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Inhibition of Carcinogen-induced Activity of γ-Glutamyl Transpeptidase by Certain Dietary Constituents in Mouse Skin

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Biomedical and Environmental Sciences 1999年第1期12卷 110-115页

作者： YOGESHWER SHUKLA ALKA SINGH and bhawna srivastava(Environmental Carcinogenesis Division, Industrial Toxicology Research Centre,P. O. Box 80, M. C. Marg, Lucknow-226 001, India) Industrial Toxicology Research Centre 印度

Cancer chemoprevention, a desirable and important facet of biomedical research, Provides a practical approach to identify potentially useful inhibitors of cancer development, and offers an opportunity to study the mechanism of carcinogenesis. During the recent past a nuInber of compounds have been tested for their anticarcinogenic potential specially constituents of human diet. The enzyme y-glutamyl transpeptidase (CGT), which catalyses the transfer of glutamyl gnups of peptides to other peptides and amino acids, has been proposed as a marker of cell proliferation and neoplasia. It also serves as a tool to evaluate the carcinogenic and cocareinogenic poential of environmental toxicants. In the present investigations, GGT activity induced by carcinogenic polycyclic aromatic hydrocarbons, viz. 7, 12-dimethyl-benz(a) anthracene (DMBA) and benzo(a)Pyrene (BaP was significantly inhibited by diallylsulfide (DAS) and indole-3-carbinol (13C) in mouse skin. DAS and 13C are Constituents of garlic. A significant inhibition in GGT levels was also observed in a strong mitogen (12-o-tetradecanoyl phorbol-13-acelate) induced activity by pretreatment of DAS/13C in mouse skin. Therefore these dielary constituents seem to be strong modifiers of chemically induced carcinogenesis.

关键词： inhibition carcinogen γ-glutamyl mouse skin

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Experimental Studies on Thermal Performance of a Pulsating Heat Pipe with Methanol/DI Water

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Journal of Electronics Cooling and Thermal Control 2013年第1期3卷 27-34页

作者： bhawna Verma Vijay Lakshmi Yadav Kaushal Kumar srivastava Department of Chemical Engineering Indian Institute of Technology Banaras Hindu University Varanasi India

The effect of working fluid on the start-up and thermal performance in terms of thermal resistance and heat transfer coefficient of a pulsating heat pipe have been studied in the present paper. Methanol and de-ionized water has been selected as the working fluid. The minimum startup power for DI water was obtained at 50% filling ratio and for methanol at 40%. The optimum filling ratio in terms of minimum startup power and minimum thermal resistance was 50% for DI water and 40% for methanol. The minimum thermal resistances for DI water and methanol were observed at vertical orientation. The evaporator side heat transfer coefficient for water was slightly more, while the condenser side heat transfer coefficient was appreciably more than that of methanol. Studies were also conducted for start-up time and temperature at different orientations and it was found that the PHP charged with methanol worked efficiently at all orientations.

关键词： Pulsating Heat Pipe Start-Up Power Working Fluid Thermal Resistance Heat Transfer Coefficient

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Assessing the Impacts of Climate Change on Crop Yields in Different Agro-climatic Zones of India

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Journal of Atmospheric Science Research 2020年第4期3卷 16-27页

作者： Naveen P Singh bhawna Anand S K srivastava K V Rao S K Bal M Prabhakar ICAR-National Institute of Agricultural Economics&Policy Research(NIAP) New DelhiIndia ICAR-Central Research Institute for Dryland Agriculture(CRIDA) HyderabadIndia

The study attempts to estimate and predict climate impact on crop yields using future temperature projections under two climate emissions scenarios of RCP 4.5 and 8.5 for three different time periods(2030s,2050s and 2080s)across Agro-climatic zones(ACZ)of *** the period 1966-2011,a significant rise was observed in both the annual mean maximum and minimum temperature across *** recorded an annual decline in Himalayan Regions and Gangetic Plains and a rise in Coastal Regions,Plateau&Hills and Western Dry *** results showed high heterogeneity in climate impact on kharif and rabi crop yields(with both negative and positive estimates)across *** was found that rainfall had a positive effect on most of crop yields,but was not sufficient enough to counterbalance the impact of *** in crop yield were more pronounced for higher emission scenario of RCP ***,it was evident that the relative impacts of climate change and the associated vulnerability vary by ACZs,hence comprehensive crop and region-specific adaptation measures should be emphasized that helps in enhancing resilience of agricultural system in short to medium term.

关键词： Agro-climatic zones Climate change Crop yields RCPs

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