Volatile organic compounds for the detection of hepatocellular carcinoma—A scoping review

作     者：Sayed Metwaly Alicja Psica Opeyemi Sogaolu Irfan Ahmed Ashis Mukhopadhya Mirela Delibegovic Mohamed Bekheit 

作者机构：Division of Internal MedicineAberdeen Royal InfirmaryNHS GrampianScotlandAberdeenAB252ZDUnited Kingdom Aberdeen Cardiovascular and Diabetes CentreSchool of MedicineMedical Sciences and NutritionUniversity of AberdeenForesterhill Health CampusAberdeenAB252ZDUnited Kingdom Department of Critical Care MedicineUniversity of CalgaryAlberta T2N 2T9Canada Department of General SurgeryAberdeen Royal InfirmaryNHS GrampianScotlandAberdeen AB252ZDUnited Kingdom Pakistan Kidney and Liver Institute and Research CentreLahore 54000Pakistan HépaticaCentre of Integrated HPB CareElite HospitalAlexandria 21325Egypt 

出 版 物：《iLIVER》 (国际肝胆健康（英文）)

年 卷 期：2024年第3卷第1期

页      面：45-51页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：funded by the endowment fund NHS Grampian as part of the project(IRAS 250335) 

主　　题：Hepatocellular carcinoma Volatile organic compounds Metabolomics 

摘      要：Hepatocellular carcinoma(HCC)is an increasingly common and the second leading cause of cancer mortality worldwide with a 5-year survival rate about 12%.Less than 20%of HCC patients are eligible to curative treatment owing to the late ***,there is a need for a readily accessible,early screening *** scoping review critically appraises and synthesizes the current published knowledge about the use of exhaled volatile organic compounds(VOCs)as a potential noninvasive means for HCC detection aiming to advance this nascent field.A systematic electronic search was *** search strategy included all studies published until the 24th of March 2023 using a combination of relevant *** search yielded 9 publications using the Preferred Reporting Items for Systematic Reviews and Meta-analyses *** of the studies described in vitro experiments,and seven clinical studies were conducted on small groups of ***,42 headspace gases were analyzed in the in vitro ***,the clinical studies included 420 HCC patients and 630 *** studies reported potential role for a combination of VOCs in the diagnosis of ***,there is lack of *** there appears to be promise in VOCs research associated with HCC,there is no single volatile biomarker in exhaled breath attributed to HCC and data from extracted studies indicates a lack of *** multicentre population studies are required to verify the existence of VOCs linked to HCC.