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iLIVER 2024年第1期3卷 45-51页

作者： Sayed Metwaly alicja Psica Opeyemi Sogaolu Irfan Ahmed Ashis Mukhopadhya Mirela Delibegovic Mohamed Bekheit Division of Internal Medicine Aberdeen Royal InfirmaryNHS GrampianScotlandAberdeenAB252ZDUnited Kingdom Aberdeen Cardiovascular and Diabetes Centre School of MedicineMedical Sciences and NutritionUniversity of AberdeenForesterhill Health CampusAberdeenAB252ZDUnited Kingdom Department of Critical Care Medicine University of CalgaryAlberta T2N 2T9Canada Department of General Surgery Aberdeen Royal InfirmaryNHS GrampianScotlandAberdeen AB252ZDUnited Kingdom Pakistan Kidney and Liver Institute and Research Centre Lahore 54000Pakistan Hépatica Centre of Integrated HPB CareElite HospitalAlexandria 21325Egypt

Hepatocellular carcinoma(HCC)is an increasingly common and the second leading cause of cancer mortality worldwide with a 5-year survival rate about 12%.Less than 20%of HCC patients are eligible to curative treatment owing to the late ***,there is a need for a readily accessible,early screening *** scoping review critically appraises and synthesizes the current published knowledge about the use of exhaled volatile organic compounds(VOCs)as a potential noninvasive means for HCC detection aiming to advance this nascent field.A systematic electronic search was *** search strategy included all studies published until the 24th of March 2023 using a combination of relevant *** search yielded 9 publications using the Preferred Reporting Items for Systematic Reviews and Meta-analyses *** of the studies described in vitro experiments,and seven clinical studies were conducted on small groups of ***,42 headspace gases were analyzed in the in vitro ***,the clinical studies included 420 HCC patients and 630 *** studies reported potential role for a combination of VOCs in the diagnosis of ***,there is lack of *** there appears to be promise in VOCs research associated with HCC,there is no single volatile biomarker in exhaled breath attributed to HCC and data from extracted studies indicates a lack of *** multicentre population studies are required to verify the existence of VOCs linked to HCC.

关键词： Hepatocellular carcinoma Volatile organic compounds Metabolomics

Modulating p-type doping of two-dimensional material palladium diselenide

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Nano Research 2024年第4期17卷 3232-3244页

作者： Jiali Yang Yu Liu En-Yang Wang Jinbo Pang Shirong Huang Thomas Gemming Jinshun Bi alicja Bachmatiuk Hao Jia Shu-Xian Hu Chongyun Jiang Hong Liu Gianaurelio Cuniberti Weijia Zhou Mark H Rümmeli Institute for Advanced Interdisciplinary Research(iAIR) University of JinanJinan 250022China Institute for Materials Chemistry Leibniz Institute for Solid State and Materials Research Dresden(IFW Dresden)20 Helmholtz StrasseDresden 01069Germany State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China College of Energy Soochow Institute for Energy and Materials Innovations Soochow UniversitySuzhou 215006China Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province Soochow UniversitySuzhou 215006China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 101408China Institute of Microelectronics of Tianjin Binhai New Area Tianjin 300451China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Lukasiewicz Research Network PORT Polish Center for Technology DevelopmentStablowicka 147Wroclaw 54-066Poland School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China College of electronic information and optical engineering Nankai UniversityTianjin 300350China Centre of Polymer and Carbon Materials Polish Academy of SciencesM.Curie Sklodowskiej 34Zabrze 41-819Poland Center for Energy and Environmental Technologies VŠB-Technical University of Ostrava17.Listopadu 15Ostrava 70833Czech Republic State Key Laboratory of Crystal Materials Center of Bio&Micro/Nano Functional MaterialsShandong UniversityJinan 250100China Dresden Center for Computational Materials Science Technische Universität DresdenDresden 01062Germany Dresden Center for Intelligent Materials(GCL DCIM) Technische Universität DresdenDresden 01062Germany Institute for Materials Science and Max Bergmann Center of Biomaterials Technische Universität DresdenDresden 01069Germany Center for Advancing Electronics Dresden Technische Universität DresdenDresden 01069Germany

The van der Waals heterostructures have evolved as novel materials for complementing the Si-based semiconductor ***-10 noble metal dichalcogenides(e.g.,PtS_(2),PtSe_(2),PdS_(2),and PdSe_(2))have been listed into two-dimensional(2D)materials toolkit to assemble van der Waals *** them,PdSe_(2) demonstrates advantages of high stability in air,high mobility,and wide tunable ***,the regulation of p-type doping of PdSe_(2) remains unsolved problem prior to fabricating p–n junction as a fundamental platform of semiconductor ***,a quantitative method for the controllable doping of PdSe_(2) is yet to be *** this study,the doping level of PdSe_(2) was correlated with the concentration of Lewis acids,for example,SnCl_(4),used for *** the transfer characteristics,the threshold voltage(the gate voltage corresponding to the minimum drain current)increased after SnCl_(4) soaking ***_(2) transistors were soaked in SnCl_(4) solutions with five different *** threshold voltages from the as-obtained transfer curves were extracted for linear fitting to the threshold voltage versus doping concentration correlation *** study provides in-depth insights into the controllable p-type doping of PdSe_(2).It may also push forward the research of the regulation of conductivity behaviors of 2D materials.

关键词： two-dimensional(2D)materials Lewis acid treatment p-type doping field-effect transistors transfer characteristic

Stepwise multiple regression method of greenhouse gas emission modeling in the energy sector in Poland

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Journal of Environmental Sciences 2015年第4期27卷 47-54页

作者： alicja Kolasa-Wiecek Department of Economics and Regional Research Faculty of Economy and Management Opole University of Technology

The energy sector in Poland is the source of 81% of greenhouse gas（GHG） emissions. Poland,among other European Union countries, occupies a leading position with regard to coal consumption. Polish energy sector actively participates in efforts to reduce GHG emissions to the atmosphere, through a gradual decrease of the share of coal in the fuel mix and development of renewable energy sources. All evidence which completes the knowledge about issues related to GHG emissions is a valuable source of information. The article presents the results of modeling of GHG emissions which are generated by the energy sector in Poland. For a better understanding of the quantitative relationship between total consumption of primary energy and greenhouse gas emission, multiple stepwise regression model was applied. The modeling results of CO2 emissions demonstrate a high relationship（0.97） with the hard coal consumption variable. Adjustment coefficient of the model to actual data is high and equal to 95%. The backward step regression model, in the case of CH4 emission, indicated the presence of hard coal（0.66）, peat and fuel wood（0.34）, solid waste fuels, as well as other sources（- 0.64） as the most important variables. The adjusted coefficient is suitable and equals R2= 0.90. For N2 O emission modeling the obtained coefficient of determination is low and equal to 43%. A significant variable influencing the amount of N2 O emission is the peat and wood fuel consumption.

关键词： Greenhouse gases Burning of fossil fuels Energy sector Backward stepwise regression modeling

Present and future possibilities for early diagnosis of hepatocellular carcinoma

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World Journal of Gastroenterology 2010年第4期16卷 418-424页

作者： Piotr Stefaniuk Janusz Cianciara alicja Wiercinska-Drapalo Department of Hepatology and Acquired Immuno-deficiencies Warsaw Medical University37Wolska StWarsaw 01-201Poland

Hepatocellular carcinoma(HCC) represents the fifth most common cancer in the world,and the third most frequent oncological cause of *** incidence of HCC is on the *** typically develops in patients with chronic liver diseases,and cirrhosis,usually with viral etiology,is the strongest predisposing *** HCC diagnosis is a multistage process including clinical,laboratory,imaging and pathological *** prognosis of HCC is mostly poor,because of detection at an advanced,non-resectable *** curative treatment(surgery) is limited and really possible only for cases with small HCC *** this reason,more effective surveillance strategies should be used to screen for early occurrence of HCC targeted to the population at *** far,the generally accepted serological marker is α-fetoprotein(AFP).Its diagnostic accuracy is unsatisfactory and questionable because of low sensitivity,therefore there is a strong demand by clinicians for new HCC-specific *** this review,we will focus on other biomarkers that seem to improve HCC diagnosis,such as AFP-L3,des-γ-carboxyprothrombin,α-l-fucosidase,,γ-glutamyl transferase,glypican-3,squamous cell carcinoma antigen,a new generation of immunoglobulin M-immunocomplexes,and very promising geneexpression profiling.

关键词： Hepatocellular carcinoma Chronic hepatitis Liver cirrhosis Cancer screening Surveillance Biological markers

Plasma matrix metalloproteinase-1 and tissue inhibitor of metalloproteinase-1 as biomarkers of ulcerative colitis activity

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World Journal of Gastroenterology 2003年第12期9卷 2843-2845页

作者： alicja Wiercinska-Drapalo Jerzy Jaroszewicz Robert Flisiak Danuta Prokopowicz Department of Infectious Diseases Intestinal Diseases UnitMedical University of BialystokPoland

AIM:Overexpression of mucosal metalloproteinases(MMP) has been demonstrated recently in inflammatory bowel *** activity can be counterbalanced by the tissue inhibitor of metalloproteinases(TIMP).The aim of this study was to evaluate the effect of ulcerative colitis(UC)on MMP- 1 and TIMP-1 plasma concentrations,as two possible biomarkers of the disease activity. METHODS:MMP-1 and TIMP-1 plasma concentrations were measured with an enzyme immunoassay in 16 patients with endoscopically confirmed active UC. RESULTS:Plasma concentrations of both MMP-1(13.7±0.2 ng/ml)and TIMP-1(799±140 ng/ml)were significantly elevated in UC patients in comparison to healthy controls (11.9±0.9 ng/ml and 220±7 ng/ml respectively).There was no correlation between TIMP-1 and MMP-1 concentrations (r=0.02).TIMP-1 levels revealed significant positive correlations with scored endoscopic degree of mucosal injury, disease activity index and clinical activity index values as well as C-reactive protein *** was no correlation between MMP-1 and laboratory,clinical or endoscopic indices of the disease ***: These results confirm the role of both MMP- 1 and TIMP-1 in the pathogenesis of ulcerative colitis. However only TIMP-1 can be useful as a biomarker of the disease activity, demonstrating association with clinical and endoscopic pictures.

关键词： Adult Aged Biological Markers C-Reactive Protein Colitis, Ulcerative Comparative Study Female Humans Interstitial Collagenase Male Middle Aged Reference Values Tissue Inhibitor of Metalloproteinase-1

Stochastic energy-demand analyses with random input parameters for the single-family house

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Building Simulation 2022年第3期15卷 357-371页

作者： Marcin Koniorczyk Witold Grymin Marcin Zygmunt Dalia Bednarska alicja Wieczorek Dariusz Gawin Lodz University of Technology Department of Building Physics and Building MaterialsPoland

In the analyses of the uncertainty propagation of buildings’energy-demand,the Monte Carlo method is commonly *** this study we present two alternative approaches:the stochastic perturbation method and the transformed random variable *** energy-demand analysis is performed for the representative single-family house in *** investigation is focused on two independent variables,considered as uncertain,the expanded polystyrene thermal conductivity and external temperature;however the generalization on any countable number of parameters is ***,the propagation of the uncertainty in the calculations of the energy consumption has been investigated using two aforementioned *** stochastic perturbation method is used to determine the expected value and central moments of the energy consumption,while the transformed random variable method allows to obtain the explicit form of energy consumption probability density function and further characteristic parameters like quantiles of energy *** calculated data evinces a high accordance with the results obtained by means of the Monte Carlo *** most important conclusions are related to the computational cost reduction,simplicity of the application and the appropriateness of the proposed approaches for the buildings’energy-demand calculations.

关键词： energy demand stochastic analysis transformed random variable method thermal conductivity probability distribution random multivariable

Epidemiological characteristics of inflammatory bowel disease in North-Eastern Poland

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World Journal of Gastroenterology 2005年第17期11卷 2630-2633页

作者： alicja Wiercinska-Drapalo Jerzy Jaroszewicz Robert Flisiak Danuta Prokopowicz Department of Infectious Diseases Intestinal Diseases Unit Medical University of Bialystok15-540 BialystokZurawia str. 14Poland

AIM:To provide the clinical and epidemiological data of inflammatory bowel disease (IBD) patients of North-Eastern Poland. METHODS: A total of 248 IBD patients diagnosed and hospitalized in the Department of Infectious Diseases in Bialystok between 1990 and 2003 were included in the study. We analyzed age, sex, education, characteristics of job, type of the environment, discontinuation of employment due to IBD, colitis extent, need of surgical treatment, and coexistence of other diseases. RESULTS: Two hundred and thirty-three IBD patients (94%) were diagnosed as ulcerative colitis (DC), and only 15 (6%) were diagnosed as Crohn's disease (CD). Patients with CD were significantly younger at the time of diagnosis and male predominance was observed. The mean age of the patients at the time UC diagnosis was 44.9±1.1 years. Histogram of the age of patients showed the characteristic biphasic distribution with two peaks between 20 and 40 years and between 60 and 70 years. The predominant form of UC was left sided colitis, which affected almost 80% of the studied population. The most extensive form - pancolitis was present in 34 patients (15%). Only 6% of UC patients required surgery, whereas 36% of CD patients underwent surgery (P<0.005). Among coexisting disorders, cholelithiasis was the most prevalent and demonstrated in 35 patients (14%), pulmonary disorders were diagnosed in 2%, and psoriasis in 1.4%. Since 1998, the number of admitted IBD patients has slightly increased. CONCLUSION: Occurrence of UC in Poland is much higher than that of CD. The majority of UC cases are diagnosed in young people (20-40 years) with the predominance of male patients. The most common clinical form of UC is left sided colitis.

关键词： IBDepidemiology Extraintestinal manifestations Employment discontinuation

The Integration of Architectural Ceramics and Environmental Design as an Artistic Expression in Public Spaces-a Design at East Park in Wroclaw

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The Integration of Architectural Ceramics and Environmental ...

作者： alicja Osinska 华东师范大学

学位级别：硕士

陶瓷在人类历史上具有重要的意义,是考古发现的宝贵知识来源。考古学家通过研究古代陶瓷的应用形式,探索诸多社会关系的同时,也发现了这种材料在艺术、工艺和建筑中的广泛应用。如今,陶瓷材料的用途极为广泛,涵盖了传统的现代艺术形式(... 详细信息

陶瓷在人类历史上具有重要的意义,是考古发现的宝贵知识来源。考古学家通过研究古代陶瓷的应用形式,探索诸多社会关系的同时,也发现了这种材料在艺术、工艺和建筑中的广泛应用。如今,陶瓷材料的用途极为广泛,涵盖了传统的现代艺术形式(如艺术陶瓷)、建筑陶瓷、室内设计、甚至包括牙科和航空等科学领域。然而,陶瓷作为艺术品似乎已经被现代设计所遗忘。本研究旨在调查建筑陶瓷在当代环境设计项目中的艺术层面应用。本案例研究探讨了建筑陶瓷的艺术表现与环境设计的融合。研究结果清晰表明,公共空间中陶瓷与环境设计相结合的相关研究和出版物较为缺乏。本次调研通过探索环境设计的主要过程与步骤,旨在为学科的未来课程设计提供具有结构性的参考,以填补这一领域的空白。不同地区的气候条件决定了材料特性的不同,因此本文强调陶瓷在不同地方应用的可能性。对从事建筑陶瓷工作的设计师的案例研究进行了研究,以将研究定位在论文对世界各地区发生的现象的假设中。此方法提供了一个可能的设计过程系统,可以作为该领域其他从业者的模型。最终提交的内容包括论文、环境比较、案例研究比较、设计建议以及研究结论。

关键词：建筑陶瓷环境设计当代陶瓷艺术外墙陶瓷公共陶瓷艺术

Plasma interleukin-18 reflects severity of ulcerative colitis

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World Journal of Gastroenterology 2005年第4期11卷 605-608页

作者： alicja Wiercinska-Drapalo Flobert Flisiak Jerzy Jaroszewicz Danuta Prokopowicz Department of Infectious Diseases Intestinal Diseases Unit Medical University of BialystokZurawia str. 1415-540 Biaystok Poland

AIM: The aim of this study was to evaluate the association between ulcerative colitis activity and plasma or mucosal concentrations of interleukin (IL)-18. METHODS: 11-18 concentrations were measured in plasma and mucosal samples from 15 patients with active ulcerative colitis (UC). RESULTS: The mean plasma concentration of IL-18 measured in all patients (422±88 pg/mL) doubled the mean value in healthy controls (206±32 pg/mL); however, the difference was not statistically significant. Plasma IL-18 levels revealed a significant positive correlation with scored endoscopic degree of mucosal injury, disease activity index, clinical activity index and C-reactive protein concentration. The mean concentration of plasma IL-18 was significantly higher in patients with severe ulcerative colitis (535±115 pg/mL) than in patients with mild ulcerative colitis (195±41 pg/mL), and in healthy controls. Although the mucosal mean IL-18 concentration in severe ulcerative colitis (2 523±618 pg/mg protein) doubled values observed in mild one (1347±308 pg/mg protein), there was no statistically significant difference. CONCLUSION: Plasma IL-18 can be considered as a surrogate marker helpful in evaluation of ulcerative colitis activity.

关键词： Ulcerative colitis Interleukin-18