be mitigated,as minerals and heavy metals could be leached out(up to-99.15%)by an additional wash step and organic contamination undergoes thermal cracking during *** presented study could be a next step in upcycling considerable waste streams from the wood sector through localised and non-fossil-based AC production.

关键词： Sustainable resources Waste wood Forestry residue Activated carbon Chemical activation Pyrolysis Porosity Functionalized surface

Periprocedural management of hemostatic alterations in patients with cirrhosis and vascular liver disorders: a step forward of the American Association for the Study of Liver Diseases

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Hepatobiliary Surgery and Nutrition 2023年第1期12卷 105-109页

作者： Jose Ignacio Fortea angela Puente Javier Crespo Emilio Fabrega Gastroenterology and Hepatology Department Clinical and Translational Research in Digestive DiseasesValdecilla Research Institute(IDIVAL)Marques de Valdecilla University HospitalSantanderSpain

“Time flies over us,but leaves its shadow behind”(Nathaniel Hawthorne,1860,The Marble Faun).The shadow that separates the latest guidance on vascular liver disorders of the American Association for the Study of Liver Diseases(AASLD)from its former counterpart is 12 years long(1,2).Along the course,several guidelines from different societies have been published on this topic(3-7).As acknowledged in the preamble,the lack of high-quality evidence in the field led the AASLD to commission a guidance from an expert panel based on formal review and analysis of the *** thus differs from other guidelines that perform systematic reviews with explicit methods of searching,selection,and rating the quality of evidence and,if appropriate,meta-analysis on certain clinical questions(2).

关键词： Portal hypertension cirrhosis vascular liver disorders hemostasis bleeding thrombosis

The promise of precision medicine:how biomarkers are shaping the future of cholangiocarcinoma treatment

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Hepatobiliary Surgery and Nutrition 2023年第3期12卷 457-461页

作者： Rocio I.R.Macias Lorenza Rimassa angela Lamarca Experimental Hepatology and Drug Targeting(HEVEPHARM) IBSALUniversity of SalamancaSalamancaSpain National Institute for the Study of Liver and Gastrointestinal Diseases(CIBERehd) Carlos III National Health InstituteMadridSpain Department of Biomedical Sciences Humanitas UniversityPieve Emanuele(Milan)Italy Medical Oncology and Hematology Unit Humanitas Cancer CenterIRCCS Humanitas Research HospitalRozzano(Milan)Italy Department of Oncology OncoHealth InstituteFundación Jiménez Díaz University HospitalMadridSpain Department of Medical Oncology The Christie NHS FoundationManchesterUK Division of Cancer Sciences University of ManchesterManchesterUK

Cholangiocarcinoma(CCA)is the second most frequent primary malignant neoplasm of the hepatobiliary ***,CCA is often diagnosed at an advanced stage,when potentially curative surgical treatments are not *** probability of achieving complete resection in patients who undergo surgery is about 25%(1)and even when complete tumor removal is achieved,the risk of recurrence is greater than 50%.Identification and validation of reliable biomarkers is crucial for the early detection,accurate diagnosis,appropriate staging/prognosis,therapy selection and effective monitoring of patients with biliary tract cancers(BTCs)(Figure 1).Achieving early diagnosis remains a challenge to improve survival and,although many promising biomarkers have been identified(2),to date none have reached clinical practice.

关键词： Biliary cancer biomarker immunotherapy precision medicine targeted therapy

Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR):A critical overview on the most promising applications of molecular scissors in oral medicine

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BIOCELL 2022年第8期46卷 1837-1842页

作者： MARCO TATULLO LUISA LIMONGELLI ROSA MARIA MARANO ALESSANDRA VALLETTA angela TEMPESTA SANDRO RENGO Department of Basic Medical Sciences Neurosciences and Sense OrgansUniversity of Bari Aldo MoroBari74124Italy Department of Interdisciplinary Medicine University of Bari Aldo MoroBari74124Italy Marrelli Health-Tecnologica Research Institute Biomedical SectionStem Cells and Medical Genetics UnitsCrotone88900Italy Department of Neurosciences Reproductive and Odontostomatological SciencesUniversity of Naples Federico IINaples80131Italy

The scientific community is continuously working to translate the novel biomedical techniques into effective medical ***-Cas9 system(Clustered Regularly Interspaced Short Palindromic Repeats-9),commonly known as the“molecular scissor”,represents a recently developed biotechnology able to improve the quality and the efficacy of traditional treatments,related to several human diseases,such as chronic diseases,neurodegenerative pathologies and,interestingly,oral *** course,dental medicine has notably increased the use of biotechnologies to ensure modern and conservative approaches:in this landscape,the use of CRISPR-Cas9 system may speed and personalize the traditional therapies,ensuring a good predictability of clinical *** aim of this critical overview is to provide evidence on CRISPR efficacy,taking into specific account its applications in oral medicine.

关键词： Clustered Regularly Interspaced Short Palindromic Repeats(CRISPR) Dentistry Stem cells

Frontline remote sensing tool to locate hidden traits in root and tuber crops

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Molecular Plant 2022年第10期15卷 1500-1502页

作者： Ezhilmathi angela Joseph Fernando Michael Gomez Selvaraj Alfredo Delgado Ismail Rabbi Peter Kulakow The Alliance of Bioversity International and International Center for Tropical Agriculture(CIAT) Km17RectaCali-PalmiraApartadoAereo6713Cali 763537Colombia IDS GeoRadar North America 14818 West 6th AvenueUnit 1-A GoldenColorado80401USA International Institute of Tropical Agriculture PMB 5320Oyo RoadIbadanOyoState200001Nigeria

Root and tuber crops(RTCs)play an important role in alleviating poverty,improving health and nutrition,and providing excellent opportunities for improving the livelihoods of smallholder farmers in countries like sub-Saharan *** roots and tubers are edible starch materials that are stored in the subterranean stems,roots(cassava and sweet potatoes),rhizomes(canna and arrow roots),corms(taros and cocoyams),and tubers(potatoes and yams)(Chandrasekara and Kumar,2016).

关键词： roots crops Starch

Role of lipid rafts in liver health and disease

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World Journal of Gastroenterology 2011年第20期17卷 2520-2535页

作者： angela Dolganiuc Department of Medicine University of Massachusetts Medical School

Liver diseases are an increasingly common cause of morbidity and mortality; new approaches for investigation of mechanisms of liver diseases and identification of therapeutic targets are emergent. Lipid rafts (LRs) are specialized domains of cellular membranes that are enriched in saturated lipids; they are small, mobile, and are key components of cellular architecture, protein partition to cellular membranes, and signaling events. LRs have been identified in the membranes of all liver cells, parenchymal and non-parenchymal; more importantly, LRs are active participants in multiple physiological and pathological conditions in individual types of liver cells. This article aims to review experimental-based evidence with regard to LRs in the liver, from the perspective of the liver as a whole organ composed of a multitude of cell types. We have gathered up-to-date information related to the role of LRs in individual types of liver cells, in liver health and diseases, and identified the possibilities of LR-dependent therapeutic targets in liver diseases.

关键词：肝疾病健康脂筏肝脏疾病 LRS 细胞膜肝细胞识别机制

Effects of functional foods, nutraceuticals, and herbal products on pancreas

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Chinese Medical Journal 2023年第5期136卷 619-620页

作者： angela Saviano Christian Zanza Yaroslava Longhitano Enrico Celestino Nista Francesco Franceschi Veronica Ojetti Department of Emergency Medicine Fondazione Policlinico Universitario Agostino GemelliIRCCSRomeItaly Foundation“Ospedale Alba-Bra”and Department of Anesthesia Critical Care and Emergency MedicineMichele and Pietro Ferrero HospitalVerdunoItaly Department of Anesthesiology and Perioperative Medicine University of PittsburghPittsburghPAUSA Department of Gastroenterology Fondazione Policlinico Universitario Agostino GemelliIRCCSRomeItaly.

To the Editor:Today functional foods,nutraceuticals,and herbal products are becoming a part of human daily *** patient’s interest and demand for them are ***,healthcare systems and people have shown an increased desire to prevent some diseases and to improve their *** data about the properties and side effects of these products on the pancreas are still lacking,and more studies are required to provide a definitive opinion on their clinical benefits and *** industry of functional foods,nutraceuticals,and herbal products is gaining popularity.

关键词： herbal functional becoming

AdipoRon and Pancreatic Ductal Adenocarcinoma:a future perspective in overcoming chemotherapyinduced resistance?

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Cancer Drug Resistance 2022年第3期5卷 625-636页

作者： Luigi Sapio angela Ragone Annamaria Spina Alessia Salzillo Silvio Naviglio Department of Precision Medicine University of Campania“Luigi Vanvitelli”Naples 80138Italy

The latest scientific knowledge has provided additional insights accountable for the worst prognosis for pancreatic ductal adenocarcinoma(PDAC).Among the causative factors,the aptitude to develop resistance towards approved medications denotes the master key for understanding the lack of improvement in PDAC survival over the *** though several compounds have achieved encouraging results at preclinical stage,no new adjuvant agents have reached the bedside of PDAC patients *** adiponectin receptor agonist AdipoRon is emerging as a promising anticancer drug in different cancer models,particularly in *** on the existing findings,we recently reinforced its candidacy in PDAC cells,proposing AdipoRon either as a suitable partner in gemcitabinebased treatment or as an effective drug in resistant *** the current state-of-the-art,herein we provide a critical perspective on AdipoRon to figure out whether this receptor agonist can potentially be considered a future therapeutic choice in overcoming chemotherapy-induced resistance,expressly in PDAC.

关键词： PDAC AdipoRon gemcitabine resistance

A head-to-toe makeover for classical sequencing-by-synthesis helps users to squeeze more out of each base

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National Science Review 2019年第1期6卷 3-4页

作者： Jianbin Wang angela Wu School of Life Sciences Tsinghua University Division of Life Science Hong Kong University of Science and Technology Department of Chemical and Biological Engineering Hong Kong University of Science and Technology

Today, many next-generation sequencing (NGS) methods, technologies and platforms have been developed that allow users to produce Tera base pairs of data in less than one day or ultralong reads covering multiple genes. By far the most popular NGS approach to date is cyclic sequencing-by-synthesis (SBS),whereby each DNA template’s complementary strand is synthesized by DNA polymerase and, as the new strand grows base by base, the identity of each

关键词： A head-to-toe makeover for classical sequencing-by-synthesis helps users to squeeze more out of each base