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Miniature,highly sensitive MOSCAP ring modulators in co-optimized electronic-photonic CMOS

Photonics Research 2022年第1期10卷 I0001-I0007页

作者： HAYK GEVORGYAN anatol khilo MARK T.WADE VLADIMIR M.STOJANOVIC MILOS A.POPOVIC Department of Electrical and Computer Engineering Boston UniversityBostonMassachusetts 02215USA Ayar Labs Inc. EmeryvilleCalifornia 94608USA Department of Electrical Engineering and Computer Sciences University of California BerkeleyBerkeleyCalifornia 94709USA

Convergence of high-performance silicon photonics and electronics,monolithically integrated in state-of-the-art CMOS platforms,is the holy grail for enabling the ultimate efficiencies,performance,and scaling of electronicphotonic *** requires the emergence of platforms that combine state-of-the-art RF transistors with optimized silicon photonics,and a generation of photonic device technology with ultralow energies,increased operating spectrum,and the elimination of power-hungry thermal *** this paper,in a co-optimized monolithic electronics-photonics platform(GlobalFoundries 45 CLO),we turn the metal-oxide-semiconductor(MOS) field-effect transistor’s basic structure into a novel,highly efficient MOS capacitor ring *** has the smallest ring cavity(1.5 μm radius),largest corresponding spur-free free spectral range(FSR=8.5 THz),and record 30 GHz/V shift efficiency in the O-band among silicon modulators demonstrated to *** 1 V_(pp) RF drive,we show an open optical eye while electro-optically tuning the modulator to track over 400 pm(69 GHz) change in the laser wavelength(using 2.5 V_(DC) range).A 90 GHz maximum electro-optic resonance shift is demonstrated with under 40 nW of power,providing a strong nonthermal tuning mechanism in a CMOS photonics *** modulator has a separately optimized body layer but shares the gate device layer and the gate oxide with 45 nm transistors,while meeting all CMOS manufacturability design *** type of convergent evolution of electronics and photonics may be the future of platforms for high-performance systemson-chip.

关键词： tuning modulator electronic

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Anticancer activity of Aloe vera and Calligonum comosum extracts separetely on hepatocellular carcinoma cells

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Asian Pacific Journal of Tropical Biomedicine 2015年第5期5卷 375-381页

作者： Maram Shalabi Kh.khilo Mahmoud M.Zakaria Mahmoud G.Elsebaei Walied Abdo Walaa Awadin Department of Biochemistry Faculty of Veterinary Medicine Mansoura University Department of Biochemistry Faculty of Veterinary Medicine Kafrelsheikh University Urology and Nephrology Center Mansoura University Department of Pathology Faculty of Veterinary Medicine Kafrelsheikh University Department of Pathology Faculty of Veterinary Medicine Mansoura University

Objective: To investigate the in vitro anticancer effect of Aloe vera(A. vera) and Calligonum comosum(C. comosum) extracts against hepatocellular carcinoma(HepG 2) cells. Methods: Hep G2 cells were tested against different doses of A. vera and C. comosum. Viability of the cells was assessed by MTT assay. Evaluation of apoptosis and DNA damage in HepG 2 cells were performed using annexin V apoptosis detection kit. The expression of p53 and anti-apoptotic(Bcl-2) were tested by real time-PCR and flow cytometer analyser. Hematoxylin and eosin stained sections from untreated and treated HepG 2 cells were observed using light ***: The IC50 values of A. vera and C. comosum extracts were(10.45 ± 0.31) and(9.60 ± 0.01) μg/mL respectively. The extracts separately increased cytotoxicity against HepG 2 cells in a time and dose dependent manners. Also, it apparently induced apoptosis through increase P53 and decrease Bcl-2 genes ***: The results indicated that the extracts could have anti-hepatocarcinogenic effect, at least in part, through modulation of apoptosis.

关键词： HepG2 Hepatocellular carcinoma Aloe vera Calligonum comosum Apoptosis

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