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What benefit can be obtained from magnetic resonance imaging diagnosis with artificial intelligence in prostate cancer compared with clinical assessments?

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Military Medical Research 2024年第2期11卷 268-286页

作者： Li-Tao Zhao Zhen-Yu Liu Wan-Fang Xie Li-Zhi Shao jian Lu Jie Tian jian-gang Liu School of Engineering Medicine Beihang UniversityBeijing 100191China School of Biological Science and Medical Engineering Beihang UniversityBeijing 100191China CAS Key Laboratory of Molecular Imaging Institute of AutomationBeijing 100190China University of Chinese Academy of Sciences Beijing 100080China Department of Urology Peking University Third HospitalPeking UniversityBeijing 100191China Key Laboratory of Big Data‑Based Precision Medicine(Beihang University) Ministry of Industry and Information Technology of the People's Republic of ChinaBeijing 100191China Beijing Engineering Research Center of Cardiovascular Wisdom Diagnosis and Treatment Beijing 100029China

The present study aimed to explore the potential of artificial intelligence(AI)methodology based on magnetic resonance(MR)images to aid in the management of prostate cancer(PCa).To this end,we reviewed and summarized the studies comparing the diagnostic and predictive performance for PCa between AI and common clinical assessment methods based on MR images and/or clinical characteristics,thereby investigating whether AI methods are generally superior to common clinical assessment methods for the diagnosis and prediction fields of ***,we found that,in the included studies of the present study,AI methods were generally equal to or better than the clinical assessment methods for the risk assessment of PCa,such as risk stratification of prostate lesions and the prediction of therapeutic outcomes or PCa *** particular,for the diagnosis of clinically significant PCa,the AI methods achieved a higher summary receiver operator characteristic curve(SROC-AUC)than that of the clinical assessment methods(0.87 vs.0.82).For the prediction of adverse pathology,the AI methods also achieved a higher SROC-AUC than that of the clinical assessment methods(0.86 vs.0.75).Second,as revealed by the radiomics quality score(RQS),the studies included in the present study presented a relatively high total average RQS of 15.2(11.0–20.0).Further,the scores of the individual RQS elements implied that the AI models in these studies were constructed with relatively perfect and standard radiomics processes,but the exact generalizability and clinical practicality of the AI models should be further validated using higher levels of evidence,such as prospective studies and open-testing datasets.

关键词： Clinically significant prostate cancer Adverse pathology Radiomics quality score Artificial intelligence Magnetic resonance imaging

Urban rail transit disruption management: Research progress and future directions

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Frontiers of Engineering Management 2024年第1期11卷 79-91页

作者： Lebing WANG jian gang JIN Lijun SUN Der-Horng LEE School of Naval Architecture Ocean&Civil Engineeringand State Key Laboratory of Ocean EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Civil Engineering McGill UniversityMontrealQuebec H3A 0C3Canada ZJU-UIUC Institute Zhejiang UniversityHaining 314400China

Urban rail transit (URT) disruptions present considerable challenges due to several factors: i) a high probability of occurrence, arising from facility failures, disasters, and vandalism;ii) substantial negative effects, notably the delay of numerous passengers;iii) an escalating frequency, attributable to the gradual aging of facilities;and iv) severe penalties, including substantial fines for abnormal operation. This article systematically reviews URT disruption management literature from the past decade, categorizing it into pre-disruption and post-disruption measures. The pre-disruption research focuses on reducing the effects of disruptions through network analysis, passenger behavior analysis, resource allocation for protection and backup, and enhancing system resilience. Conversely, post-disruption research concentrates on restoring normal operations through train rescheduling and bus bridging services. The review reveals that while post-disruption strategies are thoroughly explored, pre-disruption research is predominantly analytical, with a scarcity of practical pre-emptive solutions. Moreover, future research should focus more on increasing the interchangeability of transport modes, reinforcing redundancy relationships between URT lines, and innovating post-disruption strategies.

关键词： urban rail transit disruption management resilient network train rescheduling bus bridging services

Long Non-coding RNA PCED1B Antisense RNA 1 Promotes Cell Proliferation and Invasion in Hepatocellular Carcinoma by Regulating the MicroRNA-34a/CD44 Axis

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Current Medical Science 2024年第3期44卷 503-511页

作者： jian-gang BI Qi LI Yu-sheng GUO Li-ping LIU Shi-yun BAO Ping XU Department of Hepatobiliary and Pancreatic Surgery Shenzhen People's HospitalThe Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Endocrinology Shenzhen People's HospitalThe Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China

Objective This study aimed to examine the role of long non-coding RNA PCED1B antisense RNA 1(PCED1B-AS1)in the development of hepatocellular carcinoma(HCC).Methods A total of 62 pairs of HCC tissues and adjacent non-tumor tissues were obtained from 62 HCC *** interactions of PCED1B-AS1 and microRNA-34a(miR-34a)were detected by dual luciferase activity assay and RNA pull-down *** RNA expression levels of PCED1B-AS1,miR-34a and CD44 were detected by RT-qPCR,and the protein expression level of CD44 was determined by Western *** cell proliferation was detected by cell proliferation assay,and the cell invasion and migration by transwell invasion *** HCC tumor growth after PCED1B-AS1 was downregulated was determined by in vivo animal *** PCED1B-AS1 was highly expressed in HCC tissues,which was associated with poor survival of HCC ***,PCED1B-AS1 interacted with miR-34a in HCC cells,but they did not regulate the expression of each ***,PCED1B-AS1 increased the expression level of CD44,which was targeted by *** cell proliferation and invasion assay revealed that miR-34a inhibited the proliferation and invasion of HCC in vitro,while CD44 exhibited the opposite ***,PCED1B-AS1 suppressed the role of ***,the knockdown of PCED1B-AS1 repressed the HCC tumor growth in nude mice in *** PCED1B-AS1 may play an oncogenic role by regulating the miR-34a/CD44 axis in HCC.

关键词： long non-coding RNA PCED1B antisense RNA 1(PCED1B-AS1) hepatocellular carcinoma microRNA-34a(miR-34a) CD44 proliferation invasion

Arsenic and fluoride co-enrichment of groundwater in the loess areas and associated human health risks:A case study of Dali County in the Guanzhong Basin

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China Geology 2024年第3期7卷 445-459页

作者： Rui-ping Liu Fei Liu Hua-qing Chen Yu-ting Yang Hua Zhu You-ning Xu jian-gang Jiao Refaey M El-Wardany Xi'an Center China Geological SurveyMinistry of Natural ResourcesXi'an 710054China Observation and Research Station of Environmental Geology of Typical Mines in Shaanxi Province MNRXi'an 710054China Key Laboratory for Geo-hazards in Loess Area MNRXi'an 710054China Dalian Ocean and Fishery Comprehensive Administration Supervision Lochus Dalian 116000China Pingliang City Development and Reform Commission Pingliang 744000China School of Earth Science and Resources Chang’an UniversityXi'an 710054China Faculty of Science Al-Azhar UniversityAssiut 71524Egypt

This study aims to reveal the occurrence and origin of typical groundwater with high arsenic and fluoride concentrations in the loess area of the Guanzhong Basin—a Neogene faulted *** findings are as follows:(1)Groundwater samples with high arsenic and fluoride concentrations collected from the loess area and the terraces of the Weihe River accounted for 26%and 30%,respectively,of the total samples,with primary hydrochemical type identified as HCO_(3)-*** karst and sand areas exhibit relatively high groundwater quality,serving as preferred sources for water *** is recommended that local governments fully harness groundwater in these areas;(2)groundwater with high arsenic and fluoride concentrations in the loess area and the alluvial plain of rivers in Dali County is primarily distributed within the Guanzhong Basin,which represents the drainage zone of groundwater;(3)arsenic and fluoride in groundwater originate principally from natural and anthropogenic sources;(4)the human health risk assessments reveal that long-term intake of groundwater with high arsenic and fluoride concentrations pose cancer or non-cancer risks,which are more serious to kids compared to *** study provides a theoretical basis for the prevention and treatment of groundwater with high arsenic and fluoride concentrations in loess areas.

关键词： Arsenic Fluoride Groundwater Cancer risk Kid and adult Human health risk assessment Hydrogeological survey engineering Environmental geological survey engineering Loess areas

Inetetamab combined with S-1 and oxaliplatin as first-line treatment for human epidermal growth factor receptor 2-positive gastric cancer

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World Journal of Gastroenterology 2024年第40期30卷 4367-4375页

作者： Ying Kong Qi Dong Peng Jin Ming-Yan Li Li Ma Qi-Jun Yi Yu-E Miao Hai-Yan Liu jian-gang Liu Department of Oncology The Second Affiliated Hospital of Shandong First Medical UniversityTai’an 271000Shandong ProvinceChina Department of Gastrointestinal Surgery The Second Affiliated Hospital of Shandong First Medical UniversityTai’an 271000Shandong ProvinceChina

BACKGROUND Patients with human epidermal growth factor receptor 2(HER2)-positive advanced gastric cancer have poor *** combined with chemotherapy is the first-line standard treatment for HER2-positive advanced gastric *** is a novel anti-HER2 drug,and its efficacy and safety in gastric cancer have not yet been *** To evaluate the efficacy and safety of the S-1 plus oxaliplatin(SOX)regimen combined with inetetamab as a first-line treatment for HER2-positive advanced gastric *** Thirty-eight patients with HER2-positive advanced gastric cancer or gastroeso-phageal junction adenocarcinoma were randomly divided into two groups:One group received inetetamab combined with the SOX regimen,and the other group received trastuzumab combined with the SOX *** 4-6 cycles,patients with stable disease received maintenance *** primary endpoints were progression-free survival(PFS)and overall survival(OS),and the secondary endpoints were the objective response rate,disease control rate,and adverse events(AEs).RESULTS Thirty-seven patients completed the trial,with 18 patients in the inetetamab group and 19 patients in the trastuzumab *** the inetetamab group,the median PFS was 8.5 months,whereas it was 7.3 months in the trastuzumab group(P=0.046);this difference was *** median OS in the inetetamab group vs the trastuzumab group was 15.4 months vs 14.3 months(P=0.33),and the objective response rate was 50%vs 42%(P=0.63),respectively;these differences were not *** AEs included leukopenia,thrombocytopenia,nausea,and *** incidence rates of grade≥3 AEs were 56%in the inetetamab group and 47%in the trastuzumab group(P=0.63),with no significant *** In the first-line treatment of HER2-positive advanced gastric cancer,inetetamab and trastuzumab showed comparable *** inetetamab group showed superior PFS,and both groups had good safety.

关键词： Human epidermal growth factor receptor 2-positive Advanced gastric cancer Inetetamab Trastuzumab Efficacy Safety

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从保护到流通:我国数据治理范式反思

苏州大学学报（哲学社会科学版） 2024年第1期45卷 100-110页

作者：商建刚上海政法学院经济法学院上海201701

“以保护促进流通”的策略仍然是当前数据治理的首要逻辑,在此策略基础上,形成了以数据权益保护为基础的数据治理范式。然而,以数据权益保护为核心的治理范式影响了数据库赋权、竞争法保护的司法实践,阻碍了数据流通利用,进而影响数据... 详细信息

“以保护促进流通”的策略仍然是当前数据治理的首要逻辑,在此策略基础上,形成了以数据权益保护为基础的数据治理范式。然而,以数据权益保护为核心的治理范式影响了数据库赋权、竞争法保护的司法实践,阻碍了数据流通利用,进而影响数据要素价值的实现,需重新进行数据治理范式选择。通过考察我国顶层设计与社会实践、欧盟的数据治理立法进程、美国数据治理制度的发展趋势发现,数据的价值实现有赖于数据流通。但是,目前尚未形成相应治理范式对数据流通予以支撑。证成数据流通治理范式,并以此为基础指导建构我国数据基础法律制度,已成为当务之急。我国数据治理范式应以数据分类分级为工具,以有利于数据流通为前提,以数据权益保护为保障,结合不同应用场景赋予数据主体相应的数据权益,才能呼应数据“三权分置”的顶层设计。

关键词：数据流通理论数据权益保护数据三权分置数据基础法律制度数据治理范式

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中国共产党的文艺制度与文化领导权建构

文艺理论研究 2024年第1期44卷 1-14页

作者：杨建刚涂荣臻山东大学文艺美学研究中心

文艺制度是中国共产党建构文化领导权的重要途径之一。党的文艺制度是马克思主义文艺理论中国化、时代化的重要成果,其建构经历了从“以苏为师”到自主探索的发展过程。中国共产党在革命、建设、改革开放与中国特色社会主义新时代的不... 详细信息

文艺制度是中国共产党建构文化领导权的重要途径之一。党的文艺制度是马克思主义文艺理论中国化、时代化的重要成果,其建构经历了从“以苏为师”到自主探索的发展过程。中国共产党在革命、建设、改革开放与中国特色社会主义新时代的不同阶段,基于文化领导权建构的需要,探索并建立了会议制度、组织制度、生产制度等一系列文艺制度。文艺会议制度确立了党对文艺工作的意识形态引领的基本原则与方向,文艺组织制度确保了党对文艺工作者的团结与动员,增强了文艺界的向心力,文艺生产制度则推动了党领导下的社会主义核心价值观的培育与弘扬。一百年来,中国共产党根据不同阶段对文艺性质的不同认识和文艺功能的不同定位,与时俱进地调整对文艺工作的领导方式与管理方法,不断推进文艺治理能力和治理体系的现代化。通过一系列文艺制度建设,党逐步确立和巩固了文化领导权,丰富和发展了中国马克思主义文艺理论,并完善和深化了中国特色社会主义制度体系。

关键词：中国共产党文艺制度文化领导权

“左联”成立前后中国左翼文坛对马克思主义文艺思想的接受

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江淮论坛 2024年第3期 162-170页

作者：王建刚许楠浙江大学传媒与国际文化学院杭州310012

“左联”成立前后,随着“革命文学”论战走向深入,中国左翼文坛开始自觉地翻译与介绍马克思主义文艺思想。在这一过程中,苏俄的无产阶级文学和日本的左翼文艺运动给了中国文艺界极大的启示,它们因此成为中国接受马克思主义的重要桥梁。... 详细信息

“左联”成立前后,随着“革命文学”论战走向深入,中国左翼文坛开始自觉地翻译与介绍马克思主义文艺思想。在这一过程中,苏俄的无产阶级文学和日本的左翼文艺运动给了中国文艺界极大的启示,它们因此成为中国接受马克思主义的重要桥梁。这一时期,中国文坛对马克思主义文艺思想的翻译与介绍主要集中在两个方面,即科学的唯物史观和艺术社会学思想。鲁迅和瞿秋白等人在这方面做了大量工作,为马克思主义文艺思想的中国化作出了重要贡献。

关键词：左翼文坛马克思主义文艺思想唯物史观艺术社会学

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“后理论”的行动纲领、基本诉求与价值取向

山东社会科学 2024年第5期 47-56页

作者：杨建刚张林轩山东大学文艺美学研究中心

“后理论”的核心问题是对“大写的理论”的反思与重构,它标志着理论研究步入了需要重新探索自身的功能效用、生长模式、价值诉求以及未来走向的新阶段。“后理论”的行动纲领是从神谕式的“大写的理论”转向“小理论”,以此明确理论应... 详细信息

“后理论”的核心问题是对“大写的理论”的反思与重构,它标志着理论研究步入了需要重新探索自身的功能效用、生长模式、价值诉求以及未来走向的新阶段。“后理论”的行动纲领是从神谕式的“大写的理论”转向“小理论”,以此明确理论应具备的实践导向和价值关怀。“后理论”的基本诉求是回归文学,推动理论与文学之间的互动与共生,使理论能够从丰富的文学经验中获取养分。“后理论”的价值取向是反对传统的人文主义和人类中心主义的思维范式,积极参与后人类主体性的建构。同时,“后理论”倡导将理论置于纷繁复杂的现实世界之中,并承担起帮助人们在不稳定状况中继续向好而生的重要使命。

关键词：后理论大写的理论小理论后人类