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Pesticide Residue Control in the Years 1983-1985

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Biomedical and Environmental Sciences 1989年第3期2卷 287-294页

作者： IVANO CAMONI alfonso di muccio MARIA SANDRA BELLISAI MARIO BERSACCHI PAOLO CITTI Istituto Superiore di Sanita Lab. Tossicologia Applicata Viale Regina Elena Rome Italy Ministero

Levels of organochlorinated, organophosphate, dithiocarbamic, benzimidazolic, and phthalimidic compounds, as well as some other pesticide residues obtained from Regional Laboratories in the years 1983-1985, were assembled and presented as a part of a study aimed at evaluating food contamination. Approximately 2000 samples of vegetables, fruits, cereals, and food of animal origin were analyzed by local laboratories during the years 1983, 1984, and 1985. Samples were randomly obtained from the market, at production levels, or sometimes at custom sites. Approximately 10,000 determinations of single compounds or classes of compounds were carried out. The analytical results are presented and compared with the Italian maximum residue limits. In the majority of the samples analyzed, either there were no residues or the residues were below the permitted level for the specific pesticide in each commodity. High levels of residues were present in a few cases, mainly with respect to some fungicides in fruits and vegetables and chlorinated compounds in some animal products. (c)1989 Academic Press, Inc.

关键词： Pesticide Residue Control in the Years 1983-1985

Voltage controlled iontronic switches:a computational method to predict electrowetting in hydrophobically gated nanopores

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International Journal of Smart and Nano Materials 2024年第1期15卷 165-185页

作者： Goncalo Paulo Alberto Gubbiotti Giovanni di muccio Alberto Giacomello dipartimento di Ingegneria Meccanica e Aerospaziale Sapienza Universita di RomaRomeItaly

Reliable and controllable switches are crucial in nanofluidics and *** channels found in nature serve as a rich source of inspiration due to their intricate mechanisms modulated by stimuli like pressure,temperature,chemical species,and *** artifi-cial replication of the properties of these channels is challenging due to their complex chemistry,limited stability range,and intricate moving parts,allosterically ***,we can harness some of the gating mechanisms of ion channels for nanofluidic and iontronic *** theoretical and computational study explores the use of electrowetting in simple hydrophobic nanopores to control their conductance using an external applied *** employ restrained molecular dynamics to calculate the free energy required for wetting a model nanopore under different *** a simple theory,we generate free energy profles across a wide voltage *** also computed transition rates between conductive and non-conductive states,showing their voltage depen-dence and how this behavior can impair memory to the system,resembling the memristor behavior voltage-gated channels in the *** proposed framework provides a promising avenue for designing and controlling hydrophobic nanopores via electrowet-ting,enabling potential applications in neuromorphic iontronics.

关键词： Electrowetting lontronics hydrophobic gating

An innovative heterogeneous transfer learning framework to enhance the scalability of deep reinforcement learning controllers in buildings with integrated energy systems

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Building Simulation 2024年第5期17卷 739-770页

作者： Davide Coraci Silvio Brandi Tianzhen Hong alfonso Capozzoli Politecnico di Torino Department of EnergyTEBE research groupBAEDA Lab.Corso Duca degli Abruzzi 24Torino10129Italy Building Technology and Urban Systems division Lawrence Berkeley National LaboratoryOne Cyclotron RoadBerkeleyCA 94720USA

Deep Reinforcement Learning(DRL)-based control shows enhanced performance in the management of integrated energy systems when compared with Rule-Based Controllers(RBCs),but it still lacks scalability and generalisation due to the necessity of using tailored models for the training *** Learning(TL)is a potential solution to address this ***,existing TL applications in building control have been mostly tested among buildings with similar features,not addressing the need to scale up advanced control in real-world scenarios with diverse energy *** paper assesses the performance of an online heterogeneous TL strategy,comparing it with RBC and offline and online DRL controllers in a simulation setup using EnergyPlus and *** study tests the transfer in both transductive and inductive settings of a DRL policy designed to manage a chiller coupled with a Thermal Energy Storage(TES).The control policy is pre-trained on a source building and transferred to various target buildings characterised by an integrated energy system including photovoltaic and battery energy storage systems,different building envelope features,occupancy schedule and boundary conditions(e.g.,weather and price signal).The TL approach incorporates model slicing,imitation learning and fine-tuning to handle diverse state spaces and reward functions between source and target *** show that the proposed methodology leads to a reduction of 10% in electricity cost and between 10% and 40% in the mean value of the daily average temperature violation rate compared to RBC and online DRL ***,online TL maximises self-sufficiency and self-consumption by 9% and 11% with respect to ***,online TL achieves worse performance compared to offline DRL in either transductive or inductive ***,offline Deep Reinforcement Learning(DRL)agents should be trained at least for 15 episodes to reach the same level of performance as the online

关键词： transfer learning reinforcement learning building control building energy management

Anatomical and functional changes after dexamethasone implant and ranibizumab in diabetic macular edema: a retrospective cohort study

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International Journal of Ophthalmology(English edition) 2019年第10期12卷 1589-1597页

作者： Leonardo Mastropasqua Silvio di Staso Rossella D’Aloisio Alessandra Mastropasqua Luca diAntonio alfonso Senatore Marco Ciancaglini Marta di Nicola Giuseppe di Martino DanieleTognetto Lisa Toto Department of Medicine and Science of Ageing OphthalmologyClinicUniversity“G.d’Annunzio”Chieti-PescaraChieti66100Italy Department of Life Health and Environmental SciencesOphthalmology ClinicUniversity of L’AquilaL’Aquila67100Italy Department of Medicine Surgery and Health SciencesEyeClinicUniversity of TriesteTrieste34129Italy Department of Medical Oral and Biotechnological SciencesLaboratory of BiostatisticsUniversity“G.d’Annunzio”Chieti-PescaraChieti66100Italy Department of Medicine and Science of Ageing School ofHygiene and Preventive MedicineUniversity“G.d’Annunzio”Chieti-PescaraChieti66100Italy

AIM: To investigate the efficacy and safety of ranibizumab(RZB group) and dexamethasone implant(DEX group) intravitreal treatments in patients with treatment-na?ve center involved diabetic macular edema(DME) by means of functional and morphological ***: This retrospective cohort study included 50 eyes of 50 patients with DME treated either with RBZ or DEX. Best-corrected visual acuity(BCVA) and microperimetry were evaluated at baseline and during a 6-month follow-up. In addition, central macular thickness(CMT) by means of structural optical coherence tomography(OCT) and retinal capillary plexus density and choriocapillary density by means of OCT angiography were assessed in all ***: Functional and morphological parameters significantly improved during the study period in both groups. BCVA improved significantly in both groups witha greater increase in the DEX group compared to the RBZ group(P=0.030). Microperimetry significantly differed during follow-up between the two treatments(P=0.031). In both groups CMT significantly decreased(Pdifferences between the two groups. A statistically significant increase of deep capillary plexus density was detected in both groups at 30 d after therapy. The retreatment rate was 0.70±0.10 and 0.65±0.10 in the RBZ group and 0.65±0.10 and 0.50±0.11 in DEX group at 120 and 180 d respectively. Two out of 25 patients in DEX group showed intraocular pressure increase requiring hypotonic eye ***: Both treatments are very effective for DME treatment during 6 mo of follow-up with a lower retreatment rate in DEX group.

关键词： optical coherence tomography angiography diabetic macular edema intravitreal dexamethasone implant intravitreal ranibizumab injections

Investigation of compensatory postures with videofluoromanometry in dysphagia patients

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World Journal of Gastroenterology 2012年第23期18卷 2973-2978页

作者： Antonio Solazzo Luigi Monaco Lucia Del Vecchio Stefania Tamburrini Francesca Iacobellis Daniela Berritto Nunzia Luisa Pizza alfonso Reginelli Natale di Martino Roberto Grassi Department of Radiology Magrassi-Lanzara Second University of Naples 80138 Napoli Italy Department of Gerontology Geriatrics and Metabolic Diseases Second University of Naples 80138 Napoli Italy Department of Pathology of the Head and Neck Oral Cavity and Audio-verbal Communication Second University of Naples 80138 Napoli Italy UOC diagnostic Imaging PO Pellegrini 80134 Napoli Italy

AIM: To investigate the effectiveness of head compensatory postures to ensure safe oropharyngeal transit. METHODS: A total of 321 dysphagia patients were enrolled and assessed with videofluoromanometry (VFM). The dysphagia patients were classified as follows: safe transit; penetration without aspiration; aspiration before, during or after swallowing; multiple aspirations and no transit. The patients with aspiration or no transit were tested with VFM to determine whether compensatory postures could correct their swallowing disorder. RESULTS: VFM revealed penetration without aspiration in 71 patients (22.1%); aspiration before swallowing in 17 patients (5.3%); aspiration during swallowing in 32 patients (10%); aspiration after swallowing in 21 patients (6.5%); multiple aspirations in six patients (1.9%); no transit in five patients (1.6%); and safe transit in 169 patients (52.6%). Compensatory postures guaranteed a safe transit in 66/75 (88%) patients with aspiration or no transit. A chin-down posture achieved a safe swallow in 42/75 (56%) patients, a head-turned posture in 19/75 (25.3%) and a hyperextended head posture in 5/75 (6.7%). The compensatory postures were not effective in 9/75 (12%) cases. CONCLUSION: VFM allows the speech-language therapist to choose the most effective compensatory posture without a trial-and-error process and check the effectiveness of the posture.

关键词： Aspiration Compensatory postures Oro-pharyngeal dysphagia Videofluoromanometry Chin-down posture Head-turned Hyperextended head

A data analytics-based tool for the detection and diagnosis of anomalous daily energy patterns in buildings

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Building Simulation 2021年第1期14卷 131-147页

作者： Marco Savino Piscitelli Silvio Brandi alfonso Capozzoli Fu Xiao Department of Energy“Galileo Ferraris” TEBE research groupPolitecnico di TorinoTurinItaly Department of Building Services Engineering The Hong Kong Polytechnic UniversityHong KongChina

In this paper,a tool for the detection and diagnosis of anomalous electrical daily energy patterns relative to a transformer substation of a university campus was developed and *** an innovative pattern recognition analysis consisting in a multi-step clustering process,six clusters of anomalous daily load profiles were identified and isolated in two-year historical data of total electrical energy *** infrequent electrical load profiles were found to be strongly affected,in terms of both shape and magnitude,by the energy consumption behaviour related to the heating/cooling mechanical ***,a fault-free predictive model,which uses artificial neural network(ANN)in combination with a Regression Tree,was developed to detect anomalous trends of the electrical energy *** model was able to detect the 93.7%of the anomalous profiles and only the 5%of fault-free days were wrongly predicted as ***,a diagnosis phase was conceived and validated with a testing data set.A number of daily abnormal load profiles were detected and compared with the centroids of the anomalous clusters identified in the pattern-recognition *** work led to the development of a flexible intelligent tool useful for operating a continuous commissioning of the campus facilities.

关键词： anomaly detection data analytics energy management pattern recognition prediction models

Activity and safety of pegylated liposomal doxorubicin,5-fluorouracil and folinic acid in inoperable hepatocellular carcinoma:A phase Ⅱ study

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World Journal of Gastroenterology 2007年第48期13卷 6553-6557页

作者： Giuseppe di Lorenzo Antonio Rea Chiara Carlomagno Stefano Pepe Giovannella Palmieri Roberto Labianca Antonio Chirianni alfonso De Stefano Vincenzo Esposito Sabino De Placido Vincenzo Montesarchio dipartimento di Endocrinologia e Oncologia Molecolare e Clinica Università degli Studi Federico Ⅱ Naples Italy divisione di Oncologia Azienda Ospedaliera Cotugno Naples Italy Oncology Section Ospedali Riuniti Bergamo Italy

AIM: To improve the results of New therapeutic strategies in hepatocellular carcinoma (HCC). We have conducted a phase Ⅱ study with pegylated liposomal doxorubicin (PLD), 5-fluorouracil (5FU) and folinic acid (FA). METHODS: Thirty-one patients with hystologically- confirmed, inoperable HCC, received combination chemotherapy with PLD 25 mg/mq on d 1, 5FU 1200 mg/mq in 48 h continuous infusion, and oral FA 30 mg on d 1 and 2 every 3 wk until disease progression or intolerable toxicity. RESULTS: The median age was 65 years (range 41-82) and 28 patients were hepatitis C virus seropositive (90%). The majority of patients were Child-Pugh Class B (55%). Two patients showed a partial response (PR), and 16 had stable disease (SD). With a median follow-up of 14 mo, the median time to progression of all evaluable patients was 4 mo (95% CI 1.7-7). Median overall survival was 9 mo (95% CI 3-24 mo). After 1 year, 9 of 18 PR/SD patients were alive. Chemotherapy was well tolerated. CONCLUSION: PLD/FU/FA combination seems capable of achieving durable stabilization of HCC. The manageable toxicity supports a role for combination with other anticancer agents.

关键词： Pegylated liposomal doxorubicin 5-fluorouracil Folinic acid Hepatocellular carcinoma

Business Cycle and the Riskiness of Italian Firm： An Empirical Analysis

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Journal of Modern Accounting and Auditing 2012年第1期8卷 66-76页

作者： Filippo di Pietro Giuseppe Lusignani Dolores Oliver alfonso University of Seville Spain University of Bologna Italy

Given the importance of the relationship between default rates and business cycles, we examine the ability of macroeconomic variables, explaining changes on the default rate of Italian companies. Via a VAR （vector autoregressive） model and an analysis of individual equations, we find a significant influence of short-term interest rates, and the growth rate of gross domestic product （GDP） in the euro area, on the default rate of Italian companies in the period 1985-2004. Using the selected macroeconomic variables,

关键词：意大利实证分析周期商业风险国内生产总值宏观经济向量自回归

Experimental Tests on a Pre-Heated Combustion Chamber for Ultra Micro Gas Turbine Device: Air/Fuel Ratio Evaluation

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Engineering（科研） 2016年第11期8卷 789-805页

作者： Roberto Capata Kliton Kylykbashi alfonso Calabria Mario di Veroli Department of Mechanical and Aerospace Engineering University of Roma “Sapienza” Roma Italy

Current portable power generators are mainly based on internal combustion engine since they present higher values of efficiency comparing to other engines;the main reason why internal combustion engine is not convenient for micro power generation (5 - 30 kW) is because of their heaviness. Micro and ultra micro gas turbine devices, based on a micro compressor and a micro turbine installed on the same shaft, are more suitable for this scope for several reasons. Micro turbine systems have many advantages over reciprocating engine generators, such as higher power density (with respect to size and weight), extremely low emissions and few, or just one, moving part. Those designed with foil bearings and air-cooling operate without oil, coolants or other hazardous materials. Micro turbines also have the advantage of having the majority of their waste heat contained in their relatively high temperature exhaust. Micro turbines offer several potential advantages compared to other technologies for small-scale power generation, including: a small number of moving parts, compact size, lightweight, greater efficiency, lower emissions, lower electricity costs, and opportunities to utilize waste fuels. The object of this study is the experimental tests on a stand-alone gas turbine device with a pre-heated combustion chamber (CC), to validate the fuel consumption reduction, compared to an actual and commercial device, used on air models.

关键词： Experimental Tests Combustion Chamber Ultra Micro Gas Turbine Fuel Consumption