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Optimization of tracheoesophageal fistula model established with Tshaped magnet system based on magnetic compression technique

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World Journal of Gastroenterology 2024年第16期30卷 2272-2280页

作者： Miao-Miao Zhang Jian-Qi Mao Lin-Xin Shen ai-hua Shi Xin Lyu Jia Ma Yi Lyu Xiao-Peng Yan Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Shaanxi Provincial Key Laboratory of Magnetic Medicine The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Zonglian College Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Pulmonary and Critical Care Medicine The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Department of Surgical Oncology Shaanxi Provincial People’s HospitalXi’an 710068Shaanxi ProvinceChina

BACKGROUND The magnetic compression technique has been used to establish an animal model of tracheoesophageal fistula(TEF),but the commonly shaped magnets present limitations of poor homogeneity of TEF and poor model *** designed a Tshaped magnet system to overcome these problems and verified its effectiveness via animal *** To investigate the effectiveness of a T-shaped magnet system for establishing a TEF model in beagle *** Twelve beagles were randomly assigned to groups in which magnets of the Tshaped scheme(study group,n=6)or normal magnets(control group,n=6)were implanted into the trachea and esophagus separately under *** time,operation success rate,and accidental injury were *** operation,the presence and timing of cough and the time of magnet shedding were *** in the control group were euthanized after X-ray and gastroscopy to confirm establishment of TEFs after coughing,and gross specimens of TEFs were *** in the study group were euthanized after X-ray and gastroscopy 2 wk after surgery,and gross specimens were *** size was measured in all animals,and then harvested fistula specimens were examined by hematoxylin and eosin(HE)and Masson trichrome *** The operation success rate was 100%for both *** time did not differ between the study group(5.25 min±1.29 min)and the control group(4.75 min±1.70 min;P=0.331).No bleeding,perforation,or unplanned magnet attraction occurred in any animal during the *** the early postoperative period,all dogs ate freely and were generally in good *** in the control group had severe cough after drinking water at 6-9 d after surgery.X-ray indicated that the magnets had entered the stomach,and gastroscopy showed TEF *** specimens of TEFs from the control group showed the formation of fistulas with a diameter of 4.94 mm±1.29 mm(range,3.52-6.56 mm).HE and Masson trichrome staining showed s

关键词： Magnetic surgery Magnetic compression technique Tracheoesophageal fistula Magnet Animal model Beagles

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Construction and validation of a neovascular glaucoma nomogram in patients with diabetic retinopathy after pars plana vitrectomy

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World Journal of Diabetes 2024年第4期15卷 654-663页

作者： Yi Shi Yan-Xin Zhang Ming-Fei Jiao Xin-Jun Ren Bo-Jie Hu ai-hua Liu Xiao-Rong Li Surgical Retina Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China Glaucoma Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China Ocular Trauma Tianjin Key Laboratory of Retinal Functions and DiseasesTianjin Branch of National Clinical Research Center for Ocular DiseaseEye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China

BACKGROUND Neovascular glaucoma(NVG)is likely to occur after pars plana vitrectomy(PPV)for diabetic retinopathy(DR)in some patients,thus reducing the expected *** the risk factors for NVG occurrence and building effective risk prediction models are currently required for clinical *** To develop a visual risk profile model to explore factors influencing DR after *** We retrospectively selected 151 patients with DR undergoing *** patients were divided into the NVG(NVG occurrence)and No-NVG(No NVG occurrence)groups according to the occurrence of NVG within 6 months after *** risk factors for postoperative NVG were screened by logistic regression.A nomogram prediction model was established using R software,and the model’s prediction accuracy was verified internally and externally,involving the receiver operator characteristic curve and correction *** After importing the data into a logistic regression model,we concluded that a posterior capsular defect,preoperative vascular endothelial growth factor≥302.90 pg/mL,glycosylated hemoglobin≥9.05%,aqueous fluid interleukin 6(IL-6)≥53.27 pg/mL,and aqueous fluid IL-10≥9.11 pg/mL were independent risk factors for postoperative NVG in patients with DR(P<0.05).A nomogram model was established based on the aforementioned independent risk factors,and a computer simulation repeated sampling method was used to internally and externally verify the nomogram *** area under the curve(AUC),sensitivity,and specificity of the model were 0.962[95%confidence interval(95%CI):0.932-0.991],91.5%,and 82.3%,*** AUC,sensitivity,and specificity of the external validation were 0.878(95%CI:0.746-0.982),66.7%,and 95.7%,*** A nomogram constructed based on the risk factors for postoperative NVG in patients with DR has a high prediction *** study can help formulate relevant preventive and treatment measures.

关键词： Diabetic retinopathy Retinopathy Neovascular Glaucoma Risk factors Nomogram

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高校跨学科创业团队内部治理机理

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科学学研究 2024年第6期42卷 1278-1287页

作者：陈艾华吴伟浙江理工大学法政学院浙江杭州311103 浙江大学公共管理学院浙江杭州310058

跨学科创业团队是高校开展学术创业的关键载体,加强高校跨学科创业团队内部治理是提升高校科技成果转化力、助推国家创新体系构建的重要举措。高校跨学科创业团队是学术创业绩效提升的源头,其内部如何进行治理,尚缺乏系统而全面的理论... 详细信息

跨学科创业团队是高校开展学术创业的关键载体,加强高校跨学科创业团队内部治理是提升高校科技成果转化力、助推国家创新体系构建的重要举措。高校跨学科创业团队是学术创业绩效提升的源头,其内部如何进行治理,尚缺乏系统而全面的理论与实证研究。本文以高校跨学科创业团队为调查对象,理论结合实证剖析了高校跨学科创业团队内部治理机理与规律,研究发现:在高校跨学科创业团队中,变革型领导对跨学科合作以及学术创业绩效均具有正向影响;跨学科合作在变革型领导和学术创业绩效之间发挥着部分中介效应;冲突中的关系冲突在变革型领导和跨学科合作的不同维度之间既发挥着负向调节效应又发挥着正向调节效应,冲突中的任务冲突在变革型领导和跨学科合作中的合作质量两者之间的关系中具有不显著的负向调节效应。本文的发现强调了高校跨学科创业团队生产力物化过程的匹配规律,也为高校跨学科创业团队内部治理过程中核心要素的耦合提供了证据。

关键词：跨学科创业团队学术创业内部治理

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Risk factors for renal outcomes in children with antineutrophil cytoplasmic antibody-associated vasculitis:a nationwide retrospective study in China

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World Journal of Pediatrics 2024年第5期20卷 506-516页

作者： Li-Wen Tan Jun-Li Wan Chun-hua Zhu Hong Xu Zheng-Kun Xia Li-Zhi Chen Xiao-Chuan Wu Fang Wang Xiao-Rong Liu Cheng-Guang Zhao Xiao-Zhong Li Jian-hua Mao Xiao-Wen Wang Wen-Yan huang Yu-Hong Li Jian-Jiang Zhang Shi-Pin Feng Jun Yang Jiao-Jiao Liu Chun-Lin Gao Li-Ping Rong Lan-Jun Shuai Ke Xu He-Jia Zhang Qiu Li ai-hua Zhang Mo Wang Department of Nephrology Children’s Hospital of Chongqing Medical UniversityZhongshan 2nd Rd.136Chongqing400014China Ministry of Education Key Laboratory of Child Development and Disorders National Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Pediatrics Children’s Hospital of Chongqing Medical UniversityChongqingChina Department of Nephrology Children’s Hospital of Nanjing Medical University72 Guangzhou RoadNanjing210008China Department of Nephrology Children’s Hospital of Fudan UniversityNational Paediatric Medical Center of ChinaShanghaiChina Department of Pediatrics Jinling HospitalNanjing Medical UniversityNanjingChina Department of Pediatrics Jinling HospitalThe First School of Clinical MedicineSouthern Medical UniversityNanjingChina Department of Pediatrics Jinling HospitalMedical School of Nanjing UniversityNanjingChina Department of Pediatric Nephrology and Rheumatology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhouChina Department of Pediatrics The Second Xiangya Hospital of Central South UniversityChangshaChina Department of Pediatrics Peking University First HospitalBeijingChina Department of Nephrology Beijing Children’s HospitalCapital Medical UniversityBeijing100045China National Center for Children’s Health BeijingChina Department of Pediatrics Shengjing Hospital of China Medical UniversityShenyangChina Department of Nephrology and Immunology Children’s Hospital of Soochow UniversitySuzhouChina Department of Nephrology Children HospitalZhejiang University School of MedicineHangzhouChina Department of Nephrology Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science&TechnologyWuhanChina Department of Nephrology and Rheumatology Shanghai Children’s HospitalSchool

Background Pediatric antineutrophil cytoplasmic antibody-associated vasculitis(AAV)is a life-threatening systemic vasculitis featured by liability to renal ***,there are few studies on the risk factors and predictive models for renal outcomes of AAV in *** Data from 179 AAV children in multiple centers between January 2012 and March 2020 were collected *** risk factors and predictive model of end-stage renal disease(ESRD)in AAV were *** Renal involvement was the most typical manifestation(95.5%),and the crescent was the predominant pathological lesion(84.9%).The estimated glomerular filtration rate(eGFR)was evaluated in 114 patients,of whom 59.6%developed ESRD,and the median time to ESRD was 3.20 *** eGFR[P=0.006,odds ratio(OR)=0.955,95%confidence interval(CI)=0.924–0.987]and the percentages of global glomerulosclerosis(pGGS;P=0.018,OR=1.060,95%CI=1.010–1.112)were independent risk factors for ESRD of renal *** on the pGGS and eGFR at renal biopsy,we developed three risk grades of ESRD and one predictive *** Kaplan‒Meier curve indicated that renal outcomes were significantly different in different risk grades(P<0.001).Compared with serum creatinine at baseline,the predictive model had higher accuracy(0.86 versus 0.58,P<0.001)and a lower coefficient of variation(0.07 versus 0.92)in external *** Renal involvement is the most common manifestation of pediatric AAV in China,of which more than half deteriorates into *** predictive model based on eGFR at renal biopsy and the pGGS may be stable and accurate in speculating the risk of ESRD in AAV children.

关键词： Antineutrophil cytoplasmic antibody End-stage renal disease Glomerulonephritis Pediatric nephrology Vasculitis

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Single-center retrospective study of the diagnostic value of doubleballoon enteroscopy in Meckel’s diverticulum with bleeding

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1043-1054页

作者： Tian He Chao Yang Jing Wang Ji-Sheng Zhong ai-hua Li Ya-Jing Yin Li-Ling Luo Chun-Mei Rao Nian-Fen Mao Qiang Guo Zan Zuo Wen Zhang Ping Wan Yunnan Digestive Endoscopy Clinical Medical Center Department of GastroenterologyThe First People’s Hospital of Yunnan ProvinceThe Affiliated Hospital of Kunming University of Science and TechnologyKunming 650032Yunnan ProvinceChina Department of Medicine Kunming University of Science and TechnologyKunming 650093Yunnan ProvinceChina School of Medicine Yunnan University of Traditional Chinese MedicineKunming 650011Yunnan ProvinceChina Department of Gastroenterology Qujing Hospital of Traditional Chinese MedicineQujing 655000Yunnan ProvinceChina Department of Gastroenterology Yunnan University of Traditional Chinese MedicineKunming 650011Yunnan ProvinceChina

BACKGROUND The study aimed to analyze the characteristic clinical manifestations of patients with intestinal disease Meckel’s diverticulum(MD)complicated by digestive tract ***,we aimed to evaluate the value of double-balloon enteroscopy(DBE)in MD diagnosis and the prognosis after laparoscopic diverticula *** To evaluate the value of DBE in the diagnosis and the prognosis after laparoscopic diverticula resection for MD with *** The study retrospectively analyzed relevant data from 84 MD patients treated between January 2015 and March 2022 and recorded their clinical manifestations,auxiliary examination,and follow-up after laparoscopic resection of ***(1)Among 84 MD patients complicated with hemorrhage,77 were male,and 7 were female with an average age of 31.31±10.75 *** incidence was higher in men than in women of different ages;(2)Among the 84 MD patients,65(78.40%)had defecated dark red stools,and 50(58.80%)had no accompanying symptoms during bleeding,indicating that most MD bleeding appeared a dark red stool without accompanying symptoms;(3)The shock index of 71 patients(85.20%)was30%;(4)The DBE-positive rate was 100%(54/54),99mTcpertechnetate-positive scanning rate was 78%(35/45)compared with capsule endoscopy(36%)and small intestine computed tomography(19%).These results suggest that DBE and 99mTc-pertechnetate scans had significant advantages in diagnosing MD and bleeding,especially DBE was a highly precise examination method in MD diagnosis;(5)A total of 54 MD patients with hemorrhage underwent DBE examination before *** endoscopy revealed many mucosal manifestations including normal appearance,inflammatory changes,ulcerative changes,diverticulum inversion,and nodular hyperplasia,with ulcerative changes being the most common(53.70%).This suggests that diverticular mucosal u

关键词： Meckel’s diverticulum with bleeding Double-balloon colonoscopy 99mTc-pertechnetate scanning Capsule endoscopy Ectopic gastric mucosa

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Prognostic value and predictive model of tumor markers in stageⅠtoⅢgastric cancer patients

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World Journal of Clinical Oncology 2024年第8期15卷 1033-1047页

作者： ai-hua Sun Xin-Yu Zhang Yang-Yang huang Lei Chen Qing Wang Xiao-Cong Jiang Department of Radiotherapy Oncology Huizhou Municipal Central HospitalHuizhou 516001Guangdong ProvinceChina Department of Hepatobiliary Surgery Fujian Provincial HospitalFuzhou 350001China Department of General Surgery Xiang'an Hospital of Xiamen UniversityXiamen 361102Fujian ProvinceChina

BACKGROUND Preoperative serum tumor markers have been widely used in the diagnosis and treatment of gastric cancer ***,few studies have evaluated the prognosis of gastric cancer patients by establishing statistical models with multiple serum tumor *** To explore the prognostic value and predictive model of tumor markers in stage I and III gastric cancer *** From October 2018 to April 2020,a total of 1236 patients with stage I to III gastric cancer after surgery were included in our *** relationship between serum tumor markers and clinical and pathological data were *** established a statistical model to predict the prognosis of gastric cancer based on the results of COX regression *** survival(OS)was also compared across different stages of gastric *** The deadline for follow-up was May 31,2023.A total of 1236 patients were included in our *** analysis found that age,clinical stage,T and N stage,tumor location,differentiation,Borrmann type,size,and four serum tumor markers were prognostic factors of OS(Pained from the statistical model,we found that patients with high scores had poorer survival time(P<0.05).Furthermore,in stage I patients,the 3-year OS for scores 0-3 ranged from 96.85%,95%,85%,and 80%.In stage II patients,the 3-year OS for scores 0-4 were 88.6%,76.5%,90.5%,65.5%and 60%.For stage III patients,3-year OS for scores 0-6 were 70.9%,68.3%,64.1%,50.9%,38.4%,18.5%and 5.2%.We also analyzed the mean survival of patients with different *** stage I patients,the mean OS was 55.980 *** stage II,the mean OS was 51.550 *** mean OS for stage III was 39.422 *** Our statistical model can effectively predict the prognosis of gastric cancer patients.

关键词： Gastric cancer Tumor marker Prognosis Overall survival Model

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3T磁共振直肠小视野APT成像

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生物化学与生物物理进展 2024年第6期51卷 1471-1478页

作者：柴旭斌王翌何子骏刘爱华薛蓉中国科学院生物物理研究所脑与认知科学国家重点实验室北京100101 中国科学院大学北京100049 首都医科大学北京天坛医院北京市神经外科研究所北京100070 首都医科大学北京脑重大疾病研究院北京100069 天津中医药大学公共卫生与健康科学学院天津301617 清华大学医学院生物医学工程系北京100084

目的化学交换饱和转移(CEST)成像技术已成为诊断与脑部和全身疾病代谢相关变化的有用工具,通过计算与水分子相邻化合物的可交换质子的含量进行定量分析。具体而言,酰胺质子转移(APT)CEST技术通过比较可交换的内源性蛋白质或肽的含量变... 详细信息

目的化学交换饱和转移(CEST)成像技术已成为诊断与脑部和全身疾病代谢相关变化的有用工具,通过计算与水分子相邻化合物的可交换质子的含量进行定量分析。具体而言,酰胺质子转移(APT)CEST技术通过比较可交换的内源性蛋白质或肽的含量变化来区分正常组织与脑卒中和脑肿瘤组织。在体内的小器官病变诊断中,小视野(rFOV)成像技术已被广泛应用,本研究旨在应用rFOV成像技术来识别直肠中的CEST信号,探讨rFOV成像技术在直肠疾病临床诊断中的潜在效用,并为直肠疾病的放化疗提供代谢影像信息。方法使用3.0T磁共振成像扫描仪对11名健康志愿者进行了横断面全视野(Full_FOV)和rFOV CEST成像。设置的分辨率分别为2.5×2.5×6 mm3和1.5×1.5×6 mm3。采用了0.7μT和2μT两种预饱和脉冲。rFOV成像采用了ZOOM成像方法。对于2μT的饱和脉冲,采用了±3.5 ppm的MTRasym方法进行定量分析,而对于0.7μT的饱和脉冲,则采用Lorentzian Difference的方法来量化CEST的对比度图和曲线。结果相较于Full_FOV成像,rFOV方法可以在保持较好对比度的同时将扫描时间减半。与Full_FOV方法相比,rFOV成像方法可以得出与Full_FOV方法几乎相同的Z谱和MTRasym曲线。此外,以大约3 min的时间可以实现1.5 mm×1.5 mm分辨率的rFOV成像。这种r FOV成像方法可以更好地显示出整个直肠的解剖细节,包括CEST成像对比图及定量分析曲线。结论CEST MRI在直肠疾病诊断方面具有较高价值,采用rFOV技术可以提供更高的空间和时间分辨率。由于其在直肠疾病诊断方面的潜力,CEST MRI可以作为临床诊断直肠疾病的首选。

关键词：化学交换饱和转移成像小视野全视野直肠

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董事高管背景与公司竞争战略发展——企业数字化转型的调节效应

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科学管理研究 2024年第3期42卷 89-96页

作者：张质彬张涵熊爱华山东工商学院经济学院山东烟台264005 山东社会科学院经济研究所山东济南250014 山东财经大学工商管理学院山东济南250014

公司竞争战略是提高自身竞争优势的重要动力。研究具有高管背景的董事对公司竞争战略发展的影响,并选取2010-2021沪深A股上市公司样本数据进行实证检验。研究发现,董事的高管背景明显强化了公司竞争战略,促进了公司成本领先战略和差异... 详细信息

公司竞争战略是提高自身竞争优势的重要动力。研究具有高管背景的董事对公司竞争战略发展的影响,并选取2010-2021沪深A股上市公司样本数据进行实证检验。研究发现,董事的高管背景明显强化了公司竞争战略,促进了公司成本领先战略和差异化战略的发展;进一步地,从企业生命周期角度出发,在公司成长期和衰退期阶段,相比成本领先战略,董事的高管背景明显重视公司的差异化战略;而成熟期阶段,董事的高管背景对成本领先战略和差异化战略均有正向影响。研究有助于深入理解董事的高管背景与公司竞争战略之间的关系,重视“高管经历”董事在我国公司经营过程中的重要作用,也可以为公司治理领域下董事会治理提供理论和实践价值。

关键词：公司竞争战略董事高管背景

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肺腺癌乳腺转移超声及超声造影表现1例

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中国临床医学影像杂志 2024年第7期35卷 517-518页

作者：吕菲菲臧爱华康复大学青岛医院(青岛市市立医院)超声科山东青岛266000

病例女,64岁。因“查体发现左乳低回声结节6天”入院。既往史无特殊。查体:左乳6点可触及一“花生米”大小肿物,质稍硬,无压痛,局部皮肤无红肿、溃破,挤压乳头无溢液。双侧腋窝及锁骨下未触及明显肿物。辅助检查:常规超声(图1~5)示左乳... 详细信息

病例女,64岁。因“查体发现左乳低回声结节6天”入院。既往史无特殊。查体:左乳6点可触及一“花生米”大小肿物,质稍硬,无压痛,局部皮肤无红肿、溃破,挤压乳头无溢液。双侧腋窝及锁骨下未触及明显肿物。辅助检查:常规超声(图1~5)示左乳6点距乳头5 cm探及0.9 cm×0.8 cm极低回声结节,边缘欠光整,可见小分叶,结节内未见钙化灶,后方衰减不著,周边腺体结构未见扭曲,结节内未见明显血流信号,常规超声诊断:左乳极低回声结节,符合BI-RADS 4b类。

关键词：肺腺癌乳腺肿瘤超声检查

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建筑结构隔震技术研究进展

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工程力学 2024年第5期41卷 39-54页

作者：潘鹏曾一曹迎日艾华浩王海深清华大学土木工程系北京100084 土木工程安全与耐久教育部重点实验室清华大学北京100084

建筑结构隔震技术通过在建筑结构底部或中间楼层设置隔震装置,延长结构的自振周期,并提供适当的阻尼使得结构的响应大幅度减小,能够更有效地保护房屋结构以及室内设备的安全,可显著提升建筑震后功能可恢复能力。目前建筑结构隔震技术已... 详细信息

建筑结构隔震技术通过在建筑结构底部或中间楼层设置隔震装置,延长结构的自振周期,并提供适当的阻尼使得结构的响应大幅度减小,能够更有效地保护房屋结构以及室内设备的安全,可显著提升建筑震后功能可恢复能力。目前建筑结构隔震技术已经有较为成熟的技术产品和工程应用,已广泛应用于住宅、医院、学校、博物馆和图书馆等建筑中。随着《建设工程抗震管理条例》的颁布,预期隔震技术将有更广阔的应用场景。隔震建筑也将逐步从低层、简单建筑结构向高层、复杂建筑结构的方向发展。目前常用的隔震装置存在着抗拉能力不足、对竖向地震或竖向环境振动减振效果不足、控制频宽窄、适应性不足以及使用状态及损伤状态难以监测等问题。为此,众多学者针对以上问题进行了深入研究,开发了抗拉隔震支座、三维隔震(振)支座、半主动隔震支座和隔震支座的健康监测系统,为扩展隔震技术的应用范围提供了解决方法。目前,相关研究偏重于新型隔震装置的性能研究,未来应全面考虑新型隔震装置对于建筑的影响,提出配套的设计方法,并进行示范性工程应用,加快隔震技术的推广。

关键词：隔震技术抗拉支座三维隔震(振)支座半主动隔震系统健康监测综述

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