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Renin-angiotensin system in the central nervous system:focus on Huntington’s disease

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Neural Regeneration Research 2023年第10期18卷 2206-2207页

作者： aline Silva de Miranda Antonio Lucio Teixeira Laboratório de Neurobiologia Departamento de MorfologiaInstituto de Ciências BiológicasUniversidade Federal de Minas Gerais(UFMG)Belo HorizonteMGBrasil Laboratório Interdisciplinar de Investigação Médica(LIIM) Faculdade de MedicinaUniversidade Federal de Minas Gerais(UFMG)Belo HorizonteMGBrasil Neuropsychiatry Program Department of Psychiatry and Behavioral SciencesMcGovern Medical SchoolUniversity of Texas Health Science Center at HoustonTXUSA Faculdade Santa Casa BH Belo HorizonteMGBrasil

The renin-angiotensin system(RAS)was originally conceived as a circulating hormonal system involved in the regulation of cardiovascular and renal *** the discovery of local RAS components in diverse organs,including t... 详细信息

关键词： Huntington organs angiotensin

Corneal stem cells and tissue engineering: Current advances and future perspectives

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World Journal of Stem Cells 2015年第5期7卷 806-814页

作者： aline Lütz de Araujo JoséAlvaro Pereira Gomes Clínica Lentecor Porto Alegre-RS 90570041Brazil department of Ophthalmology and Visual Sciences Universidade Federal de São PauloSao Paulo-SP 04023062Brazil

Major advances are currently being made in regenerative medicine for cornea. Stem cell-based therapies represent a novel strategy that may substitute conventional corneal transplantation, albeit there aremany challenges ahead given the singularities of each cellular layer of the cornea. This review recapitulates the current data on corneal epithelial stem cells, corneal stromal stem cells and corneal endothelial cell progenitors. Corneal limbal autografts containing epithelial stem cells have been transplanted in humans for more than 20 years with great successful rates, and researchers now focus on ex vivo cultures and other cell lineages to transplant to the ocular surface. A small population of cells in the corneal endothelium was recently reported to have self-renewal capacity, although they do not proliferate in vivo. Two main obstacles have hindered endothelial cell transplantation to date: culture protocols and cell delivery methods to the posterior cornea in vivo. Human corneal stromal stem cells have been identified shortly after the recognition of precursors of endothelial cells. Stromal stem cells may have the potential to provide a direct cell-based therapeutic approach when injected to corneal scars. Furthermore, they exhibit the ability to deposit organized connective tissue in vitro and may be useful in corneal stroma engineering in the future. Recent advances and future perspectives in the field are discussed.

关键词： Cornea Stem cells Cell-based therapy Limbal transplantation Tissue engineering Cornealendothelium

^(11)C-PK11195 plasma metabolization has the same rate in multiple sclerosis patients and healthy controls:a cross-sectional study

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Neural Regeneration Research 2021年第12期16卷 2494-2498页

作者： aline Morais de Souza Milena Sales Pitombeira Larissa Estessi de Souza Fabio Luiz Navarro Marques Carlos Alberto Buchpiguel Caroline Cristiano Real Daniele de Paula Faria Laboratory of Nuclear Medicine(LIM43) Department of Radiology and OncologyFaculdade de Medicina FMUSPUniversidade de Sao PauloSao PauloSPBrazil department of Neurology Faculdade de Medicina FMUSPUniversidade de Sao PauloSao PauloSPBrazil

^(11)C-PK11195 is a positron emitter tracer used for Positron Emission Tomography(PET)imaging of innate immune cell activation in studies of neuroinflammatory *** the image quantitative analysis,it is necessary to quantify the intact fraction of this tracer in the arterial plasma during imaging acquisition(plasma intact fraction).Due to the complexity and costs involved in this analysis it is important to evaluate the real necessity of individual analysis in each 11C-PK11195 PET imaging *** purpose of this study is to compare 11CPK11195 plasma metabolization rate between healthy controls and multiple sclerosis(MS)patients and evaluate the interference of sex,age,treatment,and disease phenotype in the tracer intact fraction measured in arterial plasma samples.11C-PK11195 metabolization rate in arterial plasma was quantified by high performance liquid chromatography in samples from MS patients(n=50)and healthy controls(n=23)at 20,45,and 60 minutes after 11C-PK11195 *** were also stratified by sex,age,treatment type,and MS *** results showed no significant differences in the metabolization rate of healthy controls and MS patients,or in the stratified *** conclusion,11C-PK11195 metabolization has the same rate in patients with MS and healthy controls,which is not affected by sex,age,treatment,and disease ***,these findings could contribute to exempting the necessity for tracer metabolization determination in all 11C-PK11195 PET imaging acquisition,by using a population metabolization rate *** study procedures were approved by the Ethics Committee for Research Projects Analysis of the Hospital das Clinicas of the University of Sao Paulo Medical School(approval No.624.065)on April 23,2014.

关键词： ^(11)C-PK11195 HPLC kinetic modeling metabolization multiple sclerosis neuroinflammation PET imaging PET tracer radiometabolites

Evaluation of viability to simulated gastrointestinal tract passage of probiotic strains and pioneer bioaccessibility analyses of antioxidants in chocolate

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Food Bioscience 2023年第2期52卷 1258-1267页

作者： Jocelane Zoldan Ivan de Marco Silvani Verruck aline Iamin Gomide Claudio Eduardo Leite Cartabiano Gilberto Vinicius de Melo Pereira Juliano de dea Lindner department of Food Science and Technology Universidade Federal Santa Catarina(UFSC)FlorianopolisSCBrazil Nanovetores Group.Florianopolis SCBrazil department of Chemical and Food Engineering UFSCFlorianopolisSCBrazil department of Bioprocess Engineering and Biotechnology Universidade Federal do Parana(UFPR)CuritibaPRBrazil

Chocolate is appreciated worldwide for its flavor and antioxidant *** study aims to evaluate the viability of Lactiplantibacillus plantarum,Lacticaseibacillus casei,and Bacillus subtilis in milk and 70%cocoa chocolates during *** incorporated with free and microencapsulated strains were subjected to a gastrointestinal tract(GIT)in vitro passage *** indicate that survival depends on the strain used;*** presented the highest performance,with values above 8.0 log CFU/*** simulation demonstrated strains survival during the passage through all the phases,with intestinal phase average values above 7.9 log CFU/g for *** and ***;a factor attributed to the protection provided by the chocolate *** to phenolics,flavonoids,and antioxidants was also higher in all samples simulated analysis,and 70%cocoa chocolates showed the highest *** chocolates showed high acceptance in the sensorial *** maintenance of the viability of potential probiotic microorganisms in the food matrix,and the high content of antioxidant compounds,indicate the great potential of chocolate for the diversification of probiotic foods currently available in the market.

关键词： Cell viability Gastrointestinal simulation Antioxidant activity Sensory analysis Chocolate Probiotics

Nutrition and exercise can attenuate inflammatory and psychobiological changes in hypoxia?

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Asian Pacific Journal of Tropical Biomedicine 2017年第1期7卷 86-90页

作者： aline Venticinque Caris Wanessa Ysis Valdir de Aquino Lemos Ricardo Bottura Ronaldo Vagner Thomatieli dos Santos department of Psychobiology Federal University of Sao Paulo(UNIFESP)SantosBrazil department of Bioscience Federal University of Sao Paulo(UNIFESP)SantosBrazil

Exposure to hypoxia causes damage in several physiological systems, whose tissues are dependent on the O2 supply. Recently, there has been growing attention on the immunosuppressive and inflammatory potential of the hypoxia, including stimulation, nuclear factor kappa B pathway in macrophages and Th2 response from lymphocytes. These changes may result in transient immunosuppression and happen at the same time to worsening of cognition and other psychobiological aspects. Furthermore, exercise and nutrition, especially glutamine supplementation may provide important role, not pharmacological partially reversing the effects of hypoxia. In fact, recent studies show that moderate exercise can improve cognition in people exposed to hypoxia while the exercise associated with glutamine supplementation can reverse the increase in inflammatory markers and the Th1/Th2 balance. This review aims to bring the light of the discussion about nonpharmacological ways to prevent the effects of hypoxia on the connection between the immune system and the central nervous system.

关键词： Physical exercise High altitude Inflammation Cognition Glutamine

Chemical profile and antimicrobial activity of Secondatia floribunda A. DC(Apocynaceae)

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Asian Pacific Journal of Tropical Biomedicine 2017年第8期7卷 739-749页

作者： Daiany Alves Ribeiro Sarah Soares Damasceno aline Augusti Boligon Irwin Rose Alencar de Menezes Marta Maria de Almeida Souza JoséGalberto Martins da Costa Programa de Pós-Graduacao em Etnobiologia e Conservacao da Natureza Universidade Regional do Cariri departamento de Química Biológica Laboratório de Pesquisas de Produtos NaturaisUniversidade Regional do Cariri Laboratório de Fitoquímica Universidade Federal de Santa Maria departamento de Química Biológica Laboratório de Farmacologia e Química MolecularUniversidade Regional do Cariri departamento de Ciências Biológicas Laboratório de Ecologia VegetalUniversidade Regional do Cariri

To establish the chemical profile, and to evaluate the antibacterial and modulatory activity of the ethanolic extracts of the stalk’s inner bark and heartwood of Secondatia *** of total phenols and flavonoids was determined by the Folin-Ciocalteu method and aluminum chloride, respectively. Phenolic compounds were identified and quantified by HPLC-DAD (High Performance Liquid Chromatography-Diodearray detector) and the Infrared Spectroscopy was performed using the measure by Attenuated Total Reflectance with Fourier Transform (ATR-FTIR). Antibacterial assays for determination of the Minimum Inhibitory Concentration (MIC) and modification of aminoglycosides were performed by *** spectra showed similar characteristics, having among its main absorption bands hydroxyl group (OH). The antibacterial activity showed clinically significant results for the strains of Staphylococcus aureus and Escherichia coli. In modulation assay, synergic and antagonistic effect for both extracts was observed. Heartwood extract in combination with antibiotics showed a significant MIC reduction at 19.8% (P < 0.000 1)-79.3% (P < 0.01).ConclusionsThis study is the first report of chemical and biological information of Secondatia floribunda suggesting that it is clinically relevant source of a new antibacterial therapy, especially due to the presence of significant levels of phenolic compounds.

关键词： Chemical composition HPLC Cinchonain Natural product Modification resistance

Influence of fire on woody vegetation of savanna and forest formations in the Cerrado biome

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Journal of Forestry Research 2023年第5期34卷 1207-1216页

作者： aline das Gracas Costa Fillipe Tamiozzo Pereira Torres Gumercindo Souza Lima Fabiano Rodrigues de Melo Carlos Moreira Miquelino Eleto Torres Bruno Leao Said Schettini Vicente Paulo Santana Neto AndréLuiz Lopes de Faria department of Forest Engineering Federal University of VicosaUFVVicosaMG 36570-900Brazil department of Geography Federal University of VicosaUFVVicosaMG 36570-900Brazil

Wildfires have environmental,economic,and social impacts,and can shape the landscape and benefit ecosystems such as the *** study evaluated the diversity,similarity,and floristic and structural differences of woody savanna and forest formations of the Cerrado,when affected and not affected by ***-eight 25-400m2 plots were randomly allocated and divided into Burnt Cerrado and Unburnt Cerrado,Burnt Forest,and Unburnt Forest,and divided into three levels of inclusion according to diameter class(smaller than 2 cm,2-5 cm and larger than5 cm).Species were identified,DBH and height measured,and phyto sociological parameters such as volume,diversity,and floristic similarity *** Cerrado had lower diversity,density,and dominance at all inclusion levels compared to the Unburnt Cerrado,and showed similarities between treatments at the inclusion *** Forest had smaller differences in diversity,density,and dominance than Unburnt *** formation was similar at level 1 of inclusion and in the total ***,it was dissimilar at lower *** lower density and diversity of species at the lowest levels of inclusion was associated with mortality from fire.

关键词： Biodiversity Brazil Burning Floristic Phytosociology

Therapeutic potential of periodontal ligament stem cells

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World Journal of Stem Cells 2021年第6期13卷 605-618页

作者： aline Queiroz Emmanuel Albuquerque-Souza Leticia Miquelitto Gasparoni Bruno Nunes de França Cibele Pelissari Marília Trierveiler Marinella Holzhausen Laboratory of Stem Cell Biology in dentistry-LABITRON Department of Oral and Maxillofacial PathologySchool of DentistryUniversity of São PauloSão Paulo 05508-000Brazil department of Stomatology Division of PeriodonticsSchool of DentistryUniversity of São PauloSão Paulo 05508-000Brazil

Inflammatory periodontal disease known as periodontitis is one of the most common conditions that affect human teeth and often leads to tooth *** to the complexity of the periodontium,which is composed of several tissues,its regeneration and subsequent return to a homeostatic state is challenging with the therapies currently *** therapy is increasingly becoming an alternative in regenerative medicine/dentistry,especially therapies using mesenchymal stem cells,as they can be isolated from a myriad of *** ligament stem cells(PDLSCs)are probably the most adequate to be used as a cell source with the aim of regenerating the *** insights have also highlighted PDLSCs as promising immunomodulator *** this review,we explore the state of knowledge regarding the properties of PDLSCs,as well as their therapeutic potential,describing current and future clinical applications based on tissue engineering techniques.

关键词： Periodontal ligament stem cell Mesenchymal stem cell Regenerative dentistry Therapeutics Immunology Cellular

Antiulcerogenic activity of Scutia buxifolia on gastric ulcers induced by ethanol in rats

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Acta Pharmaceutica Sinica B 2014年第5期4卷 358-367页

作者： aline Augusti Boligon Robson Borba de Freitas Thiele Faccim de Brum Emily Pansera Waczuk Cláudia Vargas Klimaczewski Daiana Silva deÁvila Margareth Linde Athayde Liliane de Freitas Bauermann department of Industrial Pharmacy Center of Health SciencesFederal University of Santa MariaSanta Maria 97105-900RSBrazil department of Physiology and Pharmacology Center of Health SciencesFederal University of Santa MariaSanta Maria 97105-900RSBrazil department of Biochemistry Federal University of PampaUruguaiana 97500-970RSBrazil

Gastric ulcers affect many people around the world and their development is a result of the imbalance between aggressive and protective factors in the gastric *** buxifolia,commonly known as coronilha,has attracted the interest of the scientific community due to its pharmacological properties and its potential therapeutic *** this study,the preventive effects of the crude extract of Scutia buxifolia(ceSb)against gastric ulcer induced by 70%ethanol were evaluated in male Wistar *** addition,the composition of ceSb was clarified by high-performance liquid chromato-graphy(HPLC).*** extract(100,200 and 400 mg/kg body weight)attenuated oxidative and histopathological features induced by ***,all evaluated doses of ceSb caused significant(Pdependent increase in sulfhydryl groups(NPSH)levels,catalase(CAT)and superoxide dismutase(SOD)***,the administration of ceSb reversed the increase in lipid peroxidation produced by *** protective effect of the extract could be attributed to antioxidant compounds present in the ceSb,such as flavonoids and phenolic acids,which were quantified by ***,an antioxidant effect of the extract leads to a protection on gastric *** results indicate that *** could have a beneficial role against ethanol toxicity by preventing oxidative stress and gastric tissue injury.

关键词： Scutia buxifolia Antioxidant Gastric ulcer HPLC