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MicroRNAs as potential diagnostic biomarkers for bipolar disorder

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Neural Regeneration Research 2025年第6期20卷 1681-1695页

作者： Bridget Martinez Philip v.Peplow Department of Pharmacology University of Nevada-RenoRenoNVUSA Department of Medicine University of Nevada-RenoRenoNVUSA Department of Anatomy University of OtagoDunedinNew Zealand

Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class c) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder

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Neural Regeneration Research 2025年第7期20卷 1957-1970页

Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life ***,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress *** addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate *** suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress *** performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSD)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to December *** included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum *** of these studies had also used whole *** studies were excluded as they did not involve microRNA *** of the studies had collected samples from adult male veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult *** measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString *** six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSD subjects compared to *** miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSD and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/

关键词： biomarker diagnosis microRNA peripheral blood mononuclear cells plasma extracellular vesicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAURABH R.KIRAN D.SINGH R.vAISH v.S.cHAUHAN School of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the c0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

关键词： finite element method (FEM) nonlinear Green-Lagrange inverse hyperbolic shear deformation theory (IHSDT) bio-inspired composite plate helicoidal O322

Influence of cobalt on performance of cu-ceO2 catalysts for preferential oxidation of cO

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Journal of Rare Earths 2020年第9期38卷 941-950,I0001页

作者： Sachin Malwadkar Parthasarathi Bera c.v.v.Satyanarayana catalysis Division CSIR-National Chemical LaboratoryPune 411008India Surface Engineering Division CSIR-National Aerospace LaboratoriesBengaluru 560017India

copper and cobalt oxides supported on ceO2 were investigated for preferential oxidation of carbon monoxide(cO-PROX)in the presence of excess hydrogen and cO2.(cuo)1-x(co3 O4)x/3-(ceO2)2.5(x=0,0.25,0.50,0.75,0.85 and 1)catalysts were prepared by coprecipitation *** mixed oxide catalysts were characterized by several physicochemical techniques,such as BET surface area(SBET),X-ray diffraction(XRD),high resolution transmission electron microscopy(HRTEM),temperature programmed reduction(TPR)and X-ray photoelectron spectroscopy(XPS).XRD studies show the peaks related to cuO and co3 O4 phases in copper and cobalt containing ceO2 *** average particle size of the ceO2 crystallites is in the range of 8-10 nm as evaluated from HRTEM *** studies demonstrate that cu,co and ce in(cuO)1-x(co3O4)x/3-(ceO2)2.5 catalysts are presented in+2 and+1,+3 and+2 and+4 and+3 oxidation states,*** catalyst with x=0.75 shows better activity and selectivity towards *** the catalyst with only copper(cuO-ceO2,x=0)shows good activity but reverse water gas shift(RWGS)reaction is noticed at high *** the other hand,RWGS reaction is suppressed on the cobalt containing cuO-ceO2 *** on ceO2 with x=1 shows hardly any activity for PRoX reaction at low *** methanation activity is observed on cuO-ceO2 or co3O4-ceO2 *** contrast,combination of copper and cobalt on ceO2 shows methanation of cO where enhanced activity is observed with increasing in cobalt content.

关键词： cO-PROX cu-ceO2 XRD XPS Methanation H2O addition

Effect of sintering temperature on the chemical bonding,electronic structure and electrical transport properties of β-Ga_(1.9)Fe_(0.1)O_(3) compounds

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Journal of Materials Science & Technology 2021年第8期67卷 135-144页

作者： Swadipta Roy c.v.Ramana center for Advanced Materials Research(cMR) University of Texas at El PasoEl Paso500 W University AveEl PasoTX79968United States

A model system,which is based on iron(Fe)doped gallium oxide(Ga_(2)O_(3))(Ga_(1.9)Fe_(0.1)O_(3)),has been considered to elucidate the combined effect of transition-metal ion doping and processing temperature on the chemistry,local structure and chemical bonding,and electrical transport properties of a wide band gap oxide(Ga_(2)O_(3)).The Ga_(1.9)Fe_(0.1)O_(3) compounds were synthesized using standard high-temperature solid state reaction *** effect of processing conditions in terms of different calcination and sintering environments on the structural and electrical properties of Ga_(1.9)Fe_(0.1)O_(3) compounds is studied in *** characterization by Raman spectroscopy revealed that Ga_(1.9)Fe_(0.1)O_(3) compounds exhibit monoclinic crystal symmetry,which is quite similar to the intrinsic parental crystal structure,though Fedoping induces lattice *** temperature(T_(sint))which was varied in the range of 900-1200℃,has significant impact on the structure,chemical bonding,and electrical properties of Ga_(1.9)Fe_(0.1)O_(3) *** spectroscopic measurements indicate the proper densification of the Ga_(1.9)Fe_(0.1)O_(3) compounds achieved through complete Fe diffusion into the parent Ga_(2)O_(3) lattice which is evident at the highest sintering *** X-ray photoelectron spectroscopy validates the chemical states of the constituent elements in Ga_(1.9)Fe_(0.1)O_(3) *** electrical properties of Ga_(1.9)Fe_(0.1)O_(3) fully controlled by T_(sint),which governed the grain size and microstructural *** temperature and frequency dependent electrical measurements demonstrated the salient features of the Fe doped Ga_(2)O_(3) *** activation energy determined from Arrhenius equation is 0.5 e *** results demonstrate that control over structure,morphology,chemistry and electrical properties of the Ga_(1.9)Fe_(0.1)O_(3) compounds can be achieved by optimizing T_(sint).

关键词： Ga_(2)O_(3)compounds Fe-doping Raman spectroscopy chemical bonding Electrical properties

Size Effects of the critical Temperature in Ferroelectric Thin Films

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communications in Theoretical Physics 2007年第7期48卷 183-188页

作者： v.c.Lo Institute of Physics and center for condensed Matter Physics Chinese Academy of SciencesBeijing 100080China

The size effects of the critical behaviors for the systems of interacting spins are discussed extensively *** this paper,the finite-size dependence of the critical temperature and susceptibility of the ferroelectric thinfilm are investigated numerically based on the four-state Potts model with the nearest-neighbor interactions between thedipole *** four orientations of the domains exist in the ferroelectric film and the movement of the domainwalls determines the polarization switching process besides the boundary conditions of the *** critical exponentsare obtained and our investigations show that the boundary conditions play the important roles for the ferroelectricproperties of the thin films and the critical behavior of the thin films strongly depends on the feature of the surface.

关键词： ferroelectric thin film critical temperature size effects

Multifunctional A356 alloy/PKSAnp composites:Microstructure and mechanical properties

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Defence Technology（防务技术） 2020年第3期16卷 731-736页

作者： v.S.Aigbodion I.c.Ezema Department of Metallurgical and Materials Engineering University of NigeriaNsukkaNigeria

Mechanical properties and microstructure of multifunctional composites produced with palm kernel shell ash nano particle(PKSAnp)-A356 alloy composites was *** composites were produced using Double layer feeding stir casting method(DLF-ScM) by adding 1 wt%-4 wt.% *** microstructure,density,electrical and mechanical properties were *** results shows that there was a uniform distribution of the PKSAnp in A356 *** mismatch at the interface between the PKSAnp and A356 alloy was 4.26%.Improvement of 30.47%,41.91%,49.52%,40.90% and 65.09% were obtained for hardness values,tensile,yield strength,%elongation and impact energy at 4 wt% *** work has established that the developed composites can be used for multifunctional applications where combination of toughness and strength is vital.

关键词： PKSAnp A356 alloy Microstructure Electrical and mechanical properties

comment on “constraining the smoothness parameter and dark energy using observational H(z) data”

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Research in Astronomy and Astrophysics 2011年第6期11卷 637-640页

作者： v.c.Busti R.c.Santos Instituto de Astronomia Geofísica e Ciências AtmosféricasUniversidade de So PauloSo Paulo05508-090 SPBrazil Departamento de ciê ncias Exatas e da Terra Universidade Federal de So Paulo(UNIFESP)Diadema09972-270 SPBrazil

We discuss a recent analysis by Yu et al.[RAA 11,125（2011）] about constraints on the smoothness parameter α and dark energy models using observational H（z） *** is argued here that their procedure is conceptually inconsistent with the basic assumptions underlying the adopted Dyer-Roeder *** order to properly quantify the influence of the H（z） data on the smoothness parameter α,a χ2-test involving a sample of type Ia supernovae and H（z） data in the context of a flat ΛcDM model is *** result is confronted with an earlier approach discussed by Santos et al.（2008） without H（z） *** the（Ωm,α） plane,it is found that such parameters are now restricted to be in the intervals 0.66 ≤ α ≤ 1.0 and 0.27 ≤ Ωm ≤ 0.37 within the 95.4 confidence level（2σ）,and,therefore,are fully compatible with the homogeneous *** basic conclusion is that a joint analysis involving H（z） data can indirectly improve our knowledge about the influence of the ***,this happens only because the H（z） data provide tighter constraints on the matter density parameter Ωm.

关键词： cosmology — dark energy — cosmological parameters

Analysis on critical Success Factors for Agile Manufacturing Evaluation in Original Equipment Manufacturing Industry-An AHP Approach

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chinese Journal of Mechanical Engineering 2016年第5期29卷 880-888页

作者： c Ajay Guru Dev v S Senthil Kumar Department of Mechanical Engineering CEG Anna University

Manufacturing industries are facing challenges in the implementation of agile manufacturing in their products and processes. Agility is widely accepted as a new competitive concept in the manufacturing sector in fulfilling varying customer demand. Thus, evaluation of agile manufacturing in industries has become a necessity. The success of an organisation depends on its ability to manage finding the critical success factors and give them special and continued attention in order to bring about high performance. This paper proposes a set of critical success factors （cSFs） for evaluating agile manufacturing considered appropriate for the manufacturing sector. The analytical hierarchy process （AHP） method is applied for prioritizing the success factors, by summarizing the opinions of experts. It is believed that the proposed cSFs enable and assist manufacturing industries to achieve a higher performance in agile manufacturing so as to increase competitiveness.

关键词： critical success factor analytic hierarchy process pairwise comparison